-
1
-
-
84924271853
-
Global cancer statistics 2012
-
Torre, L. A. et al. Global cancer statistics, 2012. CA Cancer J. Clin. 65, 87-108 (2015).
-
(2015)
CA Cancer J. Clin
, vol.65
, pp. 87-108
-
-
Torre, L.A.1
-
2
-
-
44249086425
-
Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship
-
Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E. & Adjei, A. A. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83, 584-594 (2008).
-
(2008)
Mayo Clin. Proc
, vol.83
, pp. 584-594
-
-
Molina, J.R.1
Yang, P.2
Cassivi, S.D.3
Schild, S.E.4
Adjei, A.A.5
-
3
-
-
84877642129
-
Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed.: American College of Chest Physicians evidence-based clinical practice guidelines
-
Alberg, A. J., Brock, M. V., Ford, J. G., Samet, J. M. & Spivack, S. D. Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed.: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143, e1S-e29S (2013).
-
(2013)
Chest
, vol.143
, pp. e1S-e29S
-
-
Alberg, A.J.1
Brock, M.V.2
Ford, J.G.3
Samet, J.M.4
Spivack, S.D.5
-
4
-
-
34648815009
-
Lung cancer in never smokers-a different disease
-
Sun, S., Schiller, J. H. & Gazdar, A. F. Lung cancer in never smokers-a different disease. Nat. Rev. Cancer 7, 778-790 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 778-790
-
-
Sun, S.1
Schiller, J.H.2
Gazdar, A.F.3
-
5
-
-
13444300937
-
Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study
-
Vineis, P. et al. Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study. Br. Med. J. 330, 277 (2005).
-
(2005)
Br. Med. J
, vol.330
, pp. 277
-
-
Vineis, P.1
-
6
-
-
0030873467
-
The accumulated evidence on lung cancer and environmental tobacco smoke
-
Hackshaw, A. K., Law, M. R. & Wald, N. J. The accumulated evidence on lung cancer and environmental tobacco smoke. Br. Med. J. 315, 980-988 (1997).
-
(1997)
Br. Med. J
, vol.315
, pp. 980-988
-
-
Hackshaw, A.K.1
Law, M.R.2
Wald, N.J.3
-
7
-
-
85017359616
-
Nicotine, carcinogen, and toxin exposure in long-term e-cigarette and nicotine replacement therapy users: A cross-sectional study
-
Shahab, L. et al. Nicotine, carcinogen, and toxin exposure in long-term e-cigarette and nicotine replacement therapy users: a cross-sectional study. Ann. Intern. Med. 166, 390-400 (2017).
-
(2017)
Ann. Intern. Med
, vol.166
, pp. 390-400
-
-
Shahab, L.1
-
8
-
-
57349139100
-
Varenicline for tobacco dependence
-
Hays, J. T. & Ebbert, J. O. Varenicline for tobacco dependence. N. Engl. J. Med. 359, 2018-2024 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 2018-2024
-
-
Hays, J.T.1
Ebbert, J.O.2
-
9
-
-
84924912222
-
Electronic nicotine delivery systems: A policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology
-
Brandon, T. H. et al. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. J. Clin. Oncol. 33, 952-963 (2015).
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 952-963
-
-
Brandon, T.H.1
-
10
-
-
84907808265
-
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
-
Zhang, J. et al. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346, 256-259 (2014).
-
(2014)
Science
, vol.346
, pp. 256-259
-
-
Zhang, J.1
-
11
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
-
12
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
-
Turke, A. B. et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 17, 77-88 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
-
13
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao, W. et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2, e17 (2005).
-
(2005)
PLoS Med
, vol.2
, pp. e17
-
-
Pao, W.1
-
14
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding, L. et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455, 1069-1075 (2008).
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
-
15
-
-
85028561562
-
Precision diagnosis and treatment for advanced non-small-cell lung cancer
-
Reck, M. & Rabe, K. F. Precision diagnosis and treatment for advanced non-small-cell lung cancer. N. Engl. J. Med. 377, 849-861 (2017).
-
(2017)
N. Engl. J. Med
, vol.377
, pp. 849-861
-
-
Reck, M.1
Rabe, K.F.2
-
16
-
-
0042964835
-
P53 mutations and survival in stage i non-small-cell lung cancer: Results of a prospective study
-
Ahrendt, S. A. et al. p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. J. Natl. Cancer Inst. 95, 961-970 (2003).
-
(2003)
J. Natl. Cancer Inst
, vol.95
, pp. 961-970
-
-
Ahrendt, S.A.1
-
17
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543-550 (2014).
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
18
-
-
85027893400
-
Integrative clinical genomics of metastatic cancer
-
Robinson, D. R. et al. Integrative clinical genomics of metastatic cancer. Nature 548, 297-303 (2017).
-
(2017)
Nature
, vol.548
, pp. 297-303
-
-
Robinson, D.R.1
-
19
-
-
84962301577
-
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
-
McGranahan, N. et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351, 1463-1469 (2016).
-
(2016)
Science
, vol.351
, pp. 1463-1469
-
-
McGranahan, N.1
-
20
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509-2520 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
-
21
-
-
84961858396
-
STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment
-
Koyama, S. et al. STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment. Cancer Res. 76, 999-1008 (2016).
-
(2016)
Cancer Res
, vol.76
, pp. 999-1008
-
-
Koyama, S.1
-
22
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 (2012).
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
23
-
-
85032427297
-
Systemic therapy for stage IV non-small-cell lung cancer: American society of clinical oncology clinical practice guideline update
-
Hanna, N. et al. Systemic therapy for stage IV non-small-cell lung cancer: american society of clinical oncology clinical practice guideline update. J. Clin. Oncol. 35, 3484-3515 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. 3484-3515
-
-
Hanna, N.1
-
24
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller, J. H. et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N. Engl. J. Med. 346, 92-98 (2002).
-
(2002)
N. Engl. J. Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
-
25
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advancedstage non-small-cell lung cancer
-
Scagliotti, G. V. et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advancedstage non-small-cell lung cancer. J. Clin. Oncol. 26, 3543-3551 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
-
26
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler, A. et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 355, 2542-2550 (2006).
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
-
27
-
-
84937518476
-
Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): An open-label, randomised, controlled phase 3 trial
-
Thatcher, N. et al. Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial. Lancet Oncol. 16, 763-774 (2015).
-
(2015)
Lancet Oncol
, vol.16
, pp. 763-774
-
-
Thatcher, N.1
-
28
-
-
84906903314
-
Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
-
Garon, E. B. et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384, 665-673 (2014).
-
(2014)
Lancet
, vol.384
, pp. 665-673
-
-
Garon, E.B.1
-
29
-
-
84994087188
-
Lung cancer: Current therapies and new targeted treatments
-
Hirsch, F. R. et al. Lung cancer: current therapies and new targeted treatments. Lancet 389, 299-311 (2017).
-
(2017)
Lancet
, vol.389
, pp. 299-311
-
-
Hirsch, F.R.1
-
30
-
-
84959324583
-
The IASLC lung cancer staging project: Proposals for revision of the tnm stage groupings in the forthcoming (Eighth) Edition of the TNM classification for lung cancer
-
Goldstraw, P. et al. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J. Thorac. Oncol. 11, 39-51 (2016).
-
(2016)
J. Thorac. Oncol
, vol.11
, pp. 39-51
-
-
Goldstraw, P.1
-
31
-
-
85029232301
-
Adjuvant systemic therapy and adjuvant radiation therapy for stage i to IIIA completely resected non-small-cell lung cancers: American Society of Clinical Oncology/Cancer Care Ontario clinical practice guideline update
-
Kris, M. G. et al. Adjuvant systemic therapy and adjuvant radiation therapy for stage I to IIIA completely resected non-small-cell lung cancers: American Society of Clinical Oncology/Cancer Care Ontario clinical practice guideline update. J. Clin. Oncol. 35, 2960-2974 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. 2960-2974
-
-
Kris, M.G.1
-
32
-
-
85021054103
-
Robotic versus video-assisted lobectomy/segmentectomy for lung cancer: A meta-analysis
-
Liang, H. et al. Robotic versus video-assisted lobectomy/segmentectomy for lung cancer: a meta-analysis. Ann. Surg. https://doi.org/10.1097/SLA.0000000000002346 (2017).
-
(2017)
Ann. Surg
-
-
Liang, H.1
-
33
-
-
85019871910
-
Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis
-
Chi, A., Chen, H., Wen, S., Yan, H. & Liao, Z. Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis. Radiother. Oncol. 123, 346-354 (2017).
-
(2017)
Radiother. Oncol
, vol.123
, pp. 346-354
-
-
Chi, A.1
Chen, H.2
Wen, S.3
Yan, H.4
Liao, Z.5
-
34
-
-
0025009172
-
A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer
-
Dillman, R. O. et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N. Engl. J. Med. 323, 940-945 (1990).
-
(1990)
N. Engl. J. Med
, vol.323
, pp. 940-945
-
-
Dillman, R.O.1
-
35
-
-
80054072961
-
Sequential vs. Concurrent chemoradiation for stage III non-small cell lung cancer: Randomized phase III trial RTOG 9410
-
Curran, W. J., Jr et al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410. J. Natl. Cancer Inst. 103, 1452-1460 (2011).
-
(2011)
J. Natl. Cancer Inst
, vol.103
, pp. 1452-1460
-
-
Curran, W.J.1
-
36
-
-
52649131951
-
Lung cancer
-
Herbst, R. S., Heymach, J. V. & Lippman, S. M. Lung cancer. N. Engl. J. Med. 359, 1367-1380 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1367-1380
-
-
Herbst, R.S.1
Heymach, J.V.2
Lippman, S.M.3
-
37
-
-
76149135054
-
Trends in stage distribution for patients with non-small cell lung cancer: A National Cancer Database survey
-
Morgensztern, D., Ng, S. H., Gao, F. & Govindan, R. Trends in stage distribution for patients with non-small cell lung cancer: a National Cancer Database survey. J. Thorac. Oncol. 5, 29-33 (2010).
-
(2010)
J. Thorac. Oncol
, vol.5
, pp. 29-33
-
-
Morgensztern, D.1
Ng, S.H.2
Gao, F.3
Govindan, R.4
-
38
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
-
Fukuoka, M. et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J. Clin. Oncol. 21, 2237-2246 (2003).
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
-
39
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris, M. G. et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. J. Am. Med. Assoc. 290, 2149-2158 (2003).
-
(2003)
J. Am. Med. Assoc
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
-
40
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd, F. A. et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353, 123-132 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
-
41
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
42
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
43
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova, K. et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-1203 (2007).
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
-
44
-
-
84966405086
-
FDA approval summary: Nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinumbased chemotherapy
-
Kazandjian, D. et al. FDA approval summary: nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinumbased chemotherapy. Oncologist 21, 634-642 (2016).
-
(2016)
Oncologist
, vol.21
, pp. 634-642
-
-
Kazandjian, D.1
-
45
-
-
84900829967
-
Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
-
Kris, M. G. et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. J. Am. Med. Assoc. 311, 1998-2006 (2014).
-
(2014)
J. Am. Med. Assoc
, vol.311
, pp. 1998-2006
-
-
Kris, M.G.1
-
46
-
-
84921425147
-
The EGFR family: Not so prototypical receptor tyrosine kinases
-
Lemmon, M. A., Schlessinger, J. & Ferguson, K. M. The EGFR family: not so prototypical receptor tyrosine kinases. Cold Spring Harb. Perspect. Biol. 6, a020768 (2014).
-
(2014)
Cold Spring Harb. Perspect. Biol
, vol.6
, pp. a020768
-
-
Lemmon, M.A.1
Schlessinger, J.2
Ferguson, K.M.3
-
47
-
-
77956268839
-
Understanding resistance to EGFR inhibitors-impact on future treatment strategies
-
Wheeler, D. L., Dunn, E. F. & Harari, P. M. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat. Rev. Clin. Oncol. 7, 493-507 (2010).
-
(2010)
Nat. Rev. Clin. Oncol
, vol.7
, pp. 493-507
-
-
Wheeler, D.L.1
Dunn, E.F.2
Harari, P.M.3
-
48
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma, S. V., Bell, D. W., Settleman, J. & Haber, D. A. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7, 169-181 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
Haber, D.A.4
-
49
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok, T. S. et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361, 947-957 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
-
50
-
-
79960702788
-
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS)
-
Fukuoka, M. et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS). J. Clin. Oncol. 29, 2866-2874 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
-
51
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo, M. et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362, 2380-2388 (2010).
-
(2010)
N. Engl. J. Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
-
52
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi, T. et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 11, 121-128 (2010).
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
-
53
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou, C. et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12, 735-742 (2011).
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
-
54
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell, R. et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13, 239-246 (2012).
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
-
55
-
-
85015712569
-
Afatinib versus gefitinib in patients with EGFR mutationpositive advanced non-small-cell lung cancer: Overall survival data from the phase IIb LUX-Lung 7 trial
-
Paz-Ares, L. et al. Afatinib versus gefitinib in patients with EGFR mutationpositive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial. Ann. Oncol. 28, 270-277 (2017).
-
(2017)
Ann. Oncol
, vol.28
, pp. 270-277
-
-
Paz-Ares, L.1
-
56
-
-
85029907586
-
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): A randomised, open-label, phase 3 trial
-
Wu, Y. L. et al. Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial. Lancet Oncol. 18, 1454-1466 (2017).
-
(2017)
Lancet Oncol
, vol.18
, pp. 1454-1466
-
-
Wu, Y.L.1
-
57
-
-
84921892043
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): Analysis of overall survival data from two randomised, phase 3 trials
-
Yang, J. C. et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 16, 141-151 (2015).
-
(2015)
Lancet Oncol
, vol.16
, pp. 141-151
-
-
Yang, J.C.1
-
58
-
-
33947224133
-
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification
-
Okabe, T. et al. Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer Res. 67, 2046-2053 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 2046-2053
-
-
Okabe, T.1
-
59
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi, S. et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 352, 786-792 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
-
60
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist, L. V. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 3, 75ra26 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 75ra26
-
-
Sequist, L.V.1
-
61
-
-
84905366894
-
Acquired resistance to TKIs in solid tumours: Learning from lung cancer
-
Camidge, D. R., Pao, W. & Sequist, L. V. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat. Rev. Clin. Oncol. 11, 473-481 (2014).
-
(2014)
Nat. Rev. Clin. Oncol
, vol.11
, pp. 473-481
-
-
Camidge, D.R.1
Pao, W.2
Sequist, L.V.3
-
62
-
-
84928739294
-
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
-
Jnne, P. A. et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N. Engl. J. Med. 372, 1689-1699 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 1689-1699
-
-
Jnne, P.A.1
-
63
-
-
85013382512
-
Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer
-
Mok, T. S. et al. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N. Engl. J. Med. 376, 629-640 (2017).
-
(2017)
N. Engl. J. Med
, vol.376
, pp. 629-640
-
-
Mok, T.S.1
-
64
-
-
85040652883
-
Osimertinib in untreated EGFR-mutated advanced non-small cell lung cancer
-
Soria, J. C. et al. Osimertinib in untreated EGFR-mutated advanced non-small cell lung cancer. N. Engl. J. Med. http://doi.org/10.1056/NEJMoa1713137 (2017).
-
N. Engl. J. Med
, vol.2017
-
-
Soria, J.C.1
-
65
-
-
84930755018
-
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
-
Thress, K. S. et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat. Med. 21, 560-562 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 560-562
-
-
Thress, K.S.1
-
66
-
-
84938196408
-
The allelic context of the C797S mutation acquired upon treatment with third-generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies
-
Niederst, M. J. et al. The allelic context of the C797S mutation acquired upon treatment with third-generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies. Clin. Cancer Res. 21, 3924-3933 (2015).
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 3924-3933
-
-
Niederst, M.J.1
-
67
-
-
84973322897
-
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
-
Jia, Y. et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature 534, 129-132 (2016).
-
(2016)
Nature
, vol.534
, pp. 129-132
-
-
Jia, Y.1
-
68
-
-
85015236659
-
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer
-
Uchibori, K. et al. Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Nat. Commun. 8, 14768 (2017).
-
(2017)
Nat. Commun
, vol.8
, pp. 14768
-
-
Uchibori, K.1
-
69
-
-
85011891356
-
Targeting ALK: Precision medicine takes on drug resistance
-
Lin, J. J., Riely, G. J. & Shaw, A. T. Targeting ALK: precision medicine takes on drug resistance. Cancer Discov. 7, 137-155 (2017).
-
(2017)
Cancer Discov
, vol.7
, pp. 137-155
-
-
Lin, J.J.1
Riely, G.J.2
Shaw, A.T.3
-
70
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561-566 (2007).
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
-
71
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak, E. L. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
-
72
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw, A. T. et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 368, 2385-2394 (2013).
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
-
73
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon, B. J. et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N. Engl. J. Med. 371, 2167-2177 (2014).
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 2167-2177
-
-
Solomon, B.J.1
-
74
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw, A. T. et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N. Engl. J. Med. 370, 1189-1197 (2014).
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
-
75
-
-
84959324643
-
Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: A single-group, multicentre, phase 2 trial
-
Shaw, A. T. et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol. 17, 234-242 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 234-242
-
-
Shaw, A.T.1
-
76
-
-
85020586637
-
Brigatinib in patients with crizotinib-refractory anaplastic lymphoma kinase-positive non-small-cell lung cancer: A randomized, multicenter phase II trial
-
Kim, D. W. et al. Brigatinib in patients with crizotinib-refractory anaplastic lymphoma kinase-positive non-small-cell lung cancer: a randomized, multicenter phase II trial. J. Clin. Oncol. 35, 2490-2498 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. 2490-2498
-
-
Kim, D.W.1
-
77
-
-
85010189205
-
First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): A randomised, open-label, phase 3 study
-
Soria, J. C. et al. First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study. Lancet 389, 917-929 (2017).
-
(2017)
Lancet
, vol.389
, pp. 917-929
-
-
Soria, J.C.1
-
78
-
-
85019146993
-
Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): An open-label, randomised phase 3 trial
-
Hida, T. et al. Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial. Lancet 390, 29-39 (2017).
-
(2017)
Lancet
, vol.390
, pp. 29-39
-
-
Hida, T.1
-
79
-
-
85027524894
-
Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer
-
Peters, S. et al. Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer. N. Engl. J. Med. 377, 829-838 (2017).
-
(2017)
N. Engl. J. Med
, vol.377
, pp. 829-838
-
-
Peters, S.1
-
80
-
-
84994065677
-
Molecular mechanisms of resistance to first-and secondgeneration ALK inhibitors in ALK-rearranged lung cancer
-
Gainor, J. F. et al. Molecular mechanisms of resistance to first-and secondgeneration ALK inhibitors in ALK-rearranged lung cancer. Cancer Discov. 6, 1118-1133 (2016).
-
(2016)
Cancer Discov
, vol.6
, pp. 1118-1133
-
-
Gainor, J.F.1
-
81
-
-
85032007777
-
Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: An international, multicentre, open-label, single-arm first-in-man phase 1 trial
-
Shaw, A. T. et al. Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial. Lancet Oncol. 18, 1590-1599 (2017).
-
(2017)
Lancet Oncol
, vol.18
, pp. 1590-1599
-
-
Shaw, A.T.1
-
82
-
-
85015933289
-
Oncogene addiction in non-small cell lung cancer: Focus on ROS1 inhibition
-
Facchinetti, F. et al. Oncogene addiction in non-small cell lung cancer: focus on ROS1 inhibition. Cancer Treat. Rev. 55, 83-95 (2017).
-
(2017)
Cancer Treat. Rev
, vol.55
, pp. 83-95
-
-
Facchinetti, F.1
-
83
-
-
84911372597
-
Crizotinib in ROS1-rearranged non-small-cell lung cancer
-
Shaw, A. T. et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N. Engl. J. Med. 371, 1963-1971 (2014).
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 1963-1971
-
-
Shaw, A.T.1
-
84
-
-
85028517391
-
Open-label, multicenter, phase II study of ceritinib in patients with non-small-cell lung cancer harboring Ros1 rearrangement
-
Lim, S. M. et al. Open-label, multicenter, phase II study of ceritinib in patients with non-small-cell lung cancer harboring Ros1 rearrangement. J. Clin. Oncol. 35, 2613-2618 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. 2613-2618
-
-
Lim, S.M.1
-
85
-
-
84879088863
-
Acquired resistance to crizotinib from a mutation in CD74-ROS1
-
Awad, M. M. et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N. Engl. J. Med. 368, 2395-2401 (2013).
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2395-2401
-
-
Awad, M.M.1
-
86
-
-
84892655145
-
Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer
-
Davies, K. D. et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS One 8, e82236 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e82236
-
-
Davies, K.D.1
-
87
-
-
80053014471
-
Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
-
Marchetti, A. et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J. Clin. Oncol. 29, 3574-3579 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 3574-3579
-
-
Marchetti, A.1
-
88
-
-
84883022821
-
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer
-
Cardarella, S. et al. Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin. Can. Res. 19, 4532-4540 (2013).
-
(2013)
Clin. Can. Res
, vol.19
, pp. 4532-4540
-
-
Cardarella, S.1
-
89
-
-
84939864059
-
Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
-
Hyman, D. M. et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N. Engl. J. Med. 373, 726-736 (2015).
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 726-736
-
-
Hyman, D.M.1
-
90
-
-
84964329499
-
Dabrafenib in patients with BRAF(V600E)-positive advanced non-small-cell lung cancer: A single-arm, multicentre, open-label, phase 2 trial
-
Planchard, D. et al. Dabrafenib in patients with BRAF(V600E)-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial. Lancet Oncol. 17, 642-650 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 642-650
-
-
Planchard, D.1
-
91
-
-
84991059363
-
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: An open-label, multicentre phase 2 trial
-
Planchard, D. et al. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol. 17, 984-993 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 984-993
-
-
Planchard, D.1
-
92
-
-
84938805958
-
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
-
Frampton, G. M. et al. Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov. 5, 850-859 (2015).
-
(2015)
Cancer Discov
, vol.5
, pp. 850-859
-
-
Frampton, G.M.1
-
93
-
-
84938815085
-
Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
-
Paik, P. K. et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov. 5, 842-849 (2015).
-
(2015)
Cancer Discov
, vol.5
, pp. 842-849
-
-
Paik, P.K.1
-
94
-
-
84964388926
-
MET exon 14 mutations in non-small-cell lung cancer are associated with advanced age and stage-dependent MET genomic amplification and c-Met overexpression
-
Awad, M. M. et al. MET exon 14 mutations in non-small-cell lung cancer are associated with advanced age and stage-dependent MET genomic amplification and c-Met overexpression. J. Clin. Oncol. 34, 721-730 (2016).
-
(2016)
J. Clin. Oncol
, vol.34
, pp. 721-730
-
-
Awad, M.M.1
-
95
-
-
84880661427
-
Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
-
Mazires, J. et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J. Clin. Oncol. 31, 1997-2003 (2013).
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 1997-2003
-
-
Mazires, J.1
-
96
-
-
84961659480
-
Lung cancer patients with HER2 mutations treated with chemotherapy and HER2-targeted drugs: Results from the European EUHER2 cohort
-
Mazires, J. et al. Lung cancer patients with HER2 mutations treated with chemotherapy and HER2-targeted drugs: results from the European EUHER2 cohort. Ann. Oncol. 27, 281-286 (2016).
-
(2016)
Ann. Oncol
, vol.27
, pp. 281-286
-
-
Mazires, J.1
-
97
-
-
84857929267
-
KIF5B-RET fusions in lung adenocarcinoma
-
Kohno, T. et al. KIF5B-RET fusions in lung adenocarcinoma. Nat. Med. 18, 375-377 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 375-377
-
-
Kohno, T.1
-
98
-
-
85003533203
-
Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: An open-label, single-centre, phase 2, single-arm trial
-
Drilon, A. et al. Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial. Lancet Oncol. 17, 1653-1660 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 1653-1660
-
-
Drilon, A.1
-
99
-
-
85018282184
-
Targeting RET in patients with RET-rearranged lung cancers: Results from the global, multicenter RET registry
-
Gautschi, O. et al. Targeting RET in patients with RET-rearranged lung cancers: results from the global, multicenter RET registry. J. Clin. Oncol. 35, 1403-1410 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. 1403-1410
-
-
Gautschi, O.1
-
100
-
-
85028758374
-
The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers
-
Hyman, D. M. et al. The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers. J. Clin. Oncol. 35, LBA2501-LBA2501 (2017).
-
(2017)
J. Clin. Oncol
, vol.35
, pp. LBA2501-LBA2501
-
-
Hyman, D.M.1
-
101
-
-
85028777325
-
A next-generation TRK kinase inhibitor overcomes acquired resistance to prior TRK kinase inhibition in patients with TRK fusion-positive solid tumors
-
Drilon, A. et al. A next-generation TRK kinase inhibitor overcomes acquired resistance to prior TRK kinase inhibition in patients with TRK fusion-positive solid tumors. Cancer Discov. 7, 963-972 (2017).
-
(2017)
Cancer Discov
, vol.7
, pp. 963-972
-
-
Drilon, A.1
-
102
-
-
0026060863
-
The treatment of malignant tumors by repeated inoculations of erysipelas. with a report of ten original cases. 1893
-
Coley, W. B. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin. Orthop. Relat. Res. (262):3-11 (1991).
-
(1991)
Clin. Orthop. Relat. Res
, vol.262
, pp. 3-11
-
-
Coley, W.B.1
-
103
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
104
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
105
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793-800 (2002).
-
(2002)
Nat. Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
-
106
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai, Y. et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99, 12293-12297 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 12293-12297
-
-
Iwai, Y.1
-
107
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
108
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon, E. B. et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
-
109
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst, R. S. et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515, 563-567 (2014).
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
-
110
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer, J. et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373, 123-135 (2015).
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
-
111
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei, H. et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N. Engl. J. Med. 373, 1627-1639 (2015).
-
(2015)
N. Engl. J. Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
-
112
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst, R. S. et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387, 1540-1550 (2016).
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
-
113
-
-
85008239423
-
Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): A phase 3, open-label, multicentre randomised controlled trial
-
Rittmeyer, A. et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 389, 255-265 (2017).
-
(2017)
Lancet
, vol.389
, pp. 255-265
-
-
Rittmeyer, A.1
-
114
-
-
84994802263
-
Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer
-
Reck, M. et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N. Engl. J. Med. 375, 1823-1833 (2016).
-
(2016)
N. Engl. J. Med
, vol.375
, pp. 1823-1833
-
-
Reck, M.1
-
115
-
-
85020964772
-
First-line nivolumab in stage IV or recurrent non-small-cell lung cancer
-
Carbone, D. P. et al. First-line nivolumab in stage IV or recurrent non-small-cell lung cancer. N. Engl. J. Med. 376, 2415-2426 (2017).
-
(2017)
N. Engl. J. Med
, vol.376
, pp. 2415-2426
-
-
Carbone, D.P.1
-
116
-
-
84995700066
-
Diminished but not dead: Chemotherapy for the treatment of NSCLC
-
Herbst, R. S. & Sznol, M. Diminished but not dead: chemotherapy for the treatment of NSCLC. Lancet Oncol. 17, 1464-1465 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 1464-1465
-
-
Herbst, R.S.1
Sznol, M.2
-
117
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang, C. H. et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 162, 1229-1241 (2015).
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
-
118
-
-
84880747672
-
Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
-
Zitvogel, L., Galluzzi, L., Smyth, M. J. & Kroemer, G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 39, 74-88 (2013).
-
(2013)
Immunity
, vol.39
, pp. 74-88
-
-
Zitvogel, L.1
Galluzzi, L.2
Smyth, M.J.3
Kroemer, G.4
-
119
-
-
84994430500
-
Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: A randomised, phase 2 cohort of the open-label KEYNOTE-021 study
-
Langer, C. J. et al. Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol. 17, 1497-1508 (2016).
-
(2016)
Lancet Oncol
, vol.17
, pp. 1497-1508
-
-
Langer, C.J.1
-
120
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran, M. A., Montalvo, W., Yagita, H. & Allison, J. P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl Acad. Sci. USA 107, 4275-4280 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
121
-
-
85007425840
-
Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): Results of an open-label, phase 1, multicohort study
-
Hellmann, M. D. et al. Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study. Lancet Oncol. 18, 31-41 (2017).
-
(2017)
Lancet Oncol
, vol.18
, pp. 31-41
-
-
Hellmann, M.D.1
-
122
-
-
85041095180
-
Primary, adaptive, and acquired resistance to cancer immunotherapy
-
Sharma, P., Hu-Lieskovan, S., Wargo, J. A. & Ribas, A. Primary, adaptive, and acquired resistance to cancer immunotherapy. Nat. Med. 23, 1362-1368 (2017).
-
(2017)
Nat. Med
, vol.23
, pp. 1362-1368
-
-
Sharma, P.1
Hu-Lieskovan, S.2
Wargo, J.A.3
Ribas, A.4
-
123
-
-
84934288076
-
Combinatorial strategies for the induction of immunogenic cell death
-
Bezu, L. et al. Combinatorial strategies for the induction of immunogenic cell death. Front. Immunol. 6, 187 (2015).
-
(2015)
Front. Immunol
, vol.6
, pp. 187
-
-
Bezu, L.1
-
124
-
-
84986597644
-
Oncolytic viruses in cancer treatment: A review
-
Lawler, S. E., Speranza, M. C., Cho, C. F. & Chiocca, E. A. Oncolytic viruses in cancer treatment: a review. JAMA Oncol. 3, 841-849 (2017).
-
(2017)
JAMA Oncol
, vol.3
, pp. 841-849
-
-
Lawler, S.E.1
Speranza, M.C.2
Cho, C.F.3
Chiocca, E.A.4
-
125
-
-
84901008789
-
Control of the immune response by pro-angiogenic factors
-
Voron, T. et al. Control of the immune response by pro-angiogenic factors. Front. Oncol. 4, 70 (2014).
-
(2014)
Front. Oncol
, vol.4
, pp. 70
-
-
Voron, T.1
-
126
-
-
85027944490
-
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
-
Tian, L. et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature 544, 250-254 (2017).
-
(2017)
Nature
, vol.544
, pp. 250-254
-
-
Tian, L.1
-
127
-
-
85024396858
-
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
-
Sahin, U. et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature 547, 222-226 (2017).
-
(2017)
Nature
, vol.547
, pp. 222-226
-
-
Sahin, U.1
-
128
-
-
85037334618
-
Impaired HLA class i antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer
-
Gettinger, S. et al. Impaired HLA class I antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer. Cancer Discov. 7, 1420-1435 (2017).
-
(2017)
Cancer Discov
, vol.7
, pp. 1420-1435
-
-
Gettinger, S.1
-
129
-
-
84983216790
-
Mutations associated with acquired resistance to PD-1 blockade in melanoma
-
Zaretsky, J. M. et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N. Engl. J. Med. 375, 819-829 (2016).
-
(2016)
N. Engl. J. Med
, vol.375
, pp. 819-829
-
-
Zaretsky, J.M.1
-
130
-
-
84880664259
-
Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
-
Holmgaard, R. B., Zamarin, D., Munn, D. H., Wolchok, J. D. & Allison, J. P. Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210, 1389-1402 (2013).
-
(2013)
J. Exp. Med
, vol.210
, pp. 1389-1402
-
-
Holmgaard, R.B.1
Zamarin, D.2
Munn, D.H.3
Wolchok, J.D.4
Allison, J.P.5
-
131
-
-
85032655147
-
Durvalumab after chemoradiotherapy in stage III non-smallcell lung cancer
-
Antonia, S. J. et al. Durvalumab after chemoradiotherapy in stage III non-smallcell lung cancer. N. Engl. J. Med. 377, 1919-1929 (2017).
-
(2017)
N. Engl. J. Med
, vol.377
, pp. 1919-1929
-
-
Antonia, S.J.1
-
132
-
-
84990050278
-
Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer
-
Oxnard, G. R. et al. Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer. J. Clin. Oncol. 34, 3375-3382 (2016).
-
(2016)
J. Clin. Oncol
, vol.34
, pp. 3375-3382
-
-
Oxnard, G.R.1
-
133
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim, E. S. et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov. 1, 44-53 (2011).
-
(2011)
Cancer Discov
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
-
134
-
-
84927606243
-
Lung master protocol (lung-map)-A biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: Swog s1400
-
Herbst, R. S. et al. Lung Master Protocol (Lung-MAP)-A biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: SWOG S1400. Clin. Cancer Res. 21, 1514-1524 (2015).
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 1514-1524
-
-
Herbst, R.S.1
-
135
-
-
85035788250
-
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
-
Blakely, C. M. et al. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat. Genet. 49, 1693-1704 (2017).
-
(2017)
Nat. Genet
, vol.49
, pp. 1693-1704
-
-
Blakely, C.M.1
-
136
-
-
85019743651
-
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
-
Abbosh, C. et al. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature 545, 446-451 (2017).
-
(2017)
Nature
, vol.545
, pp. 446-451
-
-
Abbosh, C.1
-
137
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N. A. et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
-
138
-
-
85016548232
-
Elements of cancer immunity and the cancerimmune set point
-
Chen, D. S. & Mellman, I. Elements of cancer immunity and the cancerimmune set point. Nature 541, 321-330 (2017).
-
(2017)
Nature
, vol.541
, pp. 321-330
-
-
Chen, D.S.1
Mellman, I.2
-
139
-
-
85032896356
-
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
-
Romero, R. et al. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat. Med. 23, 1362-1368 (2017).
-
(2017)
Nat. Med
, vol.23
, pp. 1362-1368
-
-
Romero, R.1
|