메뉴 건너뛰기




Volumn 45, Issue 3, 2019, Pages 213-223

Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications

Author keywords

Fatty liver; Liver enzymes; NAFLD; NASH; SGLT2 inhibitor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; GAMMA GLUTAMYLTRANSFERASE; IPRAGLIFLOZIN; LUSEOGLIFLOZIN; METFORMIN; PIOGLITAZONE; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; TOFOGLIFLOZIN; ANTIDIABETIC AGENT;

EID: 85061542721     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/j.diabet.2019.01.008     Document Type: Review
Times cited : (117)

References (98)
  • 2
    • 84962661546 scopus 로고    scopus 로고
    • EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
    • European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 64 (2016), 1388–1402.
    • (2016) J Hepatol , vol.64 , pp. 1388-1402
  • 3
    • 85062480923 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies
    • [Epub ahead of print, Aug 30. pii: S2213-8587(18)30154-2]
    • Stefan, N, Haring, HU, Cusi, K, Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies. Lancet Diabetes Endocrinol, 2018, 10.1016/S2213-8587(18)30154-2 [Epub ahead of print, Aug 30. pii: S2213-8587(18)30154-2].
    • (2018) Lancet Diabetes Endocrinol
    • Stefan, N.1    Haring, H.U.2    Cusi, K.3
  • 4
    • 85054984602 scopus 로고    scopus 로고
    • Global perspectives on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • [Epub ahead of print]
    • Younossi, Z, Tacke, F, Arrese, M, Sharma, BC, Mostafa, I, Bugianesi, E, et al. Global perspectives on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Hepatology, 2018, 10.1002/hep.30251 [Epub ahead of print].
    • (2018) Hepatology
    • Younossi, Z.1    Tacke, F.2    Arrese, M.3    Sharma, B.C.4    Mostafa, I.5    Bugianesi, E.6
  • 5
    • 84930656108 scopus 로고    scopus 로고
    • NAFLD: a multisystem disease
    • Byrne, CD, Targher, G, NAFLD: a multisystem disease. J Hepatol 62 (2015), S47–S64.
    • (2015) J Hepatol , vol.62 , pp. S47-S64
    • Byrne, C.D.1    Targher, G.2
  • 6
    • 85019439188 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
    • Adams, LA, Anstee, QM, Tilg, H, Targher, G, Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut 66 (2017), 1138–1153.
    • (2017) Gut , vol.66 , pp. 1138-1153
    • Adams, L.A.1    Anstee, Q.M.2    Tilg, H.3    Targher, G.4
  • 7
    • 84937635957 scopus 로고    scopus 로고
    • Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
    • Scheen, AJ, Esser, N, Paquot, N, Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control. Diabetes Metab 41 (2015), 183–194.
    • (2015) Diabetes Metab , vol.41 , pp. 183-194
    • Scheen, A.J.1    Esser, N.2    Paquot, N.3
  • 8
    • 84910147372 scopus 로고    scopus 로고
    • Oxidative stress, cardiolipin and mitochondrial dysfunction in non-alcoholic fatty liver disease
    • Paradies, G, Paradies, V, Ruggiero, FM, Petrosillo, G, Oxidative stress, cardiolipin and mitochondrial dysfunction in non-alcoholic fatty liver disease. World J Gastroenterol 20 (2014), 14205–14218.
    • (2014) World J Gastroenterol , vol.20 , pp. 14205-14218
    • Paradies, G.1    Paradies, V.2    Ruggiero, F.M.3    Petrosillo, G.4
  • 9
    • 85054466162 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: potential contribution for diabetic complications and cardiovascular disease
    • Bonnet, F, Scheen, AJ, Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: potential contribution for diabetic complications and cardiovascular disease. Diabetes Metab 44 (2018), 457–464.
    • (2018) Diabetes Metab , vol.44 , pp. 457-464
    • Bonnet, F.1    Scheen, A.J.2
  • 10
    • 85056651473 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter inhibitors and oxidative stress: An update
    • Yaribeygi, H, Atkin, SL, Butler, AE, Sahebkar, A, Sodium-glucose cotransporter inhibitors and oxidative stress: An update. J Cell Physiol 234 (2019), 3231–3237.
    • (2019) J Cell Physiol , vol.234 , pp. 3231-3237
    • Yaribeygi, H.1    Atkin, S.L.2    Butler, A.E.3    Sahebkar, A.4
  • 11
    • 85051413612 scopus 로고    scopus 로고
    • Current guidelines for the management of non-alcoholic fatty liver disease: a systematic review with comparative analysis
    • Leoni, S, Tovoli, F, Napoli, L, Serio, I, Ferri, S, Bolondi, L, Current guidelines for the management of non-alcoholic fatty liver disease: a systematic review with comparative analysis. World J Gastroenterol 24 (2018), 3361–3373.
    • (2018) World J Gastroenterol , vol.24 , pp. 3361-3373
    • Leoni, S.1    Tovoli, F.2    Napoli, L.3    Serio, I.4    Ferri, S.5    Bolondi, L.6
  • 12
    • 85038094859 scopus 로고    scopus 로고
    • Current and future pharmacological therapies for NAFLD/NASH
    • Sumida, Y, Yoneda, M, Current and future pharmacological therapies for NAFLD/NASH. J Gastroenterol 53 (2018), 362–376.
    • (2018) J Gastroenterol , vol.53 , pp. 362-376
    • Sumida, Y.1    Yoneda, M.2
  • 13
    • 85049848920 scopus 로고    scopus 로고
    • The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD)
    • Iogna Prat, L, Tsochatzis, EA, The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD). Hormones (Athens)17 (2018), 219–229.
    • (2018) Hormones (Athens) , vol.17 , pp. 219-229
    • Iogna Prat, L.1    Tsochatzis, E.A.2
  • 16
    • 84961615237 scopus 로고    scopus 로고
    • Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction
    • Komiya, C, Tsuchiya, K, Shiba, K, Miyachi, Y, Furuke, S, Shimazu, N, et al. Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction. PLoS One, 11, 2016, e0151511.
    • (2016) PLoS One , vol.11 , pp. e0151511
    • Komiya, C.1    Tsuchiya, K.2    Shiba, K.3    Miyachi, Y.4    Furuke, S.5    Shimazu, N.6
  • 17
    • 85049038376 scopus 로고    scopus 로고
    • Cardiovascular effects of new oral glucose-lowering agents: DPP-4 and SGLT-2 inhibitors
    • Scheen, AJ, Cardiovascular effects of new oral glucose-lowering agents: DPP-4 and SGLT-2 inhibitors. Circ Res 122 (2018), 1439–1459.
    • (2018) Circ Res , vol.122 , pp. 1439-1459
    • Scheen, A.J.1
  • 18
    • 85056318982 scopus 로고    scopus 로고
    • Effects of glucose-lowering agents on renal surrogate endpoints and hard clinical outcomes in patients with type 2 diabetes
    • [Epub ahead of print, pii: S1262-3636(18)30197-6]
    • Scheen, AJ, Effects of glucose-lowering agents on renal surrogate endpoints and hard clinical outcomes in patients with type 2 diabetes. Diabetes Metab, 2018, 10.1016/j.diabet.2018.10.003 [Epub ahead of print, pii: S1262-3636(18)30197-6].
    • (2018) Diabetes Metab
    • Scheen, A.J.1
  • 19
    • 85054523094 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA)and the European Association for the Study of Diabetes (EASD)
    • Davies, MJ, D'Alessio, DA, Fradkin, J, Kernan, WN, Mathieu, C, Mingrone, G, et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA)and the European Association for the Study of Diabetes (EASD). Diabetologia 61 (2018), 2461–2498.
    • (2018) Diabetologia , vol.61 , pp. 2461-2498
    • Davies, M.J.1    D'Alessio, D.A.2    Fradkin, J.3    Kernan, W.N.4    Mathieu, C.5    Mingrone, G.6
  • 20
    • 85035024998 scopus 로고    scopus 로고
    • Comparison of ipragliflozin and pioglitazone effects on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, 24-week, open-label, active-controlled trial
    • Ito, D, Shimizu, S, Inoue, K, Saito, D, Yanagisawa, M, Inukai, K, et al. Comparison of ipragliflozin and pioglitazone effects on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, 24-week, open-label, active-controlled trial. Diabetes Care 40 (2017), 1364–1372.
    • (2017) Diabetes Care , vol.40 , pp. 1364-1372
    • Ito, D.1    Shimizu, S.2    Inoue, K.3    Saito, D.4    Yanagisawa, M.5    Inukai, K.6
  • 21
    • 85040734374 scopus 로고    scopus 로고
    • Luseogliflozin improves liver fat deposition compared to metformin in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective randomized controlled pilot study
    • Shibuya, T, Fushimi, N, Kawai, M, Yoshida, Y, Hachiya, H, Ito, S, et al. Luseogliflozin improves liver fat deposition compared to metformin in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective randomized controlled pilot study. Diabetes Obes Metab 20 (2018), 438–442.
    • (2018) Diabetes Obes Metab , vol.20 , pp. 438-442
    • Shibuya, T.1    Fushimi, N.2    Kawai, M.3    Yoshida, Y.4    Hachiya, H.5    Ito, S.6
  • 22
    • 85049567851 scopus 로고    scopus 로고
    • Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study
    • Eriksson, JW, Lundkvist, P, Jansson, PA, Johansson, L, Kvarnstrom, M, Moris, L, et al. Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study. Diabetologia 61 (2018), 1923–1934.
    • (2018) Diabetologia , vol.61 , pp. 1923-1934
    • Eriksson, J.W.1    Lundkvist, P.2    Jansson, P.A.3    Johansson, L.4    Kvarnstrom, M.5    Moris, L.6
  • 23
    • 85052836880 scopus 로고    scopus 로고
    • Effect of empagliflozin on liver fat in patients with type 2 diabetes and non-alcoholic fatty liver disease: a randomized controlled trial (E-LIFT Trial)
    • Kuchay, MS, Krishan, S, Mishra, SK, Farooqui, KJ, Singh, MK, Wasir, JS, et al. Effect of empagliflozin on liver fat in patients with type 2 diabetes and non-alcoholic fatty liver disease: a randomized controlled trial (E-LIFT Trial). Diabetes Care 41 (2018), 1801–1808.
    • (2018) Diabetes Care , vol.41 , pp. 1801-1808
    • Kuchay, M.S.1    Krishan, S.2    Mishra, S.K.3    Farooqui, K.J.4    Singh, M.K.5    Wasir, J.S.6
  • 24
    • 85054316426 scopus 로고    scopus 로고
    • Evaluation of the effects of dapagliflozin, an SGLT2 inhibitor, on hepatic steatosis and fibrosis by transient elastography in patients with type 2 diabetes and non-alcoholic fatty liver disease
    • Shimizu, M, Suzuki, K, Kato, K, Jojima, T, Iijima, T, Murohisa, T, et al. Evaluation of the effects of dapagliflozin, an SGLT2 inhibitor, on hepatic steatosis and fibrosis by transient elastography in patients with type 2 diabetes and non-alcoholic fatty liver disease. Diabetes Obes Metab 21 (2019), 285–292.
    • (2019) Diabetes Obes Metab , vol.21 , pp. 285-292
    • Shimizu, M.1    Suzuki, K.2    Kato, K.3    Jojima, T.4    Iijima, T.5    Murohisa, T.6
  • 25
    • 84994497585 scopus 로고    scopus 로고
    • Luseogliflozin, a sodium glucose co-transporter 2 inhibitor, alleviates hepatic impairment in Japanese patients with type 2 diabetes
    • Kusunoki, M, Natsume, Y, Sato, D, Tsutsui, H, Miyata, T, Tsutsumi, K, et al. Luseogliflozin, a sodium glucose co-transporter 2 inhibitor, alleviates hepatic impairment in Japanese patients with type 2 diabetes. Drug Res 66 (2016), 603–606.
    • (2016) Drug Res , vol.66 , pp. 603-606
    • Kusunoki, M.1    Natsume, Y.2    Sato, D.3    Tsutsui, H.4    Miyata, T.5    Tsutsumi, K.6
  • 26
    • 85028766250 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body composition and liver tests in patients with non-alcoholic steatohepatitis associated with type 2 diabetes mellitus: a prospective, open-label, uncontrolled study
    • Tobita, H, Sato, S, Miyake, T, Ishihara, S, Kinoshita, Y, Effects of dapagliflozin on body composition and liver tests in patients with non-alcoholic steatohepatitis associated with type 2 diabetes mellitus: a prospective, open-label, uncontrolled study. Curr Ther Res Clin Exp 87 (2017), 13–19.
    • (2017) Curr Ther Res Clin Exp , vol.87 , pp. 13-19
    • Tobita, H.1    Sato, S.2    Miyake, T.3    Ishihara, S.4    Kinoshita, Y.5
  • 27
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu, WT, Leiter, LA, Yoon, KH, Arias, P, Niskanen, L, Xie, J, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet 382 (2013), 941–950.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3    Arias, P.4    Niskanen, L.5    Xie, J.6
  • 29
    • 84947998361 scopus 로고    scopus 로고
    • Effect of canagliflozin on liver function tests in patients with type 2 diabetes
    • Leiter, LA, Forst, T, Polidori, D, Balis, DA, Xie, J, Sha, S, Effect of canagliflozin on liver function tests in patients with type 2 diabetes. Diabetes Metab 42 (2016), 25–32.
    • (2016) Diabetes Metab , vol.42 , pp. 25-32
    • Leiter, L.A.1    Forst, T.2    Polidori, D.3    Balis, D.A.4    Xie, J.5    Sha, S.6
  • 30
    • 85041796920 scopus 로고    scopus 로고
    • Diagnosis of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Non-invasive tests are enough
    • Castera, L, Diagnosis of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Non-invasive tests are enough. Liver Int 38:Suppl 1 (2018), 67–70.
    • (2018) Liver Int , vol.38 , pp. 67-70
    • Castera, L.1
  • 31
    • 85008262665 scopus 로고    scopus 로고
    • Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus
    • Seko, Y, Sumida, Y, Tanaka, S, Mori, K, Taketani, H, Ishiba, H, et al. Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus. Hepatol Res 47 (2017), 1072–1078.
    • (2017) Hepatol Res , vol.47 , pp. 1072-1078
    • Seko, Y.1    Sumida, Y.2    Tanaka, S.3    Mori, K.4    Taketani, H.5    Ishiba, H.6
  • 32
    • 84910117367 scopus 로고    scopus 로고
    • External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals
    • Cuthbertson, DJ, Weickert, MO, Lythgoe, D, Sprung, VS, Dobson, R, Shoajee-Moradie, F, et al. External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals. Eur J Endocrinol 171 (2014), 561–569.
    • (2014) Eur J Endocrinol , vol.171 , pp. 561-569
    • Cuthbertson, D.J.1    Weickert, M.O.2    Lythgoe, D.3    Sprung, V.S.4    Dobson, R.5    Shoajee-Moradie, F.6
  • 33
    • 85016590472 scopus 로고    scopus 로고
    • Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an association with glucose-lowering effects
    • Takase, T, Nakamura, A, Miyoshi, H, Yamamoto, C, Atsumi, T, Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an association with glucose-lowering effects. Endocr J 64 (2017), 363–367.
    • (2017) Endocr J , vol.64 , pp. 363-367
    • Takase, T.1    Nakamura, A.2    Miyoshi, H.3    Yamamoto, C.4    Atsumi, T.5
  • 34
    • 85060605141 scopus 로고    scopus 로고
    • Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results)
    • Tabuchi, H, Maegawa, H, Tobe, K, Nakamura, I, Uno, S, Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results). Endocr J 66 (2019), 31–41.
    • (2019) Endocr J , vol.66 , pp. 31-41
    • Tabuchi, H.1    Maegawa, H.2    Tobe, K.3    Nakamura, I.4    Uno, S.5
  • 35
    • 84966421122 scopus 로고    scopus 로고
    • Non-invasive assessment of liver fibrosis: between prediction/prevention of outcomes and cost-effectiveness
    • Stasi, C, Milani, S, Non-invasive assessment of liver fibrosis: between prediction/prevention of outcomes and cost-effectiveness. World J Gastroenterol 22 (2016), 1711–1720.
    • (2016) World J Gastroenterol , vol.22 , pp. 1711-1720
    • Stasi, C.1    Milani, S.2
  • 36
    • 85048597520 scopus 로고    scopus 로고
    • Dapagliflozin significantly reduced liver fat accumulation associated with a decrease in abdominal subcutaneous fat in patients with inadequately controlled type 2 diabetes mellitus
    • Kurinami, N, Sugiyama, S, Yoshida, A, Hieshima, K, Miyamoto, F, Kajiwara, K, et al. Dapagliflozin significantly reduced liver fat accumulation associated with a decrease in abdominal subcutaneous fat in patients with inadequately controlled type 2 diabetes mellitus. Diabetes Res Clin Pract 142 (2018), 254–263.
    • (2018) Diabetes Res Clin Pract , vol.142 , pp. 254-263
    • Kurinami, N.1    Sugiyama, S.2    Yoshida, A.3    Hieshima, K.4    Miyamoto, F.5    Kajiwara, K.6
  • 37
  • 38
    • 84925507275 scopus 로고    scopus 로고
    • The association of non-alcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Al Rifai, M, Silverman, MG, Nasir, K, Budoff, MJ, Blankstein, R, Szklo, M, et al. The association of non-alcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 239 (2015), 629–633.
    • (2015) Atherosclerosis , vol.239 , pp. 629-633
    • Al Rifai, M.1    Silverman, M.G.2    Nasir, K.3    Budoff, M.J.4    Blankstein, R.5    Szklo, M.6
  • 39
    • 85021756786 scopus 로고    scopus 로고
    • Concomitant screening for liver fibrosis and steatosis in French type 2 diabetic patients using Fibroscan
    • Roulot, D, Roudot-Thoraval, F, Nkontchou, G, Kouacou, N, Costes, JL, Elourimi, G, et al. Concomitant screening for liver fibrosis and steatosis in French type 2 diabetic patients using Fibroscan. Liver Int 37 (2017), 1897–1906.
    • (2017) Liver Int , vol.37 , pp. 1897-1906
    • Roulot, D.1    Roudot-Thoraval, F.2    Nkontchou, G.3    Kouacou, N.4    Costes, J.L.5    Elourimi, G.6
  • 40
    • 85054349322 scopus 로고    scopus 로고
    • Feasibility and efficacy of transient elastography using the XL probe to diagnose liver fibrosis and cirrhosis: a meta-analysis
    • Xia, B, Wang, F, Friedrich-Rust, M, Zhou, F, Zhu, J, Yang, H, et al. Feasibility and efficacy of transient elastography using the XL probe to diagnose liver fibrosis and cirrhosis: a meta-analysis. Medicine (Baltimore), 97, 2018, e11816.
    • (2018) Medicine (Baltimore) , vol.97 , pp. e11816
    • Xia, B.1    Wang, F.2    Friedrich-Rust, M.3    Zhou, F.4    Zhu, J.5    Yang, H.6
  • 41
    • 85042524553 scopus 로고    scopus 로고
    • Effects of a sodium-glucose cotransporter 2 inhibitor in non-alcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies
    • Akuta, N, Watanabe, C, Kawamura, Y, Arase, Y, Saitoh, S, Fujiyama, S, et al. Effects of a sodium-glucose cotransporter 2 inhibitor in non-alcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies. Hepatol Commun 1 (2017), 46–52.
    • (2017) Hepatol Commun , vol.1 , pp. 46-52
    • Akuta, N.1    Watanabe, C.2    Kawamura, Y.3    Arase, Y.4    Saitoh, S.5    Fujiyama, S.6
  • 42
    • 85059533640 scopus 로고    scopus 로고
    • Effects of canagliflozin on body composition and hepatic fat content in type 2 diabetes patients with non-alcoholic fatty liver disease
    • [Epub ahead of print]
    • Inoue, M, Hayashi, A, Taguchi, T, Arai, R, Sasaki, S, Takano, K, et al. Effects of canagliflozin on body composition and hepatic fat content in type 2 diabetes patients with non-alcoholic fatty liver disease. J Diabetes Investig, 2018, 10.1111/jdi.12980 [Epub ahead of print].
    • (2018) J Diabetes Investig
    • Inoue, M.1    Hayashi, A.2    Taguchi, T.3    Arai, R.4    Sasaki, S.5    Takano, K.6
  • 43
    • 85052796632 scopus 로고    scopus 로고
    • Effect of luseogliflozin on hepatic fat content in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective, single-arm trial (LEAD trial)
    • Sumida, Y, Murotani, K, Saito, M, Tamasawa, A, Osonoi, Y, Yoneda, M, et al. Effect of luseogliflozin on hepatic fat content in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective, single-arm trial (LEAD trial). Hepatol Res 49 (2019), 64–71.
    • (2019) Hepatol Res , vol.49 , pp. 64-71
    • Sumida, Y.1    Murotani, K.2    Saito, M.3    Tamasawa, A.4    Osonoi, Y.5    Yoneda, M.6
  • 44
    • 85054423976 scopus 로고    scopus 로고
    • Effects of canagliflozin on fatty liver indexes in patients with type 2 diabetes: a meta-analysis of randomized controlled trials
    • Li, B, Wang, Y, Ye, Z, Yang, H, Cui, X, Wang, Z, et al. Effects of canagliflozin on fatty liver indexes in patients with type 2 diabetes: a meta-analysis of randomized controlled trials. J Pharm Pharm Sci 21 (2018), 222–235.
    • (2018) J Pharm Pharm Sci , vol.21 , pp. 222-235
    • Li, B.1    Wang, Y.2    Ye, Z.3    Yang, H.4    Cui, X.5    Wang, Z.6
  • 45
    • 85054746424 scopus 로고    scopus 로고
    • Effect of dapagliflozin on alanine aminotransferase improvement in type 2 diabetes mellitus with non-alcoholic fatty liver disease
    • Choi, DH, Jung, CH, Mok, JO, Kim, CH, Kang, SK, Kim, BY, Effect of dapagliflozin on alanine aminotransferase improvement in type 2 diabetes mellitus with non-alcoholic fatty liver disease. Endocrinol Metab (Seoul)33 (2018), 387–394.
    • (2018) Endocrinol Metab (Seoul) , vol.33 , pp. 387-394
    • Choi, D.H.1    Jung, C.H.2    Mok, J.O.3    Kim, C.H.4    Kang, S.K.5    Kim, B.Y.6
  • 46
    • 85057743699 scopus 로고    scopus 로고
    • Efficacy of canagliflozin against non-alcoholic fatty liver disease: a prospective cohort study
    • Itani, T, Ishihara, T., Efficacy of canagliflozin against non-alcoholic fatty liver disease: a prospective cohort study. Obes Sci Pract 4 (2018), 477–482.
    • (2018) Obes Sci Pract , vol.4 , pp. 477-482
    • Itani, T.1    Ishihara, T.2
  • 47
    • 85027337209 scopus 로고    scopus 로고
    • Ipragliflozin, a sodium glucose co-transporter 2 inhibitor, reduces intrahepatic lipid content and abdominal visceral fat volume in patients with type 2 diabetes
    • Ohta, A, Kato, H, Ishii, S, Sasaki, Y, Nakamura, Y, Nakagawa, T, et al. Ipragliflozin, a sodium glucose co-transporter 2 inhibitor, reduces intrahepatic lipid content and abdominal visceral fat volume in patients with type 2 diabetes. Expert Opin Pharmacother 18 (2017), 1433–1438.
    • (2017) Expert Opin Pharmacother , vol.18 , pp. 1433-1438
    • Ohta, A.1    Kato, H.2    Ishii, S.3    Sasaki, Y.4    Nakamura, Y.5    Nakagawa, T.6
  • 48
    • 85054614373 scopus 로고    scopus 로고
    • Ipragliflozin ameliorates liver damage in non-alcoholic fatty liver disease
    • Miyake, T, Yoshida, S, Furukawa, S, Sakai, T, Tada, F, Senba, H, et al. Ipragliflozin ameliorates liver damage in non-alcoholic fatty liver disease. Open Med (Wars)13 (2018), 402–409.
    • (2018) Open Med (Wars) , vol.13 , pp. 402-409
    • Miyake, T.1    Yoshida, S.2    Furukawa, S.3    Sakai, T.4    Tada, F.5    Senba, H.6
  • 49
    • 84962619117 scopus 로고    scopus 로고
    • Effectiveness of ipragliflozin, a sodium-glucose co-transporter 2 inhibitor, as a second-line treatment for non-alcoholic fatty liver disease patients with type 2 diabetes mellitus who do not respond to incretin-based therapies including glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors
    • Ohki, T, Isogawa, A, Toda, N, Tagawa, K, Effectiveness of ipragliflozin, a sodium-glucose co-transporter 2 inhibitor, as a second-line treatment for non-alcoholic fatty liver disease patients with type 2 diabetes mellitus who do not respond to incretin-based therapies including glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors. Clin Drug Investig 36 (2016), 313–319.
    • (2016) Clin Drug Investig , vol.36 , pp. 313-319
    • Ohki, T.1    Isogawa, A.2    Toda, N.3    Tagawa, K.4
  • 50
    • 85041594784 scopus 로고    scopus 로고
    • Tofogliflozin decreases body fat mass and improves peripheral insulin resistance
    • Matsuba, R, Matsuba, I, Shimokawa, M, Nagai, Y, Tanaka, Y, Tofogliflozin decreases body fat mass and improves peripheral insulin resistance. Diabetes Obes Metab 20 (2018), 1311–1315.
    • (2018) Diabetes Obes Metab , vol.20 , pp. 1311-1315
    • Matsuba, R.1    Matsuba, I.2    Shimokawa, M.3    Nagai, Y.4    Tanaka, Y.5
  • 51
    • 85041539533 scopus 로고    scopus 로고
    • Dapagliflozin and empagliflozin ameliorate hepatic dysfunction among Chinese subjects with diabetes in part through glycemic improvement: a single-center, retrospective, observational study
    • Lee, PCH, Gu, Y, Yeung, MY, Fong, CHY, Woo, YC, Chow, WS, et al. Dapagliflozin and empagliflozin ameliorate hepatic dysfunction among Chinese subjects with diabetes in part through glycemic improvement: a single-center, retrospective, observational study. Diabetes Ther 9 (2018), 285–295.
    • (2018) Diabetes Ther , vol.9 , pp. 285-295
    • Lee, P.C.H.1    Gu, Y.2    Yeung, M.Y.3    Fong, C.H.Y.4    Woo, Y.C.5    Chow, W.S.6
  • 52
    • 85061335533 scopus 로고    scopus 로고
    • Impact of SGLT2 inhibitor to histological features and glucose metabolism of non-alcoholic fatty liver disease complicated by diabetes mellitus
    • [Epub ahead of print]
    • Akuta, N, Kawamura, Y, Watanabe, C, Nishimura, A, Okubo, M, Mori, Y, et al. Impact of SGLT2 inhibitor to histological features and glucose metabolism of non-alcoholic fatty liver disease complicated by diabetes mellitus. Hepatol Res, 2018, 10.1111/hepr.13304 [Epub ahead of print].
    • (2018) Hepatol Res
    • Akuta, N.1    Kawamura, Y.2    Watanabe, C.3    Nishimura, A.4    Okubo, M.5    Mori, Y.6
  • 53
    • 85059003392 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in type 2 diabetes mellitus patients with biopsy-proven non-alcoholic steatohepatitis classified as stage 1-3 fibrosis
    • Seko, Y, Nishikawa, T, Umemura, A, Yamaguchi, K, Moriguchi, M, Yasui, K, et al. Efficacy and safety of canagliflozin in type 2 diabetes mellitus patients with biopsy-proven non-alcoholic steatohepatitis classified as stage 1-3 fibrosis. Diabetes Metab Syndr Obes 11 (2018), 835–843.
    • (2018) Diabetes Metab Syndr Obes , vol.11 , pp. 835-843
    • Seko, Y.1    Nishikawa, T.2    Umemura, A.3    Yamaguchi, K.4    Moriguchi, M.5    Yasui, K.6
  • 54
    • 85031712678 scopus 로고    scopus 로고
    • The improvement of the hepatic histological findings in a patient with non-alcoholic steatohepatitis with type 2 diabetes after the administration of the sodium-glucose cotransporter 2 inhibitor ipragliflozin
    • Takeda, A, Irahara, A, Nakano, A, Takata, E, Koketsu, Y, Kimata, K, et al. The improvement of the hepatic histological findings in a patient with non-alcoholic steatohepatitis with type 2 diabetes after the administration of the sodium-glucose cotransporter 2 inhibitor ipragliflozin. Intern Med 56 (2017), 2739–2744.
    • (2017) Intern Med , vol.56 , pp. 2739-2744
    • Takeda, A.1    Irahara, A.2    Nakano, A.3    Takata, E.4    Koketsu, Y.5    Kimata, K.6
  • 56
    • 85041599877 scopus 로고    scopus 로고
    • Cardiovascular outcome studies in type 2 diabetes: comparison between SGLT2 inhibitors and GLP-1 receptor agonists
    • Scheen, AJ, Cardiovascular outcome studies in type 2 diabetes: comparison between SGLT2 inhibitors and GLP-1 receptor agonists. Diabetes Res Clin Pract 143 (2018), 88–100.
    • (2018) Diabetes Res Clin Pract , vol.143 , pp. 88-100
    • Scheen, A.J.1
  • 58
    • 85036498397 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease increases risk of incident chronic kidney disease: A systematic review and meta-analysis
    • Mantovani, A, Zaza, G, Byrne, CD, Lonardo, A, Zoppini, G, Bonora, E, et al. Non-alcoholic fatty liver disease increases risk of incident chronic kidney disease: A systematic review and meta-analysis. Metabolism 79 (2018), 64–76.
    • (2018) Metabolism , vol.79 , pp. 64-76
    • Mantovani, A.1    Zaza, G.2    Byrne, C.D.3    Lonardo, A.4    Zoppini, G.5    Bonora, E.6
  • 59
    • 85047660397 scopus 로고    scopus 로고
    • Cardiometabolic effects of antidiabetic drugs in non-alcoholic fatty liver disease
    • [Epub ahead of print]
    • Rix, I, Steen Pedersen, J, Storgaard, H, Gluud, LL, Cardiometabolic effects of antidiabetic drugs in non-alcoholic fatty liver disease. Clin Physiol Funct Imaging, 2018, 10.1111/cpf.12526 [Epub ahead of print].
    • (2018) Clin Physiol Funct Imaging
    • Rix, I.1    Steen Pedersen, J.2    Storgaard, H.3    Gluud, L.L.4
  • 60
    • 85052558182 scopus 로고    scopus 로고
    • SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review
    • Verma, S, McMurray, JJV, SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia 61 (2018), 2108–2117.
    • (2018) Diabetologia , vol.61 , pp. 2108-2117
    • Verma, S.1    McMurray, J.J.V.2
  • 62
    • 85067910987 scopus 로고    scopus 로고
    • Effect of sodium-glucose cotransporter type 2 inhibitors on liver fat in patients with type 2 diabetes: hepatic beyond cardiovascular and renal protection?
    • Scheen, AJ, Effect of sodium-glucose cotransporter type 2 inhibitors on liver fat in patients with type 2 diabetes: hepatic beyond cardiovascular and renal protection?. Ann Transl Med, 6, 2018, S68.
    • (2018) Ann Transl Med , vol.6 , pp. S68
    • Scheen, A.J.1
  • 63
    • 85037698584 scopus 로고    scopus 로고
    • Ipragliflozin and sodium glucose transporter 2 inhibitors to reduce liver fat: will the prize we sought be won?
    • Pafili, K, Maltezos, E, Papanas, N, Ipragliflozin and sodium glucose transporter 2 inhibitors to reduce liver fat: will the prize we sought be won?. Expert Opin Pharmacother 19 (2018), 185–187.
    • (2018) Expert Opin Pharmacother , vol.19 , pp. 185-187
    • Pafili, K.1    Maltezos, E.2    Papanas, N.3
  • 64
    • 85059501499 scopus 로고    scopus 로고
    • SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
    • Zelniker, TA, Wiviott, SD, Raz, I, Im, K, Goodrich, EL, Bonaca, MP, et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet 393 (2019), 31–39.
    • (2019) Lancet , vol.393 , pp. 31-39
    • Zelniker, T.A.1    Wiviott, S.D.2    Raz, I.3    Im, K.4    Goodrich, E.L.5    Bonaca, M.P.6
  • 65
    • 85044240071 scopus 로고    scopus 로고
    • Ertugliflozin: first global approval
    • Markham, A, Ertugliflozin: first global approval. Drugs 78 (2018), 513–519.
    • (2018) Drugs , vol.78 , pp. 513-519
    • Markham, A.1
  • 66
    • 85050110454 scopus 로고    scopus 로고
    • Sotagliflozin: a dual sodium-glucose co-transporter-1 and -2 inhibitor for the management of Type 1 and Type 2 diabetes mellitus
    • Sims, H, Smith, KH, Bramlage, P, Minguet, J, Sotagliflozin: a dual sodium-glucose co-transporter-1 and -2 inhibitor for the management of Type 1 and Type 2 diabetes mellitus. Diabet Med 35 (2018), 1037–1048.
    • (2018) Diabet Med , vol.35 , pp. 1037-1048
    • Sims, H.1    Smith, K.H.2    Bramlage, P.3    Minguet, J.4
  • 67
    • 85058976257 scopus 로고    scopus 로고
    • Of mice and men: is there a future for metformin in the treatment of hepatic steatosis?
    • [Epub ahead of print]
    • Green, CJ, Marjot, T, Tomlinson, JW, Hodson, L, Of mice and men: is there a future for metformin in the treatment of hepatic steatosis?. Diabetes Obes Metab, 2018, 10.1111/dom.13592 [Epub ahead of print].
    • (2018) Diabetes Obes Metab
    • Green, C.J.1    Marjot, T.2    Tomlinson, J.W.3    Hodson, L.4
  • 68
    • 85054137788 scopus 로고    scopus 로고
    • Rationale and design of the STOP-OB study for evaluating the effects of tofogliflozin and glimepiride on fat deposition in type 2 diabetes patients treated with metformin/DPP-4 inhibitor dual therapy
    • Ishihara, H, Anai, M, Seino, H, Kitazawa, T, Ohashi, H, Ai, M, et al. Rationale and design of the STOP-OB study for evaluating the effects of tofogliflozin and glimepiride on fat deposition in type 2 diabetes patients treated with metformin/DPP-4 inhibitor dual therapy. Diabetes Ther 9 (2018), 2117–2125.
    • (2018) Diabetes Ther , vol.9 , pp. 2117-2125
    • Ishihara, H.1    Anai, M.2    Seino, H.3    Kitazawa, T.4    Ohashi, H.5    Ai, M.6
  • 69
    • 84876523499 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4: a key player in chronic liver disease
    • Itou, M, Kawaguchi, T, Taniguchi, E, Sata, M, Dipeptidyl peptidase-4: a key player in chronic liver disease. World J Gastroenterol 19 (2013), 2298–2306.
    • (2013) World J Gastroenterol , vol.19 , pp. 2298-2306
    • Itou, M.1    Kawaguchi, T.2    Taniguchi, E.3    Sata, M.4
  • 70
    • 84969801284 scopus 로고    scopus 로고
    • Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial
    • Cui, J, Philo, L, Nguyen, P, Hofflich, H, Hernandez, C, Bettencourt, R, et al. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol 65 (2016), 369–376.
    • (2016) J Hepatol , vol.65 , pp. 369-376
    • Cui, J.1    Philo, L.2    Nguyen, P.3    Hofflich, H.4    Hernandez, C.5    Bettencourt, R.6
  • 71
    • 84985993965 scopus 로고    scopus 로고
    • Long-term pioglitazone treatment for patients with non-alcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial
    • Cusi, K, Orsak, B, Bril, F, Lomonaco, R, Hecht, J, Ortiz-Lopez, C, et al. Long-term pioglitazone treatment for patients with non-alcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial. Ann Intern Med 165 (2016), 305–315.
    • (2016) Ann Intern Med , vol.165 , pp. 305-315
    • Cusi, K.1    Orsak, B.2    Bril, F.3    Lomonaco, R.4    Hecht, J.5    Ortiz-Lopez, C.6
  • 72
    • 85019007103 scopus 로고    scopus 로고
    • Thiazolidinediones and advanced liver fibrosis in non-alcoholic steatohepatitis: a meta-analysis
    • Musso, G, Cassader, M, Paschetta, E, Gambino, R, Thiazolidinediones and advanced liver fibrosis in non-alcoholic steatohepatitis: a meta-analysis. JAMA Intern Med 177 (2017), 633–640.
    • (2017) JAMA Intern Med , vol.177 , pp. 633-640
    • Musso, G.1    Cassader, M.2    Paschetta, E.3    Gambino, R.4
  • 73
    • 84872864369 scopus 로고    scopus 로고
    • Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program
    • Armstrong, MJ, Houlihan, DD, Rowe, IA, Clausen, WH, Elbrond, B, Gough, SC, et al. Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program. Aliment Pharmacol Ther 37 (2013), 234–242.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 234-242
    • Armstrong, M.J.1    Houlihan, D.D.2    Rowe, I.A.3    Clausen, W.H.4    Elbrond, B.5    Gough, S.C.6
  • 74
    • 85053721623 scopus 로고    scopus 로고
    • Dulaglutide decreases plasma aminotransferases in people with Type 2 diabetes in a pattern consistent with liver fat reduction: a post hoc analysis of the AWARD programme
    • Cusi, K, Sattar, N, Garcia-Perez, LE, Pavo, I, Yu, M, Robertson, KE, et al. Dulaglutide decreases plasma aminotransferases in people with Type 2 diabetes in a pattern consistent with liver fat reduction: a post hoc analysis of the AWARD programme. Diabet Med 35 (2018), 1434–1439.
    • (2018) Diabet Med , vol.35 , pp. 1434-1439
    • Cusi, K.1    Sattar, N.2    Garcia-Perez, L.E.3    Pavo, I.4    Yu, M.5    Robertson, K.E.6
  • 75
    • 84973644267 scopus 로고    scopus 로고
    • Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy
    • Dutour, A, Abdesselam, I, Ancel, P, Kober, F, Mrad, G, Darmon, P, et al. Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy. Diabetes Obes Metab 18 (2016), 882–891.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 882-891
    • Dutour, A.1    Abdesselam, I.2    Ancel, P.3    Kober, F.4    Mrad, G.5    Darmon, P.6
  • 76
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong, MJ, Gaunt, P, Aithal, GP, Barton, D, Hull, D, Parker, R, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 387 (2016), 679–690.
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3    Barton, D.4    Hull, D.5    Parker, R.6
  • 77
  • 78
    • 85043762831 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and cardiovascular protection. Class effect or not?
    • Scheen, AJ, GLP-1 receptor agonists and cardiovascular protection. Class effect or not?. Diabetes Metab 44 (2018), 193–196.
    • (2018) Diabetes Metab , vol.44 , pp. 193-196
    • Scheen, A.J.1
  • 79
    • 84995632414 scopus 로고    scopus 로고
    • Editorial: can glucagon like peptide 1 (GLP1)agonists or sodium-glucose co-transporter 2 (SGLT2)inhibitors ameliorate non-alcoholic steatohepatitis in people with or without diabetes?
    • Athyros, VG, Katsiki, N, Karagiannis, A, Editorial: can glucagon like peptide 1 (GLP1)agonists or sodium-glucose co-transporter 2 (SGLT2)inhibitors ameliorate non-alcoholic steatohepatitis in people with or without diabetes?. Curr Vasc Pharmacol 14 (2016), 494–497.
    • (2016) Curr Vasc Pharmacol , vol.14 , pp. 494-497
    • Athyros, V.G.1    Katsiki, N.2    Karagiannis, A.3
  • 80
    • 85052908886 scopus 로고    scopus 로고
    • SGLT2 inhibitors and incretin agents: associations with alanine aminotransferase activity in type 2 diabetes
    • Bajaj, HS, Brown, RE, Bhullar, L, Sohi, N, Kalra, S, Aronson, R, SGLT2 inhibitors and incretin agents: associations with alanine aminotransferase activity in type 2 diabetes. Diabetes Metab 44 (2018), 493–499.
    • (2018) Diabetes Metab , vol.44 , pp. 493-499
    • Bajaj, H.S.1    Brown, R.E.2    Bhullar, L.3    Sohi, N.4    Kalra, S.5    Aronson, R.6
  • 81
    • 85020473445 scopus 로고    scopus 로고
    • Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor
    • DeFronzo, RA, Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor. Diabetes Obes Metab 19 (2017), 1353–1362.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 1353-1362
    • DeFronzo, R.A.1
  • 83
    • 84940575211 scopus 로고    scopus 로고
    • Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus
    • Kovacs, CS, Seshiah, V, Merker, L, Christiansen, AV, Roux, F, Salsali, A, et al. Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus. Clin Ther 37 (2015), 1773–1788.
    • (2015) Clin Ther , vol.37 , pp. 1773-1788
    • Kovacs, C.S.1    Seshiah, V.2    Merker, L.3    Christiansen, A.V.4    Roux, F.5    Salsali, A.6
  • 84
    • 84994508611 scopus 로고    scopus 로고
    • Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial
    • Frias, JP, Guja, C, Hardy, E, Ahmed, A, Dong, F, Ohman, P, et al. Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol 4 (2016), 1004–1016.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 1004-1016
    • Frias, J.P.1    Guja, C.2    Hardy, E.3    Ahmed, A.4    Dong, F.5    Ohman, P.6
  • 85
    • 85042458412 scopus 로고    scopus 로고
    • Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10): a 24-week, randomised, double-blind, placebo-controlled trial
    • Ludvik, B, Frias, JP, Tinahones, FJ, Wainstein, J, Jiang, H, Robertson, KE, et al. Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10): a 24-week, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 6 (2018), 370–381.
    • (2018) Lancet Diabetes Endocrinol , vol.6 , pp. 370-381
    • Ludvik, B.1    Frias, J.P.2    Tinahones, F.J.3    Wainstein, J.4    Jiang, H.5    Robertson, K.E.6
  • 86
    • 85040349772 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: a 52-week, open-label, single-arm study
    • Seino, Y, Yabe, D, Sasaki, T, Fukatsu, A, Imazeki, H, Ochiai, H, et al. Sodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: a 52-week, open-label, single-arm study. J Diabetes Investig 9 (2018), 332–340.
    • (2018) J Diabetes Investig , vol.9 , pp. 332-340
    • Seino, Y.1    Yabe, D.2    Sasaki, T.3    Fukatsu, A.4    Imazeki, H.5    Ochiai, H.6
  • 87
    • 85053920215 scopus 로고    scopus 로고
    • Weight loss associated with sodium-glucose cotransporter-2 inhibition: a review of evidence and underlying mechanisms
    • Lee, PC, Ganguly, S, Goh, SY, Weight loss associated with sodium-glucose cotransporter-2 inhibition: a review of evidence and underlying mechanisms. Obes Rev 19 (2018), 1630–1641.
    • (2018) Obes Rev , vol.19 , pp. 1630-1641
    • Lee, P.C.1    Ganguly, S.2    Goh, S.Y.3
  • 88
    • 0031913573 scopus 로고    scopus 로고
    • Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty
    • Luyckx, FH, Desaive, C, Thiry, A, Dewe, W, Scheen, AJ, Gielen, JE, et al. Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty. Int J Obes 22 (1998), 222–226.
    • (1998) Int J Obes , vol.22 , pp. 222-226
    • Luyckx, F.H.1    Desaive, C.2    Thiry, A.3    Dewe, W.4    Scheen, A.J.5    Gielen, J.E.6
  • 89
    • 85034752819 scopus 로고    scopus 로고
    • The association between the dosage of SGLT2 inhibitor and weight reduction in type 2 diabetes patients: a meta-analysis
    • Cai, X, Yang, W, Gao, X, Chen, Y, Zhou, L, Zhang, S, et al. The association between the dosage of SGLT2 inhibitor and weight reduction in type 2 diabetes patients: a meta-analysis. Obesity 26 (2018), 70–80.
    • (2018) Obesity , vol.26 , pp. 70-80
    • Cai, X.1    Yang, W.2    Gao, X.3    Chen, Y.4    Zhou, L.5    Zhang, S.6
  • 90
    • 85039561505 scopus 로고    scopus 로고
    • Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes
    • Tang, L, Wu, Y, Tian, M, Sjostrom, CD, Johansson, U, Peng, XR, et al. Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes. Am J Physiol Endocrinol Metab 313 (2017), 563–576.
    • (2017) Am J Physiol Endocrinol Metab , vol.313 , pp. 563-576
    • Tang, L.1    Wu, Y.2    Tian, M.3    Sjostrom, C.D.4    Johansson, U.5    Peng, X.R.6
  • 91
    • 85044500198 scopus 로고    scopus 로고
    • Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
    • Garvey, WT, Van Gaal, L, Leiter, LA, Vijapurkar, U, List, J, Cuddihy, R, et al. Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. Metabolism 85 (2018), 32–37.
    • (2018) Metabolism , vol.85 , pp. 32-37
    • Garvey, W.T.1    Van Gaal, L.2    Leiter, L.A.3    Vijapurkar, U.4    List, J.5    Cuddihy, R.6
  • 92
    • 84951832157 scopus 로고    scopus 로고
    • Adipokines in non-alcoholic fatty liver disease
    • Polyzos, SA, Kountouras, J, Mantzoros, CS, Adipokines in non-alcoholic fatty liver disease. Metabolism 65 (2016), 1062–1079.
    • (2016) Metabolism , vol.65 , pp. 1062-1079
    • Polyzos, S.A.1    Kountouras, J.2    Mantzoros, C.S.3
  • 93
    • 85017476975 scopus 로고    scopus 로고
    • Uric acid is associated with inflammatory biomarkers and induces inflammation via activating the NF-kappaB signaling pathway in HepG2 cells
    • Spiga, R, Marini, MA, Mancuso, E, Di Fatta, C, Fuoco, A, Perticone, F, et al. Uric acid is associated with inflammatory biomarkers and induces inflammation via activating the NF-kappaB signaling pathway in HepG2 cells. Arterioscler Thromb Vasc Biol 37 (2017), 1241–1249.
    • (2017) Arterioscler Thromb Vasc Biol , vol.37 , pp. 1241-1249
    • Spiga, R.1    Marini, M.A.2    Mancuso, E.3    Di Fatta, C.4    Fuoco, A.5    Perticone, F.6
  • 95
    • 85054304570 scopus 로고    scopus 로고
    • Serum uric acid levels and decreased estimated glomerular filtration rate in patients with type 2 diabetes: a cohort study and meta-analysis
    • Wang, J, Yu, Y, Li, X, Li, D, Xu, C, Yuan, J, et al. Serum uric acid levels and decreased estimated glomerular filtration rate in patients with type 2 diabetes: a cohort study and meta-analysis. Diabetes Metab Res Rev, 34, 2018, e3046.
    • (2018) Diabetes Metab Res Rev , vol.34 , pp. e3046
    • Wang, J.1    Yu, Y.2    Li, X.3    Li, D.4    Xu, C.5    Yuan, J.6
  • 96
    • 84954285517 scopus 로고    scopus 로고
    • High serum uric acid and risk of non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Zhou, Y, Wei, F, Fan, Y, High serum uric acid and risk of non-alcoholic fatty liver disease: A systematic review and meta-analysis. Clin Biochem 49 (2016), 636–642.
    • (2016) Clin Biochem , vol.49 , pp. 636-642
    • Zhou, Y.1    Wei, F.2    Fan, Y.3
  • 97
    • 85041260942 scopus 로고    scopus 로고
    • Association between serum uric acid and non-alcoholic fatty liver disease: a meta-analysis
    • Darmawan, G, Hamijoyo, L, Hasan, I, Association between serum uric acid and non-alcoholic fatty liver disease: a meta-analysis. Acta Med Indones 49 (2017), 136–147.
    • (2017) Acta Med Indones , vol.49 , pp. 136-147
    • Darmawan, G.1    Hamijoyo, L.2    Hasan, I.3
  • 98
    • 85040723946 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 (SGLT2)inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials
    • Zhao, Y, Xu, L, Tian, D, Xia, P, Zheng, H, Wang, L, et al. Effects of sodium-glucose co-transporter 2 (SGLT2)inhibitors on serum uric acid level: A meta-analysis of randomized controlled trials. Diabetes Obes Metab 20 (2018), 458–462.
    • (2018) Diabetes Obes Metab , vol.20 , pp. 458-462
    • Zhao, Y.1    Xu, L.2    Tian, D.3    Xia, P.4    Zheng, H.5    Wang, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.