메뉴 건너뛰기




Volumn 61, Issue 10, 2018, Pages 2108-2117

SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review

Author keywords

Cardiovascular effects; Heart failure; Mechanisms; Review; SGLT2 inhibitors

Indexed keywords

ADIPOCYTOKINE; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSIDE;

EID: 85052558182     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-018-4670-7     Document Type: Review
Times cited : (676)

References (66)
  • 1
    • 85023777061 scopus 로고    scopus 로고
    • Canagliflozin and cardiovascular and renal events in type 2 diabetes
    • PID: 28605608
    • Neal B, Perkovic V, Mahaffey KW et al (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377:644–657
    • (2017) N Engl J Med , vol.377 , pp. 644-657
    • Neal, B.1    Perkovic, V.2    Mahaffey, K.W.3
  • 2
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • PID: 26378978
    • Zinman B, Wanner C, Lachin JM et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373:2117–2128
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 3
    • 85047121888 scopus 로고    scopus 로고
    • Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial
    • Verma S, Mazer CD, Fitchett D et al (2018) Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial. Diabetologia 61:1712–1723
    • (2018) Diabetologia , vol.61 , pp. 1712-1723
    • Verma, S.1    Mazer, C.D.2    Fitchett, D.3
  • 4
    • 85043391124 scopus 로고    scopus 로고
    • Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial
    • PID: 29020355
    • Fitchett D, Butler J, van de Borne P et al (2018) Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial. Eur Heart J 39:363–370
    • (2018) Eur Heart J , vol.39 , pp. 363-370
    • Fitchett, D.1    Butler, J.2    van de Borne, P.3
  • 5
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
    • PID: 26819227
    • Fitchett D, Zinman B, Wanner C et al (2016) Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 37:1526–1534
    • (2016) Eur Heart J , vol.37 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3
  • 6
    • 85055707998 scopus 로고    scopus 로고
    • Canagliflozin and heart failure in type 2 diabetes mellitus: Results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)
    • Rådholm K, Figtree G, Perkovic V et al (2018) Canagliflozin and heart failure in type 2 diabetes mellitus: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study). Circulation. 10.1161/CIRCULATIONAHA.118.034222
    • (2018) Circulation
    • Rådholm, K.1    Figtree, G.2    Perkovic, V.3
  • 7
    • 85030655315 scopus 로고    scopus 로고
    • The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure
    • PID: 28636701
    • Verma S, McMurray JJV, Cherney DZI (2017) The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure. JAMA Cardiol 2:939–940
    • (2017) JAMA Cardiol , vol.2 , pp. 939-940
    • Verma, S.1    McMurray, J.J.V.2    Cherney, D.Z.I.3
  • 8
    • 85037670718 scopus 로고    scopus 로고
    • Heart failure: epidemiology, pathophysiology, and management of heart failure in diabetes mellitus
    • Jorsal A, Wiggers H, McMurray JJV (2018) Heart failure: epidemiology, pathophysiology, and management of heart failure in diabetes mellitus. Endocrinol Metab Clin N Am 47:117–135
    • (2018) Endocrinol Metab Clin N Am , vol.47 , pp. 117-135
    • Jorsal, A.1    Wiggers, H.2    McMurray, J.J.V.3
  • 9
  • 10
    • 85046398177 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology
    • Seferovic PM, Petrie MC, Filippatos GS et al (2018) Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 10.1002/ejhf.1170
    • (2018) Eur J Heart Fail
    • Seferovic, P.M.1    Petrie, M.C.2    Filippatos, G.S.3
  • 11
    • 85042620242 scopus 로고    scopus 로고
    • Prevalent and incident heart failure in cardiovascular outcome trials of patients with type 2 diabetes
    • PID: 29534825
    • Greene SJ, Vaduganathan M, Khan MS et al (2018) Prevalent and incident heart failure in cardiovascular outcome trials of patients with type 2 diabetes. J Am Coll Cardiol 71:1379–1390
    • (2018) J Am Coll Cardiol , vol.71 , pp. 1379-1390
    • Greene, S.J.1    Vaduganathan, M.2    Khan, M.S.3
  • 12
    • 85044730815 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
    • PID: 29449364
    • Jia G, Hill MA, Sowers JR (2018) Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res 122:624–638
    • (2018) Circ Res , vol.122 , pp. 624-638
    • Jia, G.1    Hill, M.A.2    Sowers, J.R.3
  • 13
    • 84937227669 scopus 로고    scopus 로고
    • Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes
    • PID: 25888006
    • Seferovic PM, Paulus WJ (2015) Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. Eur Heart J 36:1718–1727
    • (2015) Eur Heart J , vol.36 , pp. 1718-1727
    • Seferovic, P.M.1    Paulus, W.J.2
  • 14
    • 85047122839 scopus 로고    scopus 로고
    • Prevention of heart failure with SGLT2 inhibition: Insights from CVD-REAL
    • in press
    • Farkouh ME, Verma S (2018) Prevention of heart failure with SGLT2 inhibition: insights from CVD-REAL. J Am Coll Cardiol (in press)
    • (2018) J am Coll Cardiol
    • Farkouh, M.E.1    Verma, S.2
  • 15
    • 85025455714 scopus 로고    scopus 로고
    • Diabetes mellitus, microalbuminuria, and subclinical cardiac disease: identification and monitoring of individuals at risk of heart failure
    • PID: 28716801
    • Swoboda PP, McDiarmid AK, Erhayiem B et al (2017) Diabetes mellitus, microalbuminuria, and subclinical cardiac disease: identification and monitoring of individuals at risk of heart failure. J Am Heart Assoc 6:e005539
    • (2017) J Am Heart Assoc , vol.6
    • Swoboda, P.P.1    McDiarmid, A.K.2    Erhayiem, B.3
  • 16
    • 85019731757 scopus 로고    scopus 로고
    • Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors)
    • PID: 28522450
    • Kosiborod M, Cavender MA, Fu AZ et al (2017) Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors). Circulation 136:249–259
    • (2017) Circulation , vol.136 , pp. 249-259
    • Kosiborod, M.1    Cavender, M.A.2    Fu, A.Z.3
  • 17
    • 85048449544 scopus 로고    scopus 로고
    • Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)
    • PID: 29133604
    • Mahaffey KW, Neal B, Perkovic V et al (2018) Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study). Circulation 137:323–334
    • (2018) Circulation , vol.137 , pp. 323-334
    • Mahaffey, K.W.1    Neal, B.2    Perkovic, V.3
  • 18
    • 85047499725 scopus 로고    scopus 로고
    • Lower cardiovascular risk associated with SGLT-2i in >400,000 patients: The CVD-REAL 2 study
    • Kosiborod M, Lam CSP, Kohsaka S et al (2018) Lower cardiovascular risk associated with SGLT-2i in >400,000 patients: the CVD-REAL 2 study. J Am Coll Cardiol. 10.1016/j.jacc.2018.03.009
    • (2018) J am Coll Cardiol
    • Kosiborod, M.1    Lam, C.S.P.2    Kohsaka, S.3
  • 19
    • 84866424717 scopus 로고    scopus 로고
    • High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes
    • PID: 22618812
    • Boonman-de Winter LJ, Rutten FH, Cramer MJ et al (2012) High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia 55:2154–2162
    • (2012) Diabetologia , vol.55 , pp. 2154-2162
    • Boonman-de Winter, L.J.1    Rutten, F.H.2    Cramer, M.J.3
  • 20
    • 84964507777 scopus 로고    scopus 로고
    • SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
    • PID: 27112340
    • Sattar N, McLaren J, Kristensen SL, Preiss D, McMurray JJ (2016) SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms? Diabetologia 59:1333–1339
    • (2016) Diabetologia , vol.59 , pp. 1333-1339
    • Sattar, N.1    McLaren, J.2    Kristensen, S.L.3    Preiss, D.4    McMurray, J.J.5
  • 21
    • 85032165629 scopus 로고    scopus 로고
    • Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials
    • PID: 29061576
    • Lytvyn Y, Bjornstad P, Udell JA, Lovshin JA, Cherney DZI (2017) Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials. Circulation 136:1643–1658
    • (2017) Circulation , vol.136 , pp. 1643-1658
    • Lytvyn, Y.1    Bjornstad, P.2    Udell, J.A.3    Lovshin, J.A.4    Cherney, D.Z.I.5
  • 22
    • 85052568503 scopus 로고    scopus 로고
    • Empagliflozin (EMPA) reduces heart failure irrespective of control of blood pressure (BP), low density lipoprotein cholesterol (LDL-C), and HbA1c
    • Abstract
    • Fitchett D, McKnight J, Lee J et al (2017) Empagliflozin (EMPA) reduces heart failure irrespective of control of blood pressure (BP), low density lipoprotein cholesterol (LDL-C), and HbA1c. Diabetes 66:A312–A313 Abstract
    • (2017) Diabetes , vol.66 , pp. A312-A313
    • Fitchett, D.1    McKnight, J.2    Lee, J.3
  • 23
    • 85042792101 scopus 로고    scopus 로고
    • Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease
    • PID: 28904068
    • Wanner C, Lachin JM, Inzucchi SE et al (2018) Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease. Circulation 137:119–129
    • (2018) Circulation , vol.137 , pp. 119-129
    • Wanner, C.1    Lachin, J.M.2    Inzucchi, S.E.3
  • 24
    • 85021083050 scopus 로고    scopus 로고
    • Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes
    • PID: 28428225
    • Al-Jobori H, Daniele G, Cersosimo E et al (2017) Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes. Diabetes 66:1999–2006
    • (2017) Diabetes , vol.66 , pp. 1999-2006
    • Al-Jobori, H.1    Daniele, G.2    Cersosimo, E.3
  • 25
    • 84878947970 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeksʼ treatment with empagliflozin once daily in patients with type 2 diabetes
    • PID: 23356556
    • Heise T, Seewaldt-Becker E, Macha S et al (2013) Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeksʼ treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab 15:613–621
    • (2013) Diabetes Obes Metab , vol.15 , pp. 613-621
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3
  • 26
    • 84877652575 scopus 로고    scopus 로고
    • Empagliflozin (BI 10773), a potent and selective sglt2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • PID: 27121669
    • Seman L, Macha S, Nehmiz G et al (2013) Empagliflozin (BI 10773), a potent and selective sglt2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Drug Dev 2:152–161
    • (2013) Clin Pharmacol Drug Dev , vol.2 , pp. 152-161
    • Seman, L.1    Macha, S.2    Nehmiz, G.3
  • 27
    • 85027545481 scopus 로고    scopus 로고
    • Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure
    • Byrne NJ, Parajuli N, Levasseur JL et al (2017) Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure. JACC: Basic Translational Sci 1:347–354
    • (2017) JACC: Basic Translational Sci , vol.1 , pp. 347-354
    • Byrne, N.J.1    Parajuli, N.2    Levasseur, J.L.3
  • 28
    • 85017099681 scopus 로고    scopus 로고
    • Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?
    • PID: 28391552
    • Shi X, Verma S, Yun J et al (2017) Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial? Mol Cell Biochem 433:97–102
    • (2017) Mol Cell Biochem , vol.433 , pp. 97-102
    • Shi, X.1    Verma, S.2    Yun, J.3
  • 29
    • 85027965828 scopus 로고    scopus 로고
    • The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors
    • PID: 28836359
    • Butler J, Hamo CE, Filippatos G et al (2017) The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors. Eur J Heart Fail 19:1390–1400
    • (2017) Eur J Heart Fail , vol.19 , pp. 1390-1400
    • Butler, J.1    Hamo, C.E.2    Filippatos, G.3
  • 30
    • 85042484963 scopus 로고    scopus 로고
    • SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial
    • PID: 29301520
    • Karg MV, Bosch A, Kannenkeril D et al (2018) SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial. Cardiovasc Diabetol 17:5
    • (2018) Cardiovasc Diabetol , vol.17 , pp. 5
    • Karg, M.V.1    Bosch, A.2    Kannenkeril, D.3
  • 31
    • 85041180129 scopus 로고    scopus 로고
    • How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial
    • PID: 29203583
    • Inzucchi SE, Zinman B, Fitchett D et al (2018) How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial. Diabetes Care 41:356–363
    • (2018) Diabetes Care , vol.41 , pp. 356-363
    • Inzucchi, S.E.1    Zinman, B.2    Fitchett, D.3
  • 32
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • PID: 23668478
    • Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J (2013) Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15:853–862
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    de Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 33
    • 85034093732 scopus 로고    scopus 로고
    • Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis
    • PID: 29024278
    • Hallow KM, Helmlinger G, Greasley PJ, McMurray JJV, Boulton DW (2018) Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis. Diabetes Obes Metab 20:479–487
    • (2018) Diabetes Obes Metab , vol.20 , pp. 479-487
    • Hallow, K.M.1    Helmlinger, G.2    Greasley, P.J.3    McMurray, J.J.V.4    Boulton, D.W.5
  • 34
    • 85042152654 scopus 로고    scopus 로고
    • Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects
    • PID: 29440005
    • Wilcox CS, Shen W, Boulton DW, Leslie BR, Griffen SC (2018) Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects. J Am Heart Assoc 7:e007046
    • (2018) J Am Heart Assoc , vol.7
    • Wilcox, C.S.1    Shen, W.2    Boulton, D.W.3    Leslie, B.R.4    Griffen, S.C.5
  • 35
    • 85030993345 scopus 로고    scopus 로고
    • Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus
    • PID: 28923906
    • Striepe K, Jumar A, Ott C et al (2017) Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus. Circulation 136:1167–1169
    • (2017) Circulation , vol.136 , pp. 1167-1169
    • Striepe, K.1    Jumar, A.2    Ott, C.3
  • 36
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • PID: 26343814
    • Chilton R, Tikkanen I, Cannon CP et al (2015) Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17:1180–1193
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3
  • 37
    • 85041582283 scopus 로고    scopus 로고
    • The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels
    • PID: 29409796
    • Li H, Shin SE, Seo MS et al (2018) The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels. Life Sci 197:46–55
    • (2018) Life Sci , vol.197 , pp. 46-55
    • Li, H.1    Shin, S.E.2    Seo, M.S.3
  • 38
    • 85031924469 scopus 로고    scopus 로고
    • Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
    • PID: 29061124
    • Solini A, Giannini L, Seghieri M et al (2017) Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol 16:138
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 138
    • Solini, A.1    Giannini, L.2    Seghieri, M.3
  • 39
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME Trial: a “Thrifty Substrate” hypothesis
    • PID: 27289126
    • Ferrannini E, Mark M, Mayoux E (2016) CV protection in the EMPA-REG OUTCOME Trial: a “Thrifty Substrate” hypothesis. Diabetes Care 39:1108–1114
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 40
    • 84991106931 scopus 로고    scopus 로고
    • Empagliflozin’s fuel hypothesis: not so soon
    • PID: 27508868
    • Lopaschuk GD, Verma S (2016) Empagliflozin’s fuel hypothesis: not so soon. Cell Metab 24:200–202
    • (2016) Cell Metab , vol.24 , pp. 200-202
    • Lopaschuk, G.D.1    Verma, S.2
  • 42
    • 85031999842 scopus 로고    scopus 로고
    • The diabetic heart utilizes ketone bodies as an energy source
    • PID: 29132539
    • Mizuno Y, Harada E, Nakagawa H et al (2017) The diabetic heart utilizes ketone bodies as an energy source. Metabolism 77:65–72
    • (2017) Metabolism , vol.77 , pp. 65-72
    • Mizuno, Y.1    Harada, E.2    Nakagawa, H.3
  • 43
    • 85015064440 scopus 로고    scopus 로고
    • Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: a positron emission tomography study
    • PID: 28242634
    • Gormsen LC, Svart M, Thomsen HH et al (2017) Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: a positron emission tomography study. J Am Heart Assoc 6:e005066
    • (2017) J Am Heart Assoc , vol.6
    • Gormsen, L.C.1    Svart, M.2    Thomsen, H.H.3
  • 44
    • 85052598169 scopus 로고    scopus 로고
    • Empagliflozin induces a myocardial metabolic shift from glucose consumption to ketone metabolism that mitigates adverse cardiac remodeling and improves myocardial contractility
    • Abstract
    • Santos-Gallego CG, Ibanez JAR, San Antonio R et al (2018) Empagliflozin induces a myocardial metabolic shift from glucose consumption to ketone metabolism that mitigates adverse cardiac remodeling and improves myocardial contractility. J Am Coll Cardiol 71:A674 Abstract
    • (2018) J Am Coll Cardiol , vol.71 , pp. A674
    • Santos-Gallego, C.G.1    Ibanez, J.A.R.2    San Antonio, R.3
  • 45
    • 85031040731 scopus 로고    scopus 로고
    • Effect of empagliflozin on the metabolic signature of patients with type 2 diabetes mellitus and cardiovascular disease
    • PID: 28874423
    • Kappel BA, Lehrke M, Schutt K et al (2017) Effect of empagliflozin on the metabolic signature of patients with type 2 diabetes mellitus and cardiovascular disease. Circulation 136:969–972
    • (2017) Circulation , vol.136 , pp. 969-972
    • Kappel, B.A.1    Lehrke, M.2    Schutt, K.3
  • 46
    • 85032620814 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action
    • PID: 28768320
    • Packer M, Anker SD, Butler J, Filippatos G, Zannad F (2017) Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol 2:1025–1029
    • (2017) JAMA Cardiol , vol.2 , pp. 1025-1029
    • Packer, M.1    Anker, S.D.2    Butler, J.3    Filippatos, G.4    Zannad, F.5
  • 49
    • 84923527667 scopus 로고    scopus 로고
    • Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences
    • PID: 25616707
    • Gallo LA, Wright EM, Vallon V (2015) Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res 12:78–89
    • (2015) Diab Vasc Dis Res , vol.12 , pp. 78-89
    • Gallo, L.A.1    Wright, E.M.2    Vallon, V.3
  • 50
    • 15044351753 scopus 로고    scopus 로고
    • Cardiac remodeling and failure from molecules to man (part II)
    • PID: 15780796
    • Fedak PW, Verma S, Weisel RD, Li RK (2005) Cardiac remodeling and failure from molecules to man (part II). Cardiovasc Pathol 14:49–60
    • (2005) Cardiovasc Pathol , vol.14 , pp. 49-60
    • Fedak, P.W.1    Verma, S.2    Weisel, R.D.3    Li, R.K.4
  • 51
    • 85010842028 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
    • PID: 28132924
    • Lee TM, Chang NC, Lin SZ (2017) Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radic Biol Med 104:298–310
    • (2017) Free Radic Biol Med , vol.104 , pp. 298-310
    • Lee, T.M.1    Chang, N.C.2    Lin, S.Z.3
  • 52
    • 85052567080 scopus 로고    scopus 로고
    • Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG Outcome
    • Abstract
    • Kang S, Verma S, Teng G et al (2017) Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG Outcome. Can J Cardiol 33:S169 Abstract
    • (2017) Can J Cardiol , vol.33 , pp. S169
    • Kang, S.1    Verma, S.2    Teng, G.3
  • 54
    • 85026508106 scopus 로고    scopus 로고
    • Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease
    • PID: 28762019
    • Patel VB, Shah S, Verma S, Oudit GY (2017) Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease. Heart Fail Rev 22:889–902
    • (2017) Heart Fail Rev , vol.22 , pp. 889-902
    • Patel, V.B.1    Shah, S.2    Verma, S.3    Oudit, G.Y.4
  • 55
    • 85042173880 scopus 로고    scopus 로고
    • Do sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis
    • Packer M (2018) Do sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis. Diabetes Obes Metab. 10.1111/dom.13229
    • (2018) Diabetes Obes Metab
    • Packer, M.1
  • 56
    • 85044500198 scopus 로고    scopus 로고
    • Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
    • Timothy Garvey W, Van Gaal L, Leiter LA et al (2018) Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. Metabolism. 10.1016/j.metabol.2018.02.002
    • (2018) Metabolism
    • Timothy Garvey, W.1    van Gaal, L.2    Leiter, L.A.3
  • 57
    • 85042501860 scopus 로고    scopus 로고
    • The effect of dapagliflozin treatment on epicardial adipose tissue volume
    • PID: 29301516
    • Sato T, Aizawa Y, Yuasa S et al (2018) The effect of dapagliflozin treatment on epicardial adipose tissue volume. Cardiovasc Diabetol 17:6
    • (2018) Cardiovasc Diabetol , vol.17 , pp. 6
    • Sato, T.1    Aizawa, Y.2    Yuasa, S.3
  • 58
    • 85006172812 scopus 로고    scopus 로고
    • Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial?
    • PID: 27679584
    • Verma S, Garg A, Yan AT et al (2016) Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial? Diabetes Care 39:e212–e213
    • (2016) Diabetes Care , vol.39 , pp. e212-e213
    • Verma, S.1    Garg, A.2    Yan, A.T.3
  • 59
    • 84978252552 scopus 로고    scopus 로고
    • Research into the effect of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design
    • PID: 27422625
    • Singh JS, Fathi A, Vickneson K et al (2016) Research into the effect of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design. Cardiovasc Diabetol 15:97
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 97
    • Singh, J.S.1    Fathi, A.2    Vickneson, K.3
  • 60
    • 85025091208 scopus 로고    scopus 로고
    • Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes
    • PID: 28619659
    • Januzzi JL Jr, Butler J, Jarolim P et al (2017) Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes. J Am Coll Cardiol 70:704–712
    • (2017) J Am Coll Cardiol , vol.70 , pp. 704-712
    • Januzzi, J.L.1    Butler, J.2    Jarolim, P.3
  • 61
    • 85038950538 scopus 로고    scopus 로고
    • Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME trial
    • PID: 29133344
    • Inzucchi SE, Iliev H, Pfarr E, Zinman B (2018) Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME trial. Diabetes Care 41:e4–e5
    • (2018) Diabetes Care , vol.41 , pp. e4-e5
    • Inzucchi, S.E.1    Iliev, H.2    Pfarr, E.3    Zinman, B.4
  • 62
    • 85034212680 scopus 로고    scopus 로고
    • Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME
    • PID: 29133602
    • Verma S, Mazer CD, Al-Omran M et al (2018) Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME. Circulation 137:405–407
    • (2018) Circulation , vol.137 , pp. 405-407
    • Verma, S.1    Mazer, C.D.2    Al-Omran, M.3
  • 63
    • 85045561965 scopus 로고    scopus 로고
    • Canagliflozin improves the recovery of blood flow in an experimental model of severe limb ischemia
    • Sherman SE, Bell GI, Teoh H et al (2018) Canagliflozin improves the recovery of blood flow in an experimental model of severe limb ischemia. JACC Basic Translational Sci 3:327–329
    • (2018) JACC Basic Translational Sci , vol.3 , pp. 327-329
    • Sherman, S.E.1    Bell, G.I.2    Teoh, H.3
  • 64
    • 85047123698 scopus 로고    scopus 로고
    • Effects of liraglutide on cardiovascular events in patients with type 2 diabetes and polyvascular disease: results of the LEADER trial
    • PID: 29760228
    • Verma S, Bhatt DL, Bain SC et al (2018) Effects of liraglutide on cardiovascular events in patients with type 2 diabetes and polyvascular disease: results of the LEADER trial. Circulation 137:2179–2183
    • (2018) Circulation , vol.137 , pp. 2179-2183
    • Verma, S.1    Bhatt, D.L.2    Bain, S.C.3
  • 65
    • 85045458725 scopus 로고    scopus 로고
    • The design and rationale for the dapagliflozin effect on cardiovascular events (DECLARE) – TIMI 58 Trial
    • PID: 29898853
    • Wiviott SD, Raz I, Bonaca MP et al (2018) The design and rationale for the dapagliflozin effect on cardiovascular events (DECLARE) – TIMI 58 Trial. Am Heart J 200:83–89
    • (2018) Am Heart J , vol.200 , pp. 83-89
    • Wiviott, S.D.1    Raz, I.2    Bonaca, M.P.3
  • 66
    • 85038113623 scopus 로고    scopus 로고
    • The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study rationale, design, and baseline characteristics
    • PID: 29253846
    • Jardine MJ, Mahaffey KW, Neal B et al (2017) The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study rationale, design, and baseline characteristics. Am J Nephrol 46:462–472
    • (2017) Am J Nephrol , vol.46 , pp. 462-472
    • Jardine, M.J.1    Mahaffey, K.W.2    Neal, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.