-
1
-
-
85023777061
-
Canagliflozin and cardiovascular and renal events in type 2 diabetes
-
PID: 28605608
-
Neal B, Perkovic V, Mahaffey KW et al (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377:644–657
-
(2017)
N Engl J Med
, vol.377
, pp. 644-657
-
-
Neal, B.1
Perkovic, V.2
Mahaffey, K.W.3
-
2
-
-
84944800184
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
PID: 26378978
-
Zinman B, Wanner C, Lachin JM et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373:2117–2128
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
-
3
-
-
85047121888
-
Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial
-
Verma S, Mazer CD, Fitchett D et al (2018) Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial. Diabetologia 61:1712–1723
-
(2018)
Diabetologia
, vol.61
, pp. 1712-1723
-
-
Verma, S.1
Mazer, C.D.2
Fitchett, D.3
-
4
-
-
85043391124
-
Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial
-
PID: 29020355
-
Fitchett D, Butler J, van de Borne P et al (2018) Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial. Eur Heart J 39:363–370
-
(2018)
Eur Heart J
, vol.39
, pp. 363-370
-
-
Fitchett, D.1
Butler, J.2
van de Borne, P.3
-
5
-
-
84975698839
-
Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
-
PID: 26819227
-
Fitchett D, Zinman B, Wanner C et al (2016) Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 37:1526–1534
-
(2016)
Eur Heart J
, vol.37
, pp. 1526-1534
-
-
Fitchett, D.1
Zinman, B.2
Wanner, C.3
-
6
-
-
85055707998
-
Canagliflozin and heart failure in type 2 diabetes mellitus: Results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)
-
Rådholm K, Figtree G, Perkovic V et al (2018) Canagliflozin and heart failure in type 2 diabetes mellitus: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study). Circulation. 10.1161/CIRCULATIONAHA.118.034222
-
(2018)
Circulation
-
-
Rådholm, K.1
Figtree, G.2
Perkovic, V.3
-
7
-
-
85030655315
-
The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure
-
PID: 28636701
-
Verma S, McMurray JJV, Cherney DZI (2017) The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure. JAMA Cardiol 2:939–940
-
(2017)
JAMA Cardiol
, vol.2
, pp. 939-940
-
-
Verma, S.1
McMurray, J.J.V.2
Cherney, D.Z.I.3
-
8
-
-
85037670718
-
Heart failure: epidemiology, pathophysiology, and management of heart failure in diabetes mellitus
-
Jorsal A, Wiggers H, McMurray JJV (2018) Heart failure: epidemiology, pathophysiology, and management of heart failure in diabetes mellitus. Endocrinol Metab Clin N Am 47:117–135
-
(2018)
Endocrinol Metab Clin N Am
, vol.47
, pp. 117-135
-
-
Jorsal, A.1
Wiggers, H.2
McMurray, J.J.V.3
-
10
-
-
85046398177
-
Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology
-
Seferovic PM, Petrie MC, Filippatos GS et al (2018) Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 10.1002/ejhf.1170
-
(2018)
Eur J Heart Fail
-
-
Seferovic, P.M.1
Petrie, M.C.2
Filippatos, G.S.3
-
11
-
-
85042620242
-
Prevalent and incident heart failure in cardiovascular outcome trials of patients with type 2 diabetes
-
PID: 29534825
-
Greene SJ, Vaduganathan M, Khan MS et al (2018) Prevalent and incident heart failure in cardiovascular outcome trials of patients with type 2 diabetes. J Am Coll Cardiol 71:1379–1390
-
(2018)
J Am Coll Cardiol
, vol.71
, pp. 1379-1390
-
-
Greene, S.J.1
Vaduganathan, M.2
Khan, M.S.3
-
12
-
-
85044730815
-
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
-
PID: 29449364
-
Jia G, Hill MA, Sowers JR (2018) Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res 122:624–638
-
(2018)
Circ Res
, vol.122
, pp. 624-638
-
-
Jia, G.1
Hill, M.A.2
Sowers, J.R.3
-
13
-
-
84937227669
-
Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes
-
PID: 25888006
-
Seferovic PM, Paulus WJ (2015) Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. Eur Heart J 36:1718–1727
-
(2015)
Eur Heart J
, vol.36
, pp. 1718-1727
-
-
Seferovic, P.M.1
Paulus, W.J.2
-
14
-
-
85047122839
-
Prevention of heart failure with SGLT2 inhibition: Insights from CVD-REAL
-
in press
-
Farkouh ME, Verma S (2018) Prevention of heart failure with SGLT2 inhibition: insights from CVD-REAL. J Am Coll Cardiol (in press)
-
(2018)
J am Coll Cardiol
-
-
Farkouh, M.E.1
Verma, S.2
-
15
-
-
85025455714
-
Diabetes mellitus, microalbuminuria, and subclinical cardiac disease: identification and monitoring of individuals at risk of heart failure
-
PID: 28716801
-
Swoboda PP, McDiarmid AK, Erhayiem B et al (2017) Diabetes mellitus, microalbuminuria, and subclinical cardiac disease: identification and monitoring of individuals at risk of heart failure. J Am Heart Assoc 6:e005539
-
(2017)
J Am Heart Assoc
, vol.6
-
-
Swoboda, P.P.1
McDiarmid, A.K.2
Erhayiem, B.3
-
16
-
-
85019731757
-
Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors)
-
PID: 28522450
-
Kosiborod M, Cavender MA, Fu AZ et al (2017) Lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL study (comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors). Circulation 136:249–259
-
(2017)
Circulation
, vol.136
, pp. 249-259
-
-
Kosiborod, M.1
Cavender, M.A.2
Fu, A.Z.3
-
17
-
-
85048449544
-
Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)
-
PID: 29133604
-
Mahaffey KW, Neal B, Perkovic V et al (2018) Canagliflozin for primary and secondary prevention of cardiovascular events: results from the CANVAS Program (Canagliflozin Cardiovascular Assessment Study). Circulation 137:323–334
-
(2018)
Circulation
, vol.137
, pp. 323-334
-
-
Mahaffey, K.W.1
Neal, B.2
Perkovic, V.3
-
18
-
-
85047499725
-
Lower cardiovascular risk associated with SGLT-2i in >400,000 patients: The CVD-REAL 2 study
-
Kosiborod M, Lam CSP, Kohsaka S et al (2018) Lower cardiovascular risk associated with SGLT-2i in >400,000 patients: the CVD-REAL 2 study. J Am Coll Cardiol. 10.1016/j.jacc.2018.03.009
-
(2018)
J am Coll Cardiol
-
-
Kosiborod, M.1
Lam, C.S.P.2
Kohsaka, S.3
-
19
-
-
84866424717
-
High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes
-
PID: 22618812
-
Boonman-de Winter LJ, Rutten FH, Cramer MJ et al (2012) High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia 55:2154–2162
-
(2012)
Diabetologia
, vol.55
, pp. 2154-2162
-
-
Boonman-de Winter, L.J.1
Rutten, F.H.2
Cramer, M.J.3
-
20
-
-
84964507777
-
SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
-
PID: 27112340
-
Sattar N, McLaren J, Kristensen SL, Preiss D, McMurray JJ (2016) SGLT2 inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms? Diabetologia 59:1333–1339
-
(2016)
Diabetologia
, vol.59
, pp. 1333-1339
-
-
Sattar, N.1
McLaren, J.2
Kristensen, S.L.3
Preiss, D.4
McMurray, J.J.5
-
21
-
-
85032165629
-
Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials
-
PID: 29061576
-
Lytvyn Y, Bjornstad P, Udell JA, Lovshin JA, Cherney DZI (2017) Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials. Circulation 136:1643–1658
-
(2017)
Circulation
, vol.136
, pp. 1643-1658
-
-
Lytvyn, Y.1
Bjornstad, P.2
Udell, J.A.3
Lovshin, J.A.4
Cherney, D.Z.I.5
-
22
-
-
85052568503
-
Empagliflozin (EMPA) reduces heart failure irrespective of control of blood pressure (BP), low density lipoprotein cholesterol (LDL-C), and HbA1c
-
Abstract
-
Fitchett D, McKnight J, Lee J et al (2017) Empagliflozin (EMPA) reduces heart failure irrespective of control of blood pressure (BP), low density lipoprotein cholesterol (LDL-C), and HbA1c. Diabetes 66:A312–A313 Abstract
-
(2017)
Diabetes
, vol.66
, pp. A312-A313
-
-
Fitchett, D.1
McKnight, J.2
Lee, J.3
-
23
-
-
85042792101
-
Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease
-
PID: 28904068
-
Wanner C, Lachin JM, Inzucchi SE et al (2018) Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease. Circulation 137:119–129
-
(2018)
Circulation
, vol.137
, pp. 119-129
-
-
Wanner, C.1
Lachin, J.M.2
Inzucchi, S.E.3
-
24
-
-
85021083050
-
Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes
-
PID: 28428225
-
Al-Jobori H, Daniele G, Cersosimo E et al (2017) Empagliflozin and kinetics of renal glucose transport in healthy individuals and individuals with type 2 diabetes. Diabetes 66:1999–2006
-
(2017)
Diabetes
, vol.66
, pp. 1999-2006
-
-
Al-Jobori, H.1
Daniele, G.2
Cersosimo, E.3
-
25
-
-
84878947970
-
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeksʼ treatment with empagliflozin once daily in patients with type 2 diabetes
-
PID: 23356556
-
Heise T, Seewaldt-Becker E, Macha S et al (2013) Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeksʼ treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab 15:613–621
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 613-621
-
-
Heise, T.1
Seewaldt-Becker, E.2
Macha, S.3
-
26
-
-
84877652575
-
Empagliflozin (BI 10773), a potent and selective sglt2 inhibitor, induces dose-dependent glucosuria in healthy subjects
-
PID: 27121669
-
Seman L, Macha S, Nehmiz G et al (2013) Empagliflozin (BI 10773), a potent and selective sglt2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Drug Dev 2:152–161
-
(2013)
Clin Pharmacol Drug Dev
, vol.2
, pp. 152-161
-
-
Seman, L.1
Macha, S.2
Nehmiz, G.3
-
27
-
-
85027545481
-
Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure
-
Byrne NJ, Parajuli N, Levasseur JL et al (2017) Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure. JACC: Basic Translational Sci 1:347–354
-
(2017)
JACC: Basic Translational Sci
, vol.1
, pp. 347-354
-
-
Byrne, N.J.1
Parajuli, N.2
Levasseur, J.L.3
-
28
-
-
85017099681
-
Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?
-
PID: 28391552
-
Shi X, Verma S, Yun J et al (2017) Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial? Mol Cell Biochem 433:97–102
-
(2017)
Mol Cell Biochem
, vol.433
, pp. 97-102
-
-
Shi, X.1
Verma, S.2
Yun, J.3
-
29
-
-
85027965828
-
The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors
-
PID: 28836359
-
Butler J, Hamo CE, Filippatos G et al (2017) The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors. Eur J Heart Fail 19:1390–1400
-
(2017)
Eur J Heart Fail
, vol.19
, pp. 1390-1400
-
-
Butler, J.1
Hamo, C.E.2
Filippatos, G.3
-
30
-
-
85042484963
-
SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial
-
PID: 29301520
-
Karg MV, Bosch A, Kannenkeril D et al (2018) SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial. Cardiovasc Diabetol 17:5
-
(2018)
Cardiovasc Diabetol
, vol.17
, pp. 5
-
-
Karg, M.V.1
Bosch, A.2
Kannenkeril, D.3
-
31
-
-
85041180129
-
How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial
-
PID: 29203583
-
Inzucchi SE, Zinman B, Fitchett D et al (2018) How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial. Diabetes Care 41:356–363
-
(2018)
Diabetes Care
, vol.41
, pp. 356-363
-
-
Inzucchi, S.E.1
Zinman, B.2
Fitchett, D.3
-
32
-
-
84880850027
-
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
-
PID: 23668478
-
Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J (2013) Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15:853–862
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 853-862
-
-
Lambers Heerspink, H.J.1
de Zeeuw, D.2
Wie, L.3
Leslie, B.4
List, J.5
-
33
-
-
85034093732
-
Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis
-
PID: 29024278
-
Hallow KM, Helmlinger G, Greasley PJ, McMurray JJV, Boulton DW (2018) Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis. Diabetes Obes Metab 20:479–487
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 479-487
-
-
Hallow, K.M.1
Helmlinger, G.2
Greasley, P.J.3
McMurray, J.J.V.4
Boulton, D.W.5
-
34
-
-
85042152654
-
Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects
-
PID: 29440005
-
Wilcox CS, Shen W, Boulton DW, Leslie BR, Griffen SC (2018) Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects. J Am Heart Assoc 7:e007046
-
(2018)
J Am Heart Assoc
, vol.7
-
-
Wilcox, C.S.1
Shen, W.2
Boulton, D.W.3
Leslie, B.R.4
Griffen, S.C.5
-
35
-
-
85030993345
-
Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus
-
PID: 28923906
-
Striepe K, Jumar A, Ott C et al (2017) Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus. Circulation 136:1167–1169
-
(2017)
Circulation
, vol.136
, pp. 1167-1169
-
-
Striepe, K.1
Jumar, A.2
Ott, C.3
-
36
-
-
84945455839
-
Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
-
PID: 26343814
-
Chilton R, Tikkanen I, Cannon CP et al (2015) Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17:1180–1193
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 1180-1193
-
-
Chilton, R.1
Tikkanen, I.2
Cannon, C.P.3
-
37
-
-
85041582283
-
The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels
-
PID: 29409796
-
Li H, Shin SE, Seo MS et al (2018) The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels. Life Sci 197:46–55
-
(2018)
Life Sci
, vol.197
, pp. 46-55
-
-
Li, H.1
Shin, S.E.2
Seo, M.S.3
-
38
-
-
85031924469
-
Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
-
PID: 29061124
-
Solini A, Giannini L, Seghieri M et al (2017) Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol 16:138
-
(2017)
Cardiovasc Diabetol
, vol.16
, pp. 138
-
-
Solini, A.1
Giannini, L.2
Seghieri, M.3
-
39
-
-
84975853831
-
CV protection in the EMPA-REG OUTCOME Trial: a “Thrifty Substrate” hypothesis
-
PID: 27289126
-
Ferrannini E, Mark M, Mayoux E (2016) CV protection in the EMPA-REG OUTCOME Trial: a “Thrifty Substrate” hypothesis. Diabetes Care 39:1108–1114
-
(2016)
Diabetes Care
, vol.39
, pp. 1108-1114
-
-
Ferrannini, E.1
Mark, M.2
Mayoux, E.3
-
40
-
-
84991106931
-
Empagliflozin’s fuel hypothesis: not so soon
-
PID: 27508868
-
Lopaschuk GD, Verma S (2016) Empagliflozin’s fuel hypothesis: not so soon. Cell Metab 24:200–202
-
(2016)
Cell Metab
, vol.24
, pp. 200-202
-
-
Lopaschuk, G.D.1
Verma, S.2
-
41
-
-
74949133862
-
Myocardial fatty acid metabolism in health and disease
-
PID: 20086077
-
Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90:207–258
-
(2010)
Physiol Rev
, vol.90
, pp. 207-258
-
-
Lopaschuk, G.D.1
Ussher, J.R.2
Folmes, C.D.3
Jaswal, J.S.4
Stanley, W.C.5
-
42
-
-
85031999842
-
The diabetic heart utilizes ketone bodies as an energy source
-
PID: 29132539
-
Mizuno Y, Harada E, Nakagawa H et al (2017) The diabetic heart utilizes ketone bodies as an energy source. Metabolism 77:65–72
-
(2017)
Metabolism
, vol.77
, pp. 65-72
-
-
Mizuno, Y.1
Harada, E.2
Nakagawa, H.3
-
43
-
-
85015064440
-
Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: a positron emission tomography study
-
PID: 28242634
-
Gormsen LC, Svart M, Thomsen HH et al (2017) Ketone body infusion with 3-hydroxybutyrate reduces myocardial glucose uptake and increases blood flow in humans: a positron emission tomography study. J Am Heart Assoc 6:e005066
-
(2017)
J Am Heart Assoc
, vol.6
-
-
Gormsen, L.C.1
Svart, M.2
Thomsen, H.H.3
-
44
-
-
85052598169
-
Empagliflozin induces a myocardial metabolic shift from glucose consumption to ketone metabolism that mitigates adverse cardiac remodeling and improves myocardial contractility
-
Abstract
-
Santos-Gallego CG, Ibanez JAR, San Antonio R et al (2018) Empagliflozin induces a myocardial metabolic shift from glucose consumption to ketone metabolism that mitigates adverse cardiac remodeling and improves myocardial contractility. J Am Coll Cardiol 71:A674 Abstract
-
(2018)
J Am Coll Cardiol
, vol.71
, pp. A674
-
-
Santos-Gallego, C.G.1
Ibanez, J.A.R.2
San Antonio, R.3
-
45
-
-
85031040731
-
Effect of empagliflozin on the metabolic signature of patients with type 2 diabetes mellitus and cardiovascular disease
-
PID: 28874423
-
Kappel BA, Lehrke M, Schutt K et al (2017) Effect of empagliflozin on the metabolic signature of patients with type 2 diabetes mellitus and cardiovascular disease. Circulation 136:969–972
-
(2017)
Circulation
, vol.136
, pp. 969-972
-
-
Kappel, B.A.1
Lehrke, M.2
Schutt, K.3
-
46
-
-
85032620814
-
Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action
-
PID: 28768320
-
Packer M, Anker SD, Butler J, Filippatos G, Zannad F (2017) Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol 2:1025–1029
-
(2017)
JAMA Cardiol
, vol.2
, pp. 1025-1029
-
-
Packer, M.1
Anker, S.D.2
Butler, J.3
Filippatos, G.4
Zannad, F.5
-
49
-
-
84923527667
-
Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences
-
PID: 25616707
-
Gallo LA, Wright EM, Vallon V (2015) Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res 12:78–89
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 78-89
-
-
Gallo, L.A.1
Wright, E.M.2
Vallon, V.3
-
50
-
-
15044351753
-
Cardiac remodeling and failure from molecules to man (part II)
-
PID: 15780796
-
Fedak PW, Verma S, Weisel RD, Li RK (2005) Cardiac remodeling and failure from molecules to man (part II). Cardiovasc Pathol 14:49–60
-
(2005)
Cardiovasc Pathol
, vol.14
, pp. 49-60
-
-
Fedak, P.W.1
Verma, S.2
Weisel, R.D.3
Li, R.K.4
-
51
-
-
85010842028
-
Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
-
PID: 28132924
-
Lee TM, Chang NC, Lin SZ (2017) Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Free Radic Biol Med 104:298–310
-
(2017)
Free Radic Biol Med
, vol.104
, pp. 298-310
-
-
Lee, T.M.1
Chang, N.C.2
Lin, S.Z.3
-
52
-
-
85052567080
-
Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG Outcome
-
Abstract
-
Kang S, Verma S, Teng G et al (2017) Direct effects of empagliflozin on extracellular matrix remodeling in human cardiac fibroblasts: novel translational clues to EMPA-REG Outcome. Can J Cardiol 33:S169 Abstract
-
(2017)
Can J Cardiol
, vol.33
, pp. S169
-
-
Kang, S.1
Verma, S.2
Teng, G.3
-
53
-
-
18044366410
-
Adipokines: molecular links between obesity and atherosclerosis
-
PID: 15653761
-
Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S (2005) Adipokines: molecular links between obesity and atherosclerosis. Am J Physiol Heart Circ Physiol 288:H2031–H2041
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
, pp. H2031-H2041
-
-
Lau, D.C.1
Dhillon, B.2
Yan, H.3
Szmitko, P.E.4
Verma, S.5
-
54
-
-
85026508106
-
Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease
-
PID: 28762019
-
Patel VB, Shah S, Verma S, Oudit GY (2017) Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease. Heart Fail Rev 22:889–902
-
(2017)
Heart Fail Rev
, vol.22
, pp. 889-902
-
-
Patel, V.B.1
Shah, S.2
Verma, S.3
Oudit, G.Y.4
-
55
-
-
85042173880
-
Do sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis
-
Packer M (2018) Do sodium-glucose co-transporter-2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis. Diabetes Obes Metab. 10.1111/dom.13229
-
(2018)
Diabetes Obes Metab
-
-
Packer, M.1
-
56
-
-
85044500198
-
Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
-
Timothy Garvey W, Van Gaal L, Leiter LA et al (2018) Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. Metabolism. 10.1016/j.metabol.2018.02.002
-
(2018)
Metabolism
-
-
Timothy Garvey, W.1
van Gaal, L.2
Leiter, L.A.3
-
57
-
-
85042501860
-
The effect of dapagliflozin treatment on epicardial adipose tissue volume
-
PID: 29301516
-
Sato T, Aizawa Y, Yuasa S et al (2018) The effect of dapagliflozin treatment on epicardial adipose tissue volume. Cardiovasc Diabetol 17:6
-
(2018)
Cardiovasc Diabetol
, vol.17
, pp. 6
-
-
Sato, T.1
Aizawa, Y.2
Yuasa, S.3
-
58
-
-
85006172812
-
Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial?
-
PID: 27679584
-
Verma S, Garg A, Yan AT et al (2016) Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: an important clue to the EMPA-REG OUTCOME trial? Diabetes Care 39:e212–e213
-
(2016)
Diabetes Care
, vol.39
, pp. e212-e213
-
-
Verma, S.1
Garg, A.2
Yan, A.T.3
-
59
-
-
84978252552
-
Research into the effect of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design
-
PID: 27422625
-
Singh JS, Fathi A, Vickneson K et al (2016) Research into the effect of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design. Cardiovasc Diabetol 15:97
-
(2016)
Cardiovasc Diabetol
, vol.15
, pp. 97
-
-
Singh, J.S.1
Fathi, A.2
Vickneson, K.3
-
60
-
-
85025091208
-
Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes
-
PID: 28619659
-
Januzzi JL Jr, Butler J, Jarolim P et al (2017) Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes. J Am Coll Cardiol 70:704–712
-
(2017)
J Am Coll Cardiol
, vol.70
, pp. 704-712
-
-
Januzzi, J.L.1
Butler, J.2
Jarolim, P.3
-
61
-
-
85038950538
-
Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME trial
-
PID: 29133344
-
Inzucchi SE, Iliev H, Pfarr E, Zinman B (2018) Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME trial. Diabetes Care 41:e4–e5
-
(2018)
Diabetes Care
, vol.41
, pp. e4-e5
-
-
Inzucchi, S.E.1
Iliev, H.2
Pfarr, E.3
Zinman, B.4
-
62
-
-
85034212680
-
Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME
-
PID: 29133602
-
Verma S, Mazer CD, Al-Omran M et al (2018) Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME. Circulation 137:405–407
-
(2018)
Circulation
, vol.137
, pp. 405-407
-
-
Verma, S.1
Mazer, C.D.2
Al-Omran, M.3
-
63
-
-
85045561965
-
Canagliflozin improves the recovery of blood flow in an experimental model of severe limb ischemia
-
Sherman SE, Bell GI, Teoh H et al (2018) Canagliflozin improves the recovery of blood flow in an experimental model of severe limb ischemia. JACC Basic Translational Sci 3:327–329
-
(2018)
JACC Basic Translational Sci
, vol.3
, pp. 327-329
-
-
Sherman, S.E.1
Bell, G.I.2
Teoh, H.3
-
64
-
-
85047123698
-
Effects of liraglutide on cardiovascular events in patients with type 2 diabetes and polyvascular disease: results of the LEADER trial
-
PID: 29760228
-
Verma S, Bhatt DL, Bain SC et al (2018) Effects of liraglutide on cardiovascular events in patients with type 2 diabetes and polyvascular disease: results of the LEADER trial. Circulation 137:2179–2183
-
(2018)
Circulation
, vol.137
, pp. 2179-2183
-
-
Verma, S.1
Bhatt, D.L.2
Bain, S.C.3
-
65
-
-
85045458725
-
The design and rationale for the dapagliflozin effect on cardiovascular events (DECLARE) – TIMI 58 Trial
-
PID: 29898853
-
Wiviott SD, Raz I, Bonaca MP et al (2018) The design and rationale for the dapagliflozin effect on cardiovascular events (DECLARE) – TIMI 58 Trial. Am Heart J 200:83–89
-
(2018)
Am Heart J
, vol.200
, pp. 83-89
-
-
Wiviott, S.D.1
Raz, I.2
Bonaca, M.P.3
-
66
-
-
85038113623
-
The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study rationale, design, and baseline characteristics
-
PID: 29253846
-
Jardine MJ, Mahaffey KW, Neal B et al (2017) The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study rationale, design, and baseline characteristics. Am J Nephrol 46:462–472
-
(2017)
Am J Nephrol
, vol.46
, pp. 462-472
-
-
Jardine, M.J.1
Mahaffey, K.W.2
Neal, B.3
|