-
3
-
-
79952721660
-
Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
-
Chen J, Williams S, Ho S, Loraine H, Hagan D, Whaley JM et al. Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members. Diabetes Ther 2010; 1: 57–92.
-
(2010)
Diabetes Ther
, vol.1
, pp. 57-92
-
-
Chen, J.1
Williams, S.2
Ho, S.3
Loraine, H.4
Hagan, D.5
Whaley, J.M.6
-
4
-
-
84921788614
-
Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans
-
Lu Y, Griffen SC, Boulton DW, Leil TA. Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans. Frontiers Pharmacol 2014; 5: 274.
-
(2014)
Frontiers Pharmacol
, vol.5
, pp. 274
-
-
Lu, Y.1
Griffen, S.C.2
Boulton, D.W.3
Leil, T.A.4
-
5
-
-
0036080516
-
Expression of monosaccharide transporters in intestine of diabetic humans
-
Dyer J, Wood IS, Palejwala A, Ellis A, Shirazi-Beechey SP. Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol 2002; 282: G241–248.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.282
, pp. G241-248
-
-
Dyer, J.1
Wood, I.S.2
Palejwala, A.3
Ellis, A.4
Shirazi-Beechey, S.P.5
-
6
-
-
33644688031
-
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
-
Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 2005; 54: 3427–3434.
-
(2005)
Diabetes
, vol.54
, pp. 3427-3434
-
-
Rahmoune, H.1
Thompson, P.W.2
Ward, J.M.3
Smith, C.D.4
Hong, G.5
Brown, J.6
-
7
-
-
0028344106
-
Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes
-
Burant CF, Flink S, DePaoli AM, Chen J, Lee WS, Hediger MA et al. Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes. J Clin Invest 1994; 93: 578–585.
-
(1994)
J Clin Invest
, vol.93
, pp. 578-585
-
-
Burant, C.F.1
Flink, S.2
DePaoli, A.M.3
Chen, J.4
Lee, W.S.5
Hediger, M.A.6
-
8
-
-
78651349221
-
Biology of human sodium glucose transporters
-
Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev 2011; 91: 733–794.
-
(2011)
Physiol Rev
, vol.91
, pp. 733-794
-
-
Wright, E.M.1
Loo, D.D.2
Hirayama, B.A.3
-
9
-
-
84860183617
-
A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
-
Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med 2012; 44: 375–393.
-
(2012)
Ann Med
, vol.44
, pp. 375-393
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
Pagano, G.4
-
10
-
-
67349275999
-
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
-
Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther 2009; 85: 513–519.
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 513-519
-
-
Komoroski, B.1
Vachharajani, N.2
Feng, Y.3
Li, L.4
Kornhauser, D.5
Pfister, M.6
-
11
-
-
79956331954
-
Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
-
Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab 2011; 13: 669–672.
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 669-672
-
-
Sha, S.1
Devineni, D.2
Ghosh, A.3
Polidori, D.4
Chien, S.5
Wexler, D.6
-
12
-
-
84865479822
-
Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?
-
Liu J, Lee T, DeFronzo RA. Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans? Diabetes 2012; 61: 2199–2204.
-
(2012)
Diabetes
, vol.61
, pp. 2199-2204
-
-
Liu, J.1
Lee, T.2
DeFronzo, R.A.3
-
13
-
-
84856080046
-
Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
-
De Silva A, Bloom SR. Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity. Gut Liver 2012; 6: 10–20.
-
(2012)
Gut Liver
, vol.6
, pp. 10-20
-
-
De Silva, A.1
Bloom, S.R.2
-
14
-
-
84962360678
-
Blood Pressure Reduction: An Added Benefit of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes
-
Majewski C, Bakris GL. Blood Pressure Reduction: An Added Benefit of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes. Diabetes Care 2015; 38: 429–430.
-
(2015)
Diabetes Care
, vol.38
, pp. 429-430
-
-
Majewski, C.1
Bakris, G.L.2
-
15
-
-
85031780039
-
Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes
-
Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, Fulcher GR et al. Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes. N Engl J Med 2017; 377: 2337–2348.
-
(2017)
N Engl J Med
, vol.377
, pp. 2337-2348
-
-
Garg, S.K.1
Henry, R.R.2
Banks, P.3
Buse, J.B.4
Davies, M.J.5
Fulcher, G.R.6
-
16
-
-
85050074310
-
-
ADA 77th Scientific Sessions; 11th June;, San Diego, CA, American Diabetes Association
-
Danne T, Cariou B, Banks P, Sawhney S, Strumph P. 146-LB — 2017: 24-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem2). ADA 77th Scientific Sessions; 11th June; San Diego, CA: American Diabetes Association, 2017.
-
(2017)
146-LB — 2017: 24-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem2)
-
-
Danne, T.1
Cariou, B.2
Banks, P.3
Sawhney, S.4
Strumph, P.5
-
17
-
-
85050152748
-
-
ADA 77th Scientific Sessions; 10th June;, San Diego, CA, American Diabetes Association
-
Buse JB, Garg SK, Rosenstock J, Banks P, Sawhney S, Strumph P. 69-OR - Twenty-Four-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem1). ADA 77th Scientific Sessions; 10th June; San Diego, CA: American Diabetes Association, 2017.
-
(2017)
69-OR - Twenty-Four-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem1)
-
-
Buse, J.B.1
Garg, S.K.2
Rosenstock, J.3
Banks, P.4
Sawhney, S.5
Strumph, P.6
-
18
-
-
84877865378
-
Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion: Results of a randomized, placebo-controlled study
-
Polidori D, Sha S, Mudaliar S, Ciaraldi TP, Ghosh A, Vaccaro N et al. Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion: Results of a randomized, placebo-controlled study. Diabetes Care 2013; 36: 2154–2161.
-
(2013)
Diabetes Care
, vol.36
, pp. 2154-2161
-
-
Polidori, D.1
Sha, S.2
Mudaliar, S.3
Ciaraldi, T.P.4
Ghosh, A.5
Vaccaro, N.6
-
19
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
-
Grempler R, Thomas L, Eckhardt M, Himmelsbach F, Sauer A, Sharp DE et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 2012; 14: 83–90.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
Himmelsbach, F.4
Sauer, A.5
Sharp, D.E.6
-
20
-
-
84893299467
-
Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study
-
Stenlof K, Cefalu WT, Kim KA, Jodar E, Alba M, Edwards R et al. Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study. Curr Med Res Opin 2014; 30: 163–175.
-
(2014)
Curr Med Res Opin
, vol.30
, pp. 163-175
-
-
Stenlof, K.1
Cefalu, W.T.2
Kim, K.A.3
Jodar, E.4
Alba, M.5
Edwards, R.6
-
21
-
-
84924708763
-
Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial
-
Bailey CJ, Morales Villegas EC, Woo V, Tang W, Ptaszynska A, List JF. Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial. Diabet Med 2015; 32: 531–541.
-
(2015)
Diabet Med
, vol.32
, pp. 531-541
-
-
Bailey, C.J.1
Morales Villegas, E.C.2
Woo, V.3
Tang, W.4
Ptaszynska, A.5
List, J.F.6
-
22
-
-
84885954870
-
Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial
-
Roden M, Weng J, Eilbracht J, Delafont B, Kim G, Woerle HJ et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2013; 1: 208–219.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, pp. 208-219
-
-
Roden, M.1
Weng, J.2
Eilbracht, J.3
Delafont, B.4
Kim, G.5
Woerle, H.J.6
-
23
-
-
84943329171
-
Dapagliflozin as an adjunct therapy to insulin in the treatment of patients with type 1 diabetes mellitus
-
Tamez HE, Tamez AL, Garza LA, Hernandez MI, Polanco AC. Dapagliflozin as an adjunct therapy to insulin in the treatment of patients with type 1 diabetes mellitus. J Diabetes Metab Disord 2015; 14: 78.
-
(2015)
J Diabetes Metab Disord
, vol.14
, pp. 78
-
-
Tamez, H.E.1
Tamez, A.L.2
Garza, L.A.3
Hernandez, M.I.4
Polanco, A.C.5
-
24
-
-
84942258219
-
Empagliflozin as adjunct to insulin in patients with type 1 diabetes: a 4-week, randomized, placebo-controlled trial (EASE-1)
-
Pieber TR, Famulla S, Eilbracht J, Cescutti J, Soleymanlou N, Johansen OE et al. Empagliflozin as adjunct to insulin in patients with type 1 diabetes: a 4-week, randomized, placebo-controlled trial (EASE-1). Diabetes Obes Metab 2015; 17: 928–935.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 928-935
-
-
Pieber, T.R.1
Famulla, S.2
Eilbracht, J.3
Cescutti, J.4
Soleymanlou, N.5
Johansen, O.E.6
-
25
-
-
84962362243
-
Efficacy and Safety of Canagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, as Add-On to Insulin in Patients With Type 1 Diabetes
-
Henry RR, Thakkar P, Tong C, Polidori D, Alba M. Efficacy and Safety of Canagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, as Add-On to Insulin in Patients With Type 1 Diabetes. Diabetes Care 2015; 38: 2258–2265.
-
(2015)
Diabetes Care
, vol.38
, pp. 2258-2265
-
-
Henry, R.R.1
Thakkar, P.2
Tong, C.3
Polidori, D.4
Alba, M.5
-
26
-
-
84973562609
-
Comparison between SGLT2 Inhibitors and DPP4 Inhibitors Added to Insulin Therapy in Type 2 Diabetes: A Systematic Review with Indirect Comparison Meta-analysis
-
Min SH, Yoon JH, Hahn S, Cho YM. Comparison between SGLT2 Inhibitors and DPP4 Inhibitors Added to Insulin Therapy in Type 2 Diabetes: A Systematic Review with Indirect Comparison Meta-analysis. Diabetes Metab Res Rev 2016; 33: https://doi.org/10.1002/dmrr.2818.
-
(2016)
Diabetes Metab Res Rev
, vol.33
-
-
Min, S.H.1
Yoon, J.H.2
Hahn, S.3
Cho, Y.M.4
-
27
-
-
85006893267
-
Sodium-glucose co-transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
-
Tang H, Cui W, Li D, Wang T, Zhang J, Zhai S et al. Sodium-glucose co-transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Diabetes Obes Metab 2017; 19: 142–147.
-
(2017)
Diabetes Obes Metab
, vol.19
, pp. 142-147
-
-
Tang, H.1
Cui, W.2
Li, D.3
Wang, T.4
Zhang, J.5
Zhai, S.6
-
28
-
-
84982292524
-
An overview of the effect of sodium glucose cotransporter 2 inhibitor monotherapy on glycemic and other clinical laboratory parameters in type 2 diabetes patients
-
Wang Y, Hu X, Liu X, Wang Z. An overview of the effect of sodium glucose cotransporter 2 inhibitor monotherapy on glycemic and other clinical laboratory parameters in type 2 diabetes patients. Ther Clin Risk Manag 2016; 12: 1113–1131.
-
(2016)
Ther Clin Risk Manag
, vol.12
, pp. 1113-1131
-
-
Wang, Y.1
Hu, X.2
Liu, X.3
Wang, Z.4
-
29
-
-
84969915634
-
Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis
-
Zaccardi F, Webb DR, Htike ZZ, Youssef D, Khunti K, Davies MJ. Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis. Diabetes Obes Metab 2016; 18: 783–794.
-
(2016)
Diabetes Obes Metab
, vol.18
, pp. 783-794
-
-
Zaccardi, F.1
Webb, D.R.2
Htike, Z.Z.3
Youssef, D.4
Khunti, K.5
Davies, M.J.6
-
30
-
-
84976371974
-
Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2
-
Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S et al. Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2. J Pharmacol Exp Ther 2016; 358: 94–102.
-
(2016)
J Pharmacol Exp Ther
, vol.358
, pp. 94-102
-
-
Ohgaki, R.1
Wei, L.2
Yamada, K.3
Hara, T.4
Kuriyama, C.5
Okuda, S.6
-
31
-
-
85006893267
-
Sodium-glucose co-transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
-
Tang H, Cui W, Li D, Wang T, Zhang J, Zhai S et al. Sodium-glucose co-transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Diabetes Obes Metab 2017; 19: 142–147.
-
(2017)
Diabetes Obes Metab
, vol.19
, pp. 142-147
-
-
Tang, H.1
Cui, W.2
Li, D.3
Wang, T.4
Zhang, J.5
Zhai, S.6
-
32
-
-
84962339296
-
Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium-Glucose Cotransporter 2 Inhibition
-
Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium-Glucose Cotransporter 2 Inhibition. Diabetes Care 2015; 38: 1687–1693.
-
(2015)
Diabetes Care
, vol.38
, pp. 1687-1693
-
-
Peters, A.L.1
Buschur, E.O.2
Buse, J.B.3
Cohan, P.4
Diner, J.C.5
Hirsch, I.B.6
-
33
-
-
84962381148
-
Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program
-
Erondu N, Desai M, Ways K, Meininger G. Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program. Diabetes Care 2015; 38: 1680–1686.
-
(2015)
Diabetes Care
, vol.38
, pp. 1680-1686
-
-
Erondu, N.1
Desai, M.2
Ways, K.3
Meininger, G.4
-
34
-
-
84962053997
-
Diabetic Ketoacidosis With Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, in Patients With Type 1 Diabetes
-
Peters AL, Henry RR, Thakkar P, Tong C, Alba M. Diabetic Ketoacidosis With Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, in Patients With Type 1 Diabetes. Diabetes Care 2016; 39: 532–538.
-
(2016)
Diabetes Care
, vol.39
, pp. 532-538
-
-
Peters, A.L.1
Henry, R.R.2
Thakkar, P.3
Tong, C.4
Alba, M.5
-
35
-
-
84883180801
-
-
Titusville, NJ, Janssen Pharmaceuticals, Inc, Last accessed 14 November 2017
-
® (canagliflozin) prescribing information. Titusville, NJ: Janssen Pharmaceuticals, Inc. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204042s022lbl.pdf. Last accessed 14 November 2017.
-
® (canagliflozin) prescribing information
-
-
-
36
-
-
84992470624
-
-
Ridgefield, CT, Boehringer Ingelheim Pharmaceuticals, Inc, Accessed 21 September 2017
-
® (empagliflozin) prescribing information. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204629s008lbl.pdf. Accessed 21 September 2017.
-
® (empagliflozin) prescribing information
-
-
-
37
-
-
85034003914
-
-
Wilmington, DE, AstraZeneca Pharmaceuticals LP, Accessed 21 September 2017
-
® (dapagliflozin) prescribing information. Wilmington, DE: AstraZeneca Pharmaceuticals LP. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202293s010lbl.pdf. Accessed 21 September 2017.
-
® (dapagliflozin) prescribing information
-
-
-
39
-
-
84923510983
-
Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor
-
Lapuerta P, Zambrowicz B, Strumph P, Sands A. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor. Diab Vasc Dis Res 2015; 12: 101–110.
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 101-110
-
-
Lapuerta, P.1
Zambrowicz, B.2
Strumph, P.3
Sands, A.4
-
40
-
-
85050102265
-
-
Ann Arbor, MI, Cayman Chemical, Accessed 14 November 2016
-
Product Information: Sotagliflozin. Ann Arbor, MI: Cayman Chemical. Available at http://www.caymaneurope.com/pdfs/19141.pdf. Accessed 14 November 2016.
-
Product Information: Sotagliflozin
-
-
-
41
-
-
84864146681
-
LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
-
Zambrowicz B, Freiman J, Brown PM, Frazier KS, Turnage A, Bronner J et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther 2012; 92: 158–169.
-
(2012)
Clin Pharmacol Ther
, vol.92
, pp. 158-169
-
-
Zambrowicz, B.1
Freiman, J.2
Brown, P.M.3
Frazier, K.S.4
Turnage, A.5
Bronner, J.6
-
42
-
-
85021150292
-
LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice
-
Powell DR, Smith MG, Doree DD, Harris AL, Greer J, DaCosta CM et al. LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice. J Pharmacol Exp Ther 2017; 362: 85–97.
-
(2017)
J Pharmacol Exp Ther
, vol.362
, pp. 85-97
-
-
Powell, D.R.1
Smith, M.G.2
Doree, D.D.3
Harris, A.L.4
Greer, J.5
DaCosta, C.M.6
-
43
-
-
84882831390
-
Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects
-
Zambrowicz B, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J et al. Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects. Clin Ther 2013; 35(1162–1173): e8.
-
(2013)
Clin Ther
, vol.35
, Issue.1162-1173
-
-
Zambrowicz, B.1
Ogbaa, I.2
Frazier, K.3
Banks, P.4
Turnage, A.5
Freiman, J.6
-
44
-
-
84880320337
-
Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
-
Devineni D, Curtin CR, Polidori D, Gutierrez MJ, Murphy J, Rusch S et al. Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J Clin Pharmacol 2013; 53: 601–610.
-
(2013)
J Clin Pharmacol
, vol.53
, pp. 601-610
-
-
Devineni, D.1
Curtin, C.R.2
Polidori, D.3
Gutierrez, M.J.4
Murphy, J.5
Rusch, S.6
-
45
-
-
84883139076
-
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
-
den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud D-J, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 2013; 54: 2325–2340.
-
(2013)
J Lipid Res
, vol.54
, pp. 2325-2340
-
-
den Besten, G.1
van Eunen, K.2
Groen, A.K.3
Venema, K.4
Reijngoud, D.-J.5
Bakker, B.M.6
-
46
-
-
73249122913
-
Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus
-
Hare KJ, Knop FK, Asmar M, Madsbad S, Deacon CF, Holst JJ et al. Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus. J Clin Endocrinol Metab 2009; 94: 4679–4687.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 4679-4687
-
-
Hare, K.J.1
Knop, F.K.2
Asmar, M.3
Madsbad, S.4
Deacon, C.F.5
Holst, J.J.6
-
47
-
-
0041859261
-
Inhibition of food intake in obese subjects by peptide YY3-36
-
Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349: 941–948.
-
(2003)
N Engl J Med
, vol.349
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
Le Roux, C.W.4
Withers, D.J.5
Frost, G.S.6
-
48
-
-
84923502372
-
Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy
-
Rosenstock J, Cefalu WT, Lapuerta P, Zambrowicz B, Ogbaa I, Banks P et al. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy. Diabetes Care 2015; 38: 431–438.
-
(2015)
Diabetes Care
, vol.38
, pp. 431-438
-
-
Rosenstock, J.1
Cefalu, W.T.2
Lapuerta, P.3
Zambrowicz, B.4
Ogbaa, I.5
Banks, P.6
-
49
-
-
85050156105
-
-
ADA 77th Scientific Sessions; 10th June;, San Diego, CA, American Diabetes Association
-
Baker C, Wason S, Banks P, Sawhney S, Strumph P. 70-OR: A 12-Week Dose-Ranging Study of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem4). ADA 77th Scientific Sessions; 10th June; San Diego, CA: American Diabetes Association; 2017.
-
(2017)
70-OR: A 12-Week Dose-Ranging Study of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (inTandem4)
-
-
Baker, C.1
Wason, S.2
Banks, P.3
Sawhney, S.4
Strumph, P.5
-
50
-
-
84957842016
-
Comparison of the pharmacokinetics and pharmacodynamics of dapagliflozin in patients with type 1 versus type 2 diabetes mellitus
-
Tang W, Leil TA, Johnsson E, Boulton DW, LaCreta F. Comparison of the pharmacokinetics and pharmacodynamics of dapagliflozin in patients with type 1 versus type 2 diabetes mellitus. Diabetes Obes Metab 2016; 18: 236–240.
-
(2016)
Diabetes Obes Metab
, vol.18
, pp. 236-240
-
-
Tang, W.1
Leil, T.A.2
Johnsson, E.3
Boulton, D.W.4
LaCreta, F.5
-
51
-
-
84949293188
-
Sotagliflozin as a potential treatment for type 2 diabetes mellitus
-
Cariou B, Charbonnel B. Sotagliflozin as a potential treatment for type 2 diabetes mellitus. Expert Opin Investig Drugs 2015; 24: 1647–1656.
-
(2015)
Expert Opin Investig Drugs
, vol.24
, pp. 1647-1656
-
-
Cariou, B.1
Charbonnel, B.2
-
52
-
-
84920772335
-
LX4211 therapy reduces postprandial glucose levels in patients with type 2 diabetes mellitus and renal impairment despite low urinary glucose excretion
-
Zambrowicz B, Lapuerta P, Strumph P, Banks P, Wilson A, Ogbaa I et al. LX4211 therapy reduces postprandial glucose levels in patients with type 2 diabetes mellitus and renal impairment despite low urinary glucose excretion. Clin Ther 2015; 37(71–82): e12.
-
(2015)
Clin Ther
, vol.37
, Issue.71-82
-
-
Zambrowicz, B.1
Lapuerta, P.2
Strumph, P.3
Banks, P.4
Wilson, A.5
Ogbaa, I.6
-
53
-
-
84893727925
-
Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment
-
Macha S, Mattheus M, Halabi A, Pinnetti S, Woerle HJ, Broedl UC. Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment. Diabetes Obes Metab 2014; 16: 215–222.
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 215-222
-
-
Macha, S.1
Mattheus, M.2
Halabi, A.3
Pinnetti, S.4
Woerle, H.J.5
Broedl, U.C.6
-
54
-
-
84939996168
-
Effect of Hepatic or Renal Impairment on the Pharmacokinetics of Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor
-
Devineni D, Curtin CR, Marbury TC, Smith W, Vaccaro N, Wexler D et al. Effect of Hepatic or Renal Impairment on the Pharmacokinetics of Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor. Clin Ther 2015; 37(610–628): e4.
-
(2015)
Clin Ther
, vol.37
, Issue.610-628
-
-
Devineni, D.1
Curtin, C.R.2
Marbury, T.C.3
Smith, W.4
Vaccaro, N.5
Wexler, D.6
-
55
-
-
84897394040
-
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
-
Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 2014; 85: 962–971.
-
(2014)
Kidney Int
, vol.85
, pp. 962-971
-
-
Kohan, D.E.1
Fioretto, P.2
Tang, W.3
List, J.F.4
-
56
-
-
84921328874
-
A randomized, double-blind, placebo-controlled study on long-term efficacy and safety of ipragliflozin treatment in patients with type 2 diabetes mellitus and renal impairment: results of the long-term ASP1941 safety evaluation in patients with type 2 diabetes with renal impairment (LANTERN) study
-
Kashiwagi A, Takahashi H, Ishikawa H, Yoshida S, Kazuta K, Utsuno A et al. A randomized, double-blind, placebo-controlled study on long-term efficacy and safety of ipragliflozin treatment in patients with type 2 diabetes mellitus and renal impairment: results of the long-term ASP1941 safety evaluation in patients with type 2 diabetes with renal impairment (LANTERN) study. Diabetes Obes Metab 2015; 17: 152–160.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 152-160
-
-
Kashiwagi, A.1
Takahashi, H.2
Ishikawa, H.3
Yoshida, S.4
Kazuta, K.5
Utsuno, A.6
-
57
-
-
84866268783
-
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
-
Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M et al. Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012; 35: 1364–1379.
-
(2012)
Diabetes Care
, vol.35
, pp. 1364-1379
-
-
Inzucchi, S.E.1
Bergenstal, R.M.2
Buse, J.B.3
Diamant, M.4
Ferrannini, E.5
Nauck, M.6
-
58
-
-
84874977086
-
Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes
-
Zambrowicz B, Ding ZM, Ogbaa I, Frazier K, Banks P, Turnage A et al. Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes. Clin Ther 2013; 35(273–285): e7.
-
(2013)
Clin Ther
, vol.35
, Issue.273-285
-
-
Zambrowicz, B.1
Ding, Z.M.2
Ogbaa, I.3
Frazier, K.4
Banks, P.5
Turnage, A.6
-
59
-
-
84939621365
-
Sotagliflozin, a dual SGLT1 and SGLT2 inhibitor, as adjunct therapy to insulin in type 1 diabetes
-
Sands AT, Zambrowicz BP, Rosenstock J, Lapuerta P, Bode BW, Garg SK et al. Sotagliflozin, a dual SGLT1 and SGLT2 inhibitor, as adjunct therapy to insulin in type 1 diabetes. Diabetes Care 2015; 38: 1181–1188.
-
(2015)
Diabetes Care
, vol.38
, pp. 1181-1188
-
-
Sands, A.T.1
Zambrowicz, B.P.2
Rosenstock, J.3
Lapuerta, P.4
Bode, B.W.5
Garg, S.K.6
-
60
-
-
85050162609
-
-
ADA 77th Scientific Sessions; 11th June;, San Diego, CA, American Diabetes Association
-
Bode BW, Banks P, Sawhney S, Strumph P. 147-LB — 2017: 12-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Young Adults with Poorly Controlled Type 1 Diabetes (JDRF Study). ADA 77th Scientific Sessions; 11th June; San Diego, CA: American Diabetes Association, 2017.
-
(2017)
147-LB — 2017: 12-Week Efficacy and Safety of Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Young Adults with Poorly Controlled Type 1 Diabetes (JDRF Study)
-
-
Bode, B.W.1
Banks, P.2
Sawhney, S.3
Strumph, P.4
-
61
-
-
84962613532
-
Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
-
Wu JH, Foote C, Blomster J, Toyama T, Perkovic V, Sundstrom J et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2016; 4: 411–419.
-
(2016)
Lancet Diabetes Endocrinol
, vol.4
, pp. 411-419
-
-
Wu, J.H.1
Foote, C.2
Blomster, J.3
Toyama, T.4
Perkovic, V.5
Sundstrom, J.6
-
62
-
-
84954514891
-
Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus
-
Watts NB, Bilezikian JP, Usiskin K, Edwards R, Desai M, Law G et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 2016; 101: 157–166.
-
(2016)
J Clin Endocrinol Metab
, vol.101
, pp. 157-166
-
-
Watts, N.B.1
Bilezikian, J.P.2
Usiskin, K.3
Edwards, R.4
Desai, M.5
Law, G.6
-
64
-
-
84887072459
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of Empagliflozin in Patients with Type 2 Diabetes Mellitus
-
Heise T, Seman L, Macha S, Jones P, Marquart A, Pinnetti S et al. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of Empagliflozin in Patients with Type 2 Diabetes Mellitus. Diabetes Ther 2013; 4: 331–345.
-
(2013)
Diabetes Ther
, vol.4
, pp. 331-345
-
-
Heise, T.1
Seman, L.2
Macha, S.3
Jones, P.4
Marquart, A.5
Pinnetti, S.6
-
65
-
-
84974674472
-
Comparison of the exposure–response relationship of dapagliflozin in adult and paediatric patients with type 2 diabetes mellitus
-
Parkinson J, Tang W, Johansson CC, Boulton DW, Hamrén B. Comparison of the exposure–response relationship of dapagliflozin in adult and paediatric patients with type 2 diabetes mellitus. Diabetes Obes Metab 2016; 18: 685–692.
-
(2016)
Diabetes Obes Metab
, vol.18
, pp. 685-692
-
-
Parkinson, J.1
Tang, W.2
Johansson, C.C.3
Boulton, D.W.4
Hamrén, B.5
-
66
-
-
84891878819
-
Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2
-
Kasichayanula S, Liu X, Lacreta F, Griffen SC, Boulton DW. Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet 2014; 53: 17–27.
-
(2014)
Clin Pharmacokinet
, vol.53
, pp. 17-27
-
-
Kasichayanula, S.1
Liu, X.2
Lacreta, F.3
Griffen, S.C.4
Boulton, D.W.5
|