-
1
-
-
0033038672
-
Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
-
Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116:1413-1419
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.A.1
Younossi, Z.M.2
Gramlich, T.3
Boparai, N.4
Liu, Y.C.5
McCullough, A.J.6
-
2
-
-
84939520964
-
Clinical model for NASH and advanced fibrosis in adult patients with diabetes and NAFLD: Guidelines for referral in NAFLD
-
Bazick J, Donithan M, Neuschwander-Tetri BA, et al. Clinical model for NASH and advanced fibrosis in adult patients with diabetes and NAFLD: guidelines for referral in NAFLD. Diabetes Care 2015; 38:1347-1355
-
(2015)
Diabetes Care
, vol.38
, pp. 1347-1355
-
-
Bazick, J.1
Donithan, M.2
Neuschwander-Tetri, B.A.3
-
3
-
-
84991083809
-
Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis
-
Targher G, Byrne CD, Lonardo A, Zoppini G, Barbui C. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis. J Hepatol 2016; 65:589-600
-
(2016)
J Hepatol
, vol.65
, pp. 589-600
-
-
Targher, G.1
Byrne, C.D.2
Lonardo, A.3
Zoppini, G.4
Barbui, C.5
-
4
-
-
85041197733
-
Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: A meta-analysis
-
Mantovani A, Byrne CD, Bonora E, Targher G. Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: a meta-analysis. Diabetes Care 2018; 41:372-382
-
(2018)
Diabetes Care
, vol.41
, pp. 372-382
-
-
Mantovani, A.1
Byrne, C.D.2
Bonora, E.3
Targher, G.4
-
5
-
-
85036498397
-
Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: A systematic review and meta-analysis
-
Mantovani A, Zaza G, Byrne CD, et al. Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: a systematic review and meta-analysis. Metabolism 2018; 79:64-76
-
(2018)
Metabolism
, vol.79
, pp. 64-76
-
-
Mantovani, A.1
Zaza, G.2
Byrne, C.D.3
-
6
-
-
84880419922
-
Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches
-
Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol 2013; 28(Suppl. 1):68-76
-
(2013)
J Gastroenterol Hepatol
, vol.28
, pp. 68-76
-
-
Schuppan, D.1
Schattenberg, J.M.2
-
7
-
-
84908318982
-
Nonalcoholic fatty liver disease: Pathogenesis and therapeutics from a mitochondria-centric perspective
-
Gusdon AM, Song KX, Qu S. Nonalcoholic fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective. Oxid Med Cell Longev 2014; 2014:637027
-
(2014)
Oxid Med Cell Longev
, vol.2014
, pp. 637027
-
-
Gusdon, A.M.1
Song, K.X.2
Qu, S.3
-
8
-
-
0033231294
-
Association of nonalcoholic fatty liver disease with insulin resistance
-
Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107:450-455
-
(1999)
Am J Med
, vol.107
, pp. 450-455
-
-
Marchesini, G.1
Brizi, M.2
Morselli-Labate, A.M.3
-
9
-
-
19144372447
-
One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: A pilot study
-
Huang MA, Greenson JK, Chao C, et al. One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005; 100:1072-1081
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 1072-1081
-
-
Huang, M.A.1
Greenson, J.K.2
Chao, C.3
-
10
-
-
73449116035
-
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
-
Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010; 51:121-129
-
(2010)
Hepatology
, vol.51
, pp. 121-129
-
-
Promrat, K.1
Kleiner, D.E.2
Niemeier, H.M.3
-
11
-
-
57649229536
-
Clinical trial: Pilot study of metformin for the treatment of non-alcoholic steatohepatitis
-
Loomba R, Lutchman G, Kleiner DE, et al. Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2009; 29:172-182
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 172-182
-
-
Loomba, R.1
Lutchman, G.2
Kleiner, D.E.3
-
12
-
-
33751545838
-
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
-
Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355:2297-2307
-
(2006)
N Engl J Med
, vol.355
, pp. 2297-2307
-
-
Belfort, R.1
Harrison, S.A.2
Brown, K.3
-
13
-
-
77951874018
-
Pioglitazone, Vitamin E, or placebo for nonalcoholic steatohepatitis
-
Sanyal AJ, Chalasani N, Kowdley KV, et al.; NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362:1675-1685
-
(2010)
N Engl J Med
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
-
14
-
-
84957840942
-
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): Amulticentre, double-blind, randomised, placebo-controlled phase 2 study
-
Armstrong MJ, Gaunt P, Aithal GP, et al.; LEAN Trial Team. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): amulticentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 2016; 387:679-690
-
(2016)
Lancet
, vol.387
, pp. 679-690
-
-
Armstrong, M.J.1
Gaunt, P.2
Aithal, G.P.3
-
16
-
-
84885476895
-
Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
-
Tahara A, Kurosaki E, Yokono M, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol 2013; 715:246-255
-
(2013)
Eur J Pharmacol
, vol.715
, pp. 246-255
-
-
Tahara, A.1
Kurosaki, E.2
Yokono, M.3
-
17
-
-
84893682957
-
SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats
-
Yokono M, Takasu T, Hayashizaki Y, et al. SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats. Eur J Pharmacol 2014; 727:66-74
-
(2014)
Eur J Pharmacol
, vol.727
, pp. 66-74
-
-
Yokono, M.1
Takasu, T.2
Hayashizaki, Y.3
-
18
-
-
0035979214
-
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
-
Yamashita H, Takenoshita M, Sakurai M, et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci U S A 2001; 98:9116-9121
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9116-9121
-
-
Yamashita, H.1
Takenoshita, M.2
Sakurai, M.3
-
19
-
-
77957302090
-
Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
-
Ferré P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 2010; 12(Suppl. 2):83-92
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 83-92
-
-
Ferré, P.1
Foufelle, F.2
-
20
-
-
84953791948
-
The selective SGLT2 inhibitor ipragliflozin has a therapeutic effect on nonalcoholic steatohepatitis in mice
-
Honda Y, Imajo K, Kato T, et al. The selective SGLT2 inhibitor ipragliflozin has a therapeutic effect on nonalcoholic steatohepatitis in mice. PLoS One 2016; 11:e0146337
-
(2016)
PLoS One
, vol.11
-
-
Honda, Y.1
Imajo, K.2
Kato, T.3
-
21
-
-
84961615237
-
Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction
-
Komiya C, Tsuchiya K, Shiba K, et al. Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction. PLoS One 2016; 11:e0151511
-
(2016)
PLoS One
, vol.11
-
-
Komiya, C.1
Tsuchiya, K.2
Shiba, K.3
-
22
-
-
84947786115
-
Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus
-
Qiang S, Nakatsu Y, Seno Y, et al. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus. Diabetol Metab Syndr 2015; 7:104
-
(2015)
Diabetol Metab Syndr
, vol.7
, pp. 104
-
-
Qiang, S.1
Nakatsu, Y.2
Seno, Y.3
-
23
-
-
85016590472
-
Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: An association with glucose-lowering effects
-
Takase T, Nakamura A, Miyoshi H, Yamamoto C, Atsumi T. Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an association with glucose-lowering effects. Endocr J 2017; 64:363-367
-
(2017)
Endocr J
, vol.64
, pp. 363-367
-
-
Takase, T.1
Nakamura, A.2
Miyoshi, H.3
Yamamoto, C.4
Atsumi, T.5
-
24
-
-
84865569519
-
Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: A randomized controlled trial
-
Le TA, Chen J, Changchien C, et al.; San Diego Integrated NAFLD Research Consortium (SINC). Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 2012; 56:922-932
-
(2012)
Hepatology
, vol.56
, pp. 922-932
-
-
Le, T.A.1
Chen, J.2
Changchien, C.3
-
25
-
-
84925339397
-
Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)
-
Loomba R, Sirlin CB, Ang B, et al.; San Diego Integrated NAFLD Research Consortium (SINC). Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology 2015; 61:1239-1250
-
(2015)
Hepatology
, vol.61
, pp. 1239-1250
-
-
Loomba, R.1
Sirlin, C.B.2
Ang, B.3
-
26
-
-
84969801284
-
Sitagliptin vs. Placebo for non-alcoholic fatty liver disease: A randomized controlled trial
-
Cui J, Philo L, Nguyen P, et al. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol 2016; 65:369-376
-
(2016)
J Hepatol
, vol.65
, pp. 369-376
-
-
Cui, J.1
Philo, L.2
Nguyen, P.3
-
27
-
-
84888298670
-
Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
-
Noureddin M, Lam J, Peterson MR, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 2013; 58:1930-1940
-
(2013)
Hepatology
, vol.58
, pp. 1930-1940
-
-
Noureddin, M.1
Lam, J.2
Peterson, M.R.3
-
28
-
-
84874115167
-
Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in nonalcoholic fatty liver disease
-
Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2013; 37:630-639
-
(2013)
Aliment Pharmacol Ther
, vol.37
, pp. 630-639
-
-
Patel, N.S.1
Peterson, M.R.2
Brenner, D.A.3
Heba, E.4
Sirlin, C.5
Loomba, R.6
-
29
-
-
84888290605
-
Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis
-
Reeder SB Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis. Hepatology 2013; 58:1877-1880
-
(2013)
Hepatology
, vol.58
, pp. 1877-1880
-
-
Reeder, S.B.1
-
30
-
-
85040734374
-
Luseogliflozin improves liver fat deposition compared to metformin in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective randomized controlled pilot study
-
Shibuya T, Fushimi N, Kawai M, et al. Luseogliflozin improves liver fat deposition compared to metformin in type 2 diabetes patients with non-alcoholic fatty liver disease: a prospective randomized controlled pilot study. Diabetes Obes Metab 2018; 20:438-442
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 438-442
-
-
Shibuya, T.1
Fushimi, N.2
Kawai, M.3
-
31
-
-
85021699331
-
Effects of canagliflozin, an SGLT2 inhibitor, on hepatic function in Japanese patients with type 2 diabetes mellitus: Pooled and subgroup analyses of clinical trials
-
Seko Y, Sumida Y, Sasaki K, et al. Effects of canagliflozin, an SGLT2 inhibitor, on hepatic function in Japanese patients with type 2 diabetes mellitus: pooled and subgroup analyses of clinical trials. J Gastroenterol 2018; 53:140-151
-
(2018)
J Gastroenterol
, vol.53
, pp. 140-151
-
-
Seko, Y.1
Sumida, Y.2
Sasaki, K.3
-
32
-
-
84930791899
-
High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels
-
Portillo-Sanchez P, Bril F, Maximos M, et al. High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J Clin Endocrinol Metab 2015; 100:2231-2238
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 2231-2238
-
-
Portillo-Sanchez, P.1
Bril, F.2
Maximos, M.3
-
33
-
-
51349083814
-
Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
-
Fracanzani AL, Valenti L, Bugianesi E, et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008; 48:792-798
-
(2008)
Hepatology
, vol.48
, pp. 792-798
-
-
Fracanzani, A.L.1
Valenti, L.2
Bugianesi, E.3
-
34
-
-
0037566201
-
Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
-
Mofrad P, Contos MJ, Haque M, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003; 37:1286-1292
-
(2003)
Hepatology
, vol.37
, pp. 1286-1292
-
-
Mofrad, P.1
Contos, M.J.2
Haque, M.3
-
35
-
-
85031712678
-
The improvement of the hepatic histological findings in a patient with non-alcoholic steatohepatitis with type 2 diabetes after the administration of the sodium-glucose cotransporter 2 inhibitor ipragliflozin
-
Takeda A, Irahara A, Nakano A, et al. The improvement of the hepatic histological findings in a patient with non-alcoholic steatohepatitis with type 2 diabetes after the administration of the sodium-glucose cotransporter 2 inhibitor ipragliflozin. Intern Med 2017; 56:2739-2744
-
(2017)
Intern Med
, vol.56
, pp. 2739-2744
-
-
Takeda, A.1
Irahara, A.2
Nakano, A.3
-
36
-
-
85042524553
-
Effects of a sodium-glucose cotransporter 2 inhibitor in nonalcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies
-
Akuta N, Watanabe C, Kawamura Y, et al. Effects of a sodium-glucose cotransporter 2 inhibitor in nonalcoholic fatty liver disease complicated by diabetes mellitus: preliminary prospective study based on serial liver biopsies. Hepatol Commun 2017; 1:46-52
-
(2017)
Hepatol Commun
, vol.1
, pp. 46-52
-
-
Akuta, N.1
Watanabe, C.2
Kawamura, Y.3
-
37
-
-
84981267545
-
Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
-
Patel J, Bettencourt R, Cui J, et al. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol 2016; 9:692-701
-
(2016)
Therap Adv Gastroenterol
, vol.9
, pp. 692-701
-
-
Patel, J.1
Bettencourt, R.2
Cui, J.3
-
38
-
-
84928209634
-
Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
-
Ekstedt M, Hagström H, Nasr P, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2015; 61:1547-1554
-
(2015)
Hepatology
, vol.61
, pp. 1547-1554
-
-
Ekstedt, M.1
Hagström, H.2
Nasr, P.3
-
39
-
-
84938057875
-
Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease
-
Angulo P, Kleiner DE, Dam-Larsen S, et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 2015; 149:389-397
-
(2015)
Gastroenterology
, vol.149
, pp. 389-397
-
-
Angulo, P.1
Kleiner, D.E.2
Dam-Larsen, S.3
|