Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study

Diabetologia

Volumn 61, Issue 9, 2018, Pages 1923-1934

  Eriksson, Jan W ^a   Lundkvist, Per ^a   Jansson, Per Anders ^b   Johansson, Lars ^c   Kvarnström, Mats ^d   Moris, Linda ^e   Miliotis, Tasso ^d   Forsberg, Gun Britt ^d   Risérus, Ulf ^f   Lind, Lars ^a   Oscarsson, Jan ^d  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c ANTAROS MEDICAL   (Sweden)

^d ASTRAZENECA   (United Kingdom)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dapagliflozin; Docosahexaenoic acid; Eicosapentaenoic acid; Liver steatosis; Non alcoholic fatty liver disease; Omega 3 fatty acids; Proton density fat fraction; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 18; DAPAGLIFLOZIN; FIBROBLAST GROWTH FACTOR 21; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; METFORMIN; OMEGA 3 FATTY ACID; PLACEBO; SULFONYLUREA; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; BENZHYDRYL DERIVATIVE; BIOLOGICAL MARKER; CARBOXYLIC ACID; FATTY ACID; GLUCOSIDE;

ABDOMINAL FAT; ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL RESEARCH; CONTROLLED STUDY; CORRELATIONAL STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FAT CONTENT; FATTY ACID METABOLISM; FEMALE; GASTROINTESTINAL TRACT FUNCTION; GLUCOSE METABOLISM; HIP CIRCUMFERENCE; HUMAN; INTRA-ABDOMINAL FAT; LIPID METABOLISM; LIVER CELL DAMAGE; LIVER WEIGHT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON DENSITY FAT FRACTION; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT; SWEDEN; TREATMENT OUTCOME; TREATMENT RESPONSE; UNIVERSITY HOSPITAL; UNSPECIFIED SIDE EFFECT; WAIST CIRCUMFERENCE; CLINICAL TRIAL; COMBINATION DRUG THERAPY; COMPLICATION; INFLAMMATION; LIVER CELL; LIVER FUNCTION TEST; METABOLISM; MIDDLE AGED; MULTICENTER STUDY;

AGED; BENZHYDRYL COMPOUNDS; BIOMARKERS; CARBOXYLIC ACIDS; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FATTY ACIDS; FEMALE; GLUCOSE; GLUCOSIDES; HEPATOCYTES; HUMANS; INFLAMMATION; LIPID METABOLISM; LIVER FUNCTION TESTS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; SWEDEN;

EID: 85049567851     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-018-4675-2     Document Type: Article

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