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Volumn 11, Issue 4, 2018, Pages

Antidiabetic drugs in NAFLD: The accomplishment of two goals at once?

Author keywords

Hepatic cirrhosis; Liraglutide; Metformin; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Thiazolidinediones

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AMINOTRANSFERASE; ANTIDIABETIC AGENT; CHOLESTEROL; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; HEMOGLOBIN A1C; INSULIN; INSULIN SENSITIZING AGENT; IPRAGLIFLOZIN; LIRAGLUTIDE; MEGLITINIDE; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SOMATOMEDIN C; SULFONYLUREA;

EID: 85057011322     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph11040121     Document Type: Review
Times cited : (42)

References (117)
  • 1
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon, G.; Baranova, A.; Younossi, Z.M. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011, 34, 274–285. [CrossRef] [PubMed]
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 2
    • 68049142588 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease pathogenesis: The present and the future
    • Petta, S.; Muratore, C.; Craxì, A. Non-alcoholic fatty liver disease pathogenesis: The present and the future. Dig. Liver Dis. 2009, 41, 615–625. [CrossRef] [PubMed]
    • (2009) Dig. Liver Dis. , vol.41 , pp. 615-625
    • Petta, S.1    Muratore, C.2    Craxì, A.3
  • 3
    • 84880425040 scopus 로고    scopus 로고
    • Epidemiology and natural history of patients with NAFLD
    • Bhala, N.; Younes, R.; Bugianesi, E. Epidemiology and natural history of patients with NAFLD. Curr. Pharm. Des. 2013, 19, 5169–5176. [CrossRef] [PubMed]
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 5169-5176
    • Bhala, N.1    Younes, R.2    Bugianesi, E.3
  • 4
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study
    • Adams, L.A.; Waters, O.R.; Knuiman, M.W.; Elliott, R.R.; Olynyk, J.K. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study. Am. J. Gastroenterol. 2009, 104, 861–867. [CrossRef] [PubMed]
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3    Elliott, R.R.4    Olynyk, J.K.5
  • 5
    • 84964510429 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis
    • Ballestri, S.; Zona, S.; Targher, G.; Romagnoli, D.; Baldelli, E.; Nascimbeni, F.; Roverato, A.; Guaraldi, G.; Lonardo, A. Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis. J. Gastroenterol. Hepatol. 2016, 31, 936–944. [CrossRef] [PubMed]
    • (2016) J. Gastroenterol. Hepatol. , vol.31 , pp. 936-944
    • Ballestri, S.1    Zona, S.2    Targher, G.3    Romagnoli, D.4    Baldelli, E.5    Nascimbeni, F.6    Roverato, A.7    Guaraldi, G.8    Lonardo, A.9
  • 7
    • 84882906611 scopus 로고    scopus 로고
    • A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
    • Pais, R.; Charlotte, F.; Fedchuk, L.; Bedossa, P.; Lebray, P.; Poynard, T.; Ratziu, V. A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. J. Hepatol. 2013, 59, 550–556. [CrossRef] [PubMed]
    • (2013) J. Hepatol. , vol.59 , pp. 550-556
    • Pais, R.1    Charlotte, F.2    Fedchuk, L.3    Bedossa, P.4    Lebray, P.5    Poynard, T.6    Ratziu, V.7
  • 8
    • 84928209634 scopus 로고    scopus 로고
    • Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
    • Ekstedt, M.; Hagström, H.; Nasr, P.; Fredrikson, M.; Stål, P.; Kechagias, S.; Hultcrantz, R. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2015, 61, 1547–1554. [CrossRef] [PubMed]
    • (2015) Hepatology , vol.61 , pp. 1547-1554
    • Ekstedt, M.1    Hagström, H.2    Nasr, P.3    Fredrikson, M.4    Stål, P.5    Kechagias, S.6    Hultcrantz, R.7
  • 9
    • 84962661546 scopus 로고    scopus 로고
    • EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
    • European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol. 2016, 64, 1388–1402. [CrossRef] [PubMed]
    • (2016) J. Hepatol , vol.64 , pp. 1388-1402
  • 10
    • 84864243697 scopus 로고    scopus 로고
    • Insulin Resistance and Coronary Heart Disease in Nondiabetic Individuals
    • Reaven, G. Insulin Resistance and Coronary Heart Disease in Nondiabetic Individuals. Arterioscler. Thromb. Vasc. Biol. 2012, 32, 1754–1759. [CrossRef] [PubMed]
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1754-1759
    • Reaven, G.1
  • 12
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle, E.E.; Rodriguez, C.; Walker-Thurmond, K.; Thun, M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 2003, 348, 1625–1638. [CrossRef] [PubMed]
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 14
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998, 352, 854–865. [CrossRef]
    • (1998) Lancet , vol.352 , pp. 854-865
  • 18
    • 80051791560 scopus 로고    scopus 로고
    • Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial
    • Sofer, E.; Boaz, M.; Matas, Z.; Mashavi, M.; Shargorodsky, M. Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial. Metabolism 2011, 60, 1278–1284. [CrossRef] [PubMed]
    • (2011) Metabolism , vol.60 , pp. 1278-1284
    • Sofer, E.1    Boaz, M.2    Matas, Z.3    Mashavi, M.4    Shargorodsky, M.5
  • 19
    • 84874043029 scopus 로고    scopus 로고
    • Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: A randomized controlled pilot study
    • e6099. [CrossRef] [PubMed
    • Hajiaghamohammadi, A.A.; Ziaee, A.; Oveisi, S.; Masroor, H. Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: A randomized controlled pilot study. Hepat. Mon. 2012, 12, e6099. [CrossRef] [PubMed]
    • (2012) Hepat. Mon. , vol.12
    • Hajiaghamohammadi, A.A.1    Ziaee, A.2    Oveisi, S.3    Masroor, H.4
  • 20
    • 84879600250 scopus 로고    scopus 로고
    • Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial
    • PubMed
    • Shavakhi, A.; Minakari, M.; Firouzian, H.; Assali, R.; Hekmatdoost, A.; Ferns, G. Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial. Int. J. Prev. Med. 2013, 4, 531–537. [PubMed]
    • (2013) Int. J. Prev. Med. , vol.4 , pp. 531-537
    • Shavakhi, A.1    Minakari, M.2    Firouzian, H.3    Assali, R.4    Hekmatdoost, A.5    Ferns, G.6
  • 21
    • 85019698669 scopus 로고    scopus 로고
    • Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease
    • Feng, W.; Gao, C.; Bi, Y.; Wu, M.; Li, P.; Shen, S.; Chen, W.; Yin, T.; Zhu, D. Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease. J. Diabetes 2017, 9, 800–809. [CrossRef] [PubMed]
    • (2017) J. Diabetes , vol.9 , pp. 800-809
    • Feng, W.1    Gao, C.2    Bi, Y.3    Wu, M.4    Li, P.5    Shen, S.6    Chen, W.7    Yin, T.8    Zhu, D.9
  • 22
    • 45549091794 scopus 로고    scopus 로고
    • Clinical trial: Insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis
    • Idilman, R.; Mizrak, D.; Corapcioglu, D.; Bektas, M.; Doganay, B.; Sayki, M.; Coban, S.; Erden, E.; Soykan, I.; Emral, R. Clinical trial: Insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther. 2008, 28, 200–208. [CrossRef] [PubMed]
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 200-208
    • Idilman, R.1    Mizrak, D.2    Corapcioglu, D.3    Bektas, M.4    Doganay, B.5    Sayki, M.6    Coban, S.7    Erden, E.8    Soykan, I.9    Emral, R.10
  • 24
    • 77953368192 scopus 로고    scopus 로고
    • The Effect of Metformin and Standard Therapy versus Standard Therapy alone in Nondiabetic Patients with Insulin Resistance and Nonalcoholic Steatohepatitis (NASH): A Pilot Trial
    • Shields, W.W.; Thompson, K.E.; Grice, G.A.; Harrison, S.A.; Coyle, W.J. The Effect of Metformin and Standard Therapy versus Standard Therapy alone in Nondiabetic Patients with Insulin Resistance and Nonalcoholic Steatohepatitis (NASH): A Pilot Trial. Therap. Adv. Gastroenterol. 2009, 2, 157–163. [CrossRef] [PubMed]
    • (2009) Therap. Adv. Gastroenterol. , vol.2 , pp. 157-163
    • Shields, W.W.1    Thompson, K.E.2    Grice, G.A.3    Harrison, S.A.4    Coyle, W.J.5
  • 25
    • 67349257934 scopus 로고    scopus 로고
    • The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease
    • Nar, A.; Gedik, O. The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. Acta Diabetol. 2009, 46, 113–118. [CrossRef] [PubMed]
    • (2009) Acta Diabetol , vol.46 , pp. 113-118
    • Nar, A.1    Gedik, O.2
  • 27
    • 77956095381 scopus 로고    scopus 로고
    • Effects of metformin and weight loss on serum alanine aminotransferase activity in the diabetes prevention program
    • Krakoff, J.; Clark, J.M.; Crandall, J.P.; Wilson, C.; Molitch, M.E.; Brancati, F.L.; Edelstein, S.L.; Knowler, W.C. Diabetes Prevention Program Research Group. Effects of metformin and weight loss on serum alanine aminotransferase activity in the diabetes prevention program. Obesity 2010, 18, 1762–1767. [CrossRef] [PubMed]
    • (2010) Obesity , vol.18 , pp. 1762-1767
    • Krakoff, J.1    Clark, J.M.2    Crandall, J.P.3    Wilson, C.4    Molitch, M.E.5    Brancati, F.L.6    Edelstein, S.L.7    Knowler, W.C.8
  • 30
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials
    • Musso, G.; Cassader, M.; Rosina, F.; Gambino, R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials. Diabetologia 2012, 55, 885–904. [CrossRef] [PubMed]
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 31
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso, G.; Gambino, R.; Cassader, M.; Pagano, G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010, 52, 79–104. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 32
    • 84920155380 scopus 로고    scopus 로고
    • Metformin in non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Li, Y.; Liu, L.; Wang, B.; Wang, J.; Chen, D. Metformin in non-alcoholic fatty liver disease: A systematic review and meta-analysis. Biomed. Rep. 2013, 1, 57–64. [CrossRef] [PubMed]
    • (2013) Biomed. Rep. , vol.1 , pp. 57-64
    • Li, Y.1    Liu, L.2    Wang, B.3    Wang, J.4    Chen, D.5
  • 33
    • 78249262957 scopus 로고    scopus 로고
    • Meta-analysis: Insulin sensitizers for the treatment of non-alcoholic steatohepatitis
    • Rakoski, M.O.; Singal, A.G.; Rogers, M.A.; Conjeevaram, H. Meta-analysis: Insulin sensitizers for the treatment of non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther. 2010, 32, 1211–1221. [CrossRef] [PubMed]
    • (2010) Aliment. Pharmacol. Ther. , vol.32 , pp. 1211-1221
    • Rakoski, M.O.1    Singal, A.G.2    Rogers, M.A.3    Conjeevaram, H.4
  • 35
    • 77954365681 scopus 로고    scopus 로고
    • Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
    • Donadon, V.; Balbi, M.; Mas, M.D.; Casarin, P.; Zanette, G. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int. 2010, 30, 750–758. [CrossRef] [PubMed]
    • (2010) Liver Int , vol.30 , pp. 750-758
    • Donadon, V.1    Balbi, M.2    Mas, M.D.3    Casarin, P.4    Zanette, G.5
  • 36
    • 85050090690 scopus 로고    scopus 로고
    • Anti-cancer Effects of Metformin: Recent Evidences for its Role in Prevention and Treatment of Cancer
    • Kheirandish, M.; Mahboobi, H.; Yazdanparast, M.; Kamal, W.; Kamal, M.A. Anti-cancer Effects of Metformin: Recent Evidences for its Role in Prevention and Treatment of Cancer. Curr. Drug Metab. 2018, 19, 793–797. [CrossRef] [PubMed]
    • (2018) Curr. Drug Metab. , vol.19 , pp. 793-797
    • Kheirandish, M.1    Mahboobi, H.2    Yazdanparast, M.3    Kamal, W.4    Kamal, M.A.5
  • 37
    • 84881349527 scopus 로고    scopus 로고
    • Classical and innovative insulin sensitizing drugs for the prevention and treatment of NAFLD
    • Carulli, L.; Maurantonio, M.; Hebbard, L.; Baldelli, E.; Loria, P.; George, J. Classical and innovative insulin sensitizing drugs for the prevention and treatment of NAFLD. Curr. Pharm. Des. 2013, 19, 5280–5296. [CrossRef] [PubMed]
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 5280-5296
    • Carulli, L.1    Maurantonio, M.2    Hebbard, L.3    Baldelli, E.4    Loria, P.5    George, J.6
  • 39
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao, Z.; Yin, J.; Zhang, J.; Ward, R.E.; Martin, R.J.; Lefevre, M.; Cefalu, W.T.; Ye, J. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009, 58, 1509–1517. [CrossRef] [PubMed]
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3    Ward, R.E.4    Martin, R.J.5    Lefevre, M.6    Cefalu, W.T.7    Ye, J.8
  • 40
    • 84907689921 scopus 로고    scopus 로고
    • Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes
    • Rumberger, J.M.; Arch, J.R.S.; Green, A. Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes. PeerJ 2014, 2, e611. [CrossRef] [PubMed]
    • (2014) Peerj , vol.2
    • Rumberger, J.M.1    Arch, J.R.S.2    Green, A.3
  • 41
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
    • Maida, A.; Lamont, B.J.; Cao, X.; Drucker, D.J. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice. Diabetologia 2011, 54, 339–349. [CrossRef] [PubMed]
    • (2011) Diabetologia , vol.54 , pp. 339-349
    • Maida, A.1    Lamont, B.J.2    Cao, X.3    Drucker, D.J.4
  • 42
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • Tiikkainen, M.; Häkkinen, A.M.; Korsheninnikova, E.; Nyman, T.; Mäkimattila, S.; Yki-Järvinen, H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004, 53, 2169–2176. [CrossRef] [PubMed]
    • (2004) Diabetes , vol.53 , pp. 2169-2176
    • Tiikkainen, M.1    Häkkinen, A.M.2    Korsheninnikova, E.3    Nyman, T.4    Mäkimattila, S.5    Yki-Järvinen, H.6
  • 43
    • 79955004746 scopus 로고    scopus 로고
    • Effects of intensive insulin therapy alone and in combination with pioglitazone on body weight, composition, distribution and liver fat content in patients with type 2 diabetes
    • Shah, P.K.; Mudaliar, S.; Chang, A.R.; Aroda, V.; Andre, M.; Burke, P.; Henry, R.R. Effects of intensive insulin therapy alone and in combination with pioglitazone on body weight, composition, distribution and liver fat content in patients with type 2 diabetes. Diabetes Obes. Metab. 2011, 13, 505–510. [CrossRef] [PubMed]
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 505-510
    • Shah, P.K.1    Mudaliar, S.2    Chang, A.R.3    Aroda, V.4    Andre, M.5    Burke, P.6    Henry, R.R.7
  • 44
    • 85035024998 scopus 로고    scopus 로고
    • Comparison of Ipragliflozin and Pioglitazone Effects on Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: A Randomized, 24-Week, Open-Label, Active-Controlled Trial
    • Ito, D.; Shimizu, S.; Inoue, K.; Saito, D.; Yanagisawa, M.; Inukai, K.; Akiyama, Y.; Morimoto, Y.; Noda, M.; Shimada, A. Comparison of Ipragliflozin and Pioglitazone Effects on Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: A Randomized, 24-Week, Open-Label, Active-Controlled Trial. Diabetes Care 2017, 40, 1364–1372. [CrossRef] [PubMed]
    • (2017) Diabetes Care , vol.40 , pp. 1364-1372
    • Ito, D.1    Shimizu, S.2    Inoue, K.3    Saito, D.4    Yanagisawa, M.5    Inukai, K.6    Akiyama, Y.7    Morimoto, Y.8    Noda, M.9    Shimada, A.10
  • 48
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu, V.; Giral, P.; Jacqueminet, S.; Charlotte, F.; Hartemann-Heurtier, A.; Serfaty, L.; Podevin, P.; Lacorte, J.M.; Bernhardt, C.; Bruckert, E.; et al. Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008, 135, 100–110. [CrossRef] [PubMed]
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3    Charlotte, F.4    Hartemann-Heurtier, A.5    Serfaty, L.6    Podevin, P.7    Lacorte, J.M.8    Bernhardt, C.9    Bruckert, E.10
  • 51
    • 80055031101 scopus 로고    scopus 로고
    • Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open-label trial
    • Torres, D.M.; Jones, F.J.; Shaw, J.C.; Williams, C.D.; Ward, J.A.; Harrison, S.A. Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open-label trial. Hepatology 2011, 54, 1631–1639. [CrossRef] [PubMed]
    • (2011) Hepatology , vol.54 , pp. 1631-1639
    • Torres, D.M.1    Jones, F.J.2    Shaw, J.C.3    Williams, C.D.4    Ward, J.A.5    Harrison, S.A.6
  • 52
    • 84985993965 scopus 로고    scopus 로고
    • Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus a randomized trial
    • Cusi, K.; Orsak, B.; Bril, F.; Lomonaco, R.; Hecht, J.; Ortiz-Lopez, C.; Tio, F.; Hardies, J.; Darland, C.; Musi, N.; et al. Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus a randomized trial. Ann. Intern. Med. 2016, 165, 305–315. [CrossRef] [PubMed]
    • (2016) Ann. Intern. Med. , vol.165 , pp. 305-315
    • Cusi, K.1    Orsak, B.2    Bril, F.3    Lomonaco, R.4    Hecht, J.5    Ortiz-Lopez, C.6    Tio, F.7    Hardies, J.8    Darland, C.9    Musi, N.10
  • 53
    • 84983419781 scopus 로고    scopus 로고
    • Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis
    • Sawangjit, R.; Chongmelaxme, B.; Phisalprapa, P.; Saokaew, S.; Thakkinstian, A.; Kowdley, K.V.; Chaiyakunapruk, N. Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis. Medicine 2016, 95, e4529. [CrossRef] [PubMed]
    • (2016) Medicine , vol.95
    • Sawangjit, R.1    Chongmelaxme, B.2    Phisalprapa, P.3    Saokaew, S.4    Thakkinstian, A.5    Kowdley, K.V.6    Chaiyakunapruk, N.7
  • 54
    • 84995550141 scopus 로고    scopus 로고
    • Thiazolidinediones for nonalcoholic steatohepatitis: A meta-analysis of randomized clinical trials
    • He, L.; Liu, X.; Wang, L.; Yang, Z. Thiazolidinediones for nonalcoholic steatohepatitis: A meta-analysis of randomized clinical trials. Medicine 2016, 95, e4947. [CrossRef] [PubMed]
    • (2016) Medicine , vol.95
    • He, L.1    Liu, X.2    Wang, L.3    Yang, Z.4
  • 55
    • 85020689736 scopus 로고    scopus 로고
    • Meta-Analysis of Randomized Controlled Trials of Pharmacologic Agents in Non-alcoholic Steatohepatitis
    • Said, A.; Akhter, A. Meta-Analysis of Randomized Controlled Trials of Pharmacologic Agents in Non-alcoholic Steatohepatitis. Ann. Hepatol. 2017, 16, 538–547. [CrossRef] [PubMed]
    • (2017) Ann. Hepatol. , vol.16 , pp. 538-547
    • Said, A.1    Akhter, A.2
  • 56
    • 84945185644 scopus 로고    scopus 로고
    • Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis
    • Singh, S.; Khera, R.; Allen, A.M.; Murad, M.H.; Loomba, R. Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis. Hepatology 2015, 62, 1417–1432. [CrossRef] [PubMed]
    • (2015) Hepatology , vol.62 , pp. 1417-1432
    • Singh, S.1    Khera, R.2    Allen, A.M.3    Murad, M.H.4    Loomba, R.5
  • 58
    • 48649107300 scopus 로고    scopus 로고
    • Effects of Ramipril and Rosiglitazone on Cardiovascular and Renal Outcomes in People With Impaired Glucose Tolerance or Impaired Fasting Glucose: Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    • DREAM Trial Investigators; Dagenais, G.R.; Gerstein, H.C.; Holman, R.; Budaj, A.; Escalante, A.; Hedner, T.; Keltai, M.; Lonn, E.; McFarlane, S.; et al. Effects of Ramipril and Rosiglitazone on Cardiovascular and Renal Outcomes in People With Impaired Glucose Tolerance or Impaired Fasting Glucose: Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. Diabetes Care 2008, 31, 1007–1014. [PubMed]
    • (2008) Diabetes Care , vol.31 , pp. 1007-1014
    • Dagenais, G.R.1    Gerstein, H.C.2    Holman, R.3    Budaj, A.4    Escalante, A.5    Hedner, T.6    Keltai, M.7    Lonn, E.8    McFarlane, S.9
  • 59
    • 35848930559 scopus 로고    scopus 로고
    • Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death
    • Diamond, G.A.; Bax, L.; Kaul, S. Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death. Ann. Intern. Med. 2007, 147, 578–581. [CrossRef] [PubMed]
    • (2007) Ann. Intern. Med. , vol.147 , pp. 578-581
    • Diamond, G.A.1    Bax, L.2    Kaul, S.3
  • 60
    • 34250212715 scopus 로고    scopus 로고
    • Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
    • Nissen, S.E.; Wolski, K. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. N. Engl. J. Med. 2007, 356, 2457–2471. [CrossRef] [PubMed]
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 62
    • 84908564226 scopus 로고    scopus 로고
    • Risk of fracture with thiazolidinediones: An updated meta-analysis of randomized clinical trials
    • Zhu, Z.-N.; Jiang, Y.-F.; Ding, T. Risk of fracture with thiazolidinediones: An updated meta-analysis of randomized clinical trials. Bone 2014, 68, 115–123. [CrossRef] [PubMed]
    • (2014) Bone , vol.68 , pp. 115-123
    • Zhu, Z.-N.1    Jiang, Y.-F.2    Ding, T.3
  • 63
    • 84962052919 scopus 로고    scopus 로고
    • Pioglitazone use and risk of bladder cancer: Population based cohort study
    • Tuccori, M.; Filion, K.B.; Yin, H.; Yu, O.H.; Platt, R.W.; Azoulay, L. Pioglitazone use and risk of bladder cancer: Population based cohort study. BMJ 2016, 352, i1541. [CrossRef] [PubMed]
    • (2016) BMJ , vol.352
    • Tuccori, M.1    Filion, K.B.2    Yin, H.3    Yu, O.H.4    Platt, R.W.5    Azoulay, L.6
  • 64
    • 84896731000 scopus 로고    scopus 로고
    • Thiazolidinediones and cancer: Results of a meta-analysis of randomized clinical trials
    • Monami, M.; Dicembrini, I.; Mannucci, E. Thiazolidinediones and cancer: Results of a meta-analysis of randomized clinical trials. Acta Diabetol. 2014, 51, 91–101. [CrossRef] [PubMed]
    • (2014) Acta Diabetol , vol.51 , pp. 91-101
    • Monami, M.1    Dicembrini, I.2    Mannucci, E.3
  • 65
    • 84954367900 scopus 로고    scopus 로고
    • Time for Glucagon like peptide-1 receptor agonists treatment for patients with NAFLD?
    • Gastaldelli, A.; Marchesini, G. Time for Glucagon like peptide-1 receptor agonists treatment for patients with NAFLD? J. Hepatol. 2016, 64, 262–264. [CrossRef] [PubMed]
    • (2016) J. Hepatol. , vol.64 , pp. 262-264
    • Gastaldelli, A.1    Marchesini, G.2
  • 66
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
    • Svegliati-Baroni, G.; Saccomanno, S.; Rychlicki, C.; Agostinelli, L.; De Minicis, S.; Candelaresi, C.; Faraci, G.; Pacetti, D.; Vivarelli, M.; Nicolini, D.; et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011, 31, 1285–1297. [CrossRef] [PubMed]
    • (2011) Liver Int , vol.31 , pp. 1285-1297
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Rychlicki, C.3    Agostinelli, L.4    de Minicis, S.5    Candelaresi, C.6    Faraci, G.7    Pacetti, D.8    Vivarelli, M.9    Nicolini, D.10
  • 69
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta, N.A.; Mells, J.; Dunham, R.M.; Grakoui, A.; Handy, J.; Saxena, N.K.; Anania, F.A. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010, 51, 1584–1592. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6    Anania, F.A.7
  • 70
    • 33947156808 scopus 로고    scopus 로고
    • Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
    • Buse, J.B.; Klonoff, D.C.; Nielsen, L.L.; Guan, X.; Bowlus, C.L.; Holcombe, J.H.; Maggs, D.G.; Wintle, M.E. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin. Ther. 2007, 29, 139–153. [CrossRef] [PubMed]
    • (2007) Clin. Ther. , vol.29 , pp. 139-153
    • Buse, J.B.1    Klonoff, D.C.2    Nielsen, L.L.3    Guan, X.4    Bowlus, C.L.5    Holcombe, J.H.6    Maggs, D.G.7    Wintle, M.E.8
  • 71
    • 84907345097 scopus 로고    scopus 로고
    • Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes
    • Shao, N.; Kuang, H.Y.; Hao, M.; Gao, X.Y.; Lin, W.J.; Zou, W. Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes. Diabetes Metab. Res. Rev. 2014, 30, 521–529. [CrossRef] [PubMed]
    • (2014) Diabetes Metab. Res. Rev. , vol.30 , pp. 521-529
    • Shao, N.1    Kuang, H.Y.2    Hao, M.3    Gao, X.Y.4    Lin, W.J.5    Zou, W.6
  • 72
    • 84872864369 scopus 로고    scopus 로고
    • Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: Individual patient data meta-analysis of the LEAD program
    • Armstrong, M.J.; Houlihan, D.D.; Rowe, I.A.; Clausen, W.H.; Elbrønd, B.; Gough, S.C.; Tomlinson, J.W.; Newsome, P.N. Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: Individual patient data meta-analysis of the LEAD program. Aliment. Pharmacol. Ther. 2013, 37, 234–242. [CrossRef] [PubMed]
    • (2013) Aliment. Pharmacol. Ther. , vol.37 , pp. 234-242
    • Armstrong, M.J.1    Houlihan, D.D.2    Rowe, I.A.3    Clausen, W.H.4    Elbrønd, B.5    Gough, S.C.6    Tomlinson, J.W.7    Newsome, P.N.8
  • 73
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong, M.J.; Gaunt, P.; Aithal, G.P.; Barton, D.; Hull, D.; Parker, R.; Hazlehurst, J.M.; Guo, K.; LEAN Trial Team; Abouda, G.; et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 2016, 387, 679–690. [CrossRef]
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3    Barton, D.4    Hull, D.5    Parker, R.6    Hazlehurst, J.M.7    Guo, K.8    Abouda, G.9
  • 75
    • 85023646637 scopus 로고    scopus 로고
    • Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: A pilot randomized trial
    • Khoo, J.; Hsiang, J.; Taneja, R.; Law, N.M.; Ang, T.L. Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: A pilot randomized trial. Diabetes Obes. Metab. 2017, 19, 1814–1817. [CrossRef] [PubMed]
    • (2017) Diabetes Obes. Metab. , vol.19 , pp. 1814-1817
    • Khoo, J.1    Hsiang, J.2    Taneja, R.3    Law, N.M.4    Ang, T.L.5
  • 76
    • 84953791948 scopus 로고    scopus 로고
    • The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice
    • Honda, Y.; Imajo, K.; Kato, T.; Kessoku, T.; Ogawa, Y.; Tomeno, W.; Kato, S.; Mawatari, H.; Fujita, K.; Yoneda, M.; et al. The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice. PLoS ONE 2016, 11, e0146337. [CrossRef] [PubMed]
    • (2016) Plos ONE , vol.11
    • Honda, Y.1    Imajo, K.2    Kato, T.3    Kessoku, T.4    Ogawa, Y.5    Tomeno, W.6    Kato, S.7    Mawatari, H.8    Fujita, K.9    Yoneda, M.10
  • 77
    • 84961615237 scopus 로고    scopus 로고
    • Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction
    • Komiya, C.; Tsuchiya, K.; Shiba, K.; Miyachi, Y.; Furuke, S.; Shimazu, N.; Yamaguchi, S.; Kanno, K.; Ogawa, Y. Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction. PLoS ONE 2016, 11, e0151511. [CrossRef] [PubMed]
    • (2016) Plos ONE , vol.11
    • Komiya, C.1    Tsuchiya, K.2    Shiba, K.3    Miyachi, Y.4    Furuke, S.5    Shimazu, N.6    Yamaguchi, S.7    Kanno, K.8    Ogawa, Y.9
  • 79
    • 84885476895 scopus 로고    scopus 로고
    • Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
    • Tahara, A.; Kurosaki, E.; Yokono, M.; Yamajuku, D.; Kihara, R.; Hayashizaki, Y.; Takasu, T.; Imamura, M.; Li, Q.; Tomiyama, H.; et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur. J. Pharmacol. 2013, 715, 246–255. [CrossRef] [PubMed]
    • (2013) Eur. J. Pharmacol. , vol.715 , pp. 246-255
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3    Yamajuku, D.4    Kihara, R.5    Hayashizaki, Y.6    Takasu, T.7    Imamura, M.8    Li, Q.9    Tomiyama, H.10
  • 80
    • 84923902007 scopus 로고    scopus 로고
    • Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats
    • Hayashizaki-Someya, Y.; Kurosaki, E.; Takasu, T.; Mitori, H.; Yamazaki, S.; Koide, K.; Takakura, S. Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats. Eur. J. Pharmacol. 2015, 754, 19–24. [CrossRef] [PubMed]
    • (2015) Eur. J. Pharmacol. , vol.754 , pp. 19-24
    • Hayashizaki-Someya, Y.1    Kurosaki, E.2    Takasu, T.3    Mitori, H.4    Yamazaki, S.5    Koide, K.6    Takakura, S.7
  • 82
    • 85021690949 scopus 로고    scopus 로고
    • Effects of canagliflozin on weight loss in high-fat diet-induced obese mice
    • Ji, W.; Zhao, M.; Wang, M.; Yan, W.; Liu, Y.; Ren, S.; Lu, J.; Wang, B.; Chen, L. Effects of canagliflozin on weight loss in high-fat diet-induced obese mice. PLoS ONE 2017, 12, e0179960. [CrossRef] [PubMed]
    • (2017) Plos ONE , vol.12
    • Ji, W.1    Zhao, M.2    Wang, M.3    Yan, W.4    Liu, Y.5    Ren, S.6    Lu, J.7    Wang, B.8    Chen, L.9
  • 83
    • 84979220732 scopus 로고    scopus 로고
    • Empagliflozin (An SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
    • Jojima, T.; Tomotsune, T.; Iijima, T.; Akimoto, K.; Suzuki, K.; Aso, Y. Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes. Diabetol. Metab. Syndr. 2016, 8, 45. [CrossRef] [PubMed]
    • (2016) Diabetol. Metab. Syndr. , vol.8 , pp. 45
    • Jojima, T.1    Tomotsune, T.2    Iijima, T.3    Akimoto, K.4    Suzuki, K.5    Aso, Y.6
  • 84
    • 85029118133 scopus 로고    scopus 로고
    • Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice
    • Obara, K.; Shirakami, Y.; Maruta, A.; Ideta, T.; Miyazaki, T.; Kochi, T.; Sakai, H.; Tanaka, T.; Seishima, M.; Shimizu, M. Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice. Oncotarget 2017, 8, 58353–58363. [CrossRef] [PubMed]
    • (2017) Oncotarget , vol.8 , pp. 58353-58363
    • Obara, K.1    Shirakami, Y.2    Maruta, A.3    Ideta, T.4    Miyazaki, T.5    Kochi, T.6    Sakai, H.7    Tanaka, T.8    Seishima, M.9    Shimizu, M.10
  • 85
    • 85052836880 scopus 로고    scopus 로고
    • Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)
    • Kuchay, M.S.; Krishan, S.; Mishra, S.K.; Farooqui, K.J.; Singh, M.K.; Wasir, J.S.; Bansal, B.; Kaur, P.; Jevalikar, G.; Gill, H.K.; et al. Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial). Diabetes Care 2018, 41, 1801–1808. [CrossRef] [PubMed]
    • (2018) Diabetes Care , vol.41 , pp. 1801-1808
    • Kuchay, M.S.1    Krishan, S.2    Mishra, S.K.3    Farooqui, K.J.4    Singh, M.K.5    Wasir, J.S.6    Bansal, B.7    Kaur, P.8    Jevalikar, G.9    Gill, H.K.10
  • 87
    • 85002525061 scopus 로고    scopus 로고
    • Pharmacological aspects of the safety of gliflozins
    • Faillie, J.-L. Pharmacological aspects of the safety of gliflozins. Pharmacol. Res. 2017, 118, 71–81. [CrossRef] [PubMed]
    • (2017) Pharmacol. Res. , vol.118 , pp. 71-81
    • Faillie, J.-L.1
  • 88
    • 84943450119 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression
    • Hwang, H.J.; Jung, T.W.; Kim, B.H.; Hong, H.C.; Seo, J.A.; Kim, S.G.; Kim, N.H.; Choi, K.M.; Choi, D.S.; Baik, S.H.; et al. A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression. Biochem. Pharmacol. 2015, 98, 157–166. [CrossRef] [PubMed]
    • (2015) Biochem. Pharmacol. , vol.98 , pp. 157-166
    • Hwang, H.J.1    Jung, T.W.2    Kim, B.H.3    Hong, H.C.4    Seo, J.A.5    Kim, S.G.6    Kim, N.H.7    Choi, K.M.8    Choi, D.S.9    Baik, S.H.10
  • 89
    • 85044771043 scopus 로고    scopus 로고
    • Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver
    • Tobita, H.; Sato, S.; Yazaki, T.; Mishiro, T.; Ishimura, N.; Ishihara, S.; Kinoshita, Y. Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver. Mol. Med. Rep. 2018, 17, 6840–6846. [CrossRef] [PubMed]
    • (2018) Mol. Med. Rep. , vol.17 , pp. 6840-6846
    • Tobita, H.1    Sato, S.2    Yazaki, T.3    Mishiro, T.4    Ishimura, N.5    Ishihara, S.6    Kinoshita, Y.7
  • 90
    • 84949424443 scopus 로고    scopus 로고
    • The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice
    • Ideta, T.; Shirakami, Y.; Miyazaki, T.; Kochi, T.; Sakai, H.; Moriwaki, H.; Shimizu, M. The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice. Int. J. Mol. Sci. 2015, 16, 29207–29218. [CrossRef] [PubMed]
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 29207-29218
    • Ideta, T.1    Shirakami, Y.2    Miyazaki, T.3    Kochi, T.4    Sakai, H.5    Moriwaki, H.6    Shimizu, M.7
  • 91
    • 85052676740 scopus 로고    scopus 로고
    • Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway
    • Shen, T.; Xu, B.; Lei, T.; Chen, L.; Zhang, C.; Ni, Z. Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway. Exp. Ther. Med. 2018, 16, 3121–3128. [CrossRef] [PubMed]
    • (2018) Exp. Ther. Med. , vol.16 , pp. 3121-3128
    • Shen, T.1    Xu, B.2    Lei, T.3    Chen, L.4    Zhang, C.5    Ni, Z.6
  • 92
    • 85007193610 scopus 로고    scopus 로고
    • Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis
    • Klein, T.; Fujii, M.; Sandel, J.; Shibazaki, Y.; Wakamatsu, K.; Mark, M.; Yoneyama, H. Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis. Med. Mol. Morphol. 2014, 47, 137–149. [CrossRef] [PubMed]
    • (2014) Med. Mol. Morphol. , vol.47 , pp. 137-149
    • Klein, T.1    Fujii, M.2    Sandel, J.3    Shibazaki, Y.4    Wakamatsu, K.5    Mark, M.6    Yoneyama, H.7
  • 93
    • 84876523499 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4: A key player in chronic liver disease
    • Itou, M.; Kawaguchi, T.; Taniguchi, E.; Sata, M. Dipeptidyl peptidase-4: A key player in chronic liver disease. World J. Gastroenterol. 2013, 19, 2298–2306. [CrossRef] [PubMed]
    • (2013) World J. Gastroenterol. , vol.19 , pp. 2298-2306
    • Itou, M.1    Kawaguchi, T.2    Taniguchi, E.3    Sata, M.4
  • 96
    • 85054466680 scopus 로고    scopus 로고
    • Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease
    • Sayari, S.; Neishaboori, H.; Jameshorani, M. Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease. Clin. Mol. Hepatol. 2018, 24, 331–338. [CrossRef] [PubMed]
    • (2018) Clin. Mol. Hepatol. , vol.24 , pp. 331-338
    • Sayari, S.1    Neishaboori, H.2    Jameshorani, M.3
  • 97
    • 85007500595 scopus 로고    scopus 로고
    • Vildagliptin ameliorates biochemical, metabolic and fatty changes associated with non alcoholic fatty liver disease
    • Hussain, M.; Majeed Babar, M.Z.; Hussain, M.S.; Akhtar, L. Vildagliptin ameliorates biochemical, metabolic and fatty changes associated with non alcoholic fatty liver disease. Pak. J. Med. Sci. 2016, 32, 1396–1401. [CrossRef] [PubMed]
    • (2016) Pak. J. Med. Sci. , vol.32 , pp. 1396-1401
    • Hussain, M.1    Majeed Babar, M.Z.2    Hussain, M.S.3    Akhtar, L.4
  • 98
    • 77957149259 scopus 로고    scopus 로고
    • Dipeptidyl Peptidase-4 (DPP-4) Inhibitors in the Management of Diabetes
    • Pathak, R.; Bridgeman, M.B. Dipeptidyl Peptidase-4 (DPP-4) Inhibitors in the Management of Diabetes. Pharm. Ther. 2010, 35, 509–513.
    • (2010) Pharm. Ther. , vol.35 , pp. 509-513
    • Pathak, R.1    Bridgeman, M.B.2
  • 99
    • 0026659006 scopus 로고
    • Sulfonylureas in NIDDM
    • Groop, L.C. Sulfonylureas in NIDDM. Diabetes Care 1992, 15, 737–754. [CrossRef] [PubMed]
    • (1992) Diabetes Care , vol.15 , pp. 737-754
    • Groop, L.C.1
  • 100
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi, S.E.; Bergenstal, R.M.; Buse, J.B.; Diamant, M.; Ferrannini, E.; Nauck, M.; Peters, A.L.; Tsapas, A.; Wender, R.; Matthews, D.R.; et al. Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012, 55, 1577–1596. [CrossRef] [PubMed]
    • (2012) Diabetologia , vol.55 , pp. 1577-1596
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6    Peters, A.L.7    Tsapas, A.8    Wender, R.9    Matthews, D.R.10
  • 101
    • 84862906593 scopus 로고    scopus 로고
    • Drug-induced hypoglycaemia in type 2 diabetes
    • Inkster, B.; Zammitt, N.N.; Frier, B.M. Drug-induced hypoglycaemia in type 2 diabetes. Expert Opin. Drug Saf. 2012, 11, 597–614. [CrossRef] [PubMed]
    • (2012) Expert Opin. Drug Saf. , vol.11 , pp. 597-614
    • Inkster, B.1    Zammitt, N.N.2    Frier, B.M.3
  • 102
    • 0019783320 scopus 로고
    • Clinical pharmacokinetics of sulphonylurea hypoglycaemic drugs
    • Balant, L. Clinical pharmacokinetics of sulphonylurea hypoglycaemic drugs. Clin. Pharmacokinet. 1981, 6, 215–241. [CrossRef] [PubMed]
    • (1981) Clin. Pharmacokinet. , vol.6 , pp. 215-241
    • Balant, L.1
  • 103
    • 84856104937 scopus 로고    scopus 로고
    • Repaglinide
    • Scott, L.J. Repaglinide. Drugs 2012, 72, 249–272. [CrossRef] [PubMed]
    • (2012) Drugs , vol.72 , pp. 249-272
    • Scott, L.J.1
  • 104
    • 1442332803 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of nateglinide: A rapidly-absorbed, short-acting insulinotropic agent
    • McLeod, J.F. Clinical pharmacokinetics of nateglinide: A rapidly-absorbed, short-acting insulinotropic agent. Clin. Pharmacokinet. 2004, 43, 97–120. [CrossRef] [PubMed]
    • (2004) Clin. Pharmacokinet. , vol.43 , pp. 97-120
    • McLeod, J.F.1
  • 105
    • 84901021453 scopus 로고    scopus 로고
    • Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease
    • Scheen, A.J. Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease. Expert Opin. Drug Metab. Toxicol. 2014, 10, 839–857. [CrossRef] [PubMed]
    • (2014) Expert Opin. Drug Metab. Toxicol. , vol.10 , pp. 839-857
    • Scheen, A.J.1
  • 106
    • 80053400535 scopus 로고    scopus 로고
    • Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: Systematic review and meta-analysis
    • Pontiroli, A.E.; Miele, L.; Morabito, A. Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: Systematic review and meta-analysis. Diabetes Obes. Metab. 2011, 13, 1008–1019. [CrossRef] [PubMed]
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 1008-1019
    • Pontiroli, A.E.1    Miele, L.2    Morabito, A.3
  • 107
    • 84960090337 scopus 로고    scopus 로고
    • Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin
    • Khunti, K.; Nikolajsen, A.; Thorsted, B.L.; Andersen, M.; Davies, M.J.; Paul, S.K. Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin. Diabetes Obes. Metab. 2016, 18, 401–409. [CrossRef] [PubMed]
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 401-409
    • Khunti, K.1    Nikolajsen, A.2    Thorsted, B.L.3    Andersen, M.4    Davies, M.J.5    Paul, S.K.6
  • 108
    • 84992503607 scopus 로고    scopus 로고
    • Weight gain in insulin-treated patients by body mass index category at treatment initiation: New evidence from real-world data in patients with type 2 diabetes
    • Paul, S.K.; Shaw, J.E.; Montvida, O.; Klein, K. Weight gain in insulin-treated patients by body mass index category at treatment initiation: New evidence from real-world data in patients with type 2 diabetes. Diabetes Obes. Metab. 2016, 18, 1244–1252. [CrossRef] [PubMed]
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 1244-1252
    • Paul, S.K.1    Shaw, J.E.2    Montvida, O.3    Klein, K.4
  • 109
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle, E.E.; Kaaks, R. Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 2004, 4, 579–591. [CrossRef] [PubMed]
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 110
    • 5144234027 scopus 로고    scopus 로고
    • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    • Yang, Y.; Hennessy, S.; Lewis, J. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology 2004, 127, 1044–1050. [CrossRef] [PubMed]
    • (2004) Gastroenterology , vol.127 , pp. 1044-1050
    • Yang, Y.1    Hennessy, S.2    Lewis, J.3
  • 111
    • 84890036692 scopus 로고    scopus 로고
    • Antidiabetic Medications and the Risk of Colorectal Cancer in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis
    • Singh, S.; Singh, H.; Singh, P.P.; Murad, M.H.; Limburg, P.J. Antidiabetic Medications and the Risk of Colorectal Cancer in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis. Cancer Epidemiol. Biomark. Prev. 2013, 22, 2258–2268. [CrossRef] [PubMed]
    • (2013) Cancer Epidemiol. Biomark. Prev. , vol.22 , pp. 2258-2268
    • Singh, S.1    Singh, H.2    Singh, P.P.3    Murad, M.H.4    Limburg, P.J.5
  • 112
    • 33644759114 scopus 로고    scopus 로고
    • The Association Between Diabetes and Hepatocellular Carcinoma: A Systematic Review of Epidemiologic Evidence
    • El–Serag, H.B.; Hampel, H.; Javadi, F. The Association Between Diabetes and Hepatocellular Carcinoma: A Systematic Review of Epidemiologic Evidence. Clin. Gastroenterol. Hepatol. 2006, 4, 369–380. [CrossRef] [PubMed]
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 113
    • 15544382574 scopus 로고    scopus 로고
    • Diabetes increases the risk of hepatocellular carcinoma in the United States: A population based case control study
    • Davila, J.A. Diabetes increases the risk of hepatocellular carcinoma in the United States: A population based case control study. Gut 2005, 54, 533–539. [CrossRef] [PubMed]
    • (2005) Gut , vol.54 , pp. 533-539
    • Davila, J.A.1
  • 116
    • 84911999849 scopus 로고    scopus 로고
    • Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes
    • Zhang, X.; Harmsen, W.S.; Mettler, T.A.; Kim, W.R.; Roberts, R.O.; Therneau, T.M.; Roberts, L.R.; Chaiteerakij, R. Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology 2014, 60, 2008–2016. [CrossRef] [PubMed]
    • (2014) Hepatology , vol.60 , pp. 2008-2016
    • Zhang, X.1    Harmsen, W.S.2    Mettler, T.A.3    Kim, W.R.4    Roberts, R.O.5    Therneau, T.M.6    Roberts, L.R.7    Chaiteerakij, R.8
  • 117
    • 84911943590 scopus 로고    scopus 로고
    • Rationale for conducting a randomized trial to examine the efficacy of metformin in improving survival in cirrhosis: Pleiotropic effects hypothesis
    • Loomba, R. Rationale for conducting a randomized trial to examine the efficacy of metformin in improving survival in cirrhosis: Pleiotropic effects hypothesis. Hepatology 2014, 60, 1818–1822. [CrossRef] [PubMed]
    • (2014) Hepatology , vol.60 , pp. 1818-1822
    • Loomba, R.1


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