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Volumn 73, Issue 1, 2019, Pages 89-99

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week

(11)  Davidson, Sean M a   Ferdinandy, Péter b,c   Andreadou, Ioanna d   Bøtker, Hans Erik e   Heusch, Gerd f   Ibáñez, Borja g,h,i   Ovize, Michel j   Schulz, Rainer k   Yellon, Derek M a   Hausenloy, Derek J a,l,m,n,o   Garcia Dorado, David i,p,q  


Author keywords

cardioprotection; ischemia; myocardial infarction; reperfusion

Indexed keywords

BELNACASAN; CANGRELOR; CARIPORIDE; EXENDIN 4; TICAGRELOR;

EID: 85059103889     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2018.09.086     Document Type: Review
Times cited : (546)

References (64)
  • 1
    • 85019584227 scopus 로고    scopus 로고
    • Critical issues for the translation of cardioprotection
    • Heusch, G., Critical issues for the translation of cardioprotection. Circ Res 120 (2017), 1477–1486.
    • (2017) Circ Res , vol.120 , pp. 1477-1486
    • Heusch, G.1
  • 2
    • 85051735495 scopus 로고    scopus 로고
    • Cardioprotection research must leave its comfort zone
    • Heusch, G., Cardioprotection research must leave its comfort zone. Eur Heart J 39 (2018), 3393–3395.
    • (2018) Eur Heart J , vol.39 , pp. 3393-3395
    • Heusch, G.1
  • 3
    • 85018243638 scopus 로고    scopus 로고
    • Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
    • Hausenloy, D.J., Botker, H.E., Engstrom, T., et al. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. Eur Heart J 38 (2017), 935–941.
    • (2017) Eur Heart J , vol.38 , pp. 935-941
    • Hausenloy, D.J.1    Botker, H.E.2    Engstrom, T.3
  • 4
    • 85018173958 scopus 로고    scopus 로고
    • The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge
    • Heusch, G., Gersh, B.J., The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J 38 (2017), 774–784.
    • (2017) Eur Heart J , vol.38 , pp. 774-784
    • Heusch, G.1    Gersh, B.J.2
  • 5
    • 84911917373 scopus 로고    scopus 로고
    • Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning
    • Ferdinandy, P., Hausenloy, D.J., Heusch, G., Baxter, G.F., Schulz, R., Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev 66 (2014), 1142–1174.
    • (2014) Pharmacol Rev , vol.66 , pp. 1142-1174
    • Ferdinandy, P.1    Hausenloy, D.J.2    Heusch, G.3    Baxter, G.F.4    Schulz, R.5
  • 6
    • 85016601630 scopus 로고    scopus 로고
    • Novel targets and future strategies for acute cardioprotection: position paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
    • Hausenloy, D.J., Garcia-Dorado, D., Botker, H.E., et al. Novel targets and future strategies for acute cardioprotection: position paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc Res 113 (2017), 564–585.
    • (2017) Cardiovasc Res , vol.113 , pp. 564-585
    • Hausenloy, D.J.1    Garcia-Dorado, D.2    Botker, H.E.3
  • 7
    • 84884180824 scopus 로고    scopus 로고
    • Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling
    • Inserte, J., Hernando, V., Vilardosa, U., Abad, E., Poncelas-Nozal, M., Garcia-Dorado, D., Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling. J Am Heart Assoc, 2, 2013, e005975.
    • (2013) J Am Heart Assoc , vol.2 , pp. e005975
    • Inserte, J.1    Hernando, V.2    Vilardosa, U.3    Abad, E.4    Poncelas-Nozal, M.5    Garcia-Dorado, D.6
  • 8
    • 84938896816 scopus 로고    scopus 로고
    • Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs
    • Alburquerque-Bejar, J.J., Barba, I., Inserte, J., et al. Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs. Cardiovasc Res 107 (2015), 246–254.
    • (2015) Cardiovasc Res , vol.107 , pp. 246-254
    • Alburquerque-Bejar, J.J.1    Barba, I.2    Inserte, J.3
  • 9
    • 85001863260 scopus 로고    scopus 로고
    • Cardioprotection by remote ischemic conditioning and its signal transduction
    • Kleinbongard, P., Skyschally, A., Heusch, G., Cardioprotection by remote ischemic conditioning and its signal transduction. Pflugers Arch 469 (2017), 159–181.
    • (2017) Pflugers Arch , vol.469 , pp. 159-181
    • Kleinbongard, P.1    Skyschally, A.2    Heusch, G.3
  • 10
    • 84924123511 scopus 로고    scopus 로고
    • Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning
    • Heusch, G., Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 116 (2015), 674–699.
    • (2015) Circ Res , vol.116 , pp. 674-699
    • Heusch, G.1
  • 11
    • 0041859202 scopus 로고    scopus 로고
    • Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions
    • Ruiz-Meana, M., Garcia-Dorado, D., Pina, P., Inserte, J., Agullo, L., Soler-Soler, J., Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. Am J Physiol Heart Circ Physiol 285 (2003), H999–H1006.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H999-H1006
    • Ruiz-Meana, M.1    Garcia-Dorado, D.2    Pina, P.3    Inserte, J.4    Agullo, L.5    Soler-Soler, J.6
  • 12
    • 0031771234 scopus 로고    scopus 로고
    • Mild hypothermia reduces infarct size in the beating rabbit heart: a practical intervention for acute myocardial infarction?
    • Miki, T., Liu, G.S., Cohen, M.V., Downey, J.M., Mild hypothermia reduces infarct size in the beating rabbit heart: a practical intervention for acute myocardial infarction?. Basic Res Cardiol 93 (1998), 372–383.
    • (1998) Basic Res Cardiol , vol.93 , pp. 372-383
    • Miki, T.1    Liu, G.S.2    Cohen, M.V.3    Downey, J.M.4
  • 13
    • 84885022162 scopus 로고    scopus 로고
    • Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial
    • Ibanez, B., Macaya, C., Sanchez-Brunete, V., et al. Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial. Circulation 128 (2013), 1495–1503.
    • (2013) Circulation , vol.128 , pp. 1495-1503
    • Ibanez, B.1    Macaya, C.2    Sanchez-Brunete, V.3
  • 14
    • 84860771658 scopus 로고    scopus 로고
    • Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial
    • Selker, H.P., Beshansky, J.R., Sheehan, P.R., et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 307 (2012), 1925–1933.
    • (2012) JAMA , vol.307 , pp. 1925-1933
    • Selker, H.P.1    Beshansky, J.R.2    Sheehan, P.R.3
  • 15
    • 77249107745 scopus 로고    scopus 로고
    • Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
    • Botker, H.E., Kharbanda, R., Schmidt, M.R., et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375 (2010), 727–734.
    • (2010) Lancet , vol.375 , pp. 727-734
    • Botker, H.E.1    Kharbanda, R.2    Schmidt, M.R.3
  • 16
    • 85051195062 scopus 로고    scopus 로고
    • Reflection of cardioprotection by remote ischemic perconditioning in attenuated ST-segment elevation during ongoing coronary occlusion in pigs: evidence for cardioprotection from ischemic injury
    • Kleinbongard, P., Amanakis, G., Skyschally, A., Heusch, G., Reflection of cardioprotection by remote ischemic perconditioning in attenuated ST-segment elevation during ongoing coronary occlusion in pigs: evidence for cardioprotection from ischemic injury. Circ Res 122 (2018), 1102–1108.
    • (2018) Circ Res , vol.122 , pp. 1102-1108
    • Kleinbongard, P.1    Amanakis, G.2    Skyschally, A.3    Heusch, G.4
  • 17
    • 84962092500 scopus 로고    scopus 로고
    • Impact of the timing of metoprolol administration during STEMI on infarct size and ventricular function
    • Garcia-Ruiz, J.M., Fernandez-Jimenez, R., Garcia-Alvarez, A., et al. Impact of the timing of metoprolol administration during STEMI on infarct size and ventricular function. J Am Coll Cardiol 67 (2016), 2093–2104.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 2093-2104
    • Garcia-Ruiz, J.M.1    Fernandez-Jimenez, R.2    Garcia-Alvarez, A.3
  • 18
    • 77954789419 scopus 로고    scopus 로고
    • Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology
    • Ovize, M., Baxter, G.F., Di Lisa, F., et al. Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res 87 (2010), 406–423.
    • (2010) Cardiovasc Res , vol.87 , pp. 406-423
    • Ovize, M.1    Baxter, G.F.2    Di Lisa, F.3
  • 19
    • 0345490687 scopus 로고    scopus 로고
    • Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury
    • Hausenloy, D.J., Duchen, M.R., Yellon, D.M., Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res 60 (2003), 617–625.
    • (2003) Cardiovasc Res , vol.60 , pp. 617-625
    • Hausenloy, D.J.1    Duchen, M.R.2    Yellon, D.M.3
  • 20
    • 1542298950 scopus 로고    scopus 로고
    • Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    • Kin, H., Zhao, Z.Q., Sun, H.Y., et al. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res 62 (2004), 74–85.
    • (2004) Cardiovasc Res , vol.62 , pp. 74-85
    • Kin, H.1    Zhao, Z.Q.2    Sun, H.Y.3
  • 21
    • 33845919315 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury
    • Doukas, J., Wrasidlo, W., Noronha, G., et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A 103 (2006), 19866–19871.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19866-19871
    • Doukas, J.1    Wrasidlo, W.2    Noronha, G.3
  • 22
    • 63549108888 scopus 로고    scopus 로고
    • Cardioprotection against myocardial infarction with PTD-BIR3/RING, a XIAP mimicking protein
    • Souktani, R., Pons, S., Guegan, C., et al. Cardioprotection against myocardial infarction with PTD-BIR3/RING, a XIAP mimicking protein. J Mol Cell Cardiol 46 (2009), 713–718.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 713-718
    • Souktani, R.1    Pons, S.2    Guegan, C.3
  • 23
    • 84864301163 scopus 로고    scopus 로고
    • Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms
    • Basalay, M., Barsukevich, V., Mastitskaya, S., et al. Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms. Exp Physiol 97 (2012), 908–917.
    • (2012) Exp Physiol , vol.97 , pp. 908-917
    • Basalay, M.1    Barsukevich, V.2    Mastitskaya, S.3
  • 24
    • 84873848690 scopus 로고    scopus 로고
    • Myocardial ischemia-reperfusion injury: a neglected therapeutic target
    • Hausenloy, D.J., Yellon, D.M., Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 123 (2013), 92–100.
    • (2013) J Clin Invest , vol.123 , pp. 92-100
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 25
    • 85040555762 scopus 로고    scopus 로고
    • Area at risk and collateral circulation in a first acute myocardial infarction with occluded culprit artery. STEMI vs non-STEMI patients
    • Figueras, J., Otaegui, I., Marti, G., et al. Area at risk and collateral circulation in a first acute myocardial infarction with occluded culprit artery. STEMI vs non-STEMI patients. Int J Cardiol 259 (2018), 14–19.
    • (2018) Int J Cardiol , vol.259 , pp. 14-19
    • Figueras, J.1    Otaegui, I.2    Marti, G.3
  • 26
    • 85040602547 scopus 로고    scopus 로고
    • 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)
    • Ibanez, B., James, S., Agewall, S., et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39 (2018), 119–177.
    • (2018) Eur Heart J , vol.39 , pp. 119-177
    • Ibanez, B.1    James, S.2    Agewall, S.3
  • 27
    • 85017497647 scopus 로고    scopus 로고
    • Neutrophil stunning by metoprolol reduces infarct size
    • Garcia-Prieto, J., Villena-Gutierrez, R., Gomez, M., et al. Neutrophil stunning by metoprolol reduces infarct size. Nat Commun, 8, 2017, 14780.
    • (2017) Nat Commun , vol.8 , pp. 14780
    • Garcia-Prieto, J.1    Villena-Gutierrez, R.2    Gomez, M.3
  • 28
    • 84894242540 scopus 로고    scopus 로고
    • Cardiac fibroblasts protect cardiomyocytes against lethal ischemia-reperfusion injury
    • Abrial, M., Da Silva, C.C., Pillot, B., et al. Cardiac fibroblasts protect cardiomyocytes against lethal ischemia-reperfusion injury. J Mol Cell Cardiol 68 (2014), 56–65.
    • (2014) J Mol Cell Cardiol , vol.68 , pp. 56-65
    • Abrial, M.1    Da Silva, C.C.2    Pillot, B.3
  • 29
    • 84894239930 scopus 로고    scopus 로고
    • Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles
    • Giricz, Z., Varga, Z.V., Baranyai, T., et al. Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles. J Mol Cell Cardiol 68 (2014), 75–78.
    • (2014) J Mol Cell Cardiol , vol.68 , pp. 75-78
    • Giricz, Z.1    Varga, Z.V.2    Baranyai, T.3
  • 30
    • 84962643295 scopus 로고    scopus 로고
    • Myocardial apoptosis in heart disease: does the emperor have clothes?
    • Jose Corbalan, J., Vatner, D.E., Vatner, S.F., Myocardial apoptosis in heart disease: does the emperor have clothes?. Basic Res Cardiol, 111, 2016, 31.
    • (2016) Basic Res Cardiol , vol.111 , pp. 31
    • Jose Corbalan, J.1    Vatner, D.E.2    Vatner, S.F.3
  • 32
    • 84968764909 scopus 로고    scopus 로고
    • The coronary circulation as a target of cardioprotection
    • Heusch, G., The coronary circulation as a target of cardioprotection. Circ Res 118 (2016), 1643–1658.
    • (2016) Circ Res , vol.118 , pp. 1643-1658
    • Heusch, G.1
  • 33
    • 85020045925 scopus 로고    scopus 로고
    • Platelets, diabetes and myocardial ischemia/reperfusion injury
    • Russo, I., Penna, C., Musso, T., et al. Platelets, diabetes and myocardial ischemia/reperfusion injury. Cardiovasc Diabetol, 16, 2017, 71.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 71
    • Russo, I.1    Penna, C.2    Musso, T.3
  • 34
    • 77954374873 scopus 로고    scopus 로고
    • Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts
    • Barrabes, J.A., Inserte, J., Mirabet, M., et al. Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts. Thromb Haemost 104 (2010), 128–135.
    • (2010) Thromb Haemost , vol.104 , pp. 128-135
    • Barrabes, J.A.1    Inserte, J.2    Mirabet, M.3
  • 35
    • 84992699816 scopus 로고    scopus 로고
    • Protective effects of ticagrelor on myocardial injury after infarction
    • Vilahur, G., Gutierrez, M., Casani, L., et al. Protective effects of ticagrelor on myocardial injury after infarction. Circulation 134 (2016), 1708–1719.
    • (2016) Circulation , vol.134 , pp. 1708-1719
    • Vilahur, G.1    Gutierrez, M.2    Casani, L.3
  • 36
    • 85023744332 scopus 로고    scopus 로고
    • Dynamic edematous response of the human heart to myocardial infarction: implications for assessing myocardial area at risk and salvage
    • Fernandez-Jimenez, R., Barreiro-Perez, M., Martin-Garcia, A., et al. Dynamic edematous response of the human heart to myocardial infarction: implications for assessing myocardial area at risk and salvage. Circulation 136 (2017), 1288–1300.
    • (2017) Circulation , vol.136 , pp. 1288-1300
    • Fernandez-Jimenez, R.1    Barreiro-Perez, M.2    Martin-Garcia, A.3
  • 37
    • 0025314531 scopus 로고
    • Determinants of hemorrhagic infarcts. Histologic observations from experiments involving coronary occlusion, coronary reperfusion, and reocclusion
    • Garcia-Dorado, D., Theroux, P., Solares, J., et al. Determinants of hemorrhagic infarcts. Histologic observations from experiments involving coronary occlusion, coronary reperfusion, and reocclusion. Am J Pathol 137 (1990), 301–311.
    • (1990) Am J Pathol , vol.137 , pp. 301-311
    • Garcia-Dorado, D.1    Theroux, P.2    Solares, J.3
  • 38
    • 70449514842 scopus 로고    scopus 로고
    • Coronary microembolization: from bedside to bench and back to bedside
    • Heusch, G., Kleinbongard, P., Bose, D., et al. Coronary microembolization: from bedside to bench and back to bedside. Circulation 120 (2009), 1822–1836.
    • (2009) Circulation , vol.120 , pp. 1822-1836
    • Heusch, G.1    Kleinbongard, P.2    Bose, D.3
  • 40
    • 85029955867 scopus 로고    scopus 로고
    • The impact of irreproducibility and competing protection from P2Y12 antagonists on the discovery of cardioprotective interventions
    • Cohen, M.V., Downey, J.M., The impact of irreproducibility and competing protection from P2Y12 antagonists on the discovery of cardioprotective interventions. Basic Res Cardiol, 112, 2017, 64.
    • (2017) Basic Res Cardiol , vol.112 , pp. 64
    • Cohen, M.V.1    Downey, J.M.2
  • 41
    • 85049809862 scopus 로고    scopus 로고
    • Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function
    • Audia, J.P., Yang, X.-M., Crockett, E.S., et al. Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol, 113, 2018.
    • (2018) Basic Res Cardiol , vol.113
    • Audia, J.P.1    Yang, X.-M.2    Crockett, E.S.3
  • 42
    • 84899576786 scopus 로고    scopus 로고
    • Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia-reperfusion injury
    • Koshinuma, S., Miyamae, M., Kaneda, K., Kotani, J., Figueredo, V.M., Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia-reperfusion injury. J Anesth 28 (2014), 235–241.
    • (2014) J Anesth , vol.28 , pp. 235-241
    • Koshinuma, S.1    Miyamae, M.2    Kaneda, K.3    Kotani, J.4    Figueredo, V.M.5
  • 43
    • 84855382340 scopus 로고    scopus 로고
    • Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4
    • Galaup, A., Gomez, E., Souktani, R., et al. Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation 125 (2012), 140–149.
    • (2012) Circulation , vol.125 , pp. 140-149
    • Galaup, A.1    Gomez, E.2    Souktani, R.3
  • 44
    • 84885172325 scopus 로고    scopus 로고
    • Triple therapy greatly increases myocardial salvage during ischemia/reperfusion in the in situ rat heart
    • Yang, X.M., Cui, L., Alhammouri, A., Downey, J.M., Cohen, M.V., Triple therapy greatly increases myocardial salvage during ischemia/reperfusion in the in situ rat heart. Cardiovasc Drugs Ther 27 (2013), 403–412.
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 403-412
    • Yang, X.M.1    Cui, L.2    Alhammouri, A.3    Downey, J.M.4    Cohen, M.V.5
  • 45
    • 84959440386 scopus 로고    scopus 로고
    • Concomitant phosphodiesterase 5 inhibition enhances myocardial protection by inhaled nitric oxide in ischemia-reperfusion injury
    • Lux, A., Pokreisz, P., Swinnen, M., et al. Concomitant phosphodiesterase 5 inhibition enhances myocardial protection by inhaled nitric oxide in ischemia-reperfusion injury. J Pharmacol Exp Ther 356 (2016), 284–292.
    • (2016) J Pharmacol Exp Ther , vol.356 , pp. 284-292
    • Lux, A.1    Pokreisz, P.2    Swinnen, M.3
  • 46
    • 84886751309 scopus 로고    scopus 로고
    • Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion
    • Tratsiakovich, Y., Gonon, A.T., Kiss, A., et al. Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion. Int J Cardiol 169 (2013), 83–88.
    • (2013) Int J Cardiol , vol.169 , pp. 83-88
    • Tratsiakovich, Y.1    Gonon, A.T.2    Kiss, A.3
  • 47
    • 84960913426 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of novel adenine-hydrogen sulfide slow release hybrids designed as multitarget cardioprotective agents
    • Lougiakis, N., Papapetropoulos, A., Gikas, E., et al. Synthesis and pharmacological evaluation of novel adenine-hydrogen sulfide slow release hybrids designed as multitarget cardioprotective agents. J Med Chem 59 (2016), 1776–1790.
    • (2016) J Med Chem , vol.59 , pp. 1776-1790
    • Lougiakis, N.1    Papapetropoulos, A.2    Gikas, E.3
  • 48
    • 84858794889 scopus 로고    scopus 로고
    • A lipophilic nitric oxide donor and a lipophilic antioxidant compound protect rat heart against ischemia-reperfusion injury if given as hybrid molecule but not as a mixture
    • Rastaldo, R., Cappello, S., Di Stilo, A., Folino, A., Losano, G., Pagliaro, P., A lipophilic nitric oxide donor and a lipophilic antioxidant compound protect rat heart against ischemia-reperfusion injury if given as hybrid molecule but not as a mixture. J Cardiovasc Pharmacol 59 (2012), 241–248.
    • (2012) J Cardiovasc Pharmacol , vol.59 , pp. 241-248
    • Rastaldo, R.1    Cappello, S.2    Di Stilo, A.3    Folino, A.4    Losano, G.5    Pagliaro, P.6
  • 49
    • 23644447741 scopus 로고    scopus 로고
    • Preconditioning the diabetic heart: the importance of Akt phosphorylation
    • Tsang, A., Hausenloy, D.J., Mocanu, M.M., Carr, R.D., Yellon, D.M., Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes 54 (2005), 2360–2364.
    • (2005) Diabetes , vol.54 , pp. 2360-2364
    • Tsang, A.1    Hausenloy, D.J.2    Mocanu, M.M.3    Carr, R.D.4    Yellon, D.M.5
  • 50
    • 84958092745 scopus 로고    scopus 로고
    • Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways
    • Xue, R., Lei, S., Xia, Z.Y., et al. Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways. Clin Sci (Lond) 130 (2016), 377–392.
    • (2016) Clin Sci (Lond) , vol.130 , pp. 377-392
    • Xue, R.1    Lei, S.2    Xia, Z.Y.3
  • 51
    • 84868117729 scopus 로고    scopus 로고
    • Comparison of cardioprotective efficacy resulting from a combination of atorvastatin and ischaemic post-conditioning in diabetic and non-diabetic rats
    • Fan, Y., Yang, S., Zhang, X., Cao, Y., Huang, Y., Comparison of cardioprotective efficacy resulting from a combination of atorvastatin and ischaemic post-conditioning in diabetic and non-diabetic rats. Clin Exp Pharmacol Physiol 39 (2012), 938–943.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , pp. 938-943
    • Fan, Y.1    Yang, S.2    Zhang, X.3    Cao, Y.4    Huang, Y.5
  • 52
    • 84941308478 scopus 로고    scopus 로고
    • Cyclosporine before PCI in patients with acute myocardial infarction
    • Cung, T.T., Morel, O., Cayla, G., et al. Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373 (2015), 1021–1031.
    • (2015) N Engl J Med , vol.373 , pp. 1021-1031
    • Cung, T.T.1    Morel, O.2    Cayla, G.3
  • 53
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg, J., Vejlstrup, N., Kelbaek, H., et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J 33 (2012), 1491–1499.
    • (2012) Eur Heart J , vol.33 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3
  • 54
    • 84954434406 scopus 로고    scopus 로고
    • Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial
    • Eitel, I., Stiermaier, T., Rommel, K.P., et al. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J 36 (2015), 3049–3057.
    • (2015) Eur Heart J , vol.36 , pp. 3049-3057
    • Eitel, I.1    Stiermaier, T.2    Rommel, K.P.3
  • 55
    • 84891710243 scopus 로고    scopus 로고
    • The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction
    • Prunier, F., Angoulvant, D., Saint Etienne, C., et al. The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction. Basic Res Cardiol, 109, 2014, 400.
    • (2014) Basic Res Cardiol , vol.109 , pp. 400
    • Prunier, F.1    Angoulvant, D.2    Saint Etienne, C.3
  • 56
    • 85021815445 scopus 로고    scopus 로고
    • Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction])
    • Pasupathy, S., Tavella, R., Grover, S., et al. Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction]). Circulation 136 (2017), 894–903.
    • (2017) Circulation , vol.136 , pp. 894-903
    • Pasupathy, S.1    Tavella, R.2    Grover, S.3
  • 57
    • 84978289531 scopus 로고    scopus 로고
    • Early intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention
    • Roolvink, V., Ibanez, B., Ottervanger, J.P., et al. Early intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention. J Am Coll Cardiol 67 (2016), 2705–2715.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 2705-2715
    • Roolvink, V.1    Ibanez, B.2    Ottervanger, J.P.3
  • 58
    • 77956814199 scopus 로고    scopus 로고
    • Postconditioning by xenon and hypothermia in the rat heart in vivo
    • Schwiebert, C., Huhn, R., Heinen, A., et al. Postconditioning by xenon and hypothermia in the rat heart in vivo. Eur J Anaesthesiol 27 (2010), 734–739.
    • (2010) Eur J Anaesthesiol , vol.27 , pp. 734-739
    • Schwiebert, C.1    Huhn, R.2    Heinen, A.3
  • 59
    • 84966290881 scopus 로고    scopus 로고
    • Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation
    • Sun, J., Aponte, A.M., Menazza, S., Gucek, M., Steenbergen, C., Murphy, E., Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation. Cardiovasc Res 110 (2016), 96–106.
    • (2016) Cardiovasc Res , vol.110 , pp. 96-106
    • Sun, J.1    Aponte, A.M.2    Menazza, S.3    Gucek, M.4    Steenbergen, C.5    Murphy, E.6
  • 60
    • 84928264573 scopus 로고    scopus 로고
    • Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion
    • Yang, X.M., Cui, L., White, J., et al. Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion. Basic Res Cardiol, 110, 2015, 3.
    • (2015) Basic Res Cardiol , vol.110 , pp. 3
    • Yang, X.M.1    Cui, L.2    White, J.3
  • 61
    • 85024486364 scopus 로고    scopus 로고
    • Combined treatment with exenatide and cyclosporine A or parstatin 1-26 results in enhanced reduction of infarct size in a rabbit model
    • Alexopoulos, P., Panoutsopoulou, K., Vogiatzis, G., Koletsis, E., Dougenis, D., Tsopanoglou, N.E., Combined treatment with exenatide and cyclosporine A or parstatin 1-26 results in enhanced reduction of infarct size in a rabbit model. J Cardiovasc Pharmacol 70 (2017), 34–41.
    • (2017) J Cardiovasc Pharmacol , vol.70 , pp. 34-41
    • Alexopoulos, P.1    Panoutsopoulou, K.2    Vogiatzis, G.3    Koletsis, E.4    Dougenis, D.5    Tsopanoglou, N.E.6
  • 62
    • 77952628653 scopus 로고    scopus 로고
    • Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning
    • Xin, P., Zhu, W., Ma, S., et al. Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning. Am J Physiol Heart Circ Physiol 298 (2010), H1819–H1831.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1819-H1831
    • Xin, P.1    Zhu, W.2    Ma, S.3
  • 63
    • 79958282048 scopus 로고    scopus 로고
    • Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion
    • Huang, M.H., Wu, Y., Nguyen, V., et al. Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovasc Drugs Ther 25 (2011), 223–232.
    • (2011) Cardiovasc Drugs Ther , vol.25 , pp. 223-232
    • Huang, M.H.1    Wu, Y.2    Nguyen, V.3
  • 64
    • 84941173161 scopus 로고    scopus 로고
    • Combined vagal stimulation and limb remote ischemic perconditioning enhances cardioprotection via an anti-inflammatory pathway
    • Wang, Q., Liu, G.P., Xue, F.S., et al. Combined vagal stimulation and limb remote ischemic perconditioning enhances cardioprotection via an anti-inflammatory pathway. Inflammation 38 (2015), 1748–1760.
    • (2015) Inflammation , vol.38 , pp. 1748-1760
    • Wang, Q.1    Liu, G.P.2    Xue, F.S.3


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