Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: The IMMEDIATE randomized controlled trial

JAMA

Volumn 307, Issue 18, 2012, Pages 1925-1933

  Selker, Harry P ^a   Beshansky, Joni R ^a   Sheehan, Patricia R ^a   Massaro, Joseph M ^b   Griffith, John L ^a   D'Agostino, Ralph B ^c   Ruthazer, Robin ^a   Atkins, James M ^d   Sayah, Assaad J ^e   Levy, Michael K ^f   Richards, Michael E ^g   Aufderheide, Tom P ^h   Braude, Darren A ^g   Pirrallo, Ronald G ^h   Doyle, Delanor D ⁱ   Frascone, Ralph J ^j   Kosiak, Donald J ^k   Leaming, James M ^l   Van Gelder, Carin M ^m,n   Walter, Gert Paul ^o   Wayne, Marvin A ^p   Woolard, Robert H ^q   Opie, Lionel H ^r   Rackley, Charles E ^s   Apstein, Carl S ^b   Udelson, James E ^a   more..

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Boston University   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e CAMBRIDGE HEALTH ALLIANCE   (United States)

^f Alaska Regional Hospital   (United States)

^g UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^h MEDICAL COLLEGE OF WISCONSIN   (United States)

ⁱ MEDICAL CENTER OF CENTRAL GEORGIA   (United States)

^j REGIONS HOSPITAL   (United States)

^k Avera Health   (United States)

^l PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^m Johnson Memorial Hospital   (United States)

ⁿ Windham Community Memorial Hospital   (United States)

^o EMERSON HOSPITAL   (United States)

^p St Joseph Medical Center   (United States)

^q Paul L Foster School of Medicine   (United States)

^r UNIVERSITY OF CAPE TOWN   (South Africa)

^s GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CARDIOVASCULAR AGENT; GLUCOSE INSULIN POTASSIUM; PLACEBO; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ADULT; ADVERSE OUTCOME; ARTICLE; CAUSE OF DEATH; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; EARLY INTERVENTION; ELECTROCARDIOGRAPHY; EMERGENCY CARE; EVIDENCE BASED MEDICINE; FEMALE; HEART ARREST; HEART DISEASE; HEART INFARCTION; HUMAN; HYPERKALEMIA; INJECTION SITE REACTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; OUTPATIENT CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK REDUCTION; ST SEGMENT ELEVATION; SURVIVAL TIME; TREATMENT DURATION;

EID: 84860771658     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.426     Document Type: Article

References (22)

1. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet. 1994;343(8890):155-158.
2. Oliver MF. Sudden unexpected cardiac death. Eur Heart J. 2002;23(23):1797-1798. (Pubitemid 35398045)
3. Fath-Ordoubadi F, Beatt KJ. Glucose-insulinpotassium therapy for treatment of acute myocardial infarction: an overview of randomized placebocontrolled trials. Circulation. 1997;96(4):1152-1156. (Pubitemid 27344217)
4. Rackley CE, Russell RO Jr, Rogers WJ, Mantle JA, McDaniel HG, Papapietro SE. Clinical experience with glucose-insulin-potassium therapy in acute myocardial infarction. Am Heart J. 1981;102(6 pt 1):1038-1049. (Pubitemid 12248633)
5. Malmberg K; for the DIGAMI study group. Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ. 1997; 314(7093):1512-1515.
6. Díaz R, Paolasso EA, Piegas LS, et al; the ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group. Metabolic modulation of acute myocardial infarction. Circulation. 1998;98(21):2227-2234. (Pubitemid 28533839)
7. Apstein CS. Glucose-insulin-potassium for acute myocardial infarction: remarkable results from a new prospective, randomized trial. Circulation. 1998; 98(21):2223-2226. (Pubitemid 28533838)
8. van der Horst IC, Zijlstra F, van 't Hof AW, et al Zwolle Infarct Study Group. Glucose-insulinpotassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucoseinsulin- potassium study: a randomized trial. J Am Coll Cardiol. 2003;42(5):784-791. (Pubitemid 37059733)
9. Kurien VA, Yates PA, Oliver MF. Free fatty acids, heparin, and arrhythmias during experimental myocardial infarction. Lancet. 1969;2(7613):185-187.
10. Selker HP, Raitt MH, Schmid CH, et al. Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarction. Am J Cardiol. 2003;91(3):280-286. (Pubitemid 36143866)
11. Apstein CS, Opie LH. Glucose-insulin-potassium (GIK) for acute myocardial infarction: a negative study with a positive value. Cardiovasc Drugs Ther. 1999; 13(3):185-189. (Pubitemid 29312813)
12. Opie LH, Bruyneel K, Owen P. Effects of glucose, insulin and potassium infusion on tissue metabolic changes within first hour of myocardial infarction in the baboon. Circulation. 1975;52(1): 49-57.
13. Malmberg K, Rydén L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol. 1995; 26(1):57-65.
14. Mehta SR, Yusuf S, Díaz R, et al CREATE-ECLA Trial Group Investigators. Effect of glucose-insulinpotassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005;293(4):437-446.
15. Apstein CS. Glucose-insulin-potassium infusion and mortality in the CREATE-ECLA trial. JAMA. 2005; 293(21):2596-2597.
16. Timmer JR, Svilaas T, Ottervanger JP, et al. Glucoseinsulin- potassium infusion in patients with acute myocardial infarction without signs of heart failure: the Glucose- Insulin-Potassium Study (GIPS)-II. J Am Coll Cardiol. 2006;47(8):1730-1731.
17. Selker HP, Beshansky JR, Griffith JL, et al. Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: a doubleblind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services. Am Heart J. 2012;163(3):315-322.
18. Selker HP, Beshansky JR, Ruthazer R, et al. Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trial. Prehosp Emerg Care. 2011;15 (2):139-148.
19. Selker HP, Beshansky JR, Griffith JL; TPI Trial Investigators. Use of the electrocardiograph-based thrombolytic predictive instrument to assist thrombolytic and reperfusion therapy for acute myocardial infarction: a multicenter, randomized, controlled, clinical effectiveness trial. Ann Intern Med. 2002;137 (2):87-95. (Pubitemid 34779152)
20. Selker HP, Beshansky JR, Griffith JL, et al. Use of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI) to assist with triage of patients with chest pain or other symptoms suggestive of acute cardiac ischemia: a multicenter, controlled clinical trial. Ann Intern Med. 1998;129(11):845-855. (Pubitemid 28549811)
21. Exception from informed consent requirements for emergency research. Code of Federal Regulations. Title 21, §50.24 (2011). http://www.accessdata .fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm ?fr=50.24. Accessed November 2011.
22. Beshansky JR, Sheehan PR, Hadar N, Klima K, Selker HP. National implementation of exception from informed consent requirements for emergency research (21CFR50.24) process and 1-year experience in the IMMEDIATE trial. Clin Trials. 2010;7(4):428.