Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: Role of the PI3K/Akt and JAK2/STAT3 pathways

Clinical Science

Volumn 130, Issue 5, 2016, Pages 377-392

  Xue, Rui ^a   Lei, Shaoqing ^a,b   Xia, Zhong Yuan ^a   Wu, Yang ^a   Meng, Qingtao ^a   Zhan, Liying ^a   Su, Wating ^a   Liu, Huimin ^a   Xu, Jinjin ^a   Liu, Zhenzhen ^a   Zhou, Bin ^a   Xia, Zhengyuan ^b,c  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Diabetes; Ischaemic post conditioning; Myocardial ischaemia reperfusion injury; Phosphatase and tensin homologue deleted on chromosome 10 (PTEN)

Indexed keywords

CREATINE KINASE MB; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOPROSTANE DERIVATIVE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STAT3 PROTEIN; WORTMANNIN; BISPEROXOVANADIUM; JAK2 PROTEIN, RAT; PTEN PROTEIN, RAT; SMALL INTERFERING RNA; STAT3 PROTEIN, RAT; VANADIUM DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART PROTECTION; INSULIN DEPENDENT DIABETES MELLITUS; ISCHEMIC POSTCONDITIONING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENE SILENCING; GENETICS; HEART INFARCTION; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; GENE KNOCKDOWN TECHNIQUES; ISCHEMIC POSTCONDITIONING; JANUS KINASE 2; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; VANADIUM COMPOUNDS;

EID: 84958092745     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150496     Document Type: Article

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