Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention

Journal of the American College of Cardiology

Volumn 67, Issue 23, 2016, Pages 2705-2715

  Roolvink, Vincent ^a   Ibáñez, Borja ^b,c   Ottervanger, Jan Paul ^a   Pizarro, Gonzalo ^b,d   van Royen, Niels ^e   Mateos, Alonso ^f   Dambrink, Jan Henk E ^a   Escalera, Noemi ^b   Lipsic, Erik ^g   Albarran, Agustín ^h,i   Fernández Ortiz, Antonio ^h,j   Fernández Avilés, Francisco ^h,k   Goicolea, Javier ^h,l   Botas, Javier ^h,m   Remkes, Wouter ^a   Hernandez Jaras, Victoria ^f   Kedhi, Elvin ^a   Zamorano, José L ^h,n   Navarro, Felipe ^c,h   Alfonso, Fernando ^h,o   García Lledó, Alberto ^h,p   Alonso, Joaquin ^h,q   van Leeuwen, Maarten ^e   Nijveldt, Robin ^e   Postma, Sonja ^r   Kolkman, Evelien ^r   Gosselink, Marcel ^a   de Smet, Bart ^s   Rasoul, Saman ^t   Piek, Jan J ^u   Fuster, Valentin ^b,v   van 't Hof, Arnoud W J ^a   more..

^a ISALA HOSPITAL   (Netherlands)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c UAM)   (Spain)

^d UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f Servicio de Urgencia Medica de Madrid SUMMA 112   (Spain)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h Codigo Infarto ^*  (Spain)

ⁱ HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^j HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^k HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^l HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^m HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

ⁿ HOSPITAL RAMÓN Y CAJAL   (Spain)

^o HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^p HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^q HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^r Diagram BV   (Netherlands)

^s MEANDER MEDICAL CENTER   (Netherlands)

^t MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^u ACADEMIC MEDICAL CENTER   (Netherlands)

^v MOUNT SINAI SCHOOL OF MEDICINE   (United States)

more..

Author keywords

cardiac magnetic resonance; ejection fraction; infarct size; metoprolol

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; METOPROLOL; PLACEBO; TROPONIN T; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; BRADYCARDIA; CARDIOGENIC SHOCK; CARDIOVASCULAR MAGNETIC RESONANCE; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; EARLY INTERVENTION; FEMALE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; NETHERLANDS; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPAIN; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; ARRHYTHMIAS, CARDIAC; CINE MAGNETIC RESONANCE IMAGING; CLINICAL TRIAL; DIAGNOSTIC IMAGING; EMERGENCY HEALTH SERVICE; HEART STROKE VOLUME; INTRAVENOUS DRUG ADMINISTRATION; PREMEDICATION; ST ELEVATION MYOCARDIAL INFARCTION;

ADRENERGIC BETA-ANTAGONISTS; ARRHYTHMIAS, CARDIAC; CREATINE KINASE; DOUBLE-BLIND METHOD; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING, CINE; MALE; METOPROLOL; MIDDLE AGED; NETHERLANDS; PERCUTANEOUS CORONARY INTERVENTION; PREMEDICATION; SPAIN; ST ELEVATION MYOCARDIAL INFARCTION; STROKE VOLUME;

EID: 84978289531     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.03.522     Document Type: Article

References (26)

1. 1 Fokkema, M.L., James, S.K., Albertsson, P., et al. Population trends in percutaneous coronary intervention: 20-year results from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). J Am Coll Cardiol 61 (2013), 1222–1230.
2. 2 Van de Werf, F., Bax, J., Betriu, A., et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 29 (2008), 2909–2945.
3. 3 Dargie, H.J., Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet 357 (2001), 1385–1390.
4. 4 Feuerstein, G.Z., Yue, T.L., Cheng, H.Y., Ruffolo, R.R. Jr., Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl 11 (1993), S41–S48.
5. 5 Hammerman, H., Kloner, R.A., Briggs, L.L., Braunwald, E., Enhancement of salvage of reperfused myocardium by early beta-adrenergic blockade (timolol). J Am Coll Cardiol 3 (1984), 1438–1443.
6. 6 Rasmussen, M.M., Reimer, K.A., Kloner, R.A., Jennings, R.B., Infarct size reduction by propranolol before and after coronary ligation in dogs. Circulation 56 (1977), 794–798.
7. 7 Sederholm, et al., for The International Collaborative Study Group. Reduction of infarct size with the early use of timolol in acute myocardial infarction. N Engl J Med 310 (1984), 9–15.
8. 8 Peter, T., Heng, M.K., Singh, B.N., et al. Failure of high doses of propranolol to reduce experimental myocardial ischemic damage. Circulation 57 (1978), 534–540.
9. 9 Rude, R.E., Buja, L.M., Willerson, J.T., Propranolol in acute myocardial infarction: the MILIS experience. Am J Cardiol 57 (1986), 38F–42F.
10. 10 Yusuf, S., Sleight, P., Rossi, P., et al. Reduction in infarct size, arrhythmias and chest pain by early intravenous beta blockade in suspected acute myocardial infarction. Circulation 67 (1983), I32–I41.
11. 11 The MIAMI Trial Research Group. Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial. Eur Heart J 6 (1985), 199–226.
12. 12 Herlitz, J., Waagstein, F., Lindqvist, J., Swedberg, K., Hjalmarson, A., Effect of metoprolol on the prognosis for patients with suspected acute myocardial infarction and indirect signs of congestive heart failure (a subgroup analysis of the Goteborg Metoprolol Trial). Am J Cardiol 80 (1997), 40J–44J.
13. 13 Hanada, K., Higuma, T., Nishizaki, F., et al. Randomized study on the efficacy and safety of landiolol, an ultra-short-acting beta1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Circ J 76 (2012), 439–445.
14. 14 Ibanez, B., Macaya, C., Sanchez-Brunete, V., et al. Effect of Early Metoprolol on Infarct Size in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary PCI: the METOCARD-CNIC trial. Circulation 128 (2013), 1495–1503.
15. 15 Ibanez, B., Fuster, V., Macaya, C., et al. Study design for the “effect of METOprolol in CARDioproteCtioN during an acute myocardial InfarCtion” (METOCARD-CNIC): a randomized, controlled parallel-group, observer-blinded clinical trial of early pre-reperfusion metoprolol administration in ST-segment elevation myocardial infarction. Am Heart J 164 (2012), 473–480.e5.
16. 16 Roolvink, V., Van't Hof, A.W., van der Horst, I.C., The sooner, the better: early beta-blocker administration in patients with ST-elevation myocardial infarction. Crit Care Med 41 (2013), 1566–1568.
17. 17 Roolvink, V., Rasoul, S., Ottervanger, J.P., et al. Rationale and design of a double-blind, multicenter, randomized, placebo-controlled clinical trial of early administration of intravenous beta-blockers in patients with ST-elevation myocardial infarction before primary percutaneous coronary intervention: EARLY beta-blocker administration before primary PCI in patients with ST-elevation myocardial infarction trial. Am Heart J 168 (2014), 661–666.
18. 18 Wu, E., Ortiz, J.T., Tejedor, P., et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart 94 (2008), 730–736.
19. 19 Atar, D., Petzelbauer, P., Schwitter, J., et al. Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial. J Am Coll Cardiol 53 (2009), 720–729.
20. 20 Hirschl, M.M., Wollmann, C.G., Erhart, F., et al. Benefit of immediate beta-blocker therapy on mortality in patients with ST-segment elevation myocardial infarction. Crit Care Med 41 (2013), 1396–1404.
21. 21 First International Study of Infarct Survival Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet 2 (1986), 57–66.
22. 22 Ibanez, B., Heusch, G., Ovize, M., Van de Werf, F., Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol 65 (2015), 1454–1471.
23. 23 Pizarro, G., Fernandez-Friera, L., Fuster, V., et al. Long term benefit of early pre-reperfusion metoprolol administration in patients with acute myocardial infarction: results from the METOCARD-CNIC trial. J Am Coll Cardiol 63 (2014), 2356–2362.
24. 24 García-Ruiz, J.M., Fernández-Jiménez, R., García-Alvarez, A., et al. Impact of the timing of metoprolol administration during ongoing STEMI on infarct size and ventricular function: a METOCARD-CNIC trial substudy with an experimental validation. J Am Coll Cardiol 67 (2016), 2093–2104.
25. 25 Eppinga, R.N., Hartman, M.H., van Veldhuisen, D.J., et al. Effect of metformin treatment on lipoprotein subfractions in non-diabetic patients with acute myocardial infarction: a Glycometabolic Intervention as Adjunct to Primary Coronary Intervention in ST Elevation Myocardial Infarction (GIPS-III) Trial. PloS One, 11, 2016, e0145719.
26. 26 Belonje, A.M., Voors, A.A., van Gilst, W.H., et al. Effects of erythropoietin after an acute myocardial infarction: rationale and study design of a prospective, randomized, clinical trial (HEBE III). Am Heart J 155 (2008), 817–822.