메뉴 건너뛰기




Volumn 59, Issue 5, 2016, Pages 1776-1790

Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents

Author keywords

[No Author keywords available]

Indexed keywords

2',3' O ISOPROPYLIDENE 5' O (4 CARBAMOTHIOYLPHENYL)ADENOSINE; 2',3' O ISOPROPYLIDENE 5' O [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL]ADENOSINE; 5' O (4 CARBAMOTHIOYLPHENYL)ADENOSINE; 5' O [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL]ADENOSINE; 9 (4 ACETOXYBUTYL)ADENINE; 9 (4 HYDROXYBUTYL)ADENINE; 9 [4 [(4 CARBAMOTHIOYL)PHENYL]BUTOXY]ADENINE; 9 [4 [(4 CARBAMOYL)PHENYL]BUTOXY]ADENINE; 9 [4 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL]BUTOXY]ADENINE; ADENINE DERIVATIVE; CYCLIC GMP; ETHER; HYDROGEN SULFIDE; PROTECTIVE AGENT; UNCLASSIFIED DRUG; ADENINE; CARDIOTONIC AGENT;

EID: 84960913426     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01223     Document Type: Article
Times cited : (30)

References (47)
  • 1
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon, D. M.; Hausenloy, D. J. Myocardial reperfusion injury N. Engl. J. Med. 2007, 357, 1121-1135 10.1056/NEJMra071667
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 3
    • 84872088738 scopus 로고    scopus 로고
    • Cardioprotection: Chances and challenges of its translation to the clinic
    • Heusch, G. Cardioprotection: chances and challenges of its translation to the clinic Lancet 2013, 381, 166-175 10.1016/S0140-6736(12)60916-7
    • (2013) Lancet , vol.381 , pp. 166-175
    • Heusch, G.1
  • 4
    • 84881650891 scopus 로고    scopus 로고
    • Myocardial conditioning opportunities for clinical translation
    • Ovize, M.; Thibault, H.; Przyklenk, K. Myocardial conditioning opportunities for clinical translation Circ. Res. 2013, 113, 439-450 10.1161/CIRCRESAHA.113.300764
    • (2013) Circ. Res. , vol.113 , pp. 439-450
    • Ovize, M.1    Thibault, H.2    Przyklenk, K.3
  • 5
    • 84924123511 scopus 로고    scopus 로고
    • Molecular basis of cardioprotection signal transduction in ischemic pre-, post-, and remote conditioning
    • Heusch, G. Molecular basis of cardioprotection signal transduction in ischemic pre-, post-, and remote conditioning Circ. Res. 2015, 116, 674-699 10.1161/CIRCRESAHA.116.305348
    • (2015) Circ. Res. , vol.116 , pp. 674-699
    • Heusch, G.1
  • 6
    • 84908502441 scopus 로고    scopus 로고
    • Ischemic and postischemic conditioning of the myocardium in clinical practice: Challenges, expectations and obstacles
    • Iliodromitis, E. K.; Andreadou, I.; Iliodromitis, C.; Dagres, N. Ischemic and postischemic conditioning of the myocardium in clinical practice: Challenges, expectations and obstacles Cardiology 2014, 129, 117-125 10.1159/000362499
    • (2014) Cardiology , vol.129 , pp. 117-125
    • Iliodromitis, E.K.1    Andreadou, I.2    Iliodromitis, C.3    Dagres, N.4
  • 7
    • 0347628950 scopus 로고    scopus 로고
    • Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection
    • Oldenburg, O.; Qin, Q.; Krieg, T.; Yang, X. M.; Philipp, S.; Critz, S. D.; Cohen, M. V.; Downey, J. M. Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection Am. J. Physiol.: Heart Circ. Physiol. 2004, 286, H468-H476 10.1152/ajpheart.00360.2003
    • (2004) Am. J. Physiol.: Heart Circ. Physiol. , vol.286 , pp. H468-H476
    • Oldenburg, O.1    Qin, Q.2    Krieg, T.3    Yang, X.M.4    Philipp, S.5    Critz, S.D.6    Cohen, M.V.7    Downey, J.M.8
  • 8
    • 84860134497 scopus 로고    scopus 로고
    • The mPTP and its regulatory proteins: Final common targets of signalling pathways for protection against necrosis
    • Miura, T.; Tanno, M. The mPTP and its regulatory proteins: Final common targets of signalling pathways for protection against necrosis Cardiovasc. Res. 2012, 94, 181-189 10.1093/cvr/cvr302
    • (2012) Cardiovasc. Res. , vol.94 , pp. 181-189
    • Miura, T.1    Tanno, M.2
  • 9
    • 84862829641 scopus 로고    scopus 로고
    • Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I
    • Gharib, A.; De Paulis, D.; Li, B.; Augeul, L.; Couture-Lepetit, E.; Gomez, L.; Angoulvant, D.; Ovize, M. Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I J. Mol. Cell. Cardiol. 2012, 52, 1091-1095 10.1016/j.yjmcc.2012.02.005
    • (2012) J. Mol. Cell. Cardiol. , vol.52 , pp. 1091-1095
    • Gharib, A.1    De Paulis, D.2    Li, B.3    Augeul, L.4    Couture-Lepetit, E.5    Gomez, L.6    Angoulvant, D.7    Ovize, M.8
  • 11
    • 84894479886 scopus 로고    scopus 로고
    • Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease
    • Polhemus, D. J.; Lefer, D. J. Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease Circ. Res. 2014, 114, 730-737 10.1161/CIRCRESAHA.114.300505
    • (2014) Circ. Res. , vol.114 , pp. 730-737
    • Polhemus, D.J.1    Lefer, D.J.2
  • 16
    • 43249105340 scopus 로고    scopus 로고
    • Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide
    • Li, L.; Whiteman, M.; Guan, Y. Y.; Neo, K. L.; Cheng, Y.; Lee, S. W.; Zhao, Y.; Baskar, R.; Tan, C. H.; Moore, P. K. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide Circulation 2008, 117, 2351-2360 10.1161/CIRCULATIONAHA.107.753467
    • (2008) Circulation , vol.117 , pp. 2351-2360
    • Li, L.1    Whiteman, M.2    Guan, Y.Y.3    Neo, K.L.4    Cheng, Y.5    Lee, S.W.6    Zhao, Y.7    Baskar, R.8    Tan, C.H.9    Moore, P.K.10
  • 18
    • 56749104311 scopus 로고    scopus 로고
    • 2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: Role of protein kinases A and G
    • 2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G Br. J. Pharmacol. 2008, 155, 984-994 10.1038/bjp.2008.326
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 984-994
    • Muzaffar, S.1    Jeremy, J.Y.2    Sparatore, A.3    Del Soldato, P.4    Angelini, G.D.5    Shukla, N.6
  • 20
    • 84923810907 scopus 로고    scopus 로고
    • The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A2A receptors
    • Tian, Y.; Marshall, M.; French, B. A.; Linden, J.; Yang, Z. The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A2A receptors Basic Res. Cardiol. 2015, 110, 16 10.1007/s00395-015-0473-x
    • (2015) Basic Res. Cardiol. , vol.110 , pp. 16
    • Tian, Y.1    Marshall, M.2    French, B.A.3    Linden, J.4    Yang, Z.5
  • 22
    • 84925880426 scopus 로고    scopus 로고
    • Extracellular signalling molecules in the ischaemic/reperfused heart-druggable and translatable for cardioprotection?
    • Kleinbongard, P.; Heusch, G. Extracellular signalling molecules in the ischaemic/reperfused heart-druggable and translatable for cardioprotection? Br. J. Pharmacol. 2015, 172, 2010-2025 10.1111/bph.12902
    • (2015) Br. J. Pharmacol. , vol.172 , pp. 2010-2025
    • Kleinbongard, P.1    Heusch, G.2
  • 24
    • 0034625177 scopus 로고    scopus 로고
    • Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction
    • Marzilli, M.; Orsini, E.; Marraccini, P.; Testa, R. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction Circulation 2000, 101, 2154-2159 10.1161/01.CIR.101.18.2154
    • (2000) Circulation , vol.101 , pp. 2154-2159
    • Marzilli, M.1    Orsini, E.2    Marraccini, P.3    Testa, R.4
  • 25
    • 0034846624 scopus 로고    scopus 로고
    • Adenosine, adenosine receptors and myocardial protection: An updated overview
    • Mubagwa, K.; Flameng, W. Adenosine, adenosine receptors and myocardial protection: an updated overview Cardiovasc. Res. 2001, 52, 25-39 10.1016/S0008-6363(01)00358-3
    • (2001) Cardiovasc. Res. , vol.52 , pp. 25-39
    • Mubagwa, K.1    Flameng, W.2
  • 28
    • 84937760709 scopus 로고    scopus 로고
    • Hydrogen sulfide in pharmacology and medicine - An update
    • Bełtowski, J. Hydrogen sulfide in pharmacology and medicine-An update Pharmacol. Rep. 2015, 67, 647-658 10.1016/j.pharep.2015.01.005
    • (2015) Pharmacol. Rep. , vol.67 , pp. 647-658
    • Bełtowski, J.1
  • 29
    • 33846798044 scopus 로고    scopus 로고
    • Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative
    • Li, L.; Rossoni, G.; Sparatore, A.; Lee, L. C.; Del Soldato, P.; Moore, P. K. Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative Free Radical Biol. Med. 2007, 42, 706-719 10.1016/j.freeradbiomed.2006.12.011
    • (2007) Free Radical Biol. Med. , vol.42 , pp. 706-719
    • Li, L.1    Rossoni, G.2    Sparatore, A.3    Lee, L.C.4    Del Soldato, P.5    Moore, P.K.6
  • 37
    • 33745225625 scopus 로고    scopus 로고
    • Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts
    • Yang, X. M.; Philipp, S.; Downey, J. M.; Cohen, M. V. Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts Basic Res. Cardiol. 2006, 101, 311-318 10.1007/s00395-006-0587-2
    • (2006) Basic Res. Cardiol. , vol.101 , pp. 311-318
    • Yang, X.M.1    Philipp, S.2    Downey, J.M.3    Cohen, M.V.4
  • 38
    • 20044369754 scopus 로고    scopus 로고
    • Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model
    • du Toit, E. F.; Rossouw, E.; Salie, R.; Opie, L. H.; Lochner, A. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model Cardiovasc. Drugs Ther. 2005, 19, 23-31 10.1007/s10557-005-6894-2
    • (2005) Cardiovasc. Drugs Ther. , vol.19 , pp. 23-31
    • Du Toit, E.F.1    Rossouw, E.2    Salie, R.3    Opie, L.H.4    Lochner, A.5
  • 39
  • 41
    • 84941616201 scopus 로고    scopus 로고
    • Hydrogen sulfide and PKG in ischemia-reperfusion injury: Sources, signaling, accelerators and brakes
    • Andreadou, I.; Iliodromitis, E. K.; Szabo, C.; Papapetropoulos, A. Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes Basic Res. Cardiol. 2015, 110, 52 10.1007/s00395-015-0510-9
    • (2015) Basic Res. Cardiol. , vol.110 , pp. 52
    • Andreadou, I.1    Iliodromitis, E.K.2    Szabo, C.3    Papapetropoulos, A.4
  • 42
    • 67549130184 scopus 로고    scopus 로고
    • Determination of thiosulfate in human urine by high performance liquid chromatography
    • Chwatko, G.; Bald, E. Determination of thiosulfate in human urine by high performance liquid chromatography Talanta 2009, 79, 229-34 10.1016/j.talanta.2009.03.040
    • (2009) Talanta , vol.79 , pp. 229-234
    • Chwatko, G.1    Bald, E.2
  • 43
    • 0020483746 scopus 로고
    • Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
    • Stipanuk, M. H.; Beck, P. W. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat Biochem. J. 1982, 206, 267-277 10.1042/bj2060267
    • (1982) Biochem. J. , vol.206 , pp. 267-277
    • Stipanuk, M.H.1    Beck, P.W.2
  • 47
    • 33749341555 scopus 로고    scopus 로고
    • Pyridin-, Quinolin- and Acridinylidene Palladium Carbene Complexes as Highly Efficient C-C Coupling Catalysts
    • Schneider, S. K.; Roembke, P.; Julius, G. R.; Raubenheimer, H. G.; Herrmann, W. A. Pyridin-, Quinolin- and Acridinylidene Palladium Carbene Complexes as Highly Efficient C-C Coupling Catalysts Adv. Synth. Catal. 2006, 348, 1862-1873 10.1002/adsc.200606009
    • (2006) Adv. Synth. Catal. , vol.348 , pp. 1862-1873
    • Schneider, S.K.1    Roembke, P.2    Julius, G.R.3    Raubenheimer, H.G.4    Herrmann, W.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.