A lipophilic nitric oxide donor and a lipophilic antioxidant compound protect rat heart against ischemia-reperfusion injury if given as hybrid molecule but not as a mixture

Journal of Cardiovascular Pharmacology

Volumn 59, Issue 3, 2012, Pages 241-248

  Raffaella, Rastaldo ^a,b   Sandra, Cappello ^b   Antonella, Di Stilo ^a   Anna, Folino ^a,b   Gianni, Losano ^a,b   Pasquale, Pagliaro ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b Italian Institute for Cardiovascular Research INRC   (Italy)

Author keywords

antioxidant; hybrid compounds; infarct size; ischemia'reperfusion; myocardial protection; nitric oxide donors

Indexed keywords

2 (3 BENZENESULFONYLFUROXAN 4 YL OXYMETHYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2,5,7,8 TETRAMETHYL 2 [(3 PHENYLFUROXAN 4 YL OXY)METHYL]CHROMAN 6 OL; 3 NITROTYROSINE; 4 ETHOXY 3 PHENYLSULFONILFUROXAN; 4 METHOXY 3 PHENYLFUROXAN; 6 HYDROXY 2,2,5,7,8 PENTAMETHYLCHROMAN; ANTIOXIDANT; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HEART FUNCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HYBRID MOLECULE; ISCHEMIC POSTCONDITIONING; LIPOPHILICITY; MALE; MOLECULE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; DRUG SYNERGISM; ISCHEMIC POSTCONDITIONING; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS; RATS, WISTAR; TYROSINE;

EID: 84858794889     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31823d2dca     Document Type: Article

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