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Volumn 134, Issue 22, 2016, Pages 1708-1719

Protective Effects of Ticagrelor on Myocardial Injury after Infarction

Author keywords

cardiac imaging techniques; cardioprotection; edema; myocardial infarction; purinergic P2Y receptor antagonists

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; AQUAPORIN 4; CD36 ANTIGEN; CLOPIDOGREL; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PLACEBO; TICAGRELOR; ADENOSINE; ANTITHROMBOCYTIC AGENT; CARDIOTONIC AGENT; TICLOPIDINE;

EID: 84992699816     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.024014     Document Type: Article
Times cited : (111)

References (50)
  • 1
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox KA; Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527-533.
    • (2001) Lancet. , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3    Bertrand, M.E.4    Lewis, B.S.5    Natarajan, M.K.6    Malmberg, K.7    Rupprecht, H.8    Zhao, F.9    Chrolavicius, S.10    Copland, I.11    Fox, K.A.12
  • 2
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908-2913. doi: 10. 1161/01. CIR. 0000072771. 11429. 83.
    • (2003) Circulation. , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 5
    • 79952048493 scopus 로고    scopus 로고
    • Ticagrelor: An investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome
    • Abergel E, Nikolsky E. Ticagrelor: an investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome. Vasc Health Risk Manag. 2010;6:963-977. doi: 10. 2147/VHRM. S13263.
    • (2010) Vasc Health Risk Manag. , vol.6 , pp. 963-977
    • Abergel, E.1    Nikolsky, E.2
  • 7
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J. 2006;27:1038-1047. doi: 10. 1093/eurheartj/ehi754.
    • (2006) Eur Heart J. , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 11
    • 84894420031 scopus 로고    scopus 로고
    • Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1
    • Armstrong D, Summers C, Ewart L, Nylander S, Sidaway JE, van Giezen JJ. Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1. J Cardiovasc Pharmacol Ther. 2014;19:209-219. doi: 10. 1177/1074248413511693.
    • (2014) J Cardiovasc Pharmacol Ther. , vol.19 , pp. 209-219
    • Armstrong, D.1    Summers, C.2    Ewart, L.3    Nylander, S.4    Sidaway, J.E.5    Van Giezen, J.J.6
  • 12
    • 34250770500 scopus 로고    scopus 로고
    • Adenosine, an endogenous distress signal, modulates tissue damage and repair
    • Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14:1315-1323. doi: 10. 1038/sj. cdd. 4402132.
    • (2007) Cell Death Differ. , vol.14 , pp. 1315-1323
    • Fredholm, B.B.1
  • 13
    • 84902214445 scopus 로고    scopus 로고
    • Adenosine-mediated effects of ticagrelor: Evidence and potential clinical relevance
    • Cattaneo M, Schulz R, Nylander S. Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance. J Am Coll Cardiol. 2014;63:2503-2509. doi: 10. 1016/j. jacc. 2014. 03. 031.
    • (2014) J Am Coll Cardiol. , vol.63 , pp. 2503-2509
    • Cattaneo, M.1    Schulz, R.2    Nylander, S.3
  • 16
    • 84906936926 scopus 로고    scopus 로고
    • Chronic treatment with ticagrelor limits myocardial infarct size: An adenosine and cyclooxygenase-2-dependent effect
    • Nanhwan MK, Ling S, Kodakandla M, Nylander S, Ye Y, Birnbaum Y. Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect. Arterioscler Thromb Vasc Biol. 2014;34:2078-2085. doi: 10. 1161/ ATVBAHA. 114. 304002.
    • (2014) Arterioscler Thromb Vasc Biol. , vol.34 , pp. 2078-2085
    • Nanhwan, M.K.1    Ling, S.2    Kodakandla, M.3    Nylander, S.4    Ye, Y.5    Birnbaum, Y.6
  • 17
    • 0032941838 scopus 로고    scopus 로고
    • Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: Coronary hemodynamic and cardioprotective effects in the canine myocardium
    • McVey MJ, Smits GJ, Cox BF, Kitzen JM, Clark KL, Perrone MH. Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: coronary hemodynamic and cardioprotective effects in the canine myocardium. J Cardiovasc Pharmacol. 1999;33:703-710.
    • (1999) J Cardiovasc Pharmacol. , vol.33 , pp. 703-710
    • McVey, M.J.1    Smits, G.J.2    Cox, B.F.3    Kitzen, J.M.4    Clark, K.L.5    Perrone, M.H.6
  • 18
  • 20
    • 0033966090 scopus 로고    scopus 로고
    • Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
    • Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000;6:159-163. doi: 10. 1038/72256.
    • (2000) Nat Med. , vol.6 , pp. 159-163
    • Manley, G.T.1    Fujimura, M.2    Ma, T.3    Noshita, N.4    Filiz, F.5    Bollen, A.W.6    Chan, P.7    Verkman, A.S.8
  • 22
    • 84920596800 scopus 로고    scopus 로고
    • Is AMPK the savior of the failing heart?
    • Kim TT, Dyck JR. Is AMPK the savior of the failing heart? Trends Endocrinol Metab. 2015;26:40-48. doi: 10. 1016/j. Tem. 2014. 11. 001.
    • (2015) Trends Endocrinol Metab. , vol.26 , pp. 40-48
    • Kim, T.T.1    Dyck, J.R.2
  • 23
    • 84938074255 scopus 로고    scopus 로고
    • Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction
    • Ye Y, Birnbaum GD, Perez-Polo JR, Nanhwan MK, Nylander S, Birnbaum Y. Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction. Arterioscler Thromb Vasc Biol. 2015;35:1805-1814. doi: 10. 1161/ATVBAHA. 115. 305655.
    • (2015) Arterioscler Thromb Vasc Biol. , vol.35 , pp. 1805-1814
    • Ye, Y.1    Birnbaum, G.D.2    Perez-Polo, J.R.3    Nanhwan, M.K.4    Nylander, S.5    Birnbaum, Y.6
  • 24
    • 84926297712 scopus 로고    scopus 로고
    • Evolving therapies for myocardial ischemia/reperfusion injury
    • Ibáñez B, Heusch G, Ovize M, Van de Werf F. Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol. 2015;65:1454-1471. doi: 10. 1016/j. jacc. 2015. 02. 032.
    • (2015) J Am Coll Cardiol. , vol.65 , pp. 1454-1471
    • Ibáñez, B.1    Heusch, G.2    Ovize, M.3    Van De Werf, F.4
  • 26
    • 0345201627 scopus 로고    scopus 로고
    • Prime causes of rapid cardiomyocyte death during reperfusion
    • Piper HM, García-Dorado D. Prime causes of rapid cardiomyocyte death during reperfusion. Ann Thorac Surg. 1999;68:1913-1919.
    • (1999) Ann Thorac Surg. , vol.68 , pp. 1913-1919
    • Piper, H.M.1    García-Dorado, D.2
  • 28
    • 34249077293 scopus 로고    scopus 로고
    • Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction
    • Warth A, Eckle T, Köhler D, Faigle M, Zug S, Klingel K, Eltzschig HK, Wolburg H. Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction. Cardiology. 2007;107:402-410. doi: 10. 1159/000099060.
    • (2007) Cardiology. , vol.107 , pp. 402-410
    • Warth, A.1    Eckle, T.2    Köhler, D.3    Faigle, M.4    Zug, S.5    Klingel, K.6    Eltzschig, H.K.7    Wolburg, H.8
  • 29
    • 84875799073 scopus 로고    scopus 로고
    • Time-dependent expression patterns of cardiac aquaporins following myocardial infarction
    • Zhang HZ, Kim MH, Lim JH, Bae HR. Time-dependent expression patterns of cardiac aquaporins following myocardial infarction. J Korean Med Sci. 2013;28:402-408. doi: 10. 3346/ jkms. 2013. 28. 3. 402.
    • (2013) J Korean Med Sci. , vol.28 , pp. 402-408
    • Zhang, H.Z.1    Kim, M.H.2    Lim, J.H.3    Bae, H.R.4
  • 30
    • 84872498540 scopus 로고    scopus 로고
    • Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice
    • Lee MR, Ruby CL, Hinton DJ, Choi S, Adams CA, Young Kang N, Choi DS. Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice. Neuropsychopharmacology. 2013;38:437-445. doi: 10. 1038/ npp. 2012. 198.
    • (2013) Neuropsychopharmacology. , vol.38 , pp. 437-445
    • Lee, M.R.1    Ruby, C.L.2    Hinton, D.J.3    Choi, S.4    Adams, C.A.5    Young Kang, N.6    Choi, D.S.7
  • 31
    • 84911363465 scopus 로고    scopus 로고
    • Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum
    • Hinton DJ, Lee MR, Jang JS, Choi DS. Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum. Brain Behav. 2014;4:903-914. doi: 10. 1002/brb3. 283.
    • (2014) Brain Behav. , vol.4 , pp. 903-914
    • Hinton, D.J.1    Lee, M.R.2    Jang, J.S.3    Choi, D.S.4
  • 35
    • 84940863892 scopus 로고    scopus 로고
    • In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver
    • Peleli M, Hezel M, Zollbrecht C, Persson AE, Lundberg JO, Weitzberg E, Fredholm BB, Carlström M. In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver. Front Physiol. 2015;6:222. doi: 10. 3389/fphys. 2015. 00222.
    • (2015) Front Physiol. , vol.6 , pp. 222
    • Peleli, M.1    Hezel, M.2    Zollbrecht, C.3    Persson, A.E.4    Lundberg, J.O.5    Weitzberg, E.6    Fredholm, B.B.7    Carlström, M.8
  • 37
    • 84924123511 scopus 로고    scopus 로고
    • Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning
    • Heusch G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res. 2015;116:674-699. doi: 10. 1161/CIRCRESAHA. 116. 305348.
    • (2015) Circ Res. , vol.116 , pp. 674-699
    • Heusch, G.1
  • 39
    • 33749485077 scopus 로고    scopus 로고
    • Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: The AMISTAD-2 trial
    • Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. Eur Heart J. 2006;27:2400-2405. doi: 10. 1093/ eurheartj/ehl094.
    • (2006) Eur Heart J. , vol.27 , pp. 2400-2405
    • Kloner, R.A.1    Forman, M.B.2    Gibbons, R.J.3    Ross, A.M.4    Alexander, R.W.5    Stone, G.W.6
  • 43
    • 0036023621 scopus 로고    scopus 로고
    • Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning
    • Bolli R, Shinmura K, Tang XL, Kodani E, Xuan YT, Guo Y, Dawn B. Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. Cardiovasc Res. 2002;55:506-519.
    • (2002) Cardiovasc Res. , vol.55 , pp. 506-519
    • Bolli, R.1    Shinmura, K.2    Tang, X.L.3    Kodani, E.4    Xuan, Y.T.5    Guo, Y.6    Dawn, B.7
  • 47
    • 84878328463 scopus 로고    scopus 로고
    • Relationship between myocardial edema and regional myocardial function after reperfused acute myocardial infarction: An MR imaging study
    • Kidambi A, Mather AN, Swoboda P, Motwani M, Fairbairn TA, Greenwood JP, Plein S. Relationship between myocardial edema and regional myocardial function after reperfused acute myocardial infarction: an MR imaging study. Radiology. 2013;267:701-708. doi: 10. 1148/radiol. 12121516.
    • (2013) Radiology. , vol.267 , pp. 701-708
    • Kidambi, A.1    Mather, A.N.2    Swoboda, P.3    Motwani, M.4    Fairbairn, T.A.5    Greenwood, J.P.6    Plein, S.7
  • 48
    • 77956641191 scopus 로고    scopus 로고
    • Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model
    • Wang K, Zhou X, Huang Y, Khalil M, Wiktor D, van Giezen JJ, Penn MS. Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model. Thromb Haemost. 2010;104:609-617. doi: 10. 1160/ TH09-12-0823.
    • (2010) Thromb Haemost. , vol.104 , pp. 609-617
    • Wang, K.1    Zhou, X.2    Huang, Y.3    Khalil, M.4    Wiktor, D.5    Van Giezen, J.J.6    Penn, M.S.7
  • 50
    • 0023640005 scopus 로고
    • The rapid evolution of a myocardial infarction in an end-artery coronary preparation
    • Horneffer PJ, Healy B, Gott VL, Gardner TJ. The rapid evolution of a myocardial infarction in an end-artery coronary preparation. Circulation. 1987;76(5 pt 2):V39-V42.
    • (1987) Circulation. , vol.76 , Issue.5 , pp. V39-V42
    • Horneffer, P.J.1    Healy, B.2    Gott, V.L.3    Gardner, T.J.4


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