-
1
-
-
0021929962
-
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta
-
Maruyama I, Bell CE, Majerus PW. Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol. 1985;101(2):363-371.
-
(1985)
J Cell Biol
, vol.101
, Issue.2
, pp. 363-371
-
-
Maruyama, I.1
Bell, C.E.2
Majerus, P.W.3
-
2
-
-
0023449560
-
Preservation of thrombomodulin antigen on vascular and extravascular surfaces
-
Boffa M-C, Burke B, Haudenschild CC. Preservation of thrombomodulin antigen on vascular and extravascular surfaces. J Histochem Cytochem. 1987;35(11): 1267-1276.
-
(1987)
J Histochem Cytochem
, vol.35
, Issue.11
, pp. 1267-1276
-
-
Boffa, M.-C.1
Burke, B.2
Haudenschild, C.C.3
-
3
-
-
0026358002
-
Thrombomodulin in the central nervous system
-
Boffa MC, Jackman RW, Peyri N, Boffa JF, George B. Thrombomodulin in the central nervous system. Nouv Rev Fr Hematol. 1991; 33(6):423-429.
-
(1991)
Nouv Rev Fr Hematol
, vol.33
, Issue.6
, pp. 423-429
-
-
Boffa, M.C.1
Jackman, R.W.2
Peyri, N.3
Boffa, J.F.4
George, B.5
-
4
-
-
85050606849
-
Regulation of hematopoiesis by the coagulation receptor thrombomodulin [abstract]
-
Basu S, Hernandez I, Zogg M, Carlson K-SB, Weiler H. Regulation of hematopoiesis by the coagulation receptor thrombomodulin [abstract]. Blood. 2017;126(23). Abstract 4750.
-
(2017)
Blood
, vol.126
, Issue.23
-
-
Basu, S.1
Hernandez, I.2
Zogg, M.3
Carlson, K.-S.B.4
Weiler, H.5
-
5
-
-
0026662994
-
Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation
-
Conway EM, Nowakowski B, Steiner-Mosonyi M. Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation. Blood. 1992;80(5):1254-1263.
-
(1992)
Blood
, vol.80
, Issue.5
, pp. 1254-1263
-
-
Conway, E.M.1
Nowakowski, B.2
Steiner-Mosonyi, M.3
-
6
-
-
0031723377
-
Thrombomodulin expression in transitional cell carcinoma
-
Ordóñez NG. Thrombomodulin expression in transitional cell carcinoma. Am J Clin Pathol. 1998;110(3):385-390.
-
(1998)
Am J Clin Pathol
, vol.110
, Issue.3
, pp. 385-390
-
-
Ordóñez, N.G.1
-
7
-
-
84945445867
-
Membrane-bound thrombomodulin regulates macrophage inflammation in abdominal aortic aneurysm
-
Wang KC, Li YH, Shi GY, et al. Membrane-bound thrombomodulin regulates macrophage inflammation in abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2015;35(11):2412-2422.
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, Issue.11
, pp. 2412-2422
-
-
Wang, K.C.1
Li, Y.H.2
Shi, G.Y.3
-
8
-
-
84883034979
-
Differential gene expression in thrombomodulin (TM; CD141)(1) and TM(-) dendritic cell subsets
-
Toda M, Shao Z, Yamaguchi KD, et al. Differential gene expression in thrombomodulin (TM; CD141)(1) and TM(-) dendritic cell subsets. PLoS One. 2013;8(8):e72392.
-
(2013)
PLoS One
, vol.8
, Issue.8
-
-
Toda, M.1
Shao, Z.2
Yamaguchi, K.D.3
-
9
-
-
84958824701
-
Loss of thrombomodulin in placental dysfunction in preeclampsia
-
Turner RJ, Bloemenkamp KW, Bruijn JA, Baelde HJ. Loss of thrombomodulin in placental dysfunction in preeclampsia. Arterioscler Thromb Vasc Biol. 2016;36(4): 728-735.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, Issue.4
, pp. 728-735
-
-
Turner, R.J.1
Bloemenkamp, K.W.2
Bruijn, J.A.3
Baelde, H.J.4
-
10
-
-
0027434627
-
Detection of thrombomodulin in human lung cancer cells
-
Tamura A, Matsubara O, Hirokawa K, Aoki N. Detection of thrombomodulin in human lung cancer cells. Am J Pathol. 1993;142(1):79-85.
-
(1993)
Am J Pathol
, vol.142
, Issue.1
, pp. 79-85
-
-
Tamura, A.1
Matsubara, O.2
Hirokawa, K.3
Aoki, N.4
-
11
-
-
84929484534
-
Thrombomodulin promotes corneal epithelial wound healing
-
Huang YH, I CC, Kuo CH, et al. Thrombomodulin promotes corneal epithelial wound healing. PLoS One. 2015;10(3): e0122491.
-
(2015)
PLoS One
, vol.10
, Issue.3
-
-
Huang, Y.H.1
I, C.C.2
Kuo, C.H.3
-
12
-
-
84931565664
-
Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide
-
Efremenko AY, Seagrave J, Clewell HJ, Van Landingham C, Gentry PR, Yager JW. Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide. Environ Mol Mutagen. 2015;56(5): 477-490.
-
(2015)
Environ Mol Mutagen
, vol.56
, Issue.5
, pp. 477-490
-
-
Efremenko, A.Y.1
Seagrave, J.2
Clewell, H.J.3
Van Landingham, C.4
Gentry, P.R.5
Yager, J.W.6
-
13
-
-
84930178029
-
Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model
-
Shao Z, Nishimura T, Leung LL, Morser J. Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model. J Thromb Haemost. 2015;13(6):1090-1102.
-
(2015)
J Thromb Haemost
, vol.13
, Issue.6
, pp. 1090-1102
-
-
Shao, Z.1
Nishimura, T.2
Leung, L.L.3
Morser, J.4
-
14
-
-
0345173854
-
Human thrombomodulin gene is intron depleted: Nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control
-
Jackman RW, Beeler DL, Fritze L, Soff G, Rosenberg RD. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc Natl Acad Sci USA. 1987; 84(18):6425-6429.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, Issue.18
, pp. 6425-6429
-
-
Jackman, R.W.1
Beeler, D.L.2
Fritze, L.3
Soff, G.4
Rosenberg, R.D.5
-
15
-
-
0025174705
-
Structure and function of thrombomodulin: A natural anticoagulant
-
Dittman WA, Majerus PW. Structure and function of thrombomodulin: a natural anticoagulant. Blood. 1990;75(2):329-336.
-
(1990)
Blood
, vol.75
, Issue.2
, pp. 329-336
-
-
Dittman, W.A.1
Majerus, P.W.2
-
16
-
-
84857132899
-
The type XIV family of C-type lectin-like domain (CTLD) containing proteins
-
Conway EM. The type XIV family of C-type lectin-like domain (CTLD) containing proteins. Curr Drug Targets. 2012;13(3): 409-410.
-
(2012)
Curr Drug Targets
, vol.13
, Issue.3
, pp. 409-410
-
-
Conway, E.M.1
-
18
-
-
84857135316
-
CD248: Reviewing its role in health and disease
-
Valdez Y, Maia M, Conway EM. CD248: reviewing its role in health and disease. Curr Drug Targets. 2012;13(3):432-439.
-
(2012)
Curr Drug Targets
, vol.13
, Issue.3
, pp. 432-439
-
-
Valdez, Y.1
Maia, M.2
Conway, E.M.3
-
19
-
-
0344443722
-
Thrombomodulin-mediated cell adhesion: Involvement of its lectin-like domain
-
Huang HC, Shi GY, Jiang SJ, et al. Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain. J Biol Chem. 2003;278(47):46750-46759.
-
(2003)
J Biol Chem
, vol.278
, Issue.47
, pp. 46750-46759
-
-
Huang, H.C.1
Shi, G.Y.2
Jiang, S.J.3
-
20
-
-
0027103736
-
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation
-
Glaser CB, Morser J, Clarke JH, et al. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation. J Clin Invest. 1992;90(6): 2565-2573.
-
(1992)
J Clin Invest
, vol.90
, Issue.6
, pp. 2565-2573
-
-
Glaser, C.B.1
Morser, J.2
Clarke, J.H.3
-
21
-
-
0031730635
-
Thrombomodulin: An overview and potential implications in vascular disorders
-
Boffa MC, Karmochkine M. Thrombomodulin: an overview and potential implications in vascular disorders. Lupus. 1998;7(suppl 2):S120-S125.
-
(1998)
Lupus
, vol.7
, pp. S120-S125
-
-
Boffa, M.C.1
Karmochkine, M.2
-
22
-
-
23844451164
-
Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma
-
Ohlin AK, Larsson K, Hansson M. Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma. J Thromb Haemost. 2005;3(5):976-982.
-
(2005)
J Thromb Haemost
, vol.3
, Issue.5
, pp. 976-982
-
-
Ohlin, A.K.1
Larsson, K.2
Hansson, M.3
-
23
-
-
0030066667
-
Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: In vivo and in vitro studies
-
Boehme MW, Deng Y, Raeth U, et al. Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology. 1996;87(1):134-140.
-
(1996)
Immunology
, vol.87
, Issue.1
, pp. 134-140
-
-
Boehme, M.W.1
Deng, Y.2
Raeth, U.3
-
24
-
-
1242288387
-
Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids
-
Lohi O, Urban S, Freeman M. Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids. Curr Biol. 2004; 14(3):236-241.
-
(2004)
Curr Biol
, vol.14
, Issue.3
, pp. 236-241
-
-
Lohi, O.1
Urban, S.2
Freeman, M.3
-
25
-
-
80855138090
-
Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing
-
Cheng TL, Wu YT, Lin HY, et al. Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing. J Invest Dermatol. 2011;131(12):2486-2494.
-
(2011)
J Invest Dermatol
, vol.131
, Issue.12
, pp. 2486-2494
-
-
Cheng, T.L.1
Wu, Y.T.2
Lin, H.Y.3
-
26
-
-
0031909716
-
Characterization of soluble thrombomodulin fragments in human urine
-
Nakano M, Furutani M, Hiraishi S, Ishii H. Characterization of soluble thrombomodulin fragments in human urine. Thromb Haemost. 1998;79(2):331-337.
-
(1998)
Thromb Haemost
, vol.79
, Issue.2
, pp. 331-337
-
-
Nakano, M.1
Furutani, M.2
Hiraishi, S.3
Ishii, H.4
-
27
-
-
0025241217
-
Plasma thrombomodulin in health and diseases
-
Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood. 1990;76(10):2024-2029.
-
(1990)
Blood
, vol.76
, Issue.10
, pp. 2024-2029
-
-
Takano, S.1
Kimura, S.2
Ohdama, S.3
Aoki, N.4
-
28
-
-
0033594760
-
Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: A case-cohort study
-
Salomaa V, Matei C, Aleksic N, et al. Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: a case-cohort study. Lancet. 1999;353(9166): 1729-1734.
-
(1999)
Lancet
, vol.353
, Issue.9166
, pp. 1729-1734
-
-
Salomaa, V.1
Matei, C.2
Aleksic, N.3
-
29
-
-
44149116748
-
Assessment of coronary heart disease risk by combined analysis of coagulation factors
-
Aleksic N, Wang YW, Ahn C, Juneja HS, Folsom AR, Wu KK. Assessment of coronary heart disease risk by combined analysis of coagulation factors. Atherosclerosis. 2008; 198(2):294-300.
-
(2008)
Atherosclerosis
, vol.198
, Issue.2
, pp. 294-300
-
-
Aleksic, N.1
Wang, Y.W.2
Ahn, C.3
Juneja, H.S.4
Folsom, A.R.5
Wu, K.K.6
-
30
-
-
0022396035
-
Thrombomodulin is present in human plasma and urine
-
Ishii H, Majerus PW. Thrombomodulin is present in human plasma and urine. J Clin Invest. 1985;76(6):2178-2181.
-
(1985)
J Clin Invest
, vol.76
, Issue.6
, pp. 2178-2181
-
-
Ishii, H.1
Majerus, P.W.2
-
31
-
-
3943093083
-
The discovery of thrombomodulin
-
Esmon CT, Owen WG. The discovery of thrombomodulin. J Thromb Haemost. 2004; 2(2):209-213.
-
(2004)
J Thromb Haemost
, vol.2
, Issue.2
, pp. 209-213
-
-
Esmon, C.T.1
Owen, W.G.2
-
32
-
-
0019861825
-
Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
-
Owen WG, Esmon CT. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem. 1981;256(11):5532-5535.
-
(1981)
J Biol Chem
, vol.256
, Issue.11
, pp. 5532-5535
-
-
Owen, W.G.1
Esmon, C.T.2
-
33
-
-
0024396997
-
The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity
-
Zushi M, Gomi K, Yamamoto S, Maruyama I, Hayashi T, Suzuki K. The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity. J Biol Chem. 1989;264(18): 10351-10353.
-
(1989)
J Biol Chem
, vol.264
, Issue.18
, pp. 10351-10353
-
-
Zushi, M.1
Gomi, K.2
Yamamoto, S.3
Maruyama, I.4
Hayashi, T.5
Suzuki, K.6
-
34
-
-
0034006172
-
Solution structure of the smallest cofactor-active fragment of thrombomodulin
-
Wood MJ, Sampoli Benitez BA, Komives EA. Solution structure of the smallest cofactor-active fragment of thrombomodulin. Nat Struct Biol. 2000;7(3):200-204.
-
(2000)
Nat Struct Biol
, vol.7
, Issue.3
, pp. 200-204
-
-
Wood, M.J.1
Sampoli Benitez, B.A.2
Komives, E.A.3
-
35
-
-
0034732094
-
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
-
see comments
-
Fuentes-Prior P, Iwanaga Y, Huber R, et al. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. [see comments] Nature. 2000;404(6777): 518-525.
-
(2000)
Nature
, vol.404
, Issue.6777
, pp. 518-525
-
-
Fuentes-Prior, P.1
Iwanaga, Y.2
Huber, R.3
-
36
-
-
84857130776
-
Thrombomodulin links coagulation to inflammation and immunity
-
Morser J. Thrombomodulin links coagulation to inflammation and immunity. Curr Drug Targets. 2012;13(3):421-431.
-
(2012)
Curr Drug Targets
, vol.13
, Issue.3
, pp. 421-431
-
-
Morser, J.1
-
37
-
-
0027407874
-
The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin
-
Ye J, Esmon CT, Johnson AE. The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin. J Biol Chem. 1993;268(4):2373-2379.
-
(1993)
J Biol Chem
, vol.268
, Issue.4
, pp. 2373-2379
-
-
Ye, J.1
Esmon, C.T.2
Johnson, A.E.3
-
38
-
-
0028360746
-
Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation
-
Liu LW, Rezaie AR, Carson CW, Esmon NL, Esmon CT. Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation. J Biol Chem. 1994;269(16):11807-11812.
-
(1994)
J Biol Chem
, vol.269
, Issue.16
, pp. 11807-11812
-
-
Liu, L.W.1
Rezaie, A.R.2
Carson, C.W.3
Esmon, N.L.4
Esmon, C.T.5
-
39
-
-
0029790055
-
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
-
Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA. 1996; 93(19):10212-10216.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.19
, pp. 10212-10216
-
-
Stearns-Kurosawa, D.J.1
Kurosawa, S.2
Mollica, J.S.3
Ferrell, G.L.4
Esmon, C.T.5
-
40
-
-
0025763975
-
Different glycoforms of human thrombomodulin. Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III
-
Koyama T, Parkinson JF, Sié P, Bang NU, Müller-Berghaus G, Preissner KT. Different glycoforms of human thrombomodulin. Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III. Eur J Biochem. 1991;198(3):563-570.
-
(1991)
Eur J Biochem
, vol.198
, Issue.3
, pp. 563-570
-
-
Koyama, T.1
Parkinson, J.F.2
Sié, P.3
Bang, N.U.4
Müller-Berghaus, G.5
Preissner, K.T.6
-
41
-
-
2942738934
-
Platelet factor 4 modulation of the thrombomodulin-protein C system
-
Slungaard A. Platelet factor 4 modulation of the thrombomodulin-protein C system. Crit Care Med. 2004;32(5 Suppl):S331-S335.
-
(2004)
Crit Care Med
, vol.32
, Issue.5
, pp. S331-S335
-
-
Slungaard, A.1
-
42
-
-
0020404408
-
Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation
-
Esmon CT, Esmon NL, Harris KW. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem. 1982;257(14):7944-7947.
-
(1982)
J Biol Chem
, vol.257
, Issue.14
, pp. 7944-7947
-
-
Esmon, C.T.1
Esmon, N.L.2
Harris, K.W.3
-
43
-
-
0019789514
-
Deficiency of protein C in congenital thrombotic disease
-
Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981;68(5):1370-1373.
-
(1981)
J Clin Invest
, vol.68
, Issue.5
, pp. 1370-1373
-
-
Griffin, J.H.1
Evatt, B.2
Zimmerman, T.S.3
Kleiss, A.J.4
Wideman, C.5
-
44
-
-
0043003388
-
The discovery of activated protein C resistance
-
Dahlbäck B. The discovery of activated protein C resistance. J Thromb Haemost. 2003;1(1):3-9.
-
(2003)
J Thromb Haemost
, vol.1
, Issue.1
, pp. 3-9
-
-
Dahlbäck, B.1
-
45
-
-
84958774277
-
Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): Communication from the SSC of the ISTH
-
Foley JH, Kim PY, Hendriks D, Morser J, Gils A, Mutch NJ; Subcommittee on Fibrinolysis. Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): communication from the SSC of the ISTH. J Thromb Haemost. 2015;13(12):2277-2278.
-
(2015)
J Thromb Haemost
, vol.13
, Issue.12
, pp. 2277-2278
-
-
Foley, J.H.1
Kim, P.Y.2
Hendriks, D.3
Morser, J.4
Gils, A.5
Mutch, N.J.6
-
46
-
-
84958279850
-
Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells
-
Wu C, Kim PY, Swystun LL, Liaw PC, Weitz JI. Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells. J Thromb Haemost. 2016;14(2):366-374.
-
(2016)
J Thromb Haemost
, vol.14
, Issue.2
, pp. 366-374
-
-
Wu, C.1
Kim, P.Y.2
Swystun, L.L.3
Liaw, P.C.4
Weitz, J.I.5
-
47
-
-
0034725622
-
Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation
-
Wang W, Nagashima M, Schneider M, Morser J, Nesheim M. Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation. J Biol Chem. 2000; 275(30):22942-22947.
-
(2000)
J Biol Chem
, vol.275
, Issue.30
, pp. 22942-22947
-
-
Wang, W.1
Nagashima, M.2
Schneider, M.3
Morser, J.4
Nesheim, M.5
-
48
-
-
0029044322
-
Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor
-
Bajzar L, Manuel R, Nesheim ME. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J Biol Chem. 1995;270(24):14477-14484.
-
(1995)
J Biol Chem
, vol.270
, Issue.24
, pp. 14477-14484
-
-
Bajzar, L.1
Manuel, R.2
Nesheim, M.E.3
-
49
-
-
84988476188
-
Structure-function relationships in thrombin-activatable fibrinolysis inhibitor: Comment
-
see comments
-
Gurewich V, Pannell R. Structure-function relationships in thrombin-activatable fibrinolysis inhibitor: comment. [comment] J Thromb Haemost. 2016;14(9):1899-1900.
-
(2016)
J Thromb Haemost
, vol.14
, Issue.9
, pp. 1899-1900
-
-
Gurewich, V.1
Pannell, R.2
-
50
-
-
0036191244
-
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N
-
Campbell WD, Lazoura E, Okada N, Okada H. Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Microbiol Immunol. 2002;46(2): 131-134.
-
(2002)
Microbiol Immunol
, vol.46
, Issue.2
, pp. 131-134
-
-
Campbell, W.D.1
Lazoura, E.2
Okada, N.3
Okada, H.4
-
51
-
-
59449095007
-
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
-
Du XY, Zabel BA, Myles T, et al. Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem. 2009; 284(2):751-758.
-
(2009)
J Biol Chem
, vol.284
, Issue.2
, pp. 751-758
-
-
Du, X.Y.1
Zabel, B.A.2
Myles, T.3
-
52
-
-
85015635095
-
Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension: A possible novel therapeutic target
-
Satoh T, Satoh K, Yaoita N, et al. Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension: a possible novel therapeutic target. Circ Res. 2017;120(8):1246-1262.
-
(2017)
Circ Res
, vol.120
, Issue.8
, pp. 1246-1262
-
-
Satoh, T.1
Satoh, K.2
Yaoita, N.3
-
53
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor FB Jr, Chang A, Esmon CT, D’Angelo A, Vigano-D’Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest. 1987;79(3):918-925.
-
(1987)
J Clin Invest
, vol.79
, Issue.3
, pp. 918-925
-
-
Taylor, F.B.1
Chang, A.2
Esmon, C.T.3
D’Angelo, A.4
Vigano-D’Angelo, S.5
Blick, K.E.6
-
54
-
-
84957946623
-
Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases
-
Ito T, Kakihana Y, Maruyama I. Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases. Expert Opin Ther Targets. 2016; 20(2):151-158.
-
(2016)
Expert Opin Ther Targets
, vol.20
, Issue.2
, pp. 151-158
-
-
Ito, T.1
Kakihana, Y.2
Maruyama, I.3
-
55
-
-
2942720560
-
Structure and functions of the endothelial cell protein C receptor
-
Esmon CT. Structure and functions of the endothelial cell protein C receptor. Crit Care Med. 2004;32(5 Suppl):S298-S301.
-
(2004)
Crit Care Med
, vol.32
, Issue.5
, pp. S298-S301
-
-
Esmon, C.T.1
-
56
-
-
84886430553
-
Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
-
Burnier L, Mosnier LO. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3. Blood. 2013; 122(5):807-816.
-
(2013)
Blood
, vol.122
, Issue.5
, pp. 807-816
-
-
Burnier, L.1
Mosnier, L.O.2
-
57
-
-
85025105846
-
Occupancy of human EPCR by protein C induces b-arrestin-2 biased PAR1 signaling by both APC and thrombin
-
Roy RV, Ardeshirylajimi A, Dinarvand P, Yang L, Rezaie AR. Occupancy of human EPCR by protein C induces b-arrestin-2 biased PAR1 signaling by both APC and thrombin. Blood. 2016;128(14):1884-1893.
-
(2016)
Blood
, vol.128
, Issue.14
, pp. 1884-1893
-
-
Roy, R.V.1
Ardeshirylajimi, A.2
Dinarvand, P.3
Yang, L.4
Rezaie, A.R.5
-
58
-
-
85019709759
-
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo
-
Healy LD, Puy C, Fernández JA, et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017;292(21): 8616-8629.
-
(2017)
J Biol Chem
, vol.292
, Issue.21
, pp. 8616-8629
-
-
Healy, L.D.1
Puy, C.2
Fernández, J.A.3
-
59
-
-
80052395881
-
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation
-
Ammollo CT, Semeraro F, Xu J, Esmon NL, Esmon CT. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost. 2011;9(9): 1795-1803.
-
(2011)
J Thromb Haemost
, vol.9
, Issue.9
, pp. 1795-1803
-
-
Ammollo, C.T.1
Semeraro, F.2
Xu, J.3
Esmon, N.L.4
Esmon, C.T.5
-
60
-
-
0036719075
-
The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
-
Conway EM, Van de Wouwer M, Pollefeyt S, et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002; 196(5):565-577.
-
(2002)
J Exp Med
, vol.196
, Issue.5
, pp. 565-577
-
-
Conway, E.M.1
Van de Wouwer, M.2
Pollefeyt, S.3
-
61
-
-
58849165339
-
The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury
-
Geudens N, Van de Wouwer M, Vanaudenaerde BM, et al. The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury. Eur Respir J. 2008;32(4):862-870.
-
(2008)
Eur Respir J
, vol.32
, Issue.4
, pp. 862-870
-
-
Geudens, N.1
Van de Wouwer, M.2
Vanaudenaerde, B.M.3
-
62
-
-
33746636356
-
The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis
-
Van de Wouwer M, Plaisance S, De Vriese A, et al. The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis. J Thromb Haemost. 2006;4(8):1813-1824.
-
(2006)
J Thromb Haemost
, vol.4
, Issue.8
, pp. 1813-1824
-
-
Van de Wouwer, M.1
Plaisance, S.2
De Vriese, A.3
-
63
-
-
20944436774
-
The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
-
Abeyama K, Stern DM, Ito Y, et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest. 2005;115(5):1267-1274.
-
(2005)
J Clin Invest
, vol.115
, Issue.5
, pp. 1267-1274
-
-
Abeyama, K.1
Stern, D.M.2
Ito, Y.3
-
64
-
-
85034438879
-
Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains
-
Hayashi Y, Tsujita R, Tsubota M, et al. Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains. Biochem Biophys Res Commun. 2018;495(1):634-638.
-
(2018)
Biochem Biophys Res Commun
, vol.495
, Issue.1
, pp. 634-638
-
-
Hayashi, Y.1
Tsujita, R.2
Tsubota, M.3
-
65
-
-
84962287664
-
Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice
-
Nakamura Y, Nakano T, Irie K, et al. Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice. J Neurol Sci. 2016; 362:278-282.
-
(2016)
J Neurol Sci
, vol.362
, pp. 278-282
-
-
Nakamura, Y.1
Nakano, T.2
Irie, K.3
-
66
-
-
84894523888
-
Thrombomodulin’s lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling
-
Herzog C, Lorenz A, Gillmann HJ, et al. Thrombomodulin’s lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling. Cardiovasc Res. 2014;101(3):400-410.
-
(2014)
Cardiovasc Res
, vol.101
, Issue.3
, pp. 400-410
-
-
Herzog, C.1
Lorenz, A.2
Gillmann, H.J.3
-
67
-
-
85019072177
-
Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model
-
Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K. Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model. Exp Ther Med. 2017;13(6): 2969-2974.
-
(2017)
Exp Ther Med
, vol.13
, Issue.6
, pp. 2969-2974
-
-
Takehara, K.1
Murakami, T.2
Kuwahara-Arai, K.3
Iba, T.4
Nagaoka, I.5
Sakamoto, K.6
-
69
-
-
55749115786
-
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
-
Shi CS, Shi GY, Hsiao HM, et al. Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response. Blood. 2008;112(9): 3661-3670.
-
(2008)
Blood
, vol.112
, Issue.9
, pp. 3661-3670
-
-
Shi, C.S.1
Shi, G.Y.2
Hsiao, H.M.3
-
70
-
-
84949309396
-
The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis
-
Lattenist L, Teske G, Claessen N, Florquin S, Conway EM, Roelofs JJ. The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis. Thromb Res. 2015;136(6):1325-1331.
-
(2015)
Thromb Res
, vol.136
, Issue.6
, pp. 1325-1331
-
-
Lattenist, L.1
Teske, G.2
Claessen, N.3
Florquin, S.4
Conway, E.M.5
Roelofs, J.J.6
-
71
-
-
84862605106
-
Monocytic thrombomodulin triggers LPS- And gram-negative bacteria-induced inflammatory response
-
Ma CY, Shi GY, Shi CS, Kao YC, Lin SW, Wu HL. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012; 188(12):6328-6337.
-
(2012)
J Immunol
, vol.188
, Issue.12
, pp. 6328-6337
-
-
Ma, C.Y.1
Shi, G.Y.2
Shi, C.S.3
Kao, Y.C.4
Lin, S.W.5
Wu, H.L.6
-
72
-
-
84881496707
-
Human plasminogen kringle 1-5 inhibits angiogenesis and induces thrombomodulin degradation in a protein kinase A-dependent manner
-
Cho CF, Chen PK, Chang PC, Wu HL, Shi GY. Human plasminogen kringle 1-5 inhibits angiogenesis and induces thrombomodulin degradation in a protein kinase A-dependent manner. J Mol Cell Cardiol. 2013;63:79-88.
-
(2013)
J Mol Cell Cardiol
, vol.63
, pp. 79-88
-
-
Cho, C.F.1
Chen, P.K.2
Chang, P.C.3
Wu, H.L.4
Shi, G.Y.5
-
73
-
-
85035094459
-
Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin
-
Hsu YY, Shi GY, Wang KC, Ma CY, Cheng TL, Wu HL. Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin. Oncotarget. 2016;7(42):68122-68139.
-
(2016)
Oncotarget
, vol.7
, Issue.42
, pp. 68122-68139
-
-
Hsu, Y.Y.1
Shi, G.Y.2
Wang, K.C.3
Ma, C.Y.4
Cheng, T.L.5
Wu, H.L.6
-
74
-
-
84866544002
-
Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice
-
Zoja C, Locatelli M, Pagani C, et al. Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice. J Immunol. 2012; 189(7):3661-3668.
-
(2012)
J Immunol
, vol.189
, Issue.7
, pp. 3661-3668
-
-
Zoja, C.1
Locatelli, M.2
Pagani, C.3
-
75
-
-
84871422480
-
The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition
-
Wang H, Vinnikov I, Shahzad K, et al. The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition. Thromb Haemost. 2012; 108(6):1141-1153.
-
(2012)
Thromb Haemost
, vol.108
, Issue.6
, pp. 1141-1153
-
-
Wang, H.1
Vinnikov, I.2
Shahzad, K.3
-
76
-
-
67651166873
-
Thrombomodulin mutations in atypical hemolytic-uremic syndrome
-
Delvaeye M, Noris M, De Vriese A, et al. Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med. 2009;361(4):345-357.
-
(2009)
N Engl J Med
, vol.361
, Issue.4
, pp. 345-357
-
-
Delvaeye, M.1
Noris, M.2
De Vriese, A.3
-
77
-
-
20244382267
-
Evidence of human thrombomodulin domain as a novel angiogenic factor
-
Shi CS, Shi GY, Chang YS, et al. Evidence of human thrombomodulin domain as a novel angiogenic factor. Circulation. 2005; 111(13):1627-1636.
-
(2005)
Circulation
, vol.111
, Issue.13
, pp. 1627-1636
-
-
Shi, C.S.1
Shi, G.Y.2
Chang, Y.S.3
-
78
-
-
84929089440
-
FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis
-
Kuo CH, Sung MC, Chen PK, et al. FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis. Cardiovasc Res. 2015;105(1):107-117.
-
(2015)
Cardiovasc Res
, vol.105
, Issue.1
, pp. 107-117
-
-
Kuo, C.H.1
Sung, M.C.2
Chen, P.K.3
-
79
-
-
84863011918
-
The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen
-
Kuo CH, Chen PK, Chang BI, et al. The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen. Blood. 2012; 119(5):1302-1313.
-
(2012)
Blood
, vol.119
, Issue.5
, pp. 1302-1313
-
-
Kuo, C.H.1
Chen, P.K.2
Chang, B.I.3
-
80
-
-
84951733495
-
Thrombomodulin protects against bacterial keratitis, is antiinflammatory, but not angiogenic
-
McClellan SA, Ekanayaka SA, Li C, Jiang X, Barrett RP, Hazlett LD. Thrombomodulin protects against bacterial keratitis, is antiinflammatory, but not angiogenic. Invest Ophthalmol Vis Sci. 2015;56(13):8091-8100.
-
(2015)
Invest Ophthalmol Vis Sci
, vol.56
, Issue.13
, pp. 8091-8100
-
-
McClellan, S.A.1
Ekanayaka, S.A.2
Li, C.3
Jiang, X.4
Barrett, R.P.5
Hazlett, L.D.6
-
81
-
-
84922572309
-
Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14
-
Ma CY, Chang WE, Shi GY, et al. Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14. J Immunol. 2015;194(4):1905-1915.
-
(2015)
J Immunol
, vol.194
, Issue.4
, pp. 1905-1915
-
-
Ma, C.Y.1
Chang, W.E.2
Shi, G.Y.3
-
82
-
-
84964989323
-
LFA-1 and Mac-1 integrins bind to the serine/ threonine-rich domain of thrombomodulin
-
Kawamoto E, Okamoto T, Takagi Y, et al. LFA-1 and Mac-1 integrins bind to the serine/ threonine-rich domain of thrombomodulin. Biochem Biophys Res Commun. 2016;473(4): 1005-1012.
-
(2016)
Biochem Biophys Res Commun
, vol.473
, Issue.4
, pp. 1005-1012
-
-
Kawamoto, E.1
Okamoto, T.2
Takagi, Y.3
-
83
-
-
65449167251
-
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration
-
Elphick GF, Sarangi PP, Hyun YM, et al. Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 2009;113(17):4078-4085.
-
(2009)
Blood
, vol.113
, Issue.17
, pp. 4078-4085
-
-
Elphick, G.F.1
Sarangi, P.P.2
Hyun, Y.M.3
-
84
-
-
84884752631
-
Recombinant thrombomodulin protects mice against histone-induced lethal throm-boembolism
-
Nakahara M, Ito T, Kawahara K, et al. Recombinant thrombomodulin protects mice against histone-induced lethal throm-boembolism. PLoS One. 2013;8(9):e75961.
-
(2013)
PLoS One
, vol.8
, Issue.9
-
-
Nakahara, M.1
Ito, T.2
Kawahara, K.3
-
85
-
-
84864741032
-
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration
-
Hsu YY, Shi GY, Kuo CH, et al. Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration. FASEB J. 2012;26(8):3440-3452.
-
(2012)
FASEB J
, vol.26
, Issue.8
, pp. 3440-3452
-
-
Hsu, Y.Y.1
Shi, G.Y.2
Kuo, C.H.3
-
86
-
-
0032038825
-
Keratinocyte-specific expression of human thrombomodulin in transgenic mice: Effects on epidermal differentiation and cutaneous wound healing
-
Raife TJ, Lager DJ, Peterson JJ, Erger RA, Lentz SR. Keratinocyte-specific expression of human thrombomodulin in transgenic mice: effects on epidermal differentiation and cutaneous wound healing. J Investig Med. 1998;46(4):127-133.
-
(1998)
J Investig Med
, vol.46
, Issue.4
, pp. 127-133
-
-
Raife, T.J.1
Lager, D.J.2
Peterson, J.J.3
Erger, R.A.4
Lentz, S.R.5
-
87
-
-
0034695191
-
Inhibition of invasion and experimental metastasis of murine melanoma cells by human soluble thrombomodulin
-
Hosaka Y, Higuchi T, Tsumagari M, Ishii H. Inhibition of invasion and experimental metastasis of murine melanoma cells by human soluble thrombomodulin. Cancer Lett. 2000; 161(2):231-240.
-
(2000)
Cancer Lett
, vol.161
, Issue.2
, pp. 231-240
-
-
Hosaka, Y.1
Higuchi, T.2
Tsumagari, M.3
Ishii, H.4
-
88
-
-
84983548650
-
Thrombomodulin Influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)
-
Chang YJ, Cheng YW, Lin RK, et al. Thrombomodulin Influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT). PLoS One. 2016;11(8): e0160550.
-
(2016)
PLoS One
, vol.11
, Issue.8
-
-
Chang, Y.J.1
Cheng, Y.W.2
Lin, R.K.3
-
89
-
-
80052668558
-
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
-
Horowitz NA, Blevins EA, Miller WM, et al. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 2011;118(10): 2889-2895.
-
(2011)
Blood
, vol.118
, Issue.10
, pp. 2889-2895
-
-
Horowitz, N.A.1
Blevins, E.A.2
Miller, W.M.3
-
90
-
-
14944354759
-
Thrombomodulin: Tumour biology and prognostic implications
-
Hanly AM, Hayanga A, Winter DC, Bouchier-Hayes DJ. Thrombomodulin: tumour biology and prognostic implications. Eur J Surg Oncol. 2005;31(3):217-220.
-
(2005)
Eur J Surg Oncol
, vol.31
, Issue.3
, pp. 217-220
-
-
Hanly, A.M.1
Hayanga, A.2
Winter, D.C.3
Bouchier-Hayes, D.J.4
-
91
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3): 178-196.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, Issue.3
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
92
-
-
84973529624
-
Thrombomodulin reduces tumorigenic and metastatic potential of lung cancer cells by up-regulation of E-cadherin and down-regulation of N-cadherin expression
-
Zheng N, Huo Z, Zhang B, et al. Thrombomodulin reduces tumorigenic and metastatic potential of lung cancer cells by up-regulation of E-cadherin and down-regulation of N-cadherin expression. Biochem Biophys Res Commun. 2016; 476(4):252-259.
-
(2016)
Biochem Biophys Res Commun
, vol.476
, Issue.4
, pp. 252-259
-
-
Zheng, N.1
Huo, Z.2
Zhang, B.3
-
93
-
-
84893732359
-
Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition bio-markers
-
Tai CJ, Cheng CW, Su HY, et al. Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition bio-markers. Tumour Biol. 2014;35(1):47-54.
-
(2014)
Tumour Biol
, vol.35
, Issue.1
, pp. 47-54
-
-
Tai, C.J.1
Cheng, C.W.2
Su, H.Y.3
-
94
-
-
85026299618
-
Thrombomodulin regulates doxorubicin sensitivity through epithelial-mesenchymal transition in non-small cell lung cancer
-
Yang Y, Cheng BJ, Lu S. Thrombomodulin regulates doxorubicin sensitivity through epithelial-mesenchymal transition in non-small cell lung cancer. Eur Rev Med Phar-macol Sci. 2017;21(1):95-101.
-
(2017)
Eur Rev Med Phar-Macol Sci
, vol.21
, Issue.1
, pp. 95-101
-
-
Yang, Y.1
Cheng, B.J.2
Lu, S.3
-
95
-
-
85009729282
-
Recombinant thrombomodulin suppresses tumor growth of pancreatic cancer by blocking thrombin-induced PAR1 and NF-kB activation
-
Shirai Y, Uwagawa T, Shiba H, et al. Recombinant thrombomodulin suppresses tumor growth of pancreatic cancer by blocking thrombin-induced PAR1 and NF-kB activation. Surgery. 2017;161(6):1675-1682.
-
(2017)
Surgery
, vol.161
, Issue.6
, pp. 1675-1682
-
-
Shirai, Y.1
Uwagawa, T.2
Shiba, H.3
-
96
-
-
84973304394
-
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis
-
Bazzi ZA, Lanoue D, El-Youssef M, et al. Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis. BMC Cancer. 2016;16(1):328.
-
(2016)
BMC Cancer
, vol.16
, Issue.1
, pp. 328
-
-
Bazzi, Z.A.1
Lanoue, D.2
El-Youssef, M.3
-
97
-
-
84938739075
-
Recombinant human soluble thrombomodulin (thrombomodulin alfa) to treat disseminated intravascular coagulation in solid tumors: Results of a one-arm prospective trial
-
Tamura K, Saito H, Asakura H, et al. Recombinant human soluble thrombomodulin (thrombomodulin alfa) to treat disseminated intravascular coagulation in solid tumors: results of a one-arm prospective trial. Int J Clin Oncol. 2015;20(4):821-828.
-
(2015)
Int J Clin Oncol
, vol.20
, Issue.4
, pp. 821-828
-
-
Tamura, K.1
Saito, H.2
Asakura, H.3
-
98
-
-
0031674015
-
Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells
-
Tohda G, Oida K, Okada Y, et al. Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1998; 18(12):1861-1869.
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, Issue.12
, pp. 1861-1869
-
-
Tohda, G.1
Oida, K.2
Okada, Y.3
-
99
-
-
0034850149
-
Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis
-
Laszik ZG, Zhou XJ, Ferrell GL, Silva FG, Esmon CT. Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am J Pathol. 2001;159(3): 797-802.
-
(2001)
Am J Pathol
, vol.159
, Issue.3
, pp. 797-802
-
-
Laszik, Z.G.1
Zhou, X.J.2
Ferrell, G.L.3
Silva, F.G.4
Esmon, C.T.5
-
100
-
-
80054867174
-
Effects of statins on coronary and peripheral endothelial function in humans: A systematic review and meta-analysis of randomized controlled trials
-
Reriani MK, Dunlay SM, Gupta B, et al. Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-analysis of randomized controlled trials. Eur J Cardiovasc Prev Rehabil. 2011;18(5):704-716.
-
(2011)
Eur J Cardiovasc Prev Rehabil
, vol.18
, Issue.5
, pp. 704-716
-
-
Reriani, M.K.1
Dunlay, S.M.2
Gupta, B.3
-
101
-
-
84873117942
-
Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification
-
Son BK, Akishita M, Iijima K, et al. Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification. J Mol Cell Cardiol. 2013;56:72-80.
-
(2013)
J Mol Cell Cardiol
, vol.56
, pp. 72-80
-
-
Son, B.K.1
Akishita, M.2
Iijima, K.3
-
102
-
-
80054108282
-
Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation
-
Wei HJ, Li YH, Shi GY, et al. Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation. Cardiovasc Res. 2011;92(2):317-327.
-
(2011)
Cardiovasc Res
, vol.92
, Issue.2
, pp. 317-327
-
-
Wei, H.J.1
Li, Y.H.2
Shi, G.Y.3
-
103
-
-
85020742509
-
Recombinant thrombomodulin exerts anti-autophagic action in endothelial cells and provides anti-atherosclerosis effect in apoli-poprotein E deficient mice
-
Chen PS, Wang KC, Chao TH, et al. Recombinant thrombomodulin exerts anti-autophagic action in endothelial cells and provides anti-atherosclerosis effect in apoli-poprotein E deficient mice. Sci Rep. 2017; 7(1):3284.
-
(2017)
Sci Rep
, vol.7
, Issue.1
, pp. 3284
-
-
Chen, P.S.1
Wang, K.C.2
Chao, T.H.3
-
104
-
-
85042104540
-
Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry
-
Sanchez-Duffhues G, Garcia de Vinuesa A, Ten Dijke P. Endothelial-to-mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry. Dev Dyn. 2018;247(3):492-508.
-
(2018)
Dev Dyn
, vol.247
, Issue.3
, pp. 492-508
-
-
Sanchez-Duffhues, G.1
Garcia de Vinuesa, A.2
Ten Dijke, P.3
-
105
-
-
77950628343
-
Successful treatment of transplantation-associated thrombotic microangiopathy with recombinant human soluble thrombomodulin
-
Sakai M, Ikezoe T, Bandobashi K, Togitani K, Yokoyama A. Successful treatment of transplantation-associated thrombotic microangiopathy with recombinant human soluble thrombomodulin. Bone Marrow Transplant. 2010;45(4):803-805.
-
(2010)
Bone Marrow Transplant
, vol.45
, Issue.4
, pp. 803-805
-
-
Sakai, M.1
Ikezoe, T.2
Bandobashi, K.3
Togitani, K.4
Yokoyama, A.5
-
106
-
-
84885933700
-
Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation
-
Ikezoe T, Takeuchi A, Chi S, et al. Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation. Eur J Haematol. 2013;91(5): 442-447.
-
(2013)
Eur J Haematol
, vol.91
, Issue.5
, pp. 442-447
-
-
Ikezoe, T.1
Takeuchi, A.2
Chi, S.3
-
107
-
-
84908400456
-
Single-nucleotide polymorphisms within the thrombomodulin gene (THBD) predict mortality in patients with graft-versus-host disease
-
Rachakonda SP, Penack O, Dietrich S, et al. Single-nucleotide polymorphisms within the thrombomodulin gene (THBD) predict mortality in patients with graft-versus-host disease. J Clin Oncol. 2014;32(30):3421-3427.
-
(2014)
J Clin Oncol
, vol.32
, Issue.30
, pp. 3421-3427
-
-
Rachakonda, S.P.1
Penack, O.2
Dietrich, S.3
-
108
-
-
85027845974
-
Activated protein C protects from GvHD via PAR2/ PAR3 signalling in regulatory T-cells
-
Ranjan S, Goihl A, Kohli S, et al. Activated protein C protects from GvHD via PAR2/ PAR3 signalling in regulatory T-cells. Nat Commun. 2017;8(1):311.
-
(2017)
Nat Commun
, vol.8
, Issue.1
, pp. 311
-
-
Ranjan, S.1
Goihl, A.2
Kohli, S.3
-
109
-
-
85015316110
-
The fifth epidermal growth factor-like region of thrombomodulin alleviates murine graft-versus-host disease in a G-protein coupled receptor 15 dependent manner
-
Pan B, Wang X, Kojima S, et al. The fifth epidermal growth factor-like region of thrombomodulin alleviates murine graft-versus-host disease in a G-protein coupled receptor 15 dependent manner. Biol Blood Marrow Transplant. 2017;23(5):746-756.
-
(2017)
Biol Blood Marrow Transplant
, vol.23
, Issue.5
, pp. 746-756
-
-
Pan, B.1
Wang, X.2
Kojima, S.3
-
110
-
-
84978640121
-
The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model
-
Ikezoe T, Yang J, Nishioka C, et al. The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model. Bone Marrow Transplant. 2017;52(1): 73-79.
-
(2017)
Bone Marrow Transplant
, vol.52
, Issue.1
, pp. 73-79
-
-
Ikezoe, T.1
Yang, J.2
Nishioka, C.3
-
111
-
-
84988354427
-
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis
-
Ikezoe T, Yang J, Nishioka C, Umezawa K, Yokoyama A. Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. Bone Marrow Transplant. 2017;52(2): 245-251.
-
(2017)
Bone Marrow Transplant
, vol.52
, Issue.2
, pp. 245-251
-
-
Ikezoe, T.1
Yang, J.2
Nishioka, C.3
Umezawa, K.4
Yokoyama, A.5
-
112
-
-
35948934636
-
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
-
Isermann B, Vinnikov IA, Madhusudhan T, et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med. 2007;13(11):1349-1358.
-
(2007)
Nat Med
, vol.13
, Issue.11
, pp. 1349-1358
-
-
Isermann, B.1
Vinnikov, I.A.2
Madhusudhan, T.3
-
113
-
-
84893673690
-
Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kB/ NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis
-
Yang SM, Ka SM, Wu HL, et al. Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kB/ NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis. Diabetologia. 2014;57(2):424-434.
-
(2014)
Diabetologia
, vol.57
, Issue.2
, pp. 424-434
-
-
Yang, S.M.1
Ka, S.M.2
Wu, H.L.3
-
114
-
-
85032915667
-
NLRP3 inflammasome pathways in atherosclerosis
-
Baldrighi M, Mallat Z, Li X. NLRP3 inflammasome pathways in atherosclerosis. Atherosclerosis. 2017;267:127-138.
-
(2017)
Atherosclerosis
, vol.267
, pp. 127-138
-
-
Baldrighi, M.1
Mallat, Z.2
Li, X.3
-
115
-
-
62149108968
-
Soluble thrombomodulin protects ischemic kidneys
-
Sharfuddin AA, Sandoval RM, Berg DT, et al. Soluble thrombomodulin protects ischemic kidneys. J Am Soc Nephrol. 2009;20(3): 524-534.
-
(2009)
J Am Soc Nephrol
, vol.20
, Issue.3
, pp. 524-534
-
-
Sharfuddin, A.A.1
Sandoval, R.M.2
Berg, D.T.3
-
116
-
-
84987761241
-
Thrombomodulin attenuates inflammatory damage due to liver ischemia and reperfusion injury in mice in Toll-like receptor 4-Dependent Manner
-
Kadono K, Uchida Y, Hirao H, et al. Thrombomodulin attenuates inflammatory damage due to liver ischemia and reperfusion injury in mice in Toll-like receptor 4-Dependent Manner. Am J Transplant. 2017;17(1):69-80.
-
(2017)
Am J Transplant
, vol.17
, Issue.1
, pp. 69-80
-
-
Kadono, K.1
Uchida, Y.2
Hirao, H.3
-
117
-
-
85020922205
-
Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model
-
Hirao S, Minakata K, Masumoto H, et al. Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg. 2017;154(6):1973-1983.e1.
-
(2017)
J Thorac Cardiovasc Surg
, vol.154
, Issue.6
-
-
Hirao, S.1
Minakata, K.2
Masumoto, H.3
-
118
-
-
84954362406
-
Preeclampsia and pregnancy-related hypertensive disorders
-
Karumanchi SA, Granger JP. Preeclampsia and pregnancy-related hypertensive disorders. Hypertension. 2016;67(2): 238-242.
-
(2016)
Hypertension
, vol.67
, Issue.2
, pp. 238-242
-
-
Karumanchi, S.A.1
Granger, J.P.2
-
119
-
-
84876788429
-
Genetic variants in pre-eclampsia: A meta-analysis
-
Buurma AJ, Turner RJ, Driessen JH, et al. Genetic variants in pre-eclampsia: a meta-analysis. Hum Reprod Update. 2013;19(3): 289-303.
-
(2013)
Hum Reprod Update
, vol.19
, Issue.3
, pp. 289-303
-
-
Buurma, A.J.1
Turner, R.J.2
Driessen, J.H.3
-
120
-
-
84903647843
-
Thrombomodulin improves maternal and fetal conditions in an experimental preeclampsia rat model
-
Shin M, Hino H, Tamura M, et al. Thrombomodulin improves maternal and fetal conditions in an experimental preeclampsia rat model. J Obstet Gynaecol Res. 2014;40(5):1226-1234.
-
(2014)
J Obstet Gynaecol Res
, vol.40
, Issue.5
, pp. 1226-1234
-
-
Shin, M.1
Hino, H.2
Tamura, M.3
-
121
-
-
84939236841
-
Recombinant human thrombomodulin in acute exacerbation of idiopathic pulmonar fibrosis
-
Kataoka K, Taniguchi H, Kondoh Y, et al. Recombinant human thrombomodulin in acute exacerbation of idiopathic pulmonar fibrosis. Chest. 2015;148(2):436-443.
-
(2015)
Chest
, vol.148
, Issue.2
, pp. 436-443
-
-
Kataoka, K.1
Taniguchi, H.2
Kondoh, Y.3
-
122
-
-
85030759268
-
Inhibition of cell apoptosis and amelioration of pulmonary fibrosis by thrombomodulin
-
Fujiwara K, Kobayashi T, Fujimoto H, et al. Inhibition of cell apoptosis and amelioration of pulmonary fibrosis by thrombomodulin. Am J Pathol. 2017;187(10):2312-2322.
-
(2017)
Am J Pathol
, vol.187
, Issue.10
, pp. 2312-2322
-
-
Fujiwara, K.1
Kobayashi, T.2
Fujimoto, H.3
-
123
-
-
78650799395
-
Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells
-
Takagi T, Taguchi O, Toda M, et al. Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Am J Respir Crit Care Med. 2011;183(1): 31-42.
-
(2011)
Am J Respir Crit Care Med
, vol.183
, Issue.1
, pp. 31-42
-
-
Takagi, T.1
Taguchi, O.2
Toda, M.3
-
124
-
-
2942748200
-
Protective role of activated protein C in lung and airway remodeling
-
Suzuki K, Gabazza EC, Hayashi T, Kamada H, Adachi Y, Taguchi O. Protective role of activated protein C in lung and airway remodeling. Crit Care Med. 2004;32(5 Suppl):S262-S265.
-
(2004)
Crit Care Med
, vol.32
, Issue.5
, pp. S262-S265
-
-
Suzuki, K.1
Gabazza, E.C.2
Hayashi, T.3
Kamada, H.4
Adachi, Y.5
Taguchi, O.6
-
125
-
-
84863484876
-
Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma
-
Fujiwara A, Taguchi O, Takagi T, et al. Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma. Hai. 2012;190(2): 189-198.
-
(2012)
Hai
, vol.190
, Issue.2
, pp. 189-198
-
-
Fujiwara, A.1
Taguchi, O.2
Takagi, T.3
-
126
-
-
0020397936
-
Interactions of platelets and leukocytes with vascular endothelium: In vitro studies
-
Gimbrone MA Jr, Buchanan MR. Interactions of platelets and leukocytes with vascular endothelium: in vitro studies. Ann N Y Acad Sci. 1982;401:171-183.
-
(1982)
Ann N Y Acad Sci
, vol.401
, pp. 171-183
-
-
Gimbrone, M.A.1
Buchanan, M.R.2
-
127
-
-
33845513582
-
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: Results of a phase III, randomized, double-blind clinical trial
-
Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost. 2007;5(1): 31-41.
-
(2007)
J Thromb Haemost
, vol.5
, Issue.1
, pp. 31-41
-
-
Saito, H.1
Maruyama, I.2
Shimazaki, S.3
-
128
-
-
84883615933
-
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
-
Vincent JL, Ramesh MK, Ernest D, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013;41(9):2069-2079.
-
(2013)
Crit Care Med
, vol.41
, Issue.9
, pp. 2069-2079
-
-
Vincent, J.L.1
Ramesh, M.K.2
Ernest, D.3
-
129
-
-
84893575812
-
Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor
-
Greineder CF, Chacko AM, Zaytsev S, et al. Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS One. 2013;8(11):e80110.
-
(2013)
PLoS One
, vol.8
, Issue.11
-
-
Greineder, C.F.1
Chacko, A.M.2
Zaytsev, S.3
-
130
-
-
84955581739
-
Antithrombotic effects of Nur77 and Nor1 are mediated through upregulating thrombomodulin expression in endothelial cells
-
Yang P, Wei X, Zhang J, et al. Antithrombotic effects of Nur77 and Nor1 are mediated through upregulating thrombomodulin expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2016;36(2):361-369.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, Issue.2
, pp. 361-369
-
-
Yang, P.1
Wei, X.2
Zhang, J.3
|