The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor κB and mitogen-activated protein kinase pathways

Journal of Experimental Medicine

Volumn 196, Issue 5, 2002, Pages 565-577

  Conway, Edward M ^a,f   Van De Wouwer, Marlies ^a   Pollefeyt, Saskia ^a   Jurk, Kerstin ^b   Van Aken, Hugo ^b   De Vriese, Astrid ^a   Weitz, Jeffrey I ^c   Weiler, Hartmut ^d   Hellings, Peter W ^a   Schaeffer, Paul ^e   Herbert, Jean Marc ^e   Collen, Désiré ^a   Theilmeier, Gregor ^b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c MCMASTER UNIVERSITY   (Canada)

^d BLOOD RESEARCH INSTITUTE   (United States)

^e SANOFI   (France)

^f UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Coagulation; Endotoxin; Inflammation; Protein C; Sepsis

Indexed keywords

ANTICOAGULANT PROTEIN; CELL ADHESION MOLECULE; CELL RECEPTOR; CYTOKINE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN C; THROMBIN; THROMBOMODULIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FIBRINOLYSIS; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IMMUNOREGULATION; LEUKOCYTE ADHERENCE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TISSUE INJURY; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL ADHESION; ENDOTHELIUM, VASCULAR; FEMALE; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; LECTINS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NEUTROPHILS; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; THROMBOMODULIN;

EID: 0036719075     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020077     Document Type: Article

References (54)

1. Efficacy and safety of recombinant human activated protein C for severe sepsis
2. Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin
3. Activation of thrombin-activatable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C
4. A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation
5. The amino-terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins
6. Two distinct classes of carbohydrate-recognition domains in animal lectins
7. Thrombomodulin gene defects in families with thromboembolic disease-a report on four families
8. Plasma thrombomodulin in health and diseases
9. Urinary thrombomodulin, its isolation and characterization
10. Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: A case-cohort study
11. Structure-function analyses of thrombomodulin by gene-targeting in mice: The cytoplasmic domain is not required for normal fetal development
12. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
13. An ultrastructural study of thrombomodulin endocytosis: Internalization occurs via clathrin-coated and non-coated pits
14. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
15. Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay
16. Oncogenes in the study of endothelial cell growth and differentiation
17. Lymphatic endothelial tumors induced by intra-peritoneal injection of Freund's adjuvant
18. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr
19. Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress
20. A sensitive and facile assay for the measurement of activated protein C activity levels in vivo
21. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
22. Isolation of endothelial cells from murine tissue
23. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
24. Myocardial ischemia and reperfusion: A murine model
25. Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique
26. The role of neutrophils in myocardial ischemia-reperfusion injury
27. Characterization of a mouse model for thrombomodulin deficiency
28. Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation
29. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages
30. Role of α4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium
31. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades
32. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation
33. Modulation of endothelial cell hemostatic properties by tumor necrosis factor
34. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity
35. Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis
36. L-selectin interactions with novel mono- and multisulfated LewisX sequences in comparison with the potent ligand 3′-sulfated Lewisa
37. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin
38. C-type lectins and galectins mediate innate and adaptive immune functions: Their roles in the complement activation pathway
39. The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy
40. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense
41. Selectins and mechanisms of signal transduction
42. The alpha 4 beta 1 (very late antigen (VLA)-4, CD49d/CD29) and alpha 5 beta 1 (VLA-5, CD49e/CD29) integrins mediate beta 2 (CD11/CD18) integrin-independent neutrophil recruitment to endotoxin-induced lung inflammation
43. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis
44. Regulatory mechanisms for thrombomodulin expression in human umbilical vein endothelial cells in vitro
45. Integrins take partners: Cross-talk between integrins and other membrane receptors
46. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury
47. Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease
48. A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men
49. Protective effect of human urinary thrombomodulin on ischemia-reperfusion injury in the canine liver
50. Prognostic value and clinicopathological correlation of thrombomodulin in squamous cell carcinoma of the human lung
51. Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity
52. Inhibition of invasion and experimental metastasis of murine melanoma cells by human soluble thrombomodulin
53. Thrombomodulin gene mutations associated with myocardial infarction
54. Identification and characterization of a thrombomodulin gene mutation coding for an elongated protein with reduced expression in a kindred with myocardial infarction