Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin

Blood

Volumn 128, Issue 14, 2016, Pages 1884-1893

  Roy, Ram Vinod ^a   Ardeshirylajimi, Abdolreza ^a   Dinarvand, Peyman ^a   Yang, Likui ^a   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYGLUTAMIC ACID; ACTIVATED PROTEIN C; APC PROTEIN; BETA ARRESTIN 2; BLOOD CLOTTING FACTOR 10; DISHEVELLED 2; ENDOTHELIAL PROTEIN C RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; LIPOPOLYSACCHARIDE; PC S195A; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; UNCLASSIFIED DRUG; BETA CATENIN; CELL SURFACE RECEPTOR; DISHEVELLED PROTEIN; DVL2 PROTEIN, HUMAN; GRK5 PROTEIN, HUMAN; HIGH MOBILITY GROUP B1 PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LEUKOCYTE ANTIGEN; MUTANT PROTEIN; PROCR PROTEIN, HUMAN; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EA.HY 926 CELL LINE; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; GENE SILENCING; HELA CELL LINE; HUMAN; IN VIVO STUDY; INFLAMMATION; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; MEMBRANE MICRODOMAIN; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT;

ANIMALS; ANTIGENS, CD; BETA CATENIN; BETA-ARRESTIN 2; CYTOPROTECTION; DISHEVELLED PROTEINS; ENDOTHELIAL CELLS; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HELA CELLS; HMGB1 PROTEIN; HUMANS; INFLAMMATION; MALE; MEMBRANE MICRODOMAINS; MICE, INBRED C57BL; MUTANT PROTEINS; PROTEIN C; PROTEIN TRANSPORT; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; THROMBIN;

EID: 85025105846     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-06-720581     Document Type: Article

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