Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14

Journal of Immunology

Volumn 194, Issue 4, 2015, Pages 1905-1915

  Ma, Chih Yuan ^a,b   Chang, Wei En ^a   Shi, Guey Yueh ^a,b   Chang, Bi Ying ^a   Cheng, Sheng En ^a   Shih, Yun Tai ^a   Wu, Hua Lin ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CD14 ANTIGEN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; RECOMBINANT THROMBOMODULIN; SERINE; THREONINE; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; MACROPHAGE; MEMBRANE BINDING; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURVIVAL RATE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; IMMUNOPRECIPITATION; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; UMBILICAL VEIN;

ANIMALS; ANTIGENS, CD14; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; THROMBOMODULIN; UMBILICAL VEINS;

EID: 84922572309     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400923     Document Type: Article

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