MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

Molecular Cell

Volumn 66, Issue 5, 2017, Pages 698-710.e5

  Jaco, Isabel ^a   Annibaldi, Alessandro ^a   Lalaoui, Najoua ^b,c   Wilson, Rebecca ^a   Tenev, Tencho ^a   Laurien, Lucie ^d   Kim, Chun ^d   Jamal, Kunzah ^a   Wicky John, Sidonie ^a   Liccardi, Gianmaria ^a   Chau, Diep ^b,c   Murphy, James M ^b,c   Brumatti, Gabriela ^b,c   Feltham, Rebecca ^a,b,c   Pasparakis, Manolis ^d   Silke, John ^b,c   Meier, Pascal ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

caspase 8; cell death; complex II; cytokine; IAPs; MK2; necroptosis; p38; RIPK1; TNF

Indexed keywords

CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 14; MK2 PROTEIN; PHOSPHOTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RIPK1 PROTEIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CASP8 PROTEIN, MOUSE; FADD PROTEIN, MOUSE; MAP KINASE KINASE KINASE 7; MAP-KINASE-ACTIVATED KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; ENZYME INHIBITION; HUMAN; HUMAN CELL; MUTATION; NECROPTOSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA STABILITY; RNA TRANSCRIPTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HT-29 CELL LINE; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PHOSPHORYLATION; RNA INTERFERENCE;

ANIMALS; APOPTOSIS; CASPASE 8; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HT29 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE KINASES; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 14; MULTIPROTEIN COMPLEXES; NECROSIS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85019106871     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.05.003     Document Type: Article

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