Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

Molecular Cell

Volumn 69, Issue 4, 2018, Pages 566-580.e5

  Annibaldi, Alessandro ^a   Wicky John, Sidonie ^a   Vanden Berghe, Tom ^b,c   Swatek, Kirby N ^d   Ruan, Jianbin ^e   Liccardi, Gianmaria ^a   Bianchi, Katiuscia ^a,f   Elliott, Paul R ^d   Choi, Sze Men ^b,c   Van Coillie, Samya ^b,c   Bertin, John ^g   Wu, Hao ^e   Komander, David ^d   Vandenabeele, Peter ^b,c   Silke, John ^h,i   Meier, Pascal ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e HARVARD MEDICAL SCHOOL   (United States)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g GLAXOSMITHKLINE   (United States)

^h WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

apoptosis; caspase 8; cell death; cIAPs; inflammation; necroptosis; RIPK1; TNF; ubiquitin

Indexed keywords

CASPASE; CELLULAR INHIBITOR OF APOPTOSIS 1; CELLULAR INHIBITOR OF APOPTOSIS 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; MK2 KINASE; PROTEASOME; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UBIQUITIN; UNCLASSIFIED DRUG; BACULOVIRAL IAP REPEAT CONTAINING PROTEIN 3; I KAPPA B KINASE; MAP KINASE KINASE KINASE 7; MAP-KINASE-ACTIVATED KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSCRIPTION REGULATION; UBIQUITINATION; ANIMAL; APOPTOSIS; C57BL MOUSE; DRUG EFFECT; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BACULOVIRAL IAP REPEAT-CONTAINING 3 PROTEIN; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN; UBIQUITINATION;

EID: 85042110181     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2018.01.027     Document Type: Article

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