The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway

CNS Neuroscience and Therapeutics

Volumn 22, Issue 8, 2016, Pages 661-669

  Dong, Lin ^a,b   Li, Yu Zhen ^c   An, Hai Ting ^a,b   Wang, Ya Long ^a,b   Chen, Shi Hao ^a,b   Qian, Yan Jing ^a,b   Wang, Ke ^a,b   Zhen, Jun Li ^a,b   Fan, Zheng ^a   Gong, Xiao Li ^a,b   Zheng, Yan ^a,b   Wang, Xiao Min ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

c Cbl; Inflammation; Microglia; NF B; PI3K Akt

Indexed keywords

CBL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE ACTIVITY; ENCEPHALITIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBSTANTIA NIGRA PARS COMPACTA; WESTERN BLOTTING;

EID: 84977660914     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12557     Document Type: Article

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