Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Cell

Volumn 174, Issue 5, 2018, Pages 1293-1308.e36

  Azizi, Elham ^a   Carr, Ambrose J ^a,b   Plitas, George ^a   Cornish, Andrew E ^a   Konopacki, Catherine ^a   Prabhakaran, Sandhya ^a   Nainys, Juozas ^b,c   Wu, Kenmin ^a   Kiseliovas, Vaidotas ^a,c   Setty, Manu ^a   Choi, Kristy ^b   Fromme, Rachel M ^a   Dao, Phuong ^a   McKenney, Peter T ^a,d   Wasti, Ruby C ^d   Kadaveru, Krishna ^d   Mazutis, Linas ^a   Rudensky, Alexander Y ^a   Pe'er, Dana ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c VILNIUS UNIVERSITY   (Lithuania)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Bayesian modeling; breast cancer; single cell RNA seq; T cell activation; TCR utilization; tumor microenvironment; tumor infiltrating immune cells

Indexed keywords

RNA; SINGLE CELL RNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; TRANSCRIPTOME;

ARTICLE; BAYES THEOREM; BREAST CARCINOMA; CANCER INHIBITION; CANCER STAGING; CELL EXPANSION; CONTROLLED STUDY; ENTROPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; RNA SEQUENCE; T LYMPHOCYTE ACTIVATION; TUMOR MICROENVIRONMENT; BIOLOGY; BREAST TUMOR; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; IMMUNOLOGY; IMMUNOTHERAPY; LYMPH NODE; METABOLISM; PATHOLOGY; PROCEDURES; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; TUMOR ASSOCIATED LEUKOCYTE;

BAYES THEOREM; BREAST NEOPLASMS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNE SYSTEM; IMMUNOTHERAPY; LYMPH NODES; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGES; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 85048957607     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.05.060     Document Type: Article

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