Between-region genetic divergence reflects the mode and tempo of tumor evolution

Nature Genetics

Volumn 49, Issue 7, 2017, Pages 1015-1024

  Sun, Ruping ^a,b   Hu, Zheng ^a,b   Sottoriva, Andrea ^c   Graham, Trevor A ^d   Harpak, Arbel ^e   Ma, Zhicheng ^a,b   Fischer, Jared M ^f   Shibata, Darryl ^g   Curtis, Christina ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD CANCER INSTITUTE   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e STANFORD UNIVERSITY   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TEMOZOLOMIDE; DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER GENETICS; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; CLONAL EVOLUTION; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS CARCINOMA; EVOLUTION; FEASIBILITY STUDY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; MICROSATELLITE INSTABILITY; MOUSE; MULTIPLE CANCER; MUTATION RATE; NATURAL SELECTION; NEOPLASM; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; RADIAL BASED FUNCTION; SENSITIVITY AND SPECIFICITY; SOLID MALIGNANT NEOPLASM; SOMATIC MUTATION; SPATIAL ANALYSIS; SUPPORT VECTOR MACHINE; TUMOR GROWTH; WHOLE EXOME SEQUENCING; ADENOCARCINOMA; ALLELE; ANIMAL; BIOLOGICAL MODEL; CANCER STEM CELL; CELL CLONE; CELL DIVISION; COCARCINOGENESIS; COLORECTAL TUMOR; COMPARATIVE STUDY; COMPUTER SIMULATION; DISEASE COURSE; EXOME; GENE FREQUENCY; GENETIC SELECTION; GENETIC VARIATION; GENETICS; MALE; METABOLISM; MOLECULAR EVOLUTION; MUTATION; NUDE MOUSE; PATHOLOGY; TIME FACTOR; TUMOR VOLUME;

ADENOCARCINOMA; ALLELES; ANIMALS; CELL DIVISION; CLONE CELLS; COCARCINOGENESIS; COLORECTAL NEOPLASMS; COMPUTER SIMULATION; DISEASE PROGRESSION; DNA, NEOPLASM; EVOLUTION, MOLECULAR; EXOME; GENE FREQUENCY; GENETIC VARIATION; HUMANS; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MUTATION; NEOPLASTIC STEM CELLS; SELECTION, GENETIC; TIME FACTORS; TUMOR BURDEN;

EID: 85021728567     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3891     Document Type: Article

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