Early stage alterations in CA1 extracellular region proteins indicate dysregulation of IL6 and iron homeostasis in the 5XFAD Alzheimer's disease mouse model

Journal of Alzheimer's Disease

Volumn 61, Issue 4, 2018, Pages 1399-1410

  Gurel, Busra ^a,c   Cansev, Mehmet ^b   Sevinc, Cansu ^b   Kelestemur, Seda ^a   Ocalan, Busra ^b   Cakir, Aysen ^b   Aydin, Sami ^b   Kahveci, Nevzat ^b   Ozansoy, Mehmet ^a   Taskapilioglu, Ozlem ^b   Ulus, Ismail Hakki ^c   Başar, Merve Karayel ^c   Sahin, Betul ^d   Tuzuner, Mete Bora ^d   Baykal, Ahmet Tarik ^c  

^a ISTANBUL MEDIPOL UNIVERSITY   (Turkey)

^b ULUDAG UNIVERSITY   (Turkey)

^c ACIBADEM UNIVERSITY   (Turkey)

^d Acibadem Labmed   (Turkey)

Author keywords

Alzheimer's disease; extracellular matrix; IL6; iron; neuroinflammation; proteomics

Indexed keywords

ALPHA 1 ANTITRYPSIN 1-4; ALPHA 2 MACROGLOBULIN; ALPHA 2 MACROGLOBULIN P; AMYLOID BETA PROTEIN; BETA ACTIN LIKE PROTEIN 2; CARBONATE DEHYDRATASE II; CARBOXYLESTERASE 1C; CARBOXYLESTERASE 1D; COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK RELATED 70 KDA PROTEIN 2; HERMANSKY PUDLAK SYNDROME 1 PROTEIN HOMOLOG; INTERLEUKIN 6; IRON; KERATIN TYPE II CYTOSKELETAL 5; LIVER CARBOXYLESTERASE 1; MYOSIN 4; NEURON SPECIFIC ENOLASE; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE ZETA; SCLEROPROTEIN; SERINE PROTEASE INHIBITOR A3K; SERINE PROTEASE INHIBITOR A3M; SPECTRIN ALPHA CHAIN ERYTHROCYTIC 1; UBIQUITIN CARBOXYL TERMINAL HYDROLASE ISOZYME L1; UNCLASSIFIED DRUG; INTERLEUKIN-6, MOUSE;

5XFAD MOUSE; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; EXTRACELLULAR FLUID; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; IRON HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; ANIMAL; DISEASE MODEL; GENETICS; HOMEOSTASIS; LIQUID CHROMATOGRAPHY; METABOLISM; PATHOLOGY; PROTEOMICS; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; CA1 REGION, HIPPOCAMPAL; CHROMATOGRAPHY, LIQUID; DISEASE MODELS, ANIMAL; FEMALE; HOMEOSTASIS; INTERLEUKIN-6; IRON; MICE; MICE, TRANSGENIC; PROTEOMICS; TANDEM MASS SPECTROMETRY;

EID: 85048034279     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-170329     Document Type: Article

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