Biochemical and proteomic analysis of a potential anticancer agent: Palladium(II) saccharinate complex of terpyridine acting through double strand break formation

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 5240-5249

  Adiguzel, Zelal ^a   Baykal, Ahmet Tarik ^b   Kacar, Omer ^a   Yilmaz, Veysel T ^c   Ulukaya, Engin ^c   Acilan, Ceyda ^a  

^a Research Institute for Genetic Engineering and Biotechnology   (Turkey)

^b ISTANBUL MEDIPOL UNIVERSITY   (Turkey)

^c ULUDAG UNIVERSITY   (Turkey)

Author keywords

anticancer drugs; apoptosis; DNA double strand breaks; nonhomologous end joining; palladium(II) saccharinate complex with terpyridine; proteomics; reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CISPLATIN; HISTONE H2AX; MESSENGER RNA PRECURSOR; PALLADIUM COMPLEX; PALLADIUM SACCHARINATE; PLASMID DNA; REACTIVE OXYGEN METABOLITE; SACCHARIN SODIUM; UBIQUITIN C; UNCLASSIFIED DRUG; XRCC5 PROTEIN; COORDINATION COMPOUND; DNA HELICASE; PALLADIUM; SACCHARINATE(2,2'-6',2'-TERPYRIDINE)PALLADIUM(II); XRCC5 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BIOCHEMISTRY; BREAST CANCER CELL LINE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; ENERGY METABOLISM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEOMICS; TANDEM MASS SPECTROMETRY; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; FEMALE; HELA CELL LINE; METABOLISM; PATHOLOGY; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; COORDINATION COMPLEXES; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; FEMALE; HELA CELLS; HUMANS; PALLADIUM; PROTEOMICS; REACTIVE OXYGEN SPECIES; TANDEM MASS SPECTROMETRY;

EID: 84908868909     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5006718     Document Type: Article

References (32)

1. Zhang, J.; Wang, L.; Xing, Z.; Liu, D.; Sun, J.; Li, X.; Zhang, Y. Status of bi-and multi-nuclear platinum anticancer drug development Anticancer Agents Med. Chem. 2010, 10 (4) 272-82
2. Lebwohl, D.; Canetta, R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update Eur. J. Cancer 1998, 34 (10) 1522-34
3. Hartmann, J. T.; Lipp, H. P. Toxicity of platinum compounds Expert Opin. Pharmacother. 2003, 4 (6) 889-901
4. Shah, N.; Dizon, D. S. New-generation platinum agents for solid tumors Future Oncol. 2009, 5 (1) 33-42
5. Akdi, K.; Vilaplana, R. A.; Kamah, S.; Navarro, J. A.; Salas, J. M.; Gonzalez-Vilchez, F. Study of the biological effects and DNA damage exerted by a new dipalladium-Hmtpo complex on human cancer cells J. Inorg. Biochem. 2002, 90 (1-2) 51-60
6. El-Sherif, A. A. Coordination Chemistry of Palladium(II) Ternary Complexes with Relevant Biomolecules. In Stoichiometry and Research-The Importance of Quantity in Biomedicine, 2012 ed.; Innocenti, A., Ed.; InTech: 2012; pp 79-120.
7. Rau, T.; Eldik, R. v. Metal Ions In Biological Systems. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy; Marcel Dekker: New York, 1996; Vol. 31.
8. Miklasova, N.; Fischer-Fodor, E.; Lonnecke, P.; Tomuleasa, C. I.; Virag, P.; Schrepler, M. P.; Miklas, R.; Dumitrescu, L. S.; Hey-Hawkins, E. Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro Eur. J. Med. Chem. 2012, 49, 41-7
9. Ulukaya, E.; Ari, F.; Dimas, K.; Ikitimur, E. I.; Guney, E.; Yilmaz, V. T. Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo Eur. J. Med. Chem. 2011, 46 (10) 4957-63
10. Ulukaya, E.; Ari, F.; Dimas, K.; Sarimahmut, M.; Guney, E.; Sakellaridis, N.; Yilmaz, V. T. Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro J. Cancer Res. Clin. Oncol. 2011, 137 (10) 1425-34
11. Ruiz, J.; Villa, M. D.; Cutillas, N.; Lopez, G.; de Haro, C.; Bautista, D.; Moreno, V.; Valencia, L. Palladium(II) and platinum(II) organometallic complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor activity of the platinum compounds Inorg. Chem. 2008, 47 (11) 4490-505
12. Abu-Surrah, A. S.; Al-Sadoni, H. H.; Abdalla, M. Y. Palladium-based chemotherapeutic agents: Routes toward complexes with good antitumor activity Cancer Therapy 2008, 6, 1-10
13. Trevisan, A.; Marzano, C.; Cristofori, P.; Borella Venturini, M.; Giovagnini, L.; Fregona, D. Synthesis of a palladium(II)-dithiocarbamate complex: biological assay and nephrotoxicity in rats Arch. Toxicol. 2002, 76 (5-6) 262-8
14. Tusek-Bozic, L.; Furlani, A.; Scarcia, V.; De Clercq, E.; Balzarini, J. Spectroscopic and biological properties of palladium(II) complexes of ethyl 2-quinolylmethylphosphonate J. Inorg. Biochem. 1998, 72 (3-4) 201-10
15. Guney, E.; Yilmaz, V. T.; Sengul, A.; Buyukgungor, O. Platinum(II) and palladium(II) saccharinato complexes with 2,2′:6′,2-terpyridine: Synthesis, characterization, crystal structures, photoluminescence and thermal studies Inorg. Chim. Acta 2010, 363, 438-448
16. Downs, J. A.; Jackson, S. P. A means to a DNA end: the many roles of Ku Nat. Rev. Mol. Cell Biol. 2004, 5 (5) 367-78
17. Kacar, O.; Adiguzel, Z.; Yilmaz, V. T.; Cetin, Y.; Cevatemre, B.; Arda, N.; Baykal, A. T.; Ulukaya, E.; Acilan, C. Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent Anticancer Drugs 2014, 25 (1) 17-29
18. Baykal, A. T.; Baykal, B.; Serhatli, M.; Adiguzel, Z.; Tuncer, M. A.; Kacar, O.; Baysal, K.; Acilan Ayhan, C. Proteomic evidence for the plasticity of cultured vascular smooth muscle cells Turkish J. Biol. 2013, 37 (4) 414-425
19. Wisniewski, J. R.; Zougman, A.; Nagaraj, N.; Mann, M. Universal sample preparation method for proteome analysis Nat. Methods 2009, 6 (5) 359-62
20. Hacariz, O.; Sayers, G.; Baykal, A. T. A proteomic approach to investigate the distribution and abundance of surface and internal Fasciola hepatica proteins during the chronic stage of natural liver fluke infection in cattle J. Proteome Res. 2012, 11 (7) 3592-604
21. Keller, A.; Nesvizhskii, A. I.; Kolker, E.; Aebersold, R. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search Anal. Chem. 2002, 74 (20) 5383-92
22. Nesvizhskii, A. I.; Keller, A.; Kolker, E.; Aebersold, R. A statistical model for identifying proteins by tandem mass spectrometry Anal. Chem. 2003, 75 (17) 4646-58
23. Zhang, H. G.; Wang, J.; Yang, X.; Hsu, H. C.; Mountz, J. D. Regulation of apoptosis proteins in cancer cells by ubiquitin Oncogene 2004, 23 (11) 2009-15
24. Jesenberger, V.; Jentsch, S. Deadly encounter: ubiquitin meets apoptosis Nat. Rev. Mol. Cell Biol. 2002, 3 (2) 112-21
25. Broemer, M.; Meier, P. Ubiquitin-mediated regulation of apoptosis Trends Cell Biol. 2009, 19 (3) 130-40
26. Basu, A.; Krishnamurthy, S. Cellular responses to Cisplatin-induced DNA damage J. Nucleic Acids 2010, 2010
27. Kuo, L. J.; Yang, L. X. Gamma-H2AX-a novel biomarker for DNA double-strand breaks In Vivo 2008, 22 (3) 305-9
28. Sun, S. Y. N-acetylcysteine, reactive oxygen species and beyond Cancer Biol. Ther. 2010, 9 (2) 109-10
29. Lee, J. C.; Peter, M. E. Regulation of apoptosis by ubiquitination Immunol. Rev. 2003, 193, 39-47
30. Jeggo, P. A.; Hafezparast, M.; Thompson, A. F.; Broughton, B. C.; Kaur, G. P.; Zdzienicka, M. Z.; Athwal, R. S. Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2 Proc. Natl. Acad. Sci. U. S. A. 1992, 89 (14) 6423-7
31. Knoops, B.; Goemaere, J.; Van der Eecken, V.; Declercq, J. P. Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin Antioxid. Redox Signal. 2011, 15 (3) 817-29
32. Li, L.; Robert, C.; Rassool, F. V. The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer. DNA Repair and Human Health; InTech: 2011; Chapter 4.