Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP

Blood

Volumn 99, Issue 9, 2002, Pages 3228-3234

  Quinton, Todd M ^a   Ozdener, Fatih ^a   Dangelmaier, Carol ^a   Daniel, James L ^a   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ADENOSINE DIPHOSPHATE; CALCIUM; CHELATING AGENT; COLLAGEN; CONVULXIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FIBRINOGEN RECEPTOR; GLYCOPROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SCAVENGER; THROMBOXANE A2;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0036566534     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.9.3228     Document Type: Article

References (46)

1. More pieces of the platelet activation puzzle slide into place
2. Signaling through platelet integrin alpha IIb beta 3: Inside-out, outside-in, and sideways
3. Collagen receptor signalling in platelets: Extending the role of the ITAM
4. Molecular cloning, genomic structure, chromosomal (ocalization, and alternative splice forms of the platelet collagen receptor glycoprotein VI
5. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: A platelet-specific collagen receptor from the immunoglobulin superfamily
6. Cloning and expression of the platelet-specific collagen receptor glycoprotein VI
7. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors
8. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets
9. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
10. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
11. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
12. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets
13. Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization
14. Signaling through G proteins in platelets: To the integrins and beyond
15. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
16. Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen
17. Interaction of LAT with multiple adapter proteins in platelets activated by the GPVI selective ligand, convulxin
18. Molecular basis for ADP-induced platelet activation, I: Evidence for three distinct ADP receptors on human platelets
19. Molecular basis for ADP-induced platelet activation, II: The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
20. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors
21. Platelet adhesion to native type I collagen fibrils. Role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation
22. ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq
23. Defective platelet activation in G alpha(q)-deficient mice
24. Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation
25. FcgammaRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation
26. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: Collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity
27. Determination of platelet adhesion to collagen and the associated formation of phosphatidic acid and calcium mobilization
28. Role of P2Y1 purinoceptor in ADP-induced platelet activation
29. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
30. Protein kinase C activation is not a key step in ADP-mediated exposure of fibrinogen receptors on human platelets
31. Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by Western blotting, while collagen does: The significance of synergistic, autocrine stimulation
32. Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets
33. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
34. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
35. Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI
36. Analysis of platelet adhesion to a collagen-coated surface under flow conditions: The involvement of glycoprotein VI in the platelet adhesion
37. Glycoprotein Vi is a major collagen receptor for platelet activation: It recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not
38. Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets
39. Activation of the GP IIb-IIIa complex induced by platelet adhesion to collagen is mediated by both alpha2beta1 integrin and GP VI
40. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma chain in response to the snake venom convulxin but not to collagen
41. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1
42. Convulxin binding to platelet receptor GPVI: Competition with collagen related peptides
43. A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets
44. Protein kinase C-dependent and Ca2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: Effects of leakage of cytosolic proteins
45. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors
46. Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin