Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain

Journal of Clinical Investigation

Volumn 109, Issue 8, 2002, Pages 1031-1040

  Pinsky, David J ^a,d   Johan Broekman, M ^b   Peschon, Jacques J ^c   Stocking, Kim L ^c   Fujita, Tomoyuki ^a   Ramasamy, Ravichandran ^a   Sander Connolly Jr , E ^a   Huang, Judy ^a   Kiss, Szilard ^a   Zhang, Yuan ^a   Choudhri, Tanvir F ^a   McTaggart, Ryan A ^a   Liao, Hui ^a   Drosopoulos, Joan H F ^b   Price, Virginia L ^c   Marcus, Aaron J ^b   Maliszewski, Charles R ^c  

^a Columbia University ^*  (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c AMGEN INC   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; APYRASE; CD39 ANTIGEN; FIBRIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN PROTECTION; CONTROLLED STUDY; EXON; GENE CASSETTE; GENE INSERTION; IMMUNOREACTIVITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

EID: 0036121594     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0210649     Document Type: Article

References (37)

1. Primary prevention of stroke
2. Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation
3. x·glycosylated complement inhibitory protein
4. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke
5. Exacerbation of cerebral injury in mice which express the P-selectin gene: Identification of P-selectin blockade as a new target for the treatment of stroke
6. Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke
7. Intravenous tissue plasminogen activator for acute ischemic stroke: Feasibility, safety, and efficacy in the first year of clinical practice
8. Thromboregulation: Multicellular modulation of platelet reactivity in homeostasis and thrombosis
9. 2+)-apyrase
10. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
11. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39
12. Identification and characterization of CD39 vascular ATP diphosphohydrolase
13. Inhibition of human platelet reactivity by endothelium-derived relaxing factor from human umbilical vein endothelial cells in suspension. Blockade of aggregation and secretion by an aspirin-insensitive mechanism
14. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells
15. Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia
16. Enhanced preservation of orthotopically transplanted rat lungs by nitroglycerin but not hydralazine. Requirement for graft vascular homeostasis beyond harvest vasodilation
17. Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice
18. Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation
19. Analyses of chrombocytopenia in idiopathic thrombocytopenic purpura-prone mice by platelet transfer experiments between (NZWx BXSB)F1 and normal mice
20. cAMP-mediated vascular protection in an orthotopic rat lung transplant model: Insights into the mechanism of action of prostaglandin E1 to improve lung preservation
21. Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage
22. Gene structure and chromosome location of mouse Cd39 coding for an ecto-apyrase
23. Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice
24. Spontaneous thrombosis in mice carrying the factor V Leiden mutation
25. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
26. Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase
27. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay
28. The results of CAPRIE, IST, and CAST
29. Purification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum)
30. The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization
31. Ueber bakteriologische forschung
32. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
33. Leukocyte rolling and extravasation are severely compromised in P-selectin deficient mice
34. Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene
35. Platelets: Their role in hemostasis, thrombosis, and inflammation
36. Clinical considerations in selecting antiplatelet therapy in cerebrovascular disease
37. Effects of acetylsalicylic acid in stroke patients. Evidence of nonresponders in a subpopulation of treated patients