Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle

Journal of Cell Biology

Volumn 148, Issue 6, 2000, Pages 1187-1201

  Gill, R Montgomery ^a   Hamel, Paul A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cell cycle; Cytoplasm; E2F; Muscle differentiation; Nucleus

Indexed keywords

CYCLIN A; CYCLIN E; MYOGENIN; PROTEIN P21; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL CYCLE S PHASE; CYTOPLASM; MUSCLE DEVELOPMENT; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F2 TRANSCRIPTION FACTOR; E2F3 TRANSCRIPTION FACTOR; E2F4 TRANSCRIPTION FACTOR; E2F5 TRANSCRIPTION FACTOR; MUSCLE, SKELETAL; RATS; RECOMBINANT PROTEINS; RETINOBLASTOMA PROTEIN; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0034689001     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.148.6.1187     Document Type: Article

References (142)

1. Cyclins D1, D2 and D3 are expressed in distinct tissues during mouse embryogenesis
2. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm
3. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor
4. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
5. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
6. Adenovirus E1A inhibits cardiac myocyte-specific gene expression through its amino terminus
7. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter
8. Inhibition of muscle differentiation by the adenovirus E1a protein: Repression of the transcriptional activating function of the HLH protein Myf-5
9. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
10. Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein
11. The E2F transcription factor is a cellular target for the RB protein
12. The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells
13. RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import
14. RB associates with an E2F-Iike, sequence-specific DNA-binding protein
15. Requirement for a functional Rb-1 gene in murine development
16. Cell cycle-specific association of E2F with the p130 E1A-binding protein
17. Shared role of the pRB-related p130 and p107 proteins in limb development
18. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation
19. FACS-optimized mutants of the green fluorescent protein (GFP)
20. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4
21. Expression patterns of the E2F family of transcription factors during mouse nervous system development
22. Expression patterns of the E2F family of transcription factors during murine epithelial development
23. Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal
24. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
25. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
26. Expression of G1-phase cell cycle genes during hematopoietic lineage
27. Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms
28. Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells
29. Developmental control of the G1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F
30. E2F-induced S phase requires cyclin E
31. Differential regulation of E2F trans-activation by cyclin/cdk2 complexes
32. The regulation of E2F by pRB-family proteins
33. A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program
34. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
35. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
36. E2F-1 functions in mice to promote apoptosis and suppress proliferation
37. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
38. CRM1 is an export receptor for leucine-rich nuclear export signals
39. Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev
40. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs
41. Characterization of the human RB1 promoter and of elements involved in transcriptional regulation
42. Regulation of expression and activity of distinct pRB, E2F, D-type cyclin, and CKI family members during terminal differentiation of P19 cells
43. E2F-4, a new member of the E2F transcription factor family, interacts with p107
44. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
45. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
46. Inhibition of myogenesis by multiple cyclin-Cdk complexes. Coordinate regulation of myogenesis and cell cycle activity at the level of E2F
47. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation
48. E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes
49. SV40 T antigen inhibits expression of MyoD and myogenin, up-regulates Myf-5, but does not affect early expression of desmin or alpha 7 integrin during muscle development
50. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene
51. Isolation of the Rb-related p130 through its interaction with cdk2 and cyclins
52. A simplified system for generating recombinant adenoviruses
53. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
54. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
55. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor
56. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F
57. Regulation of retinoblastoma functions by ectopic expression of human cyclins
58. Effects of an Rb mutation in the mouse
59. Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate
60. The retinoblastoma gene family is differentially expressed during embryogenesis
61. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
62. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
63. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
64. Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation
65. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription
66. Stable expression of anti-sense Rb-1 RNA inhibits terminal differentiation of mouse myoblast C2 cells
67. Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile
68. An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells
69. The embryonal carcinoma stem cell E1a-like activity involves a differentiation-regulated transcription factor
70. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene
71. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
72. Cloning and expression of the Rb-related mouse p130 mRNA
73. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
74. The retinoblastoma protein binds to a family of E2F transcription factors
75. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
76. The adenovirus E1a-associated 130-kD protein is encoded by a member of the retino-blastoma gene family and physically interacts with cyclins A and E
77. The sub-cellular localization of E2F-4 is cell-cycle dependent
78. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
79. Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta
80. A short region of its homeodomain is necessary for Engrailed nuclear export and secretion
81. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids
82. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain
83. G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4
84. Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation
85. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
86. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway
87. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
88. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization
89. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
90. Isolation of genes which block neuronal differentiation of teratocarcinoma PCC7 cells
91. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
92. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
93. Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F
94. 1 in mammalian fibroblasts
95. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
96. Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation
97. Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor beta. A role for cyclin D1 in control of myoblast differentiation
98. Different roles for cyclins D1 and E in regulation of the G1-to-S transition
99. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system
100. Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27(Kipl)
101. Overexpression of human cyclin A advances entry into S phase
102. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle
103. Rapid detection of octamer binding proteins with 'mini extracts', prepared from a small number of cells
104. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
105. The transcription factor E2F-1 mediates the autoregulation of RB gene expression
106. The G1/S boundary-specific enhancer of the rat cdc2 promoter
107. Multiple change in E2F function and regulation occur upon muscle differentiation
108. Multicomponent differentiation-regulated transcription factors in F9 embryonal carcinoma stem cells
109. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
110. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
111. Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation
112. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation
113. Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells
114. Cells differentiating into neuralectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins
115. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofulate reductase promoter
116. The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2
117. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state
118. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
119. E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation
120. DNA synthesis is induced in adult neurons after expression of E2F1 and E1A
121. The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase
122. The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants
123. Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter
124. Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms
125. E2F activity is regulated by cell cycle-dependent changes in subcellular localization
126. Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1
127. E2F1 inhibition of transcription activation by myogenic basic helix-loop-helix regulators
128. Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression
129. Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells
130. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment
131. Identification of a signal for rapid export of proteins from the nucleus
132. Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E
133. A complex between E2F and the pRB-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation
134. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
135. SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence
136. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases
137. Retention of differentiation potentialities during prolonged cultivation of myogenic cells
138. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen
139. New perspectives on retinoblastoma family functions in differentiation
140. pRb Controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
141. The pRB-related protein p107 contains two growth suppression domains: Independent interactions with E2F and cyclin/cdk complexes
142. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins