Distinct subcellular distribution of cyclin dependent kinase 6

Cell Cycle

Volumn 8, Issue 17, 2009, Pages 2837-2843

  Kohrt, Dawn M ^a   Crary, Jennifer I ^a,b   Gocheva, Vasilena ^a   Hinds, Philip W ^b   Grossel, Martha J ^a  

^a The Holleran Center for Community Action and Public Policy   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Cdk6; Cell cycle; Cyclin dependent kinase 6; Differentiation; G1 phase; Subcellular localization

Indexed keywords

CYCLIN DEPENDENT KINASE 6; RETINOBLASTOMA PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME LOCALIZATION; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

EID: 69749120549     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.17.9521     Document Type: Article

References (26)

1. Grossel MJ, Hinds PW. From cell cycle to differentiation: an expanding role for cdk6. Cell Cycle 2006; 5:266-270 (Pubitemid 43213495)
2. Ericson KK, Krull D, Slomiany P, Grossel MJ. Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes. Mol Cancer Res 2003; 1:654-664 (Pubitemid 36870518)
3. Matushansky I, Radparvar F, Skoultchi AI. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 2003; 22:4143-4149 (Pubitemid 36876235)
4. Ogasawara T, Katagiri M, Yamamoto A, Hoshi K, Takato T, Nakamura K, et al. Osteoclast differentiation by RANKL requires NFkappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). J Bone Miner Res 2004; 19:1128-1136 (Pubitemid 41110565)
5. Ogasawara T, Kawaguchi H, Jinno S, Hoshi K, Itaka K, Takato T, et al. Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated downregulation of Cdk6. Mol Cell Biol 2004; 24:6560-6568 (Pubitemid 38944337)
6. Fujimoto T, Anderson K, Jacobsen SE, Nishikawa SI, Nerlov C. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. EMBO J 2007; 26:2361-2370 (Pubitemid 46685857)
7. Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, et al. A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res 2009; 69:810-818
8. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 2007; 67:7713-7722 (Pubitemid 47281364)
9. Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007; 67:1424-1429 (Pubitemid 46383366)
10. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008; 6:14. (Pubitemid 352003733)
11. Fahraeus R, Lane DP. The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J 1999; 18:2106-2118 (Pubitemid 29179168)
12. Grossel MJ, Baker GL, Hinds PW. cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain. J Biol Chem 1999; 274:29960-29967
13. Kwon TK, Buchholz MA, Gabrielson EW, Nordin AA. A novel cytoplasmic substrate for cdk4 and cdk6 in normal and malignant epithelial derived cells. Oncogene 1995; 11:2077-2083
14. Mahony D, Parry K, Lees E. Active cdk6 complexes are predominatly nuclear and represent only a minority of the cdk6 in T cells. Oncogene 1998; 16:603-611 (Pubitemid 28062340)
15. Nagasawa M, Melamed I, Kupfer A, Gelfand E, Lucas J. Rapid nuclear translocation and increased activity of cyclin-dependent kinase 6 after T cell activation. J Immunol 1997; 158:5146-5154 (Pubitemid 127681216)
16. van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262:2050-2054 (Pubitemid 24041887)
17. 1 arrest pathway in human gliomas: overexpression of cdk4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes Dev 1998; 12:3644-3649
18. Holland EC, Varmus HE. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc Natl Acad Sci 1998; 95:1218-1223 (Pubitemid 28124939)
19. Slomiany P, Baker T, Elliott ER, Grossel MJ. Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes. J Cell Biochem 2006; 99:635-646 (Pubitemid 44435579)
20. Coffman JA. Runx transcription factors and the developmental balance between cell proliferation and differentiation. Cell Biol Int 2003; 27:315-324 (Pubitemid 36638332)
21. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122:947-956 (Pubitemid 41345211)
22. Timmermann S, Hinds PW, Munger K. Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines. Cell Growth Differ 1997; 8:361-370 (Pubitemid 27273073)
23. Easton J, Wei T, Lahti J, Kidd V. Disruption of the cyclin D/cyclin-dependent Kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma. Cancer Res 1998; 58:2624-2632 (Pubitemid 28275436)
24. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002; 1:269-277
25. Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 2001; 15:1913-1925 (Pubitemid 32738621)
26. INK4d, CDK4, CDK6 in glioblastoma multiforme. Br J Neurosurg 2000; 14:28-32.