Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy

Journal of Nutritional Biochemistry

Volumn 57, Issue , 2018, Pages 212-227

  Varshney, Ritu ^a   Varshney, Rajat ^b   Mishra, Rutusmita ^a   Gupta, Sumeet ^c   Sircar, Debabrata ^a   Roy, Partha ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b INDIAN VETERINARY RESEARCH INSTITUTE   (India)

^c MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

Author keywords

Diabetes; ER stress; Insulin; Kaempferol; Lipophagy; Pancreatic cells

Indexed keywords

5 MONOPHOSPHATE ACTIVATED PROTEIN KINASE; FAT DROPLET; INSULIN; KAEMPFEROL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PALMITIC ACID; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ADIPOPHILIN; DDIT3 PROTEIN, RAT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KAEMPFEROL DERIVATIVE; MTOR PROTEIN, RAT; PLIN2 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

AKT/MTOR SIGNALING; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; IMMUNOBLOTTING; INSULIN RELEASE; INTRACELLULAR MEMBRANE; LIPID METABOLISM; LIPID STORAGE; LIPOPHAGOCYTOSIS; LYSOSOME; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RIN-5F CELL LINE; ANIMAL; CELL LINE; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; CELL LINE; ENDOPLASMIC RETICULUM STRESS; FEMALE; INSULIN-SECRETING CELLS; KAEMPFEROLS; LIPID METABOLISM; PALMITIC ACID; PERILIPIN-2; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR CHOP;

EID: 85046625472     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2018.02.017     Document Type: Article

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