-
1
-
-
77957940731
-
Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study
-
Ahtiluoto, S., Polvikoski, T., Peltonen, M., Solomon, A., Tuomilehto, J., Winblad, B., et al. (2010). Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 75, 1195-1202. doi: 10.1212/WNL.0b013e3181f4d7f8
-
(2010)
Neurology
, vol.75
, pp. 1195-1202
-
-
Ahtiluoto, S.1
Polvikoski, T.2
Peltonen, M.3
Solomon, A.4
Tuomilehto, J.5
Winblad, B.6
-
2
-
-
78651274000
-
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
-
Baker, L. D., Cross, D. J., Minoshima, S., Belongia, D., Watson, G. S., and Craft, S. (2011). Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68, 51-57. doi: 10.1001/archneurol.2010.225
-
(2011)
Arch. Neurol
, vol.68
, pp. 51-57
-
-
Baker, L.D.1
Cross, D.J.2
Minoshima, S.3
Belongia, D.4
Watson, G.S.5
Craft, S.6
-
3
-
-
0036816758
-
Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank
-
Barker, W. W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., et al. (2002). Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis. Assoc. Disord. 16, 203-212. doi: 10.1097/00002093-200210000-00001
-
(2002)
Alzheimer Dis. Assoc. Disord
, vol.16
, pp. 203-212
-
-
Barker, W.W.1
Luis, C.A.2
Kashuba, A.3
Luis, M.4
Harwood, D.G.5
Loewenstein, D.6
-
4
-
-
84860452103
-
Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo
-
Becker, K., Freude, S., Zemva, J., Stöhr, O., Krone, W., and Schubert, M. (2012). Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo. Neurosci. Lett. 516, 306-310. doi: 10.1016/j.neulet.2012.04.022
-
(2012)
Neurosci. Lett
, vol.516
, pp. 306-310
-
-
Becker, K.1
Freude, S.2
Zemva, J.3
Stöhr, O.4
Krone, W.5
Schubert, M.6
-
5
-
-
78751485383
-
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
-
Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., et al. (2011). Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes 60, 114-118. doi: 10.2337/db10-0329
-
(2011)
Diabetes
, vol.60
, pp. 114-118
-
-
Benedict, C.1
Brede, S.2
Schiöth, H.B.3
Lehnert, H.4
Schultes, B.5
Born, J.6
-
6
-
-
84859068426
-
Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly
-
Benedict, C., Brooks, S. J., Kullberg, J., Burgos, J., Kempton, M. J., Nordenskjöld, R., et al. (2012). Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care 35, 488-494. doi: 10.2337/dc11-2075
-
(2012)
Diabetes Care
, vol.35
, pp. 488-494
-
-
Benedict, C.1
Brooks, S.J.2
Kullberg, J.3
Burgos, J.4
Kempton, M.J.5
Nordenskjöld, R.6
-
7
-
-
3543142498
-
Intranasal insulin improves memory in humans
-
Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., et al. (2004). Intranasal insulin improves memory in humans. Psychoneuroendocrinology 29, 1326-1334. doi: 10.1016/j.psyneuen.2004.04.003
-
(2004)
Psychoneuroendocrinology
, vol.29
, pp. 1326-1334
-
-
Benedict, C.1
Hallschmid, M.2
Hatke, A.3
Schultes, B.4
Fehm, H.L.5
Born, J.6
-
8
-
-
33845695894
-
Intranasal insulin improves memory in humans: superiority of insulin aspart
-
Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., et al. (2007). Intranasal insulin improves memory in humans: superiority of insulin aspart. Neuropsychopharmacology 32, 239-243. doi: 10.1038/sj.npp.1301193
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 239-243
-
-
Benedict, C.1
Hallschmid, M.2
Schmitz, K.3
Schultes, B.4
Ratter, F.5
Fehm, H.L.6
-
9
-
-
42049089751
-
Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
-
Benedict, C., Kern, W., Schultes, B., Born, J., and Hallschmid, M. (2008). Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J. Clin. Endocrinol. Metab. 93, 1339-1344. doi: 10.1210/jc.2007-2606
-
(2008)
J. Clin. Endocrinol. Metab
, vol.93
, pp. 1339-1344
-
-
Benedict, C.1
Kern, W.2
Schultes, B.3
Born, J.4
Hallschmid, M.5
-
10
-
-
84944714835
-
Hippocampal insulin resistance and cognitive dysfunction
-
Biessels, G. J., and Reagan, L. P. (2015). Hippocampal insulin resistance and cognitive dysfunction. Nat. Rev. Neurosci. 16, 660-671. doi: 10.1038/nrn4019
-
(2015)
Nat. Rev. Neurosci
, vol.16
, pp. 660-671
-
-
Biessels, G.J.1
Reagan, L.P.2
-
11
-
-
84903220594
-
Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?
-
Biessels, G. J., and Reijmer, Y. D. (2014). Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes 63, 2244-2252. doi: 10.2337/db14-0348
-
(2014)
Diabetes
, vol.63
, pp. 2244-2252
-
-
Biessels, G.J.1
Reijmer, Y.D.2
-
12
-
-
56249148830
-
Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress
-
Bohringer, A., Schwabe, L., Richter, S., and Schachinger, H. (2008). Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology 33, 1394-1400. doi: 10.1016/j.psyneuen.2008.08.002
-
(2008)
Psychoneuroendocrinology
, vol.33
, pp. 1394-1400
-
-
Bohringer, A.1
Schwabe, L.2
Richter, S.3
Schachinger, H.4
-
13
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
-
Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J.-C., Decker, H., et al. (2012). An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J. Clin. Invest. 122, 1339-1353. doi: 10.1172/JCI57256
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
Brito-Moreira, J.4
Houzel, J.-C.5
Decker, H.6
-
14
-
-
0034680078
-
Patterns of brain activation in people at risk for Alzheimer's disease
-
Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., et al. (2000). Patterns of brain activation in people at risk for Alzheimer's disease. N. Engl. J. Med. 343, 450-456. doi: 10.1056/NEJM200008173430701
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 450-456
-
-
Bookheimer, S.Y.1
Strojwas, M.H.2
Cohen, M.S.3
Saunders, A.M.4
Pericak-Vance, M.A.5
Mazziotta, J.C.6
-
15
-
-
85047698627
-
Sniffing neuropeptides: a transnasal approach to the human brain
-
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., and Fehm, H. L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nat. Neurosci. 5, 514-516. doi: 10.1038/nn849
-
(2002)
Nat. Neurosci
, vol.5
, pp. 514-516
-
-
Born, J.1
Lange, T.2
Kern, W.3
McGregor, G.P.4
Bickel, U.5
Fehm, H.L.6
-
16
-
-
0021271479
-
Reduction of food intake and body weight by chronic intraventricular insulin infusion
-
Brief, D. J., and Davis, J. D. (1984). Reduction of food intake and body weight by chronic intraventricular insulin infusion. Brain Res. Bull. 12, 571-575
-
(1984)
Brain Res. Bull
, vol.12
, pp. 571-575
-
-
Brief, D.J.1
Davis, J.D.2
-
17
-
-
77952998595
-
Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance
-
Bruehl, H., Sweat, V., Hassenstab, J., Polyakov, V., and Convit, A. (2010). Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. J. Clin. Exp. Neuropsychol. 32, 487-493. doi: 10.1080/13803390903224928
-
(2010)
J. Clin. Exp. Neuropsychol
, vol.32
, pp. 487-493
-
-
Bruehl, H.1
Sweat, V.2
Hassenstab, J.3
Polyakov, V.4
Convit, A.5
-
18
-
-
84920627307
-
Central insulin administration improves odor-cued reactivation of spatial memory in young men
-
Brünner, Y. F., Kofoet, A., Benedict, C., and Freiherr, J. (2015). Central insulin administration improves odor-cued reactivation of spatial memory in young men. J. Clin. Endocrinol. Metab. 100, 212-219. doi: 10.1210/jc.2014-3018
-
(2015)
J. Clin. Endocrinol. Metab
, vol.100
, pp. 212-219
-
-
Brünner, Y.F.1
Kofoet, A.2
Benedict, C.3
Freiherr, J.4
-
19
-
-
84951905432
-
Novel GLP-1 (glucagon-like peptide-1) analogues and insulin in the treatment for Alzheimer's disease and other neurodegenerative diseases
-
Calsolaro, V., and Edison, P. (2015). Novel GLP-1 (glucagon-like peptide-1) analogues and insulin in the treatment for Alzheimer's disease and other neurodegenerative diseases. CNS Drugs 29, 1023-1039. doi: 10.1007/s40263-015-0301-8
-
(2015)
CNS Drugs
, vol.29
, pp. 1023-1039
-
-
Calsolaro, V.1
Edison, P.2
-
20
-
-
84961136218
-
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
-
Cedernaes, J., Osorio, R. S., Varga, A. W., Kam, K., Schiöth, H. B., and Benedict, C. (2017). Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med. Rev. 31, 102-111. doi: 10.1016/j.smrv.2016.02.002
-
(2017)
Sleep Med. Rev
, vol.31
, pp. 102-111
-
-
Cedernaes, J.1
Osorio, R.S.2
Varga, A.W.3
Kam, K.4
Schiöth, H.B.5
Benedict, C.6
-
21
-
-
84962527102
-
Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule
-
Cedernaes, J., Sand, F., Liethof, L., Lampola, L., Hassanzadeh, S., Axelsson, E. K., et al. (2016). Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule. Neurobiol. Learn. Mem. 131, 87-94. doi: 10.1016/j.nlm.2016.03.012
-
(2016)
Neurobiol. Learn. Mem
, vol.131
, pp. 87-94
-
-
Cedernaes, J.1
Sand, F.2
Liethof, L.3
Lampola, L.4
Hassanzadeh, S.5
Axelsson, E.K.6
-
22
-
-
84961208572
-
Hyperglycemia increases the production of amyloid beta-peptide leading to decreased endothelial tight junction
-
Chao, A.-C., Lee, T.-C., Juo, S.-H. H., and Yang, D.-I. (2016). Hyperglycemia increases the production of amyloid beta-peptide leading to decreased endothelial tight junction. CNS Neurosci. Ther. 22, 291-297. doi: 10.1111/cns.12503
-
(2016)
CNS Neurosci. Ther
, vol.22
, pp. 291-297
-
-
Chao, A.-C.1
Lee, T.-C.2
Juo, S.-H.H.3
Yang, D.-I.4
-
23
-
-
84883871864
-
Intranasal treatment of central nervous system dysfunction in humans
-
Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., et al. (2013). Intranasal treatment of central nervous system dysfunction in humans. Pharm. Res. 30, 2475-2484. doi: 10.1007/s11095-012-0915-1
-
(2013)
Pharm. Res
, vol.30
, pp. 2475-2484
-
-
Chapman, C.D.1
Frey, W.H.2
Craft, S.3
Danielyan, L.4
Hallschmid, M.5
Schiöth, H.B.6
-
24
-
-
84860176886
-
Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1E9 mice
-
Chua, L.-M., Lim, M.-L., Chong, P.-R., Hu, Z. P., Cheung, N. S., and Wong, B.-S. (2012). Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1E9 mice. J. Alzheimers Dis. 29, 783-791. doi: 10.3233/JAD-2012-111880
-
(2012)
J. Alzheimers Dis
, vol.29
, pp. 783-791
-
-
Chua, L.-M.1
Lim, M.-L.2
Chong, P.-R.3
Hu, Z.P.4
Cheung, N.S.5
Wong, B.-S.6
-
25
-
-
84922666525
-
Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
-
Claxton, A., Baker, L. D., Hanson, A., Trittschuh, E. H., Cholerton, B., Morgan, A., et al. (2015). Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J. Alzheimers Dis. 44, 897-906. doi: 10.3233/JAD-141791
-
(2015)
J. Alzheimers Dis
, vol.44
, pp. 897-906
-
-
Claxton, A.1
Baker, L.D.2
Hanson, A.3
Trittschuh, E.H.4
Cholerton, B.5
Morgan, A.6
-
26
-
-
84878864610
-
Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
-
Claxton, A., Baker, L. D., Wilkinson, C. W., Trittschuh, E. H., Chapman, D., Watson, G. S., et al. (2013). Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J. Alzheimers. Dis. 35, 789-797. doi: 10.3233/JAD-122308
-
(2013)
J. Alzheimers. Dis
, vol.35
, pp. 789-797
-
-
Claxton, A.1
Baker, L.D.2
Wilkinson, C.W.3
Trittschuh, E.H.4
Chapman, D.5
Watson, G.S.6
-
27
-
-
0037452760
-
Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
-
Convit, A., Wolf, O. T., Tarshish, C., and de Leon, M. J. (2003). Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc. Natl. Acad. Sci. U.S.A. 100, 2019-2022. doi: 10.1073/pnas.0336073100
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 2019-2022
-
-
Convit, A.1
Wolf, O.T.2
Tarshish, C.3
de Leon, M.J.4
-
28
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
-
29
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment
-
Craft, S., Baker, L. D., Montine, T. J., Minoshima, S., Watson, G. S., Claxton, A., et al. (2012). Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment. Arch. Neurol. 69:29. doi: 10.1001/archneurol.2011.233
-
(2012)
Arch. Neurol
, vol.69
, pp. 29
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
Minoshima, S.4
Watson, G.S.5
Claxton, A.6
-
30
-
-
85018745780
-
Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial
-
Craft, S., Claxton, A., Baker, L. D., Hanson, A. J., Cholerton, B., Trittschuh, E. H., et al. (2017). Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial. J. Alzheimers Dis. 57, 1325-1334. doi: 10.3233/JAD-161256
-
(2017)
J. Alzheimers Dis
, vol.57
, pp. 1325-1334
-
-
Craft, S.1
Claxton, A.2
Baker, L.D.3
Hanson, A.J.4
Cholerton, B.5
Trittschuh, E.H.6
-
31
-
-
84988005798
-
Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes
-
Crane, P. K., Walker, R. L., Sonnen, J., Gibbons, L. E., Melrose, R., Hassenstab, J., et al. (2016). Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes. Neurobiol. Aging 48, 72-82. doi: 10.1016/j.neurobiolaging.2016.07.021
-
(2016)
Neurobiol. Aging
, vol.48
, pp. 72-82
-
-
Crane, P.K.1
Walker, R.L.2
Sonnen, J.3
Gibbons, L.E.4
Melrose, R.5
Hassenstab, J.6
-
32
-
-
84881221053
-
Glucose levels and risk of dementia
-
Crane, P. K., Walker, R., Hubbard, R. A., Li, G., Nathan, D. M., Zheng, H., et al. (2013). Glucose levels and risk of dementia. N. Engl. J. Med. 369, 540-548. doi: 10.1056/NEJMoa1215740
-
(2013)
N. Engl. J. Med
, vol.369
, pp. 540-548
-
-
Crane, P.K.1
Walker, R.2
Hubbard, R.A.3
Li, G.4
Nathan, D.M.5
Zheng, H.6
-
33
-
-
28444491100
-
Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies
-
Cukierman, T., Gerstein, H. C., and Williamson, J. D. (2005). Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 48, 2460-2469. doi: 10.1007/s00125-005-0023-4
-
(2005)
Diabetologia
, vol.48
, pp. 2460-2469
-
-
Cukierman, T.1
Gerstein, H.C.2
Williamson, J.D.3
-
34
-
-
68149091969
-
Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report
-
Dankner, R., Chetrit, A., Shanik, M. H., Raz, I., and Roth, J. (2009). Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report. Diabetes Care 32, 1464-1466. doi: 10.2337/dc09-0153
-
(2009)
Diabetes Care
, vol.32
, pp. 1464-1466
-
-
Dankner, R.1
Chetrit, A.2
Shanik, M.H.3
Raz, I.4
Roth, J.5
-
35
-
-
84903136322
-
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
-
De Felice, F. G., and Ferreira, S. T. (2014). Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 63, 2262-2272. doi: 10.2337/db13-1954
-
(2014)
Diabetes
, vol.63
, pp. 2262-2272
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
36
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
-
De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., et al. (2009). Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106, 1971-1976. doi: 10.1073/pnas.0809158106
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.N.2
Bomfim, T.R.3
Decker, H.4
Velasco, P.T.5
Lambert, M.P.6
-
37
-
-
84856496197
-
Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
-
de la Monte, S. M. (2012). Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr. Alzheimer Res. 9, 35-66. doi: 10.2174/156720512799015037
-
(2012)
Curr. Alzheimer Res
, vol.9
, pp. 35-66
-
-
de la Monte, S.M.1
-
38
-
-
75549090376
-
The memory function of sleep
-
Diekelmann, S., and Born, J. (2010). The memory function of sleep. Nat. Rev. Neurosci. 11, 114-126. doi: 10.1038/nrn2762
-
(2010)
Nat. Rev. Neurosci
, vol.11
, pp. 114-126
-
-
Diekelmann, S.1
Born, J.2
-
39
-
-
85019761678
-
Insulin resistance predicts cognitive decline: an 11-year follow-up of a nationally representative adult population sample
-
Ekblad, L. L., Rinne, J. O., Puukka, P., Laine, H., Ahtiluoto, S., Sulkava, R., et al. (2017). Insulin resistance predicts cognitive decline: an 11-year follow-up of a nationally representative adult population sample. Diabetes Care 40, 751-758. doi: 10.2337/dc16-2001
-
(2017)
Diabetes Care
, vol.40
, pp. 751-758
-
-
Ekblad, L.L.1
Rinne, J.O.2
Puukka, P.3
Laine, H.4
Ahtiluoto, S.5
Sulkava, R.6
-
40
-
-
84894051520
-
Insulin dysfunction and Tau pathology
-
El Khoury, N. B., Gratuze, M., Papon, M.-A., Bretteville, A., and Planel, E. (2014). Insulin dysfunction and Tau pathology. Front. Cell. Neurosci. 8:22. doi: 10.3389/fncel.2014.00022
-
(2014)
Front. Cell. Neurosci
, vol.8
, pp. 22
-
-
El Khoury, N.B.1
Gratuze, M.2
Papon, M.-A.3
Bretteville, A.4
Planel, E.5
-
41
-
-
33749506795
-
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
-
Engler, H., Forsberg, A., Almkvist, O., Blomquist, G., Larsson, E., Savitcheva, I., et al. (2006). Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 129, 2856-2866. doi: 10.1093/brain/awl178
-
(2006)
Brain
, vol.129
, pp. 2856-2866
-
-
Engler, H.1
Forsberg, A.2
Almkvist, O.3
Blomquist, G.4
Larsson, E.5
Savitcheva, I.6
-
42
-
-
84963704904
-
Central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation
-
Feld, G. B., Wilhem, I., Benedict, C., Rüdel, B., Klameth, C., Born, J., et al. (2016). Central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation. Neuropsychopharmacology 41, 1540-1550. doi: 10.1038/npp.2015.312
-
(2016)
Neuropsychopharmacology
, vol.41
, pp. 1540-1550
-
-
Feld, G.B.1
Wilhem, I.2
Benedict, C.3
Rüdel, B.4
Klameth, C.5
Born, J.6
-
43
-
-
84858631674
-
The many faces of insulin-like peptide signalling in the brain
-
Fernandez, A. M., and Torres-Alemán, I. (2012). The many faces of insulin-like peptide signalling in the brain. Nat. Rev. Neurosci. 13, 225-239. doi: 10.1038/nrn3209
-
(2012)
Nat. Rev. Neurosci
, vol.13
, pp. 225-239
-
-
Fernandez, A.M.1
Torres-Alemán, I.2
-
44
-
-
26444553356
-
Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults
-
Fishel, M. A., Watson, G. S., Montine, T. J., Wang, Q., Green, P. S., Kulstad, J. J., et al. (2005). Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults. Arch. Neurol. 62, 1539-1544. doi: 10.1001/archneur.62.10.noc50112
-
(2005)
Arch. Neurol
, vol.62
, pp. 1539-1544
-
-
Fishel, M.A.1
Watson, G.S.2
Montine, T.J.3
Wang, Q.4
Green, P.S.5
Kulstad, J.J.6
-
45
-
-
84880555817
-
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence
-
Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., et al. (2013). Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs 27, 505-514. doi: 10.1007/s40263-013-0076-8
-
(2013)
CNS Drugs
, vol.27
, pp. 505-514
-
-
Freiherr, J.1
Hallschmid, M.2
Frey, W.H.3
Brünner, Y.F.4
Chapman, C.D.5
Hölscher, C.6
-
46
-
-
70349672704
-
Neuronal IGF-1 resistance reduces A accumulation and protects against premature death in a model of Alzheimer's disease
-
Freude, S., Hettich, M. M., Schumann, C., Stohr, O., Koch, L., Kohler, C., et al. (2009). Neuronal IGF-1 resistance reduces A accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J. 23, 3315-3324. doi: 10.1096/fj.09-132043
-
(2009)
FASEB J
, vol.23
, pp. 3315-3324
-
-
Freude, S.1
Hettich, M.M.2
Schumann, C.3
Stohr, O.4
Koch, L.5
Kohler, C.6
-
47
-
-
33644698732
-
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo
-
Freude, S., Plum, L., Schnitker, J., Leeser, U., Udelhoven, M., Krone, W., et al. (2005). Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes 54, 3343-3348. doi: 10.2337/diabetes.54.12.3343
-
(2005)
Diabetes
, vol.54
, pp. 3343-3348
-
-
Freude, S.1
Plum, L.2
Schnitker, J.3
Leeser, U.4
Udelhoven, M.5
Krone, W.6
-
48
-
-
15444339756
-
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
-
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., et al. (1998). Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm. 105:423. doi: 10.1007/s007020050068
-
(1998)
J Neural Transm
, vol.105
, pp. 423
-
-
Frölich, L.1
Blum-Degen, D.2
Bernstein, H.-G.3
Engelsberger, S.4
Humrich, J.5
Laufer, S.6
-
49
-
-
0033378682
-
A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
-
Frölich, L., Blum-Degen, D., Riederer, P., and Hoyer, S. (1999). A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease. Ann. N. Y. Acad. Sci. 893, 290-293
-
(1999)
Ann. N. Y. Acad. Sci
, vol.893
, pp. 290-293
-
-
Frölich, L.1
Blum-Degen, D.2
Riederer, P.3
Hoyer, S.4
-
50
-
-
85024497555
-
Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity
-
Frosch, O. H., Yau, P. L., Osorio, R. S., Rusinek, H., Storey, P., and Convit, A. (2017). Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity. Neurology 89, 249-255. doi: 10.1212/WNL.0000000000004110
-
(2017)
Neurology
, vol.89
, pp. 249-255
-
-
Frosch, O.H.1
Yau, P.L.2
Osorio, R.S.3
Rusinek, H.4
Storey, P.5
Convit, A.6
-
51
-
-
84974559551
-
In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial
-
Gejl, M., Gjedde, A., Egefjord, L., Møller, A., Hansen, S. B., Vang, K., et al. (2016). In Alzheimer's disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial. Front. Aging Neurosci. 8:108. doi: 10.3389/fnagi.2016.00108
-
(2016)
Front. Aging Neurosci
, vol.8
, pp. 108
-
-
Gejl, M.1
Gjedde, A.2
Egefjord, L.3
Møller, A.4
Hansen, S.B.5
Vang, K.6
-
52
-
-
0002792366
-
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau
-
Goedert, M., Wischik, C. M., Crowther, R. A., Walker, J. E., and Klug, A. (1988). Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. U.S.A. 85, 4051-4055
-
(1988)
Proc. Natl. Acad. Sci. U.S.A
, vol.85
, pp. 4051-4055
-
-
Goedert, M.1
Wischik, C.M.2
Crowther, R.A.3
Walker, J.E.4
Klug, A.5
-
53
-
-
0034718027
-
Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
-
Golde, T. E., Eckman, C. B., and Younkin, S. G. (2000). Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim. Biophys. Acta 1502, 172-187. doi: 10.1016/S0925-4439(00)00043-0
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 172-187
-
-
Golde, T.E.1
Eckman, C.B.2
Younkin, S.G.3
-
54
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
-
Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., et al. (2005). Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93, 105-117. doi: 10.1111/j.1471-4159.2004.02949.x
-
(2005)
J. Neurochem
, vol.93
, pp. 105-117
-
-
Griffin, R.J.1
Moloney, A.2
Kelliher, M.3
Johnston, J.A.4
Ravid, R.5
Dockery, P.6
-
55
-
-
84944803103
-
Hippocampal insulin resistance impairs spatial learning and synaptic plasticity
-
Grillo, C. A., Piroli, G. G., Lawrence, R. C., Wrighten, S. A., Green, A. J., Wilson, S. P., et al. (2015). Hippocampal insulin resistance impairs spatial learning and synaptic plasticity. Diabetes 64, 3927-3936. doi: 10.2337/db15-0596
-
(2015)
Diabetes
, vol.64
, pp. 3927-3936
-
-
Grillo, C.A.1
Piroli, G.G.2
Lawrence, R.C.3
Wrighten, S.A.4
Green, A.J.5
Wilson, S.P.6
-
56
-
-
35548931089
-
Lentivirus-mediated downregulation of hypothalamic insulin receptor expression
-
Grillo, C. A., Tamashiro, K. L., Piroli, G. G., Melhorn, S., Gass, J. T., Newsom, R. J., et al. (2007). Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiol. Behav. 92, 691-701. doi: 10.1016/j.physbeh.2007.05.043
-
(2007)
Physiol. Behav
, vol.92
, pp. 691-701
-
-
Grillo, C.A.1
Tamashiro, K.L.2
Piroli, G.G.3
Melhorn, S.4
Gass, J.T.5
Newsom, R.J.6
-
57
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., and Binder, L. I. (1986). Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U.S.A. 83, 4913-4917
-
(1986)
Proc. Natl. Acad. Sci. U.S.A
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
58
-
-
72549086623
-
Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats
-
Haj-ali, V., Mohaddes, G., and Babri, S. H. (2009). Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats. Behav. Neurosci. 123, 1309-1314. doi: 10.1037/a0017722
-
(2009)
Behav. Neurosci
, vol.123
, pp. 1309-1314
-
-
Haj-ali, V.1
Mohaddes, G.2
Babri, S.H.3
-
59
-
-
39449093463
-
Obese men respond to cognitive but not to catabolic brain insulin signaling
-
Hallschmid, M., Benedict, C., Schultes, B., Born, J., and Kern, W. (2008). Obese men respond to cognitive but not to catabolic brain insulin signaling. Int. J. Obes. 32, 275-282. doi: 10.1038/sj.ijo.0803722
-
(2008)
Int. J. Obes
, vol.32
, pp. 275-282
-
-
Hallschmid, M.1
Benedict, C.2
Schultes, B.3
Born, J.4
Kern, W.5
-
60
-
-
7044241101
-
Intranasal insulin reduces body fat in men but not in women
-
Hallschmid, M., Benedict, C., Schultes, B., Fehm, H.-L., Born, J., and Kern, W. (2004). Intranasal insulin reduces body fat in men but not in women. Diabetes 53, 3024-3029. doi: 10.2337/diabetes.53.11.3024
-
(2004)
Diabetes
, vol.53
, pp. 3024-3029
-
-
Hallschmid, M.1
Benedict, C.2
Schultes, B.3
Fehm, H.-L.4
Born, J.5
Kern, W.6
-
61
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy, J., and Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. doi: 10.1126/science.1072994
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
62
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., et al. (2002). A central role for JNK in obesity and insulin resistance. Nature 420, 333-336. doi: 10.1038/nature01137
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
-
64
-
-
84974594070
-
Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults
-
Hoscheidt, S. M., Starks, E. J., Oh, J. M., Zetterberg, H., Blennow, K., Krause, R. A., et al. (2016). Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults. J. Alzheimers Dis. 52, 1373-1383. doi: 10.3233/JAD-160110
-
(2016)
J. Alzheimers Dis
, vol.52
, pp. 1373-1383
-
-
Hoscheidt, S.M.1
Starks, E.J.2
Oh, J.M.3
Zetterberg, H.4
Blennow, K.5
Krause, R.A.6
-
65
-
-
84890528022
-
Biomarker modeling of Alzheimer's disease
-
Jack, C. R., and Holtzman, D. M. (2013). Biomarker modeling of Alzheimer's disease. Neuron 80, 1347-1358. doi: 10.1016/j.neuron.2013.12.003
-
(2013)
Neuron
, vol.80
, pp. 1347-1358
-
-
Jack, C.R.1
Holtzman, D.M.2
-
66
-
-
84872379077
-
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
-
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., et al. (2013). Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 12, 207-216. doi: 10.1016/S1474-4422(12)70291-0
-
(2013)
Lancet Neurol
, vol.12
, pp. 207-216
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Petersen, R.C.4
Weiner, M.W.5
Aisen, P.S.6
-
67
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., et al. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 9, 119-128. doi: 10.1016/S1474-4422(09)70299-6
-
(2010)
Lancet Neurol
, vol.9
, pp. 119-128
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
Shaw, L.M.4
Aisen, P.S.5
Weiner, M.W.6
-
68
-
-
85026298332
-
Impairment of the glymphatic system after diabetes
-
Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., et al. (2017). Impairment of the glymphatic system after diabetes. J. Cereb. Blood Flow Metab. 37, 1326-1337. doi: 10.1177/0271678X16654702
-
(2017)
J. Cereb. Blood Flow Metab
, vol.37
, pp. 1326-1337
-
-
Jiang, Q.1
Zhang, L.2
Ding, G.3
Davoodi-Bojd, E.4
Li, Q.5
Li, L.6
-
69
-
-
84889589925
-
Amyloid burden and neural function in people at risk for Alzheimer's disease
-
Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., et al. (2014). Amyloid burden and neural function in people at risk for Alzheimer's disease. Neurobiol. Aging 35, 576-584. doi: 10.1016/j.neurobiolaging.2013.09.028
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 576-584
-
-
Johnson, S.C.1
Christian, B.T.2
Okonkwo, O.C.3
Oh, J.M.4
Harding, S.5
Xu, G.6
-
70
-
-
84875416046
-
Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms
-
Kamal, A., Ramakers, G. M. J., Gispen, W. H., Biessels, G. J., and Al Ansari, A. (2013). Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms. Exp. Brain Res. 226, 45-51. doi: 10.1007/s00221-013-3409-4
-
(2013)
Exp. Brain Res
, vol.226
, pp. 45-51
-
-
Kamal, A.1
Ramakers, G.M.J.2
Gispen, W.H.3
Biessels, G.J.4
Al Ansari, A.5
-
71
-
-
68249134074
-
The role of apolipoprotein E in Alzheimer's disease
-
Kim, J., Basak, J. M., and Holtzman, D. M. (2009). The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303. doi: 10.1016/j.neuron.2009.06.026
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
72
-
-
85019626874
-
Effects of the insulin sensitizer metformin in alzheimer disease: pilot data from a randomized placebo-controlled crossover study
-
Koenig, A. M., Mechanic-Hamilton, D., Xie, S. X., Combs, M. F., Cappola, A. R., Xie, L., et al. (2017). Effects of the insulin sensitizer metformin in alzheimer disease: pilot data from a randomized placebo-controlled crossover study. Alzheimer Dis. Assoc. Disord. 31, 107-113. doi: 10.1097/WAD.0000000000000202
-
(2017)
Alzheimer Dis. Assoc. Disord
, vol.31
, pp. 107-113
-
-
Koenig, A.M.1
Mechanic-Hamilton, D.2
Xie, S.X.3
Combs, M.F.4
Cappola, A.R.5
Xie, L.6
-
73
-
-
0141725404
-
Intranasally administered insulin intended for prevention of type 1 diabetes-a safety study in healthy adults
-
Kupila, A., Sipilä, J., Keskinen, P., Simell, T., Knip, M., Pulkki, K., et al. (2003). Intranasally administered insulin intended for prevention of type 1 diabetes-a safety study in healthy adults. Diabetes. Metab. Res. Rev. 19, 415-420. doi: 10.1002/dmrr.397
-
(2003)
Diabetes. Metab. Res. Rev
, vol.19
, pp. 415-420
-
-
Kupila, A.1
Sipilä, J.2
Keskinen, P.3
Simell, T.4
Knip, M.5
Pulkki, K.6
-
74
-
-
34247601573
-
Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity
-
Last, D., Alsop, D. C., Abduljalil, A. M., Marquis, R. P., de Bazelaire, C., Hu, K., et al. (2007). Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care 30, 1193-1199. doi: 10.2337/dc06-2052
-
(2007)
Diabetes Care
, vol.30
, pp. 1193-1199
-
-
Last, D.1
Alsop, D.C.2
Abduljalil, A.M.3
Marquis, R.P.4
de Bazelaire, C.5
Hu, K.6
-
75
-
-
0036465353
-
Spatial memory deficit and emotional abnormality in OLETF rats
-
Li, X. L., Aou, S., Hori, T., and Oomura, Y. (2002). Spatial memory deficit and emotional abnormality in OLETF rats. Physiol. Behav. 75, 15-23. doi: 10.1016/S0031-9384(01)00627-8
-
(2002)
Physiol. Behav
, vol.75
, pp. 15-23
-
-
Li, X.L.1
Aou, S.2
Hori, T.3
Oomura, Y.4
-
76
-
-
79960896430
-
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
-
Liu, Y., Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C.-X. (2011). Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J. Pathol. 225, 54-62. doi: 10.1002/path.2912
-
(2011)
J. Pathol
, vol.225
, pp. 54-62
-
-
Liu, Y.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
Gong, C.-X.5
-
77
-
-
70349216418
-
Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease
-
Liu, Y., Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C.-X. (2009). Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. J. Neurochem. 111, 242-249. doi: 10.1111/j.1471-4159.2009.06320.x
-
(2009)
J. Neurochem
, vol.111
, pp. 242-249
-
-
Liu, Y.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
Gong, C.-X.5
-
78
-
-
84938529529
-
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
-
Lochhead, J. J., Wolak, D. J., Pizzo, M. E., and Thorne, R. G. (2015). Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. J. Cereb. Blood Flow Metab. 35, 371-381. doi: 10.1038/jcbfm.2014.215
-
(2015)
J. Cereb. Blood Flow Metab
, vol.35
, pp. 371-381
-
-
Lochhead, J.J.1
Wolak, D.J.2
Pizzo, M.E.3
Thorne, R.G.4
-
79
-
-
84879139320
-
Glucagon-like peptide-1 receptor in the brain: role in neuroendocrine control of energy metabolism and treatment target for obesity
-
Lockie, S. H. (2013). Glucagon-like peptide-1 receptor in the brain: role in neuroendocrine control of energy metabolism and treatment target for obesity. J. Neuroendocrinol. 25, 597-604. doi: 10.1111/jne.12039
-
(2013)
J. Neuroendocrinol
, vol.25
, pp. 597-604
-
-
Lockie, S.H.1
-
80
-
-
84961773449
-
Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial
-
Luchsinger, J. A., Perez, T., Chang, H., Mehta, P., Steffener, J., Pradabhan, G., et al. (2016). Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial. J. Alzheimers. Dis. 51, 501-514. doi: 10.3233/JAD-150493
-
(2016)
J. Alzheimers. Dis
, vol.51
, pp. 501-514
-
-
Luchsinger, J.A.1
Perez, T.2
Chang, H.3
Mehta, P.4
Steffener, J.5
Pradabhan, G.6
-
81
-
-
84930405360
-
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
-
MacAuley, S. L., Stanley, M., Caesar, E. E., Yamada, S. A., Raichle, M. E., Perez, R., et al. (2015). Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. J. Clin. Invest. 125, 2463-2467. doi: 10.1172/JCI79742
-
(2015)
J. Clin. Invest
, vol.125
, pp. 2463-2467
-
-
MacAuley, S.L.1
Stanley, M.2
Caesar, E.E.3
Yamada, S.A.4
Raichle, M.E.5
Perez, R.6
-
82
-
-
85008323058
-
Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline
-
MacKlin, L., Griffith, C. M., Cai, Y., Rose, G. M., Yan, X.-X., and Patrylo, P. R. (2017). Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline. Exp. Gerontol. 88, 9-18. doi: 10.1016/j.exger.2016.12.019
-
(2017)
Exp. Gerontol
, vol.88
, pp. 9-18
-
-
MacKlin, L.1
Griffith, C.M.2
Cai, Y.3
Rose, G.M.4
Yan, X.-X.5
Patrylo, P.R.6
-
83
-
-
84957061064
-
The microtubule-associated protein tau and its relevance for pancreatic beta cells
-
Maj, M., Hoermann, G., Rasul, S., Base, W., Wagner, L., and Attems, J. (2016). The microtubule-associated protein tau and its relevance for pancreatic beta cells. J. Diabetes Res. 2016:1964634. doi: 10.1155/2016/1964634
-
(2016)
J. Diabetes Res
, vol.2016
-
-
Maj, M.1
Hoermann, G.2
Rasul, S.3
Base, W.4
Wagner, L.5
Attems, J.6
-
84
-
-
5444273804
-
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
-
Mandelkow, E.-M., Thies, E., Trinczek, B., Biernat, J., and Mandelkow, E. (2004). MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J. Cell Biol. 167, 99-110. doi: 10.1083/jcb.200401085
-
(2004)
J. Cell Biol
, vol.167
, pp. 99-110
-
-
Mandelkow, E.-M.1
Thies, E.2
Trinczek, B.3
Biernat, J.4
Mandelkow, E.5
-
85
-
-
85027337943
-
Tau deletion promotes brain insulin resistance
-
Marciniak, E., Leboucher, A., Caron, E., Ahmed, T., Tailleux, A., Dumont, J., et al. (2017). Tau deletion promotes brain insulin resistance. J. Exp. Med. 214, 2257-2269. doi: 10.1084/jem.20161731
-
(2017)
J. Exp. Med
, vol.214
, pp. 2257-2269
-
-
Marciniak, E.1
Leboucher, A.2
Caron, E.3
Ahmed, T.4
Tailleux, A.5
Dumont, J.6
-
86
-
-
84886592674
-
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
-
McClean, P. L., and Hölscher, C. (2014). Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 76, 57-67. doi: 10.1016/j.neuropharm.2013.08.005
-
(2014)
Neuropharmacology
, vol.76
, pp. 57-67
-
-
McClean, P.L.1
Hölscher, C.2
-
87
-
-
77649187436
-
Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
-
McClean, P. L., Gault, V. A., Harriott, P., and Hölscher, C. (2010). Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur. J. Pharmacol. 630, 158-162. doi: 10.1016/j.ejphar.2009.12.023
-
(2010)
Eur. J. Pharmacol
, vol.630
, pp. 158-162
-
-
McClean, P.L.1
Gault, V.A.2
Harriott, P.3
Hölscher, C.4
-
88
-
-
79955749452
-
The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
-
McClean, P. L., Parthsarathy, V., Faivre, E., and Holscher, C. (2011). The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594. doi: 10.1523/JNEUROSCI.0529-11.2011
-
(2011)
J. Neurosci
, vol.31
, pp. 6587-6594
-
-
McClean, P.L.1
Parthsarathy, V.2
Faivre, E.3
Holscher, C.4
-
89
-
-
77952545095
-
Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
-
McNay, E. C., Ong, C. T., McCrimmon, R. J., Cresswell, J., Bogan, J. S., and Sherwin, R. S. (2010). Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol. Learn. Mem. 93, 546-553. doi: 10.1016/j.nlm.2010.02.002
-
(2010)
Neurobiol. Learn. Mem
, vol.93
, pp. 546-553
-
-
McNay, E.C.1
Ong, C.T.2
McCrimmon, R.J.3
Cresswell, J.4
Bogan, J.S.5
Sherwin, R.S.6
-
90
-
-
71349085957
-
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
-
Moloney, A. M., Griffin, R. J., Timmons, S., O'Connor, R., Ravid, R., and O'Neill, C. (2010). Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243. doi: 10.1016/j.neurobiolaging.2008.04.002
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 224-243
-
-
Moloney, A.M.1
Griffin, R.J.2
Timmons, S.3
O'Connor, R.4
Ravid, R.5
O'Neill, C.6
-
91
-
-
34247474865
-
Intra CA1 insulin microinjection improves memory consolidation and retrieval
-
Moosavi, M., Naghdi, N., and Choopani, S. (2007). Intra CA1 insulin microinjection improves memory consolidation and retrieval. Peptides 28, 1029-1034. doi: 10.1016/j.peptides.2007.02.010
-
(2007)
Peptides
, vol.28
, pp. 1029-1034
-
-
Moosavi, M.1
Naghdi, N.2
Choopani, S.3
-
92
-
-
84889571471
-
Impaired glycemia increases disease progression in mild cognitive impairment
-
Morris, J. K., Vidoni, E. D., Honea, R. A., and Burns, J. M., and Alzheimer's Disease Neuroimaging Initiative (2014). Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiol. Aging 35, 585-589. doi: 10.1016/j.neurobiolaging.2013.09.033
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 585-589
-
-
Morris, J.K.1
Vidoni, E.D.2
Honea, R.A.3
Burns, J.M.4
-
93
-
-
85010750365
-
Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease
-
Mullins, R. J., Mustapic, M., Goetzl, E. J., and Kapogiannis, D. (2017). Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease. Hum. Brain Mapp. 38, 1933-1940. doi: 10.1002/hbm.23494
-
(2017)
Hum. Brain Mapp
, vol.38
, pp. 1933-1940
-
-
Mullins, R.J.1
Mustapic, M.2
Goetzl, E.J.3
Kapogiannis, D.4
-
94
-
-
64549087258
-
Human cerebral neuropathology of Type 2 diabetes mellitus
-
Nelson, P. T., Smith, C. D., Abner, E. A., Schmitt, F. A., Scheff, S. W., Davis, G. J., et al. (2009). Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim. Biophys. Acta 1792, 454-469. doi: 10.1016/j.bbadis.2008.08.005
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 454-469
-
-
Nelson, P.T.1
Smith, C.D.2
Abner, E.A.3
Schmitt, F.A.4
Scheff, S.W.5
Davis, G.J.6
-
95
-
-
84870544823
-
Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase, LTP, and recognition memory
-
Nisticò, R., Cavallucci, V., Piccinin, S., Macrì, S., Pignatelli, M., Mehdawy, B., et al. (2012). Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase, LTP, and recognition memory. Neuromol. Med. 14, 262-269. doi: 10.1007/s12017-012-8184-z
-
(2012)
Neuromol. Med
, vol.14
, pp. 262-269
-
-
Nisticò, R.1
Cavallucci, V.2
Piccinin, S.3
Macrì, S.4
Pignatelli, M.5
Mehdawy, B.6
-
96
-
-
84896692580
-
Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes
-
Novak, V., Milberg, W., Hao, Y., Munshi, M., Novak, P., Galica, A., et al. (2014). Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care 37, 751-759. doi: 10.2337/dc13-1672
-
(2014)
Diabetes Care
, vol.37
, pp. 751-759
-
-
Novak, V.1
Milberg, W.2
Hao, Y.3
Munshi, M.4
Novak, P.5
Galica, A.6
-
97
-
-
0034012731
-
Intracerebroventricular insulin enhances memory in a passive-avoidance task
-
Park, C. R., Seeley, R. J., Craft, S., and Woods, S. C. (2000). Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol. Behav. 68, 509-514. doi: 10.1016/S0031-9384(99)00220-6
-
(2000)
Physiol. Behav
, vol.68
, pp. 509-514
-
-
Park, C.R.1
Seeley, R.J.2
Craft, S.3
Woods, S.C.4
-
98
-
-
84861512065
-
Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism
-
Pearson-Leary, J., and McNay, E. C. (2012). Intrahippocampal administration of amyloid-β(1-42) oligomers acutely impairs spatial working memory, insulin signaling, and hippocampal metabolism. J. Alzheimers Dis. 30, 413-422. doi: 10.3233/JAD-2012-112192
-
(2012)
J. Alzheimers Dis
, vol.30
, pp. 413-422
-
-
Pearson-Leary, J.1
McNay, E.C.2
-
99
-
-
0038100358
-
Role of protein kinase B in Alzheimer's neurofibrillary pathology
-
Pei, J.-J., Khatoon, S., An, W.-L., Nordlinder, M., Tanaka, T., Braak, H., et al. (2003). Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol. 105, 381-392. doi: 10.1007/s00401-002-0657-y
-
(2003)
Acta Neuropathol
, vol.105
, pp. 381-392
-
-
Pei, J.-J.1
Khatoon, S.2
An, W.-L.3
Nordlinder, M.4
Tanaka, T.5
Braak, H.6
-
100
-
-
3242765976
-
Fasting insulin and incident dementia in an elderly population of Japanese-American men
-
Peila, R., Rodriguez, B. L., White, L. R., and Launer, L. J. (2004). Fasting insulin and incident dementia in an elderly population of Japanese-American men. Neurology 63, 228-233. doi: 10.1212/01.WNL.0000129989.28404.9B
-
(2004)
Neurology
, vol.63
, pp. 228-233
-
-
Peila, R.1
Rodriguez, B.L.2
White, L.R.3
Launer, L.J.4
-
101
-
-
70350061949
-
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
-
Perrin, R. J., Fagan, A. M., and Holtzman, D. M. (2009). Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 461, 916-922. doi: 10.1038/nature08538
-
(2009)
Nature
, vol.461
, pp. 916-922
-
-
Perrin, R.J.1
Fagan, A.M.2
Holtzman, D.M.3
-
102
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., et al. (1998). Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J. Biol. Chem. 273, 32730-32738
-
(1998)
J. Biol. Chem
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
-
103
-
-
31844434789
-
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
-
Reger, M. A., Watson, G. S., Frey, W. H., Baker, L. D., Cholerton, B., Keeling, M. L., et al. (2006). Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol. Aging 27, 451-458. doi: 10.1016/j.neurobiolaging.2005.03.016
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 451-458
-
-
Reger, M.A.1
Watson, G.S.2
Frey, W.H.3
Baker, L.D.4
Cholerton, B.5
Keeling, M.L.6
-
104
-
-
47849123972
-
Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
-
Reger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., et al. (2008a). Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J. Alzheimers Dis. 13, 323-331. doi: 10.3233/JAD-2008-13309
-
(2008)
J. Alzheimers Dis
, vol.13
, pp. 323-331
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Baker, L.D.4
Cholerton, B.5
Fishel, M.A.6
-
105
-
-
40349091597
-
Intranasal insulin improves cognition and modulates-amyloid in early AD
-
Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., et al. (2008b). Intranasal insulin improves cognition and modulates-amyloid in early AD. Neurology 70, 440-448. doi: 10.1212/01.WNL.0000265401.62434.36
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Wilkinson, C.W.4
Baker, L.D.5
Cholerton, B.6
-
106
-
-
84901299033
-
Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
-
Roberts, R. O., Knopman, D. S., Cha, R. H., Mielke, M. M., Pankratz, V. S., Boeve, B. F., et al. (2014). Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. J. Nucl. Med. 55, 759-764. doi: 10.2967/jnumed.113.132647
-
(2014)
J. Nucl. Med
, vol.55
, pp. 759-764
-
-
Roberts, R.O.1
Knopman, D.S.2
Cha, R.H.3
Mielke, M.M.4
Pankratz, V.S.5
Boeve, B.F.6
-
107
-
-
84975862605
-
Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1a and increases in Aβ1-40/42 and phospho-tau may Abet Alzheimer development
-
Sajan, M., Hansen, B., Ivey, R., Sajan, J., Ari, C., Song, S., et al. (2016). Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1a and increases in Aβ1-40/42 and phospho-tau may Abet Alzheimer development. Diabetes 65, 1892-1903. doi: 10.2337/db15-1428
-
(2016)
Diabetes
, vol.65
, pp. 1892-1903
-
-
Sajan, M.1
Hansen, B.2
Ivey, R.3
Sajan, J.4
Ari, C.5
Song, S.6
-
108
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., et al. (2004). Role for neuronal insulin resistance in neurodegenerative diseases. Proc. Natl. Acad. Sci. U.S.A. 101, 3100-3105. doi: 10.1073/pnas.0308724101
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
-
109
-
-
7444265179
-
Brain insulin impairs amyloid-(1-40) clearance from the brain
-
Shiiki, T., Ohtsuki, S., Kurihara, A., Naganuma, H., Nishimura, K., Tachikawa, M., et al. (2004). Brain insulin impairs amyloid-(1-40) clearance from the brain. J. Neurosci. 24, 9632-9637. doi: 10.1523/JNEUROSCI.2236-04.2004
-
(2004)
J. Neurosci
, vol.24
, pp. 9632-9637
-
-
Shiiki, T.1
Ohtsuki, S.2
Kurihara, A.3
Naganuma, H.4
Nishimura, K.5
Tachikawa, M.6
-
110
-
-
77957898888
-
How does diabetes accelerate Alzheimer disease pathology?
-
Sims-Robinson, C., Kim, B., Rosko, A., and Feldman, E. L. (2010). How does diabetes accelerate Alzheimer disease pathology? Nat. Rev. Neurol. 6, 551-559. doi: 10.1038/nrneurol.2010.130
-
(2010)
Nat. Rev. Neurol
, vol.6
, pp. 551-559
-
-
Sims-Robinson, C.1
Kim, B.2
Rosko, A.3
Feldman, E.L.4
-
111
-
-
56349119351
-
Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
-
Small, S. A., and Duff, K. (2008). Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 60, 534-542. doi: 10.1016/j.neuron.2008.11.007
-
(2008)
Neuron
, vol.60
, pp. 534-542
-
-
Small, S.A.1
Duff, K.2
-
112
-
-
77952496309
-
Functional alterations in memory networks in early Alzheimer's disease
-
Sperling, R. A., Dickerson, B. C., Pihlajamaki, M., Vannini, P., LaViolette, P. S., Vitolo, O. V., et al. (2010). Functional alterations in memory networks in early Alzheimer's disease. Neuromol. Med. 12, 27-43. doi: 10.1007/s12017-009-8109-7
-
(2010)
Neuromol. Med
, vol.12
, pp. 27-43
-
-
Sperling, R.A.1
Dickerson, B.C.2
Pihlajamaki, M.3
Vannini, P.4
LaViolette, P.S.5
Vitolo, O.V.6
-
113
-
-
84930453413
-
Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOEe4 carriers
-
Starks, E. J., Patrick O'Grady, J., Hoscheidt, S. M., Racine, A. M., Carlsson, C. M., Zetterberg, H., et al. (2015). Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOEe4 carriers. J. Alzheimers. Dis. 46, 525-533. doi: 10.3233/JAD-150072
-
(2015)
J. Alzheimers. Dis
, vol.46
, pp. 525-533
-
-
Starks, E.J.1
Patrick O'Grady, J.2
Hoscheidt, S.M.3
Racine, A.M.4
Carlsson, C.M.5
Zetterberg, H.6
-
114
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
-
Steen, E., Terry, B. M., Rivera, E. J., Cannon, J. L., Neely, T. R., Tavares, R., et al. (2005). Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J. Alzheimers Dis. 7, 63-80. doi: 10.3233/JAD-2005-7107
-
(2005)
J. Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
-
115
-
-
84907762426
-
The effect of insulin and insulin-like growth factors on hippocampus-and amygdala-dependent long-term memory formation
-
Stern, S. A., Chen, D. Y., and Alberini, C. M. (2014). The effect of insulin and insulin-like growth factors on hippocampus-and amygdala-dependent long-term memory formation. Learn. Mem. 21, 556-563. doi: 10.1101/lm.029348.112
-
(2014)
Learn. Mem
, vol.21
, pp. 556-563
-
-
Stern, S.A.1
Chen, D.Y.2
Alberini, C.M.3
-
116
-
-
84872603163
-
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
-
Stöhr, O., Schilbach, K., Moll, L., Hettich, M. M., Freude, S., Wunderlich, F. T., et al. (2013). Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. Age 35, 83-101. doi: 10.1007/s11357-011-9333-2
-
(2013)
Age
, vol.35
, pp. 83-101
-
-
Stöhr, O.1
Schilbach, K.2
Moll, L.3
Hettich, M.M.4
Freude, S.5
Wunderlich, F.T.6
-
117
-
-
39749137437
-
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
-
Stranahan, A. M., Arumugam, T. V., Cutler, R. G., Lee, K., Egan, J. M., and Mattson, M. P. (2008). Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat. Neurosci. 11, 309-317. doi: 10.1038/nn2055
-
(2008)
Nat. Neurosci
, vol.11
, pp. 309-317
-
-
Stranahan, A.M.1
Arumugam, T.V.2
Cutler, R.G.3
Lee, K.4
Egan, J.M.5
Mattson, M.P.6
-
118
-
-
0027407565
-
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., et al. (1993). Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 90, 1977-1981
-
(1993)
Proc. Natl. Acad. Sci. U.S.A
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
-
119
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., et al. (2012). Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122, 1316-1338. doi: 10.1172/JCI59903
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.-Y.2
Kazi, H.3
Han, L.-Y.4
Bakshi, K.P.5
Stucky, A.6
-
120
-
-
84883824146
-
Glucose intolerance, insulin resistance, and pathological features of alzheimer disease in the baltimore longitudinal study of aging
-
Thambisetty, M., Metter, E. J., Yang, A., Dolan, H., Marano, C., Zonderman, A. B., et al. (2013). Glucose intolerance, insulin resistance, and pathological features of alzheimer disease in the baltimore longitudinal study of aging. JAMA Neurol. 70 1167-1172. doi: 10.1001/jamaneurol.2013.284
-
(2013)
JAMA Neurol
, vol.70
, pp. 1167-1172
-
-
Thambisetty, M.1
Metter, E.J.2
Yang, A.3
Dolan, H.4
Marano, C.5
Zonderman, A.B.6
-
121
-
-
85017390597
-
Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans
-
Thienel, M., Wilhelm, I., Benedict, C., Born, J., and Hallschmid, M. (2017). Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans. Neurobiol. Aging 54, 170-174. doi: 10.1016/j.neurobiolaging.2017.03.006
-
(2017)
Neurobiol. Aging
, vol.54
, pp. 170-174
-
-
Thienel, M.1
Wilhelm, I.2
Benedict, C.3
Born, J.4
Hallschmid, M.5
-
122
-
-
85018469965
-
Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation
-
van der Harg, J. M., Eggels, L., Bangel, F. N., Ruigrok, S. R., Zwart, R., Hoozemans, J. J. M., et al. (2017). Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation. Neurobiol. Dis. 103, 163-173. doi: 10.1016/j.nbd.2017.04.005
-
(2017)
Neurobiol. Dis
, vol.103
, pp. 163-173
-
-
van der Harg, J.M.1
Eggels, L.2
Bangel, F.N.3
Ruigrok, S.R.4
Zwart, R.5
Hoozemans, J.J.M.6
-
123
-
-
84911895310
-
Insulin reverses the high-fat diet-induced increase in brain a and improves memory in an animal model of Alzheimer disease
-
Vandal, M., White, P. J., Tremblay, C., St-Amour, I., Chevrier, G., Emond, V., et al. (2014). Insulin reverses the high-fat diet-induced increase in brain a and improves memory in an animal model of Alzheimer disease. Diabetes 63, 4291-4301. doi: 10.2337/db14-0375
-
(2014)
Diabetes
, vol.63
, pp. 4291-4301
-
-
Vandal, M.1
White, P.J.2
Tremblay, C.3
St-Amour, I.4
Chevrier, G.5
Emond, V.6
-
124
-
-
85021760631
-
Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease
-
Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S., et al. (2017). Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease. Neurobiol. Aging 58, 1-13. doi: 10.1016/j.neurobiolaging.2017.06.003
-
(2017)
Neurobiol. Aging
, vol.58
, pp. 1-13
-
-
Velazquez, R.1
Tran, A.2
Ishimwe, E.3
Denner, L.4
Dave, N.5
Oddo, S.6
-
125
-
-
77958592688
-
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
-
Wang, X., Zheng, W., Xie, J.-W., Wang, T., Wang, S.-L., Teng, W.-P., et al. (2010). Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Mol. Neurodegener. 5:46. doi: 10.1186/1750-1326-5-46
-
(2010)
Mol. Neurodegener
, vol.5
, pp. 46
-
-
Wang, X.1
Zheng, W.2
Xie, J.-W.3
Wang, T.4
Wang, S.-L.5
Teng, W.-P.6
-
126
-
-
84951567833
-
Tau in physiology and pathology
-
Wang, Y., and Mandelkow, E. (2016). Tau in physiology and pathology. Nat. Rev. Neurosci. 17, 5-21. doi: 10.1038/nrn.2015.1
-
(2016)
Nat. Rev. Neurosci
, vol.17
, pp. 5-21
-
-
Wang, Y.1
Mandelkow, E.2
-
127
-
-
0347413819
-
Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use
-
Watson, J. M., Sherwin, R. S., Deary, I. J., Scott, L., and Kerr, D. (2003). Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin. Sci. 104, 447-454. doi: 10.1042/cs1040447
-
(2003)
Clin. Sci
, vol.104
, pp. 447-454
-
-
Watson, J.M.1
Sherwin, R.S.2
Deary, I.J.3
Scott, L.4
Kerr, D.5
-
128
-
-
84929295476
-
Insulin resistance predicts brain amyloid deposition in late middle-aged adults
-
Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., et al. (2015). Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimers Dement. 11, 504.e1-510.e1. doi: 10.1016/j.jalz.2014.03.011
-
(2015)
Alzheimers Dement
, vol.11
, pp. 504.e1-510.e1
-
-
Willette, A.A.1
Johnson, S.C.2
Birdsill, A.C.3
Sager, M.A.4
Christian, B.5
Baker, L.D.6
-
129
-
-
27744486073
-
Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
-
Winocur, G., Greenwood, C. E., Piroli, G. G., Grillo, C., Reznikov, L. R., Reagan, L. P., et al. (2005). Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behav. Neurosci. 119, 1389-1395. doi: 10.1037/0735-7044.119.5.1389
-
(2005)
Behav. Neurosci
, vol.119
, pp. 1389-1395
-
-
Winocur, G.1
Greenwood, C.E.2
Piroli, G.G.3
Grillo, C.4
Reznikov, L.R.5
Reagan, L.P.6
-
130
-
-
0003986552
-
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
-
Wischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., et al. (1988). Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 85, 4506-4510
-
(1988)
Proc. Natl. Acad. Sci. U.S.A
, vol.85
, pp. 4506-4510
-
-
Wischik, C.M.1
Novak, M.2
Thøgersen, H.C.3
Edwards, P.C.4
Runswick, M.J.5
Jakes, R.6
-
131
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
Woods, S. C., Lotter, E. C., McKay, L. D., and Porte, D. (1979). Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282, 503-505
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte, D.4
-
132
-
-
84885775321
-
Sleep drives metabolite clearance from the adult brain
-
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., et al. (2013). Sleep drives metabolite clearance from the adult brain. Science 342, 373-377. doi: 10.1126/science.1241224
-
(2013)
Science
, vol.342
, pp. 373-377
-
-
Xie, L.1
Kang, H.2
Xu, Q.3
Chen, M.J.4
Liao, Y.5
Thiyagarajan, M.6
-
133
-
-
84903194920
-
Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease
-
Yarchoan, M., and Arnold, S. E. (2014). Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease. Diabetes 63, 2253-2261. doi: 10.2337/db14-0287
-
(2014)
Diabetes
, vol.63
, pp. 2253-2261
-
-
Yarchoan, M.1
Arnold, S.E.2
-
134
-
-
84939895058
-
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies
-
Yarchoan, M., Toledo, J. B., Lee, E. B., Arvanitakis, Z., Kazi, H., Han, L.-Y., et al. (2014). Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathol. 128, 679-689. doi: 10.1007/s00401-014-1328-5
-
(2014)
Acta Neuropathol
, vol.128
, pp. 679-689
-
-
Yarchoan, M.1
Toledo, J.B.2
Lee, E.B.3
Arvanitakis, Z.4
Kazi, H.5
Han, L.-Y.6
-
135
-
-
84962114196
-
Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes
-
Zhang, H., Hao, Y., Manor, B., Novak, P., Milberg, W., Zhang, J., et al. (2015). Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes 64, 1025-1034. doi: 10.2337/db14-1000
-
(2015)
Diabetes
, vol.64
, pp. 1025-1034
-
-
Zhang, H.1
Hao, Y.2
Manor, B.3
Novak, P.4
Milberg, W.5
Zhang, J.6
-
136
-
-
85009085851
-
An updated meta-analysis of cohort studies: diabetes and risk of Alzheimer's disease
-
Zhang, J., Chen, C., Hua, S., Liao, H., Wang, M., Xiong, Y., et al. (2017). An updated meta-analysis of cohort studies: diabetes and risk of Alzheimer's disease. Diabetes Res. Clin. Pract. 124, 41-47. doi: 10.1016/j.diabres.2016.10.024
-
(2017)
Diabetes Res. Clin. Pract
, vol.124
, pp. 41-47
-
-
Zhang, J.1
Chen, C.2
Hua, S.3
Liao, H.4
Wang, M.5
Xiong, Y.6
|