Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction

CNS Neuroscience and Therapeutics

Volumn 22, Issue 4, 2016, Pages 291-297

  Chao, A Ching ^a   Lee, Tai Chi ^b   Juo, Suh Hang Hank ^b   Yang, Ding I ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Amyloid precursor protein; High glucose; Human umbilical vein endothelial cells; Junctional permeability

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CLAUDIN 5; GLUCOSE; JUNCTIONAL ADHESION MOLECULE A; JUNCTIONAL ADHESION MOLECULE C; OCCLUDIN; PROTEIN ZO1; TIGHT JUNCTION PROTEIN; VASCULAR ENDOTHELIAL CADHERIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APP PROTEIN, HUMAN; CELL ADHESION MOLECULE; CLDN5 PROTEIN, HUMAN; JAM3 PROTEIN, HUMAN; MESSENGER RNA; OCLN PROTEIN, HUMAN; PEPTIDE FRAGMENT; TJP1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; MOLECULAR BIOLOGY; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; TIGHT JUNCTION; UMBILICAL VEIN ENDOTHELIAL CELL; CAPILLARY PERMEABILITY; CELL CULTURE; METABOLISM; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CELL ADHESION MOLECULES; CELL SURVIVAL; CELLS, CULTURED; CLAUDIN-5; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERGLYCEMIA; OCCLUDIN; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84961208572     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12503     Document Type: Article

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