Central insulin administration improves odor cued reactivation of spatial memory in young men

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 1, 2015, Pages 212-219

  Brünner, Yvonne F ^a   Kofoet, Anja ^a   Benedict, Christian ^b   Freiherr, Jessica ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CORTICOTROPIN; GLUCOSE; HYDROCORTISONE; INSULIN; LEPTIN; PLACEBO;

ACCURACY; ADULT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DELAYED RECALL; EXPERIMENTAL DESIGN; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; IMMEDIATE RECALL; INTRANASAL DRUG ADMINISTRATION; LEARNING; MALE; NORMAL HUMAN; ODOR CUED REACTIVATION OF SPATIAL MEMORY; ODOR PLACE ASSOCIATION; ODOR RECOGNITION TEST; OLFACTORY DISCRIMINATION; PLEASANTNESS; RECALL; SENSORY SYSTEM PARAMETERS; SPATIAL MEMORY; STIMULUS RESPONSE; TASK PERFORMANCE; UNIVERSITY HOSPITAL; VISUAL FEEDBACK; YOUNG ADULT; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; ODOR; PHOTOSTIMULATION;

ADMINISTRATION, INTRANASAL; ADULT; CUES; DOUBLE-BLIND METHOD; HUMANS; INSULIN; MALE; MENTAL RECALL; ODORS; PHOTIC STIMULATION; SMELL; SPATIAL MEMORY; YOUNG ADULT;

EID: 84920627307     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3018     Document Type: Article

References (43)

1. Havrankova J, Roth J, Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature. 1978; 272:827-829.
2. Sara VR, Hall K, Von Holtz H, Humbel R, Sjögren B, Wetterberg L. Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGE-1) and 2 (IGF-2) and insulin throughout the adult human brain. Neurosci Lett. 1982;34:39-44.
3. Hallschmid M, Schultes B. Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders? Diabetologia. 2009;52:2264-2269.
4. Chapman CD, Frey WH 2nd, Craft S, et al. Intranasal treatment of central nervous system dysfunction in humans. Pharm Res. 2013; 30:2475-2484.
5. Benedict C, Brede S, S chiöth HB, et al. Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes. 2011;60:114-118.
6. Benedict C, Kern W, Schultes B , Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab. 2008;93: 1339-1344.
7. Hallschmid M, Benedict C, Born J, Fehm HL, Kern W. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man. Physiology Behavior. 2004;83:55-64.
8. Hallschmid M, Higgs S, Thienel M, Ott V, Lehnert H. Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. Diabetes. 2012;61:782-78 9.
9. Hallschmid M, Benedict C, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin reduces body fat in men but not in women. Diabetes. 2004;53:3024-3029.
10. H allschmid M, Benedict C, Schultes B, Born J, Kern W. Obese men respond to cognitive but not to catabolic brain insulin signaling. Int J Obes (Lond). 2008;32:275-282.
11. Benedict C, Halls chmid M, Schmitz K, et al. Intranasal insulin improves memory in humans: superiority of insulin aspart. Neuropsychopharmacology. 2007;32:239-243.
12. Benedict C, Hallschmid M, Schultes B, Born J, Kern W. Intranasal insulin to improve memory function in humans. Neuroendocrinology. 2007;86:136-142.
13. Freiherr J, Hallschmid M, Frey WH 2nd, et al. Intranasal insulin as a t reatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs. 2013;27:505-514.
14. Krug R, Benedict C, Born J, Hallschmid M. Comparable sensitivity of postmenopa usal and young women to the effects of intranasal insulin on food intake and working memory. J Clin Endocrinol Metab. 2010;95:E468-472.
15. Novak V, Milberg W, Hao Y, et al. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care. 2014;37:751-759.
16. Schiö th HB, Craft S, Brooks SJ, Frey WH 2nd, Benedict C. Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions. Mol Neurobiol. 2012;46:4-10.
17. Benedict C, Hallschmid M, Hatke A, et al. Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29: 1326-1334.
18. Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Archives of Neurology. 2012;69:29-38.
19. De Felice FG, Ferreira ST. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes. 2014;63:2262-2272.
20. Ferreira ST,Clarke JR,Bomfim TR,De Felice FG. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease Alzheimers Dement. 2014 10 S76-83.
21. Craft S, Peskind E, Schwartz MW , Schellenberg GD, Raskind M, Porte D Jr.Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology. 1998:50:164-168.
22. Kern W, Peters A, Fruehwald-Schultes B, Deininger E, Born J, Fehm HL. Improving influence of insulin on cognitive functions in humans. Neuroendocrinology. 2001;74:270-280.
23. Reger MA, Watson GS, Frey WH 2nd, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27:451-458.
24. Reger MA, Watson GS, Green PS, et al. Intranasal insulin improves cognition and modulates beta-Amyloid in early AD. Neurology. 2008;70:440-448.
25. Brünner YF, Benedict C, Freiherr J. Intranasal insulin reduces olfactory sensitivity in normosmic humans. J Clin Endocrinol Metab. 2013;98:E1626-1630.
26. Eichenbaum H. The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behavioural Brain Res. 2001; 127:199-207.
27. Shrager Y, Bayley PJ, Bontempi B, Hopkins RO, Squire LR. Spatial memory and the human hippocampus. Proc Natl Acad Sci USA. 2007;104:2961-2966.
28. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Arch General Psychiatry. 1992;49:624-629.
29. Winter LB, Steer RA, Jon es-Hicks L, Beck AT. Screening for major depression disorders in adolescent medical outpatients with the Beck Depression Inventory for Primary Care. J Adolesc Health. 1999;24: 389-394.
30. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatrics Soc. 2005;53:695-699.
31. Freiherr J, Gordon AR , Alden EC, et al. The 40-item Monell Extended Sniffin' Sticks Identification Test (MONEX-40). J Neurosci Methods. 2012;205:10-16.
32. Kobal G,HummelT, Sekinger B, Barz S, Roscher S, Wolf S. " Sniffin' sticks" : screening of olfactory performance. Rhinology. 1996;34: 222-226.
33. Gilbert PE, Pirogovsky E, Ferdon S, Brushfield AM, Murphy C. Differential effects of normal aging on memory for odor-place and object-place associations. Exp Aging Res. 2008;34:437-452.
34. Born J, Lange T, Ker n W, McGregor GP, Bickel U, Fehm HL. Sniffing neuropeptides: a transnasal approach to the human brain. Nature Neuroscience. 2002;5:514-516.
35. Stingl KT, Kullmann S, Guthoff M, Heni M, Fritsche A, Preissl H. Insulin modulation of magnetoencephalographic resting state dynamics in lean and obese subjects. Front Syst Neurosci. 2010;4:157.
36. Zhang H, Hao Y, Manor B, N ovak P, Milberg W, Zhang J, Fang J, Novak V. 2014 Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes. Diabetes. 2014; doi: 10.2337/db14-1000.
37. Howard JD, Plailly J, GrueschowM,Haynes JD, Gottfried JA. Odor quality coding and categorization in human posterior piriform cortex. Nature Neuroscience. 2009;12:932-938.
38. Rasch B, Büc hel C, Gais S, Born J. Odor cues during slow-wave sleep prompt declarative memory consolidation. Science. 2007;315: 1426-1429.
39. Havrankova J, Schmechel D, Roth J, Brownstein M. Identification of insulin in rat brain. Proc Natl Acad Sci USA. 1978;75:5737-5741.
40. Cerf-Ducastel B, Murphy C. FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects. Brain Res. 2003;986:39-53.
41. Murphy C. Loss of olfactory function in dementing disease Physiology Behavior. 1999 66 177-182.
42. Conti MZ, Vicini-Chilovi B, Riva M, et al. Odor identification deficit predicts clinical conversion from mild cognitive impairment to dementia due to Alzheimer's disease. Arch Clin Neuropsychology. 2013;28:391-399.
43. Shemesh E, Rudich A,Harman-BoehmI, Cukierman-Yaffe T. Effect of intranasal insulin on cognitive function: a systematic review. J Clin Endocrinol Metab. 2012;97:366-376.