Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore longitudinal study of aging

JAMA Neurology

Volumn 70, Issue 9, 2013, Pages 1167-1172

  Thambisetty, Madhav ^a   Metter, E Jeffrey ^a   Yang, An ^a   Dolan, Hillary ^b   Marano, Christopher ^b   Zonderman, Alan B ^a   Troncoso, Juan C ^c   Zhou, Yun ^c   Wong, Dean F ^c   Ferrucci, Luigi ^a   Egan, Josephine ^a   Resnick, Susan M ^a   O'Brien, Richard J ^b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PITTSBURGH COMPOUND B;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAAK SCORE; COHORT ANALYSIS; CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMER DISEASE SCORE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; ORAL GLUCOSE TOLERANCE TEST; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM;

EID: 84883824146     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2013.284     Document Type: Article

References (35)

1. Bruce DG, Casey GP, Grange V, et al Fremantle Cognition in Diabetes Study. Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study. Diabetes Res Clin Pract. 2003;61(1):59-67. (Pubitemid 36808844)
2. Arvanitakis Z, Bennett DA, Wilson RS, Barnes LL. Diabetes and cognitive systems in older black and white persons. Alzheimer Dis Assoc Disord. 2010;24(1):37-42.
3. Vanhanen M, Koivisto K, Kuusisto J, et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care. 1998;21(3):398-402. (Pubitemid 28101075)
4. Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci U S A. 2003;100(4):2019-2022. (Pubitemid 36254566)
5. Yaffe K, Falvey C, Hamilton N, et al. Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Arch Neurol. 2012;69(9):1170-1175.
6. Bourdel-Marchasson I, Dubroca B, Manciet G, Decamps A, Emeriau JP, Dartigues JF. Prevalence of diabetes and effect on quality of life in older French living in the community: the PAQUID Epidemiological Survey. J Am Geriatr Soc. 1997;45(3):295-301. (Pubitemid 27114301)
7. Lindeman RD, Romero LJ, LaRue A, et al New Mexico Elder Health Survey. A biethnic community survey of cognition in participants with type 2 diabetes, impaired glucose tolerance, and normal glucose tolerance: the New Mexico Elder Health Survey. Diabetes Care. 2001;24(9):1567-1572. (Pubitemid 33716450)
8. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetesmellitus and the risk of dementia: the Rotterdam Study. Neurology. 1999;53(9):1937-1942.
9. Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology. 2010;75(22):1982-1987.
10. Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetesmellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol. 2004;61(5):661-666. (Pubitemid 38637681)
11. Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004;53(2):474-481. (Pubitemid 38174565)
12. Ohara T, Doi Y, Ninomiya T, et al. Glucose tolerance status and risk of dementia in the community: the Hisayama Study. Neurology. 2011;77(12):1126-1134.
13. Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012;69(1):29-38.
14. Sims-Robinson C, Kim B, Rosko A, Feldman EL. How does diabetes accelerate Alzheimer disease pathology? Nat Rev Neurol. 2010;6(10):551-559.
15. Espeland MA, Bryan RN, Goveas JS, et al. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging Studies. Diabetes Care. 2013;36(1):90-97.
16. Dolan D, Troncoso J, Resnick SM, Crain BJ, Zonderman AB, O'Brien RJ. Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing. Brain. 2010;133(pt 8):2225-2231.
17. Resnick SM, Sojkova J, Zhou Y, et al. Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology. 2010;74(10):807-815.
18. Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ. Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol. 2008;64(2):168-176.
19. Sojkova J, Beason-Held L, Zhou Y, et al. Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern? J Nucl Med. 2008;49(9):1465-1471.
20. Zhou Y, Resnick SM, Ye W, et al. Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease. Neuroimage. 2007;36(2):298-312. (Pubitemid 46710457)
21. Metter EJ, Windham BG, Maggio M, et al. Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. Diabetes Care. 2008;31(5):1026-1030.
22. Muller DC, Elahi D, Tobin JD, Andres R. Insulin response during the oral glucose tolerance test: the role of age, sex, body fat and the pattern of fat distribution. Aging (Milano). 1996;8(1):13-21.
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419. (Pubitemid 15018832)
24. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239-259.
25. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41(4):479-486.
26. Verbeke G, Molenberghs G. Linear Mixed Models for Longitudinal Data. New York, NY: Springer; 2000.
27. Arvanitakis Z, Schneider JA, Wilson RS, et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology. 2006;67(11):1960-1965. (Pubitemid 44967371)
28. Heitner J, Dickson D. Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects: a retrospective postmortem immunocytochemical and histofluorescent study. Neurology. 1997;49(5):1306-1311. (Pubitemid 27495634)
29. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: amethod for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):214-223. http://ajpendo.physiology.org/content/237/3/E214.reprint. Accessed August 4, 2012.
30. Matsuzaki T, Sasaki K, Tanizaki Y, et al. Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama Study. Neurology. 2010;75(9):764-770.
31. Burns JM, Honea RA, Vidoni ED, Hutfles LJ, Brooks WM, Swerdlow RH. Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochim Biophys Acta. 2012;1822(3):333-339.
32. Laron Z. Insulin and the brain. Arch Physiol Biochem. 2009;115(2):112-116.
33. Duarte AI, Moreira PI, Oliveira CR. Insulin in central nervous system: more than just a peripheral hormone. J Aging Res. 2012;2012:384017. doi:10.1155/2012/384017.
34. Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122(4):1316-1338.
35. O'Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci. 2011;34:185-204.