Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

Cell Reports

Volumn 2, Issue 4, 2012, Pages 789-798

  Almeida, Sandra ^a   Zhang, Zhijun ^a   Coppola, Giovanni ^b   Mao, Wenjie ^a   Futai, Kensuke ^a   Karydas, Anna ^c   Geschwind, Michael D ^c   Tartaglia, M Carmela ^c   Gao, Fuying ^b   Gianni, Davide ^a   Sena Esteves, Miguel ^a   Geschwind, Daniel H ^b   Miller, Bruce L ^a   Farese, Robert V ^d,e,f   Gao, Fen Biao ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; OLIGOMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRANULIN; PROTEIN SERINE THREONINE KINASE; STAUROSPORINE; TRANSCRIPTION FACTOR SOX2; WORTMANNIN;

ADULT; AGED; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; ENZYME ACTIVITY; FIBROBLAST; FRONTOTEMPORAL DEMENTIA; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METHYLATION; MICROGLIA; NERVE CELL; NEUROIMAGING; NONSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; PGRN GENE; PLURIPOTENT STEM CELL; POINT MUTATION; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STOP CODON; TRANSGENE; VOLTAGE CLAMP;

CELL LINE; DOWN-REGULATION; FRONTOTEMPORAL DEMENTIA; HAPLOINSUFFICIENCY; HETEROZYGOTE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; STAUROSPORINE;

EID: 84868129402     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.09.007     Document Type: Article

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