메뉴 건너뛰기




Volumn 2, Issue 19, 2017, Pages

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85044824257     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.94298     Document Type: Article
Times cited : (32)

References (88)
  • 1
    • 0033581935 scopus 로고    scopus 로고
    • Selecting and maintaining a diverse T-cell repertoire
    • Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature. 1999;402(6759):255–262.
    • (1999) Nature , vol.402 , Issue.6759 , pp. 255-262
    • Goldrath, AW1    Bevan, MJ.2
  • 2
    • 0033136289 scopus 로고    scopus 로고
    • Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo
    • Laufer TM, Fan L, Glimcher LH. Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo. J Immunol. 1999;162(9):5078–5084.
    • (1999) J Immunol , vol.162 , Issue.9 , pp. 5078-5084
    • Laufer, TM1    Fan, L2    Glimcher, LH.3
  • 3
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–787.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S1    Yamaguchi, T2    Nomura, T3    Ono, M.4
  • 4
    • 84979582935 scopus 로고    scopus 로고
    • Dendritic cells as gatekeepers of tolerance
    • Waisman A, Lukas D, Clausen BE, Yogev N. Dendritic cells as gatekeepers of tolerance. Semin Immunopathol. 2017;39(2):153–163.
    • (2017) Semin Immunopathol , vol.39 , Issue.2 , pp. 153-163
    • Waisman, A1    Lukas, D2    Clausen, BE3    Yogev, N.4
  • 5
    • 84899475568 scopus 로고    scopus 로고
    • Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
    • Mahmud SA, et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014;15(5):473–481.
    • (2014) Nat Immunol , vol.15 , Issue.5 , pp. 473-481
    • Mahmud, SA1
  • 6
    • 84963533918 scopus 로고    scopus 로고
    • Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen
    • Perry JS, Hsieh CS. Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen. Immunol Rev. 2016;271(1):141–155.
    • (2016) Immunol Rev , vol.271 , Issue.1 , pp. 141-155
    • Perry, JS1    Hsieh, CS.2
  • 7
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: at the interface between tolerance and immunity
    • Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity. 2010;33(2):153–165.
    • (2010) Immunity , vol.33 , Issue.2 , pp. 153-165
    • Malek, TR1    Castro, I.2
  • 8
    • 41149124867 scopus 로고    scopus 로고
    • The control of CD4+CD25+Foxp3+ regulatory T cell survival
    • Pandiyan P, Lenardo MJ. The control of CD4+CD25+Foxp3+ regulatory T cell survival. Biol Direct. 2008;3:6.
    • (2008) Biol Direct , vol.3 , pp. 6
    • Pandiyan, P1    Lenardo, MJ.2
  • 9
    • 34247564147 scopus 로고    scopus 로고
    • Nonredundant roles for Stat5a/b in directly regulating Foxp3
    • Yao Z, et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood. 2007;109(10):4368–4375.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4368-4375
    • Yao, Z1
  • 10
    • 84978634373 scopus 로고    scopus 로고
    • T cell receptor signalling in the control of regulatory T cell differentiation and function
    • Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 2016;16(4):220–233.
    • (2016) Nat Rev Immunol , vol.16 , Issue.4 , pp. 220-233
    • Li, MO1    Rudensky, AY.2
  • 11
    • 84959420152 scopus 로고    scopus 로고
    • From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
    • [published online ahead of print February 25, 2016]
    • Bacchetta R, Barzaghi F, Roncarolo MG. From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation [published online ahead of print February 25, 2016]. Ann N Y Acad Sci. doi: 10.1111/nyas.13011.
    • Ann N Y Acad Sci
    • Bacchetta, R1    Barzaghi, F2    Roncarolo, MG.3
  • 12
    • 27944445790 scopus 로고    scopus 로고
    • CZH proteins: a new family of Rho-GEFs
    • (pt 21)
    • Meller N, Merlot S, Guda C. CZH proteins: a new family of Rho-GEFs. J Cell Sci. 2005;118(pt 21):4937–4946.
    • (2005) J Cell Sci , vol.118 , pp. 4937-4946
    • Meller, N1    Merlot, S2    Guda, C.3
  • 13
    • 34548472221 scopus 로고    scopus 로고
    • GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    • Côté JF, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 2007;17(8):383–393.
    • (2007) Trends Cell Biol , vol.17 , Issue.8 , pp. 383-393
    • Côté, JF1    Vuori, K.2
  • 14
    • 84861078339 scopus 로고    scopus 로고
    • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses
    • Harada Y, et al. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012;119(19):4451–4461.
    • (2012) Blood , vol.119 , Issue.19 , pp. 4451-4461
    • Harada, Y1
  • 15
    • 70449718702 scopus 로고    scopus 로고
    • Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
    • Randall KL, et al. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol. 2009;10(12):1283–1291.
    • (2009) Nat Immunol , vol.10 , Issue.12 , pp. 1283-1291
    • Randall, KL1
  • 16
    • 84991628476 scopus 로고    scopus 로고
    • A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton
    • Janssen E, et al. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016;126(10):3837–3851.
    • (2016) J Clin Invest , vol.126 , Issue.10 , pp. 3837-3851
    • Janssen, E1
  • 17
    • 84875226021 scopus 로고    scopus 로고
    • Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency
    • Mizesko MC, et al. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013;131(3):840–848.
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.3 , pp. 840-848
    • Mizesko, MC1
  • 18
    • 80055107954 scopus 로고    scopus 로고
    • DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
    • Randall KL, et al. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med. 2011;208(11):2305–2320.
    • (2011) J Exp Med , vol.208 , Issue.11 , pp. 2305-2320
    • Randall, KL1
  • 19
    • 84938738886 scopus 로고    scopus 로고
    • The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency
    • Engelhardt KR, et al. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015;136(2):402–412.
    • (2015) J Allergy Clin Immunol , vol.136 , Issue.2 , pp. 402-412
    • Engelhardt, KR1
  • 20
    • 71149115670 scopus 로고    scopus 로고
    • Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
    • e4
    • Engelhardt KR, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009;124(6):1289–302.e4.
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.6 , pp. 1289-1302
    • Engelhardt, KR1
  • 21
    • 70949098060 scopus 로고    scopus 로고
    • Combined immunodeficiency associated with DOCK8 mutations
    • Zhang Q, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med. 2009;361(21):2046–2055.
    • (2009) N Engl J Med , vol.361 , Issue.21 , pp. 2046-2055
    • Zhang, Q1
  • 22
    • 84908440532 scopus 로고    scopus 로고
    • Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells
    • Janssen E, et al. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. J Allergy Clin Immunol. 2014;134(6):1365–1374.
    • (2014) J Allergy Clin Immunol , vol.134 , Issue.6 , pp. 1365-1374
    • Janssen, E1
  • 23
    • 84861235270 scopus 로고    scopus 로고
    • Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait
    • Al-Herz W, et al. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012;143(3):266–272.
    • (2012) Clin Immunol , vol.143 , Issue.3 , pp. 266-272
    • Al-Herz, W1
  • 24
    • 84876441426 scopus 로고    scopus 로고
    • Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients
    • Alsum Z, et al. Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients. J Clin Immunol. 2013;33(1):55–67.
    • (2013) J Clin Immunol , vol.33 , Issue.1 , pp. 55-67
    • Alsum, Z1
  • 25
    • 84863985331 scopus 로고    scopus 로고
    • Additional diverse findings expand the clinical presentation of DOCK8 deficiency
    • Sanal O, et al. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. J Clin Immunol. 2012;32(4):698–708.
    • (2012) J Clin Immunol , vol.32 , Issue.4 , pp. 698-708
    • Sanal, O1
  • 26
    • 78449249501 scopus 로고    scopus 로고
    • Dedicator of cytokinesis 8 (DOCK8) deficiency
    • Su HC. Dedicator of cytokinesis 8 (DOCK8) deficiency. Curr Opin Allergy Clin Immunol. 2010;10(6):515–520.
    • (2010) Curr Opin Allergy Clin Immunol , vol.10 , Issue.6 , pp. 515-520
    • Su, HC.1
  • 27
    • 84938738886 scopus 로고    scopus 로고
    • The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency
    • Engelhardt KR, et al. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015;136(2):402–412.
    • (2015) J Allergy Clin Immunol , vol.136 , Issue.2 , pp. 402-412
    • Engelhardt, KR1
  • 28
    • 82255181388 scopus 로고    scopus 로고
    • DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory
    • Lambe T, et al. DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol. 2011;41(12):3423–3435.
    • (2011) Eur J Immunol , vol.41 , Issue.12 , pp. 3423-3435
    • Lambe, T1
  • 29
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity. 2009;30(6):899–911.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 899-911
    • Miyara, M1
  • 30
    • 84863229506 scopus 로고    scopus 로고
    • Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
    • Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012;188(6):2712–2721.
    • (2012) J Immunol , vol.188 , Issue.6 , pp. 2712-2721
    • Kwon, HS1    Lim, HW2    Wu, J3    Schnölzer, M4    Verdin, E5    Ott, M.6
  • 31
    • 85018470498 scopus 로고    scopus 로고
    • Reduced changes in protein compared to mRNA levels across non-proliferating tissues
    • Perl K, et al. Reduced changes in protein compared to mRNA levels across non-proliferating tissues. BMC Genomics. 2017;18(1):305.
    • (2017) BMC Genomics , vol.18 , Issue.1 , pp. 305
    • Perl, K1
  • 32
    • 0141920354 scopus 로고    scopus 로고
    • Comparing protein abundance and mRNA expression levels on a genomic scale
    • Greenbaum D, Colangelo C, Williams K, Gerstein M. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol. 2003;4(9):117.
    • (2003) Genome Biol , vol.4 , Issue.9 , pp. 117
    • Greenbaum, D1    Colangelo, C2    Williams, K3    Gerstein, M.4
  • 33
    • 72949089708 scopus 로고    scopus 로고
    • Global signatures of protein and mRNA expression levels
    • de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C. Global signatures of protein and mRNA expression levels. Mol Biosyst. 2009;5(12):1512–1526.
    • (2009) Mol Biosyst , vol.5 , Issue.12 , pp. 1512-1526
    • de Sousa Abreu, R1    Penalva, LO2    Marcotte, EM3    Vogel, C.4
  • 34
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton AM, Donovan EE, Piccirillo CA, Shevach EM. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol. 2004;172(11):6519–6523.
    • (2004) J Immunol , vol.172 , Issue.11 , pp. 6519-6523
    • Thornton, AM1    Donovan, EE2    Piccirillo, CA3    Shevach, EM.4
  • 35
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med. 2002;196(2):255–260.
    • (2002) J Exp Med , vol.196 , Issue.2 , pp. 255-260
    • Jonuleit, H1    Schmitt, E2    Kakirman, H3    Stassen, M4    Knop, J5    Enk, AH.6
  • 36
    • 84927178735 scopus 로고    scopus 로고
    • Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β
    • Palomares O, et al. Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β. Genes Immun. 2014;15(8):511–520.
    • (2014) Genes Immun , vol.15 , Issue.8 , pp. 511-520
    • Palomares, O1
  • 37
    • 33845485330 scopus 로고    scopus 로고
    • Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes
    • Li QZ, et al. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 2007;147(1):60–70.
    • (2007) Clin Exp Immunol , vol.147 , Issue.1 , pp. 60-70
    • Li, QZ1
  • 38
    • 0019980968 scopus 로고
    • Acute phase reactants of mice. I. Isolation of serum amyloid P-component (SAP) and its induction by a monokine
    • Le PT, Muller MT, Mortensen RF. Acute phase reactants of mice. I. Isolation of serum amyloid P-component (SAP) and its induction by a monokine. J Immunol. 1982;129(2):665–672.
    • (1982) J Immunol , vol.129 , Issue.2 , pp. 665-672
    • Le, PT1    Muller, MT2    Mortensen, RF.3
  • 39
    • 84927172388 scopus 로고    scopus 로고
    • Molecular mechanisms of IgE class switch recombination
    • Tong P, Wesemann DR. Molecular mechanisms of IgE class switch recombination. Curr Top Microbiol Immunol. 2015;388:21–37.
    • (2015) Curr Top Microbiol Immunol , vol.388 , pp. 21-37
    • Tong, P1    Wesemann, DR.2
  • 40
    • 84959872333 scopus 로고    scopus 로고
    • Role of regulatory T cell in the pathogenesis of inflammatory bowel disease
    • Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. Role of regulatory T cell in the pathogenesis of inflammatory bowel disease. World J Gastroenterol. 2016;22(7):2195–2205.
    • (2016) World J Gastroenterol , vol.22 , Issue.7 , pp. 2195-2205
    • Yamada, A1    Arakaki, R2    Saito, M3    Tsunematsu, T4    Kudo, Y5    Ishimaru, N.6
  • 41
    • 0025834232 scopus 로고
    • The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the alpha and beta subunits of the gastric proton pump [corrected]
    • Jones CM, Callaghan JM, Gleeson PA, Mori Y, Masuda T, Toh BH. The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the alpha and beta subunits of the gastric proton pump [corrected]. Gastroenterology. 1991;101(2):287–294.
    • (1991) Gastroenterology , vol.101 , Issue.2 , pp. 287-294
    • Jones, CM1    Callaghan, JM2    Gleeson, PA3    Mori, Y4    Masuda, T5    Toh, BH.6
  • 42
    • 0023152682 scopus 로고
    • Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies
    • Tung KS, et al. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. Am J Pathol. 1987;126(2):303–314.
    • (1987) Am J Pathol , vol.126 , Issue.2 , pp. 303-314
    • Tung, KS1
  • 43
    • 84866015194 scopus 로고    scopus 로고
    • Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation
    • Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT, Vijay-Kumar M. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One. 2012;7(9):e44328.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e44328
    • Chassaing, B1    Srinivasan, G2    Delgado, MA3    Young, AN4    Gewirtz, AT5    Vijay-Kumar, M.6
  • 44
    • 85016329426 scopus 로고    scopus 로고
    • Activation and functional specialization of regulatory T cells lead to the generation of Foxp3 instability
    • Zhang Z, Zhang W, Guo J, Gu Q, Zhu X, Zhou X. Activation and functional specialization of regulatory T cells lead to the generation of Foxp3 instability. J Immunol. 2017;198(7):2612–2625.
    • (2017) J Immunol , vol.198 , Issue.7 , pp. 2612-2625
    • Zhang, Z1    Zhang, W2    Guo, J3    Gu, Q4    Zhu, X5    Zhou, X.6
  • 45
    • 84949546369 scopus 로고    scopus 로고
    • Immune homeostasis enforced by co-localized effector and regulatory T cells
    • Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015;528(7581):225–230.
    • (2015) Nature , vol.528 , Issue.7581 , pp. 225-230
    • Liu, Z1    Gerner, MY2    Van Panhuys, N3    Levine, AG4    Rudensky, AY5    Germain, RN.6
  • 46
    • 84924283592 scopus 로고    scopus 로고
    • DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity
    • Zhang Q, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med. 2014;211(13):2549–2566.
    • (2014) J Exp Med , vol.211 , Issue.13 , pp. 2549-2566
    • Zhang, Q1
  • 47
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine AG, Arvey A, Jin W, Rudensky AY. Continuous requirement for the TCR in regulatory T cell function. Nat Immunol. 2014;15(11):1070–1078.
    • (2014) Nat Immunol , vol.15 , Issue.11 , pp. 1070-1078
    • Levine, AG1    Arvey, A2    Jin, W3    Rudensky, AY.4
  • 48
    • 34047117842 scopus 로고    scopus 로고
    • T-cell-receptor-dependent actin regulatory mechanisms
    • (pt 5)
    • Huang Y, Burkhardt JK. T-cell-receptor-dependent actin regulatory mechanisms. J Cell Sci. 2007;120(pt 5):723–730.
    • (2007) J Cell Sci , vol.120 , pp. 723-730
    • Huang, Y1    Burkhardt, JK.2
  • 49
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011;332(6029):600–603.
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, OS1
  • 50
    • 84924370557 scopus 로고    scopus 로고
    • A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells
    • Hou TZ, et al. A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells. J Immunol. 2015;194(5):2148–2159.
    • (2015) J Immunol , vol.194 , Issue.5 , pp. 2148-2159
    • Hou, TZ1
  • 51
    • 84916920268 scopus 로고    scopus 로고
    • CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation
    • Thauland TJ, Koguchi Y, Dustin ML, Parker DC. CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation. J Immunol. 2014;193(12):5894–5903.
    • (2014) J Immunol , vol.193 , Issue.12 , pp. 5894-5903
    • Thauland, TJ1    Koguchi, Y2    Dustin, ML3    Parker, DC.4
  • 52
    • 38949197102 scopus 로고    scopus 로고
    • T-cell activation through immunological synapses and kinapses
    • Dustin ML. T-cell activation through immunological synapses and kinapses. Immunol Rev. 2008;221:77–89.
    • (2008) Immunol Rev , vol.221 , pp. 77-89
    • Dustin, ML.1
  • 53
    • 84964694672 scopus 로고    scopus 로고
    • Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
    • Kumari S, et al. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife. 2015;4.
    • (2015) Elife , vol.4
    • Kumari, S1
  • 54
    • 33751335857 scopus 로고    scopus 로고
    • Force sensing by mechanical extension of the Src family kinase substrate p130Cas
    • Sawada Y, et al. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell. 2006;127(5):1015–1026.
    • (2006) Cell , vol.127 , Issue.5 , pp. 1015-1026
    • Sawada, Y1
  • 55
    • 0030888235 scopus 로고    scopus 로고
    • Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
    • Dustin ML, Bromley SK, Kan Z, Peterson DA, Unanue ER. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci U S A. 1997;94(8):3909–3913.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.8 , pp. 3909-3913
    • Dustin, ML1    Bromley, SK2    Kan, Z3    Peterson, DA4    Unanue, ER.5
  • 57
    • 84875454223 scopus 로고    scopus 로고
    • Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity
    • Ham H, et al. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol. 2013;190(7):3661–3669.
    • (2013) J Immunol , vol.190 , Issue.7 , pp. 3661-3669
    • Ham, H1
  • 59
    • 84882719998 scopus 로고    scopus 로고
    • LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain
    • Smith MA, et al. LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One. 2013;8(8):e69378.
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e69378
    • Smith, MA1
  • 60
    • 84898415648 scopus 로고    scopus 로고
    • Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse
    • Kim J, et al. Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. PLoS One. 2014;9(1):e85090.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e85090
    • Kim, J1
  • 61
    • 84904727902 scopus 로고    scopus 로고
    • Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
    • Miyazaki M, et al. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014;15(8):767–776.
    • (2014) Nat Immunol , vol.15 , Issue.8 , pp. 767-776
    • Miyazaki, M1
  • 62
    • 84861039642 scopus 로고    scopus 로고
    • Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
    • Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood. 2012;119(19):4430–4440.
    • (2012) Blood , vol.119 , Issue.19 , pp. 4430-4440
    • Duhen, T1    Duhen, R2    Lanzavecchia, A3    Sallusto, F4    Campbell, DJ.5
  • 63
    • 84923035090 scopus 로고    scopus 로고
    • Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
    • Yu F, Sharma S, Edwards J, Feigenbaum L, Zhu J. Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. Nat Immunol. 2015;16(2):197–206.
    • (2015) Nat Immunol , vol.16 , Issue.2 , pp. 197-206
    • Yu, F1    Sharma, S2    Edwards, J3    Feigenbaum, L4    Zhu, J.5
  • 64
    • 84953635468 scopus 로고    scopus 로고
    • TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models
    • Zhao W, Dong Y, Wu C, Ma Y, Jin Y, Ji Y. TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models. Exp Cell Res. 2016;340(1):132–138.
    • (2016) Exp Cell Res , vol.340 , Issue.1 , pp. 132-138
    • Zhao, W1    Dong, Y2    Wu, C3    Ma, Y4    Jin, Y5    Ji, Y.6
  • 65
    • 84946771300 scopus 로고    scopus 로고
    • TIGIT predominantly regulates the immune response via regulatory T cells
    • Kurtulus S, et al. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015;125(11):4053–4062.
    • (2015) J Clin Invest , vol.125 , Issue.11 , pp. 4053-4062
    • Kurtulus, S1
  • 66
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Grinberg-Bleyer Y, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010;207(9):1871–1878.
    • (2010) J Exp Med , vol.207 , Issue.9 , pp. 1871-1878
    • Grinberg-Bleyer, Y1
  • 67
    • 80555154007 scopus 로고    scopus 로고
    • SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production
    • Takahashi R, et al. SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production. J Exp Med. 2011;208(10):2055–2067.
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 2055-2067
    • Takahashi, R1
  • 68
    • 84926621134 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients
    • Van Belle TL, et al. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS One. 2014;9(10):e109194.
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e109194
    • Van Belle, TL1
  • 69
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
    • Delgoffe GM, et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. 2013;501(7466):252–256.
    • (2013) Nature , vol.501 , Issue.7466 , pp. 252-256
    • Delgoffe, GM1
  • 70
    • 19544394721 scopus 로고    scopus 로고
    • Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells
    • Agenès F, Bosco N, Mascarell L, Fritah S, Ceredig R. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells. Immunology. 2005;115(2):179–188.
    • (2005) Immunology , vol.115 , Issue.2 , pp. 179-188
    • Agenès, F1    Bosco, N2    Mascarell, L3    Fritah, S4    Ceredig, R.5
  • 71
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219–242.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, LM1    Sage, PT2    Sharpe, AH.3
  • 72
    • 84901834681 scopus 로고    scopus 로고
    • CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes
    • Al-Banna NA, Vaci M, Slauenwhite D, Johnston B, Issekutz TB. CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes. Eur J Immunol. 2014;44(6):1633–1643.
    • (2014) Eur J Immunol , vol.44 , Issue.6 , pp. 1633-1643
    • Al-Banna, NA1    Vaci, M2    Slauenwhite, D3    Johnston, B4    Issekutz, TB.5
  • 73
    • 85015174290 scopus 로고    scopus 로고
    • Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    • Downs-Canner S, et al. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells. Nat Commun. 2017;8:14649.
    • (2017) Nat Commun , vol.8 , pp. 14649
    • Downs-Canner, S1
  • 74
    • 84948720438 scopus 로고    scopus 로고
    • Integrin αE(CD103) is involved in regulatory T-cell function in allergic contact hypersensitivity
    • Braun A, et al. Integrin αE(CD103) is involved in regulatory T-cell function in allergic contact hypersensitivity. J Invest Dermatol. 2015;135(12):2982–2991.
    • (2015) J Invest Dermatol , vol.135 , Issue.12 , pp. 2982-2991
    • Braun, A1
  • 75
    • 84877597818 scopus 로고    scopus 로고
    • BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid
    • Wang C, et al. BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. J Exp Med. 2013;210(3):475–489.
    • (2013) J Exp Med , vol.210 , Issue.3 , pp. 475-489
    • Wang, C1
  • 76
    • 0032870150 scopus 로고    scopus 로고
    • Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-α in ulcerative colitis
    • Nielsen OH, et al. Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-α in ulcerative colitis. Am J Gastroenterol. 1999;94(10):2923–2928.
    • (1999) Am J Gastroenterol , vol.94 , Issue.10 , pp. 2923-2928
    • Nielsen, OH1
  • 77
    • 84984660704 scopus 로고    scopus 로고
    • Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility
    • Ward MA, et al. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016;310(11):G973–G988.
    • (2016) Am J Physiol Gastrointest Liver Physiol , vol.310 , Issue.11 , pp. G973-G988
    • Ward, MA1
  • 78
    • 84940547063 scopus 로고    scopus 로고
    • MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells
    • Ohnmacht C, et al. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells. Science. 2015;349(6251):989–993.
    • (2015) Science , vol.349 , Issue.6251 , pp. 989-993
    • Ohnmacht, C1
  • 79
    • 84900452663 scopus 로고    scopus 로고
    • Induction of bacterial antigen-specific colitis by a simplified human microbiota consortium in gnotobiotic interleukin-10–/– mice
    • Eun CS, et al. Induction of bacterial antigen-specific colitis by a simplified human microbiota consortium in gnotobiotic interleukin-10–/– mice. Infect Immun. 2014;82(6):2239–2246.
    • (2014) Infect Immun , vol.82 , Issue.6 , pp. 2239-2246
    • Eun, CS1
  • 80
    • 84863985331 scopus 로고    scopus 로고
    • Additional diverse findings expand the clinical presentation of DOCK8 deficiency
    • Sanal O, et al. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. J Clin Immunol. 2012;32(4):698–708.
    • (2012) J Clin Immunol , vol.32 , Issue.4 , pp. 698-708
    • Sanal, O1
  • 81
    • 84994099866 scopus 로고    scopus 로고
    • Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability
    • Santos LC, et al. Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol. 2016;94(10):981–993.
    • (2016) Immunol Cell Biol , vol.94 , Issue.10 , pp. 981-993
    • Santos, LC1
  • 82
    • 84874828038 scopus 로고    scopus 로고
    • Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation
    • Faustino L, et al. Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation. J Immunol. 2013;190(6):2614–2621.
    • (2013) J Immunol , vol.190 , Issue.6 , pp. 2614-2621
    • Faustino, L1
  • 83
    • 84898681799 scopus 로고    scopus 로고
    • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    • Joller N, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014;40(4):569–581.
    • (2014) Immunity , vol.40 , Issue.4 , pp. 569-581
    • Joller, N1
  • 84
    • 84906966448 scopus 로고    scopus 로고
    • A guide to histomorphological evaluation of intestinal inflammation in mouse models
    • Erben U, et al. A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol. 2014;7(8):4557–4576.
    • (2014) Int J Clin Exp Pathol , vol.7 , Issue.8 , pp. 4557-4576
    • Erben, U1
  • 85
    • 84874207192 scopus 로고    scopus 로고
    • T lymphocyte myosin IIA is required for maturation of the immunological synapse
    • Kumari S, et al. T lymphocyte myosin IIA is required for maturation of the immunological synapse. Front Immunol. 2012;3:230.
    • (2012) Front Immunol , vol.3 , pp. 230
    • Kumari, S1
  • 86
    • 84887101406 scopus 로고    scopus 로고
    • Smart-seq2 for sensitive full-length transcriptome profiling in single cells
    • Picelli S, Björklund ÅK, Faridani OR, Sagasser S, Winberg G, Sandberg R. Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Nat Methods. 2013;10(11):1096–1098.
    • (2013) Nat Methods , vol.10 , Issue.11 , pp. 1096-1098
    • Picelli, S1    Björklund, ÅK2    Faridani, OR3    Sagasser, S4    Winberg, G5    Sandberg, R.6
  • 88
    • 84937535711 scopus 로고    scopus 로고
    • Preparation of single-cell RNA-seq libraries for next generation sequencing
    • 4.22.1–4.2217
    • Trombetta JJ, Gennert D, Lu D, Satija R, Shalek AK, Regev A. Preparation of single-cell RNA-seq libraries for next generation sequencing. Curr Protoc Mol Biol. 2014;107:4.22.1–4.2217.
    • (2014) Curr Protoc Mol Biol , vol.107
    • Trombetta, JJ1    Gennert, D2    Lu, D3    Satija, R4    Shalek, AK5    Regev, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.