Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 3, 2013, Pages 840-848

  Mizesko, Melissa C ^a   Banerjee, Pinaki P ^a   Monaco Shawver, Linda ^b   Mace, Emily M ^a   Bernal, William E ^b   Sawalle Belohradsky, Julie ^c   Belohradsky, Bernd H ^c   Heinz, Valerie ^c   Freeman, Alexandra F ^d   Sullivan, Kathleen E ^b   Holland, Steven M ^d   Torgerson, Troy R ^e   Al Herz, Waleed ^f   Chou, Janet ^g   Hanson, Imelda C ^a   Albert, Michael H ^c   Geha, Raif S ^g   Renner, Ellen D ^c   Orange, Jordan S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f KUWAIT UNIVERSITY   (Kuwait)

^g BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

actin; cytotoxicity; DOCK8 deficiency; immunologic synapse; natural killer cells

Indexed keywords

ACTIN; F ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 2; PROTEIN DEDICATOR OF CYTOKINESIS 8; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEDICATOR OF CYTOKINESIS 8 DEFICIENCY; FEMALE; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; MALE; NATURAL KILLER CELL; PATHOGENESIS; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SCHOOL CHILD;

ACTINS; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT; K562 CELLS; KILLER CELLS, NATURAL; MALE;

EID: 84875226021     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.12.1568     Document Type: Article

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