-
1
-
-
84950104119
-
Heart disease and stroke statistics-2016 update: A report from the American Heart Association
-
Mozaffarian, D. et al. Heart disease and stroke statistics-2016 update: A report from the American Heart Association. Circulation 133, E38-E360 (2016).
-
(2016)
Circulation
, vol.133
, pp. E38-E360
-
-
Mozaffarian, D.1
-
2
-
-
0037422592
-
Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises Part I: Aging arteries: A "set up" for vascular disease
-
Lakatta, E. G. & Levy, D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises Part I: Aging arteries: A "set up" for vascular disease. Circulation 107, 139-146 (2003).
-
(2003)
Circulation
, vol.107
, pp. 139-146
-
-
Lakatta, E.G.1
Levy, D.2
-
3
-
-
84883785202
-
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice
-
Donato, A. J. et al. Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell 12, 772-783 (2013).
-
(2013)
Aging Cell
, vol.12
, pp. 772-783
-
-
Donato, A.J.1
-
4
-
-
0018241902
-
Caloric restriction lowers blood pressure in the spontaneously hypertensive rat
-
Young, J. B., FAU - Mullen, D., Mullen, D., FAU - Landsberg, L. & Landsberg, L. Caloric restriction lowers blood pressure in the spontaneously hypertensive rat. Metabolism 27, 1711-1714 (1978).
-
(1978)
Metabolism
, vol.27
, pp. 1711-1714
-
-
Young, J.B.1
Fau-Mullen, D.2
Mullen, D.3
Fau-Landsberg, L.4
Landsberg, L.5
-
5
-
-
46449084157
-
Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults
-
Pierce, G. L. et al. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 52, 72-79 (2008).
-
(2008)
Hypertension
, vol.52
, pp. 72-79
-
-
Pierce, G.L.1
-
6
-
-
77950498292
-
Arterial destiffening with weight loss in overweight and obese middle-Aged and older adults
-
Dengo, A. L. et al Arterial destiffening with weight loss in overweight and obese middle-Aged and older adults. Hypertension 55, 855-861 (2010).
-
(2010)
Hypertension
, vol.55
, pp. 855-861
-
-
Dengo, A.L.1
-
7
-
-
66149088451
-
Adherence to healthy lifestyle habits in US adults, 1988-2006
-
King, D. E., Mainous, A. G. III, Carnemolla, M. & Everett, C. J. Adherence to healthy lifestyle habits in US adults, 1988-2006. Am. J. Med. 122, 528-534 (2009).
-
(2009)
Am. J. Med.
, vol.122
, pp. 528-534
-
-
King, D.E.1
Mainous, A.G.2
Carnemolla, M.3
Everett, C.J.4
-
8
-
-
84957442302
-
Effect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: A randomized clinical trial
-
Villareal, D. T. et al Effect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: A randomized clinical trial. J. Bone Miner. Res. 31, 40-51 (2016).
-
(2016)
J. Bone Miner. Res.
, vol.31
, pp. 40-51
-
-
Villareal, D.T.1
-
9
-
-
50049098339
-
The danger of weight loss in the elderly
-
Miller, S. L. & Wolfe, R. R. The danger of weight loss in the elderly. J. Nutr. Health Aging 12, 487-491 (2008).
-
(2008)
J. Nutr. Health Aging
, vol.12
, pp. 487-491
-
-
Miller, S.L.1
Wolfe, R.R.2
-
10
-
-
85003819827
-
Practical alternatives to chronic caloric restriction for optimizing vascular function with aging
-
Martens, C. R. & Deals, D. R. Practical alternatives to chronic caloric restriction for optimizing vascular function with aging. J. Physiol. 594, 7177-7195 (2016).
-
(2016)
J. Physiol.
, vol.594
, pp. 7177-7195
-
-
Martens, C.R.1
Deals, D.R.2
-
11
-
-
84883462446
-
Recent advances in calorie restriction research on aging
-
Chung, K. W. et al. Recent advances in calorie restriction research on aging. Exp. Gerontol. 48, 1049-1053 (2013).
-
(2013)
Exp. Gerontol.
, vol.48
, pp. 1049-1053
-
-
Chung, K.W.1
-
12
-
-
33646948539
-
Calorie restriction mimetics: An emerging research field
-
Ingram, D. K. et al. Calorie restriction mimetics: An emerging research field. Aging Cell 5, 97-108 (2006).
-
(2006)
Aging Cell
, vol.5
, pp. 97-108
-
-
Ingram, D.K.1
-
13
-
-
84880879892
-
NAD(+) metabolism: A therapeutic target for age-related metabolic disease
-
Mouchiroud, L., Houtkooper, R. H. & Auwerx, J. NAD(+) metabolism: A therapeutic target for age-related metabolic disease. Crit. Rev. Biochem. Mol. Biol. 48, 397-408 (2013).
-
(2013)
Crit. Rev. Biochem. Mol. Biol.
, vol.48
, pp. 397-408
-
-
Mouchiroud, L.1
Houtkooper, R.H.2
Auwerx, J.3
-
14
-
-
0034703217
-
Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S., Defossez, P. & Guarente, L. Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128 (2000).
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.1
Defossez, P.2
Guarente, L.3
-
15
-
-
80052807171
-
SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans
-
Donato, A. J. et al. SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. J. Physiol. 589, 4545-4554 (2011).
-
(2011)
J. Physiol.
, vol.589
, pp. 4545-4554
-
-
Donato, A.J.1
-
16
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen, D. et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22, 1753-1757 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
17
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto, C. et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise.
-
(2010)
Cell Metab.
, vol.11
, pp. 213-219
-
-
Canto, C.1
-
18
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-And ageinduced diabetes in mice
-
Yoshino, J., Mills, K. F., Yoon, M. J. & Imai, S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-And ageinduced diabetes in mice. Cell Metab. 14, 528-536 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
19
-
-
84864401965
-
Age-Associated changes in oxidative stress and NAD(+) metabolism in human tissue
-
Massudi, H. et al. Age-Associated changes in oxidative stress and NAD(+) metabolism in human tissue. PLoS ONE 7, e42357 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e42357
-
-
Massudi, H.1
-
20
-
-
84893442805
-
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes, A. P. et al Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155, 1624-1638 (2013).
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
-
21
-
-
84924352123
-
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
-
Zhu, X., Lu, M., Lee, B., Ugurbil, K. & Chen, W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. USA 112, 2876-2881 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 2876-2881
-
-
Zhu, X.1
Lu, M.2
Lee, B.3
Ugurbil, K.4
Chen, W.5
-
22
-
-
50949120914
-
Nicotinic acid nicotinamide and nicotinamide riboside: A molecular evaluation of NAD(+) precursor vitamins in human nutrition
-
Bogan, K. L. & Brenner, C. Nicotinic acid nicotinamide and nicotinamide riboside: A molecular evaluation of NAD(+) precursor vitamins in human nutrition. Annu. Rev. Nutr. 28, 115-130 (2008).
-
(2008)
Annu. Rev. Nutr.
, vol.28
, pp. 115-130
-
-
Bogan, K.L.1
Brenner, C.2
-
23
-
-
84861697885
-
Niacin: Chemical forms, bioavailability, and health effects
-
MacKay, D., Hathcock, J. & Guarneri, E. Niacin: chemical forms, bioavailability, and health effects. Nutr. Rev. 70, 357-366 (2012).
-
(2012)
Nutr. Rev.
, vol.70
, pp. 357-366
-
-
MacKay, D.1
Hathcock, J.2
Guarneri, E.3
-
24
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
-
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M. & Sinclair, D. A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. J. Biol. Chem. 277, 45099-45107 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
25
-
-
84907145662
-
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: Computational and experimental studies
-
Guan, X., Lin, P., Chakrabarti, R. & Knoll, E. Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies. PLoS One. 9, e107729 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e107729
-
-
Guan, X.1
Lin, P.2
Chakrabarti, R.3
Knoll, E.4
-
26
-
-
84991372712
-
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
-
Trammell, S. A. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat. Commun. 7, 12948 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 12948
-
-
Trammell, S.A.1
-
27
-
-
85004028301
-
Long-Term administration of nicotinamide mononucleotide mitigates age-Associated physiological decline in mice
-
Mills, K. F. et al. Long-Term administration of nicotinamide mononucleotide mitigates age-Associated physiological decline in mice. Cell Metab. 24, 795-806 (2016).
-
(2016)
Cell Metab.
, vol.24
, pp. 795-806
-
-
Mills, K.F.1
-
28
-
-
84991088710
-
Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle
-
Frederick, D. W. et al. Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metab. 24, 269-282 (2016).
-
(2016)
Cell Metab.
, vol.24
, pp. 269-282
-
-
Frederick, D.W.1
-
29
-
-
84960352089
-
Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
-
de Picciotto, N. E. et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell 15, 522-530 (2016).
-
(2016)
Aging Cell
, vol.15
, pp. 522-530
-
-
De Picciotto, N.E.1
-
30
-
-
85027489124
-
Circadian reprogramming in the liver identifies metabolic pathways of aging
-
Sato, S. et al. Circadian reprogramming in the liver identifies metabolic pathways of aging. Cell 170, 664-66 (2017).
-
(2017)
Cell
, vol.170
, pp. 664-666
-
-
Sato, S.1
-
31
-
-
84886398685
-
Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection
-
Chi, Y. & Sauve, A. A. Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care 16, 657-661 (2013).
-
(2013)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.16
, pp. 657-661
-
-
Chi, Y.1
Sauve, A.A.2
-
32
-
-
77952549055
-
A possibility of nutriceuticals as an anti-Aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis
-
Imai, S. A possibility of nutriceuticals as an anti-Aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol. Res. 62, 42-47 (2010).
-
(2010)
Pharmacol. Res.
, vol.62
, pp. 42-47
-
-
Imai, S.1
-
33
-
-
84991294515
-
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
-
Ratajczak, J. et al. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat. Commun. 7, 13103 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 13103
-
-
Ratajczak, J.1
-
34
-
-
84888626285
-
Targeted, LCMS-based metabolomics for quantitative measurement of NAD+ metabolites
-
Trammell, S. A. & Brenner, C. Targeted, LCMS-based metabolomics for quantitative measurement of NAD+ metabolites. Comput. Struct. Biotechnol. J. 4, e201301012 (2013).
-
(2013)
Comput. Struct. Biotechnol. J.
, vol.4
, pp. e201301012
-
-
Trammell, S.A.1
Brenner, C.2
-
35
-
-
77953631698
-
The secret life of NAD(+): An old metabolite controlling new metabolic signaling pathways
-
Houtkooper, R. H., Canto, C., Wanders, R. J. & Auwerx, J. The secret life of NAD(+): An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31, 194-223 (2010).
-
(2010)
Endocr. Rev.
, vol.31
, pp. 194-223
-
-
Houtkooper, R.H.1
Canto, C.2
Wanders, R.J.3
Auwerx, J.4
-
36
-
-
0038460302
-
The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure-The JNC 7 report
-
Chobanian, A. et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure-The JNC 7 report. JAMA-J. Am. Med. Assoc. 289, 2560-2572 (2003).
-
(2003)
JAMA-J. Am. Med. Assoc.
, vol.289
, pp. 2560-2572
-
-
Chobanian, A.1
-
37
-
-
85045622719
-
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
-
Whelton, P. K. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J. Am. Coll. Cardiol. https://doi.org/10.1016/j.jacc.2017.11.005 (2017).
-
(2017)
J. Am. Coll. Cardiol.
-
-
Whelton, P.K.1
-
38
-
-
33750318148
-
Expert consensus document on arterial stiffness: Methodological issues and clinical applications
-
Laurent, S. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J. 27, 2588-2605 (2006).
-
(2006)
Eur. Heart J.
, vol.27
, pp. 2588-2605
-
-
Laurent, S.1
-
39
-
-
27544491916
-
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G)
-
Tunaru, S., Lattig, J., Kero, J., Krause, G. & Offermanns, S. Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol. Pharmacol. 68, 1271-1280 (2005).
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1271-1280
-
-
Tunaru, S.1
Lattig, J.2
Kero, J.3
Krause, G.4
Offermanns, S.5
-
40
-
-
33751087034
-
Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells
-
Benyo, Z., Gille, A., Bennett, C. L., Clausen, B. E. & Offermanns, S. Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol. Pharmacol. 70, 1844-1849 (2006).
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1844-1849
-
-
Benyo, Z.1
Gille, A.2
Bennett, C.L.3
Clausen, B.E.4
Offermanns, S.5
-
41
-
-
22644437126
-
Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review
-
Carlson, L. Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review. J. Intern. Med. 258, 94-114 (2005).
-
(2005)
J. Intern. Med.
, vol.258
, pp. 94-114
-
-
Carlson, L.1
-
42
-
-
2342550554
-
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD(+) in fungi and humans
-
Bieganowski, P. & Brenner, C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD(+) in fungi and humans. Cell 117, 495-502 (2004).
-
(2004)
Cell
, vol.117
, pp. 495-502
-
-
Bieganowski, P.1
Brenner, C.2
-
43
-
-
84971286337
-
Nicotinamide riboside is a major NAD(+) precursor vitamin in cow milk
-
Trammell, S. A. J., Yu, L., Redpath, P., Migaud, M. E. & Brenner, C.Nicotinamide riboside is a major NAD(+) precursor vitamin in cow milk. J. Nutr. 146, 957-963 (2016).
-
(2016)
J. Nutr.
, vol.146
, pp. 957-963
-
-
Trammell, S.A.J.1
Yu, L.2
Redpath, P.3
Migaud, M.E.4
Brenner, C.5
-
44
-
-
84948439672
-
A randomized trial of intensive versus standard bloodpressure control
-
Wright, J. T. Jr. et al. A randomized trial of intensive versus standard bloodpressure control. N. Engl. J. Med. 373, 2103-2116 (2015).
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 2103-2116
-
-
Wright, J.T.1
-
45
-
-
27844598334
-
-
Centers for Disease Control and Prevention (CDC). Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention
-
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. https://wwwn.cdc.gov/nchs/nhanes/Default.aspx(2011-2016.
-
National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data
-
-
-
46
-
-
84991520016
-
Reducing the blood pressure-related burden of cardiovascular disease: Impact of achievable improvements in blood pressure prevention and control
-
Hardy, S. T. et al. Reducing the blood pressure-related burden of cardiovascular disease: impact of achievable improvements in blood pressure prevention and control. J. Am. Heart Assoc. 4, e002276 (2015).
-
(2015)
J. Am. Heart Assoc.
, vol.4
, pp. e002276
-
-
Hardy, S.T.1
-
47
-
-
85030773478
-
Prehypertension is real and can be associated with target organ damage
-
Materson, B. J., Garcia-Estrada, M., Degraff, S. B. & Preston, R. A. Prehypertension is real and can be associated with target organ damage. J. Am. Soc. Hypertens. 11, 704-708 (2017).
-
(2017)
J. Am. Soc. Hypertens.
, vol.11
, pp. 704-708
-
-
Materson, B.J.1
Garcia-Estrada, M.2
Degraff, S.B.3
Preston, R.A.4
-
48
-
-
84982816943
-
Aortic stiffness and the risk of incident mild cognitive impairment and dementia
-
Pase, M. P. et al. Aortic stiffness and the risk of incident mild cognitive impairment and dementia. Stroke 47, 2256-2261 (2016).
-
(2016)
Stroke
, vol.47
, pp. 2256-2261
-
-
Pase, M.P.1
-
49
-
-
77953713676
-
Arterial stiffness in chronic kidney disease: Causes and consequences
-
Chue, C. D., Townend, J. N., Steeds, R. P. & Ferro, C. J. Arterial stiffness in chronic kidney disease: causes and consequences. Heart 96, 817-823 (2010).
-
(2010)
Heart
, vol.96
, pp. 817-823
-
-
Chue, C.D.1
Townend, J.N.2
Steeds, R.P.3
Ferro, C.J.4
-
50
-
-
77956228506
-
Arterial stiffness is associated with low thigh muscle mass in middle-Aged to elderly men
-
Ochi, M. et al. Arterial stiffness is associated with low thigh muscle mass in middle-Aged to elderly men. Atherosclerosis 212, 327-332 (2010).
-
(2010)
Atherosclerosis
, vol.212
, pp. 327-332
-
-
Ochi, M.1
-
51
-
-
84857914911
-
Pulse wave velocity is associated with muscle mass decline: Health ABC study
-
Abbatecola, A. M. et al. Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age 34, 469-478 (2012).
-
(2012)
Age
, vol.34
, pp. 469-478
-
-
Abbatecola, A.M.1
-
52
-
-
84904514598
-
Arterial stiffness and hypertension chicken or egg?
-
Mitchell, G. F. Arterial stiffness and hypertension chicken or egg? Hypertension 64, 210-214 (2014).
-
(2014)
Hypertension
, vol.64
, pp. 210-214
-
-
Mitchell, G.F.1
-
53
-
-
14644443589
-
Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects
-
Dernellis, J. & Panaretou, M. Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects. Hypertension 45, 426-431 (2005).
-
(2005)
Hypertension
, vol.45
, pp. 426-431
-
-
Dernellis, J.1
Panaretou, M.2
-
54
-
-
84865701980
-
Aortic stiffness, blood pressure progression, and incident hypertension
-
Kaess, B. M. et al. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA-J. Am. Med. Assoc. 308, 875-881 (2012).
-
(2012)
JAMA-J. Am. Med. Assoc.
, vol.308
, pp. 875-881
-
-
Kaess, B.M.1
-
55
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
Mattagajasingh, I. et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 104, 14855-14860 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 14855-14860
-
-
Mattagajasingh, I.1
-
56
-
-
84987624171
-
Activation of SIRT1 attenuates Klotho deficiency-induced arterial stiffness and hypertension by enhancing AMP-Activated protein kinase activity
-
Gao, D. et al. Activation of SIRT1 attenuates Klotho deficiency-induced arterial stiffness and hypertension by enhancing AMP-Activated protein kinase activity. Hypertension 68, 1191-1199 (2016).
-
(2016)
Hypertension
, vol.68
, pp. 1191-1199
-
-
Gao, D.1
-
57
-
-
84862022077
-
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
Canto, C. et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15, 838-847 (2012).
-
(2012)
Cell Metab.
, vol.15
, pp. 838-847
-
-
Canto, C.1
-
58
-
-
84971290135
-
Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice
-
Trammell, S. A. J. et al. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci. Rep. 6, 26933 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 26933
-
-
Trammell, S.A.J.1
-
59
-
-
77649295811
-
NAD+metabolite levels as a function of vitamins and calorie restriction: Evidence for different mechanisms of longevity
-
Evans, C. et al NAD+metabolite levels as a function of vitamins and calorie restriction: Evidence for different mechanisms of longevity. BMC Chem. Biol. 10, 2 (2010).
-
(2010)
BMC Chem. Biol.
, vol.10
, pp. 2
-
-
Evans, C.1
-
60
-
-
0032421623
-
Arterial stiffness and hormone replacement use in healthy postmenopausal women
-
Tanaka, H., DeSouza, C. & Seals, D. Arterial stiffness and hormone replacement use in healthy postmenopausal women. J. Gerontol. A Biol. Sci. Med. Sci. 53, M344-M346 (1998).
-
(1998)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.53
, pp. M344-M346
-
-
Tanaka, H.1
DeSouza, C.2
Seals, D.3
-
61
-
-
0031975620
-
Absence of age-related increase in central arterial stiffness in physically active women
-
Tanaka, H., DeSouza, C. A. & Seals, D. R. Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler. Thromb. Vasc. Biol. 18, 127-132 (1998).
-
(1998)
Arterioscler. Thromb. Vasc. Biol.
, vol.18
, pp. 127-132
-
-
Tanaka, H.1
DeSouza, C.A.2
Seals, D.R.3
-
62
-
-
1642321736
-
Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men
-
Eskurza, I. et al. Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. Am. J. Physiol. Heart Circ. Physiol. 286, H1528-H1534 (2004).
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.286
, pp. H1528-H1534
-
-
Eskurza, I.1
-
63
-
-
0037371740
-
Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women
-
Moreau, K. L., Donato, A. J., Seals, D. R., DeSouza, C. A. & Tanaka, H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc. Res. 57, 861-868 (2003).
-
(2003)
Cardiovasc. Res.
, vol.57
, pp. 861-868
-
-
Moreau, K.L.1
Donato, A.J.2
Seals, D.R.3
DeSouza, C.A.4
Tanaka, H.5
-
64
-
-
84866347221
-
Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: A pilot study
-
Pierce, G. L. et al. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: A pilot study. Am. J. Hypertens. 25, 1050-1054 (2012).
-
(2012)
Am. J. Hypertens.
, vol.25
, pp. 1050-1054
-
-
Pierce, G.L.1
-
65
-
-
20044366744
-
Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women
-
Moreau, K. L., Gavin, K. M., Plum, A. E. & Seals, D. R. Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women. Hypertension 45, 1107-1112 (2005).
-
(2005)
Hypertension
, vol.45
, pp. 1107-1112
-
-
Moreau, K.L.1
Gavin, K.M.2
Plum, A.E.3
Seals, D.R.4
-
66
-
-
1942438660
-
Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing
-
Eskurza, I., Monahan, K. D., Robinson, J. A. & Seals, D. R. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J. Physiol. 556, 315-324 (2004).
-
(2004)
J. Physiol.
, vol.556
, pp. 315-324
-
-
Eskurza, I.1
Monahan, K.D.2
Robinson, J.A.3
Seals, D.R.4
-
67
-
-
84872332944
-
Dietary sodium restriction reverses vascular endothelial dysfunction in middle-Aged/older adults with moderately elevated systolic blood pressure
-
Jablonski, K. L. et al. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-Aged/older adults with moderately elevated systolic blood pressure. J. Am. Coll. Cardiol. 61, 335-343 (2013).
-
(2013)
J. Am. Coll. Cardiol.
, vol.61
, pp. 335-343
-
-
Jablonski, K.L.1
-
68
-
-
84905899086
-
Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: Possible role of nuclear factor kappa B
-
Walker, A. E., Kaplon, R. E., Pierce, G. L., Nowlan, M. J. & Seals, D. R. Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor kappa B. Clin. Sci. 127, 645-654 (2014).
-
(2014)
Clin. Sci.
, vol.127
, pp. 645-654
-
-
Walker, A.E.1
Kaplon, R.E.2
Pierce, G.L.3
Nowlan, M.J.4
Seals, D.R.5
-
69
-
-
84892911549
-
Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-Aged and older adults
-
Kaplon, R. E., Gano, L. B. & Seals, D. R. Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-Aged and older adults. J. Appl. Physiol. 116, 156-163 (2014).
-
(2014)
J. Appl. Physiol.
, vol.116
, pp. 156-163
-
-
Kaplon, R.E.1
Gano, L.B.2
Seals, D.R.3
-
70
-
-
0242320353
-
Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans
-
Bell, C., Jones, P. P. & Seals, D. R. Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans. J. Clin. Endocrinol. Metab. 88, 4950-4954 (2003).
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 4950-4954
-
-
Bell, C.1
Jones, P.P.2
Seals, D.R.3
-
71
-
-
33645921978
-
Thermogenic responsiveness to beta-Adrenergic stimulation is augmented in exercising versus sedentary adults: Role of oxidative stress
-
Bell, C., Stob, N. & Seals, D. Thermogenic responsiveness to beta-Adrenergic stimulation is augmented in exercising versus sedentary adults: Role of oxidative stress. J. Physiol.570, 629-635 (2006).
-
(2006)
J. Physiol.
, vol.570
, pp. 629-635
-
-
Bell, C.1
Stob, N.2
Seals, D.3
-
72
-
-
0023120630
-
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
-
Bergman, R. N., Prager, R., Volund, A. & Olefsky, J. M. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J. Clin. Invest. 79, 790-800 (1987).
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 790-800
-
-
Bergman, R.N.1
Prager, R.2
Volund, A.3
Olefsky, J.M.4
-
73
-
-
84872256593
-
Regular aerobic exercise protects against impaired fasting plasma glucose-Associated vascular endothelial dysfunction with aging
-
DeVan, A. E. et al. Regular aerobic exercise protects against impaired fasting plasma glucose-Associated vascular endothelial dysfunction with aging. Clin. Sci. 124, 325-331 (2013).
-
(2013)
Clin. Sci.
, vol.124
, pp. 325-331
-
-
DeVan, A.E.1
-
74
-
-
0034687139
-
Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
-
DeSouza, C. A. et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102, 1351-1357 (2000).
-
(2000)
Circulation
, vol.102
, pp. 1351-1357
-
-
DeSouza, C.A.1
-
75
-
-
84877129998
-
Motor assessment using the NIH toolbox
-
Reuben, D. B. et al. Motor assessment using the NIH Toolbox. Neurology 80, S65-S75 (2013).
-
(2013)
Neurology
, vol.80
, pp. S65-S75
-
-
Reuben, D.B.1
-
76
-
-
84949993634
-
Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: A pilot trial in middle-Aged and older adults
-
Justice, J. N. et al. Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: A pilot trial in middle-Aged and older adults. Aging 7, 1004-1021 (2015).
-
(2015)
Aging
, vol.7
, pp. 1004-1021
-
-
Justice, J.N.1
-
77
-
-
0029087632
-
The standing heel-rise test for ankle plantar flexion -criterion for normal
-
Lunsford, B. R. & Perry, J. The standing heel-rise test for ankle plantar flexion -criterion for normal. Phys. Ther. 75, 694-698 (1995).
-
(1995)
Phys. Ther.
, vol.75
, pp. 694-698
-
-
Lunsford, B.R.1
Perry, J.2
-
78
-
-
58849096294
-
Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations
-
Vestergaard, S. et al. Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations. J. Am. Geriatr. Soc. 57, 260-265 (2009).
-
(2009)
J. Am. Geriatr. Soc.
, vol.57
, pp. 260-265
-
-
Vestergaard, S.1
-
79
-
-
3042757997
-
Tests of stepping as indicators of mobility, balance, and fall risk in balance-impaired older adults
-
Cho, B., Scarpace, D. & Alexander, N. Tests of stepping as indicators of mobility, balance, and fall risk in balance-impaired older adults. J. Am. Geriatr. Soc. 52, 1168-1173 (2004).
-
(2004)
J. Am. Geriatr. Soc.
, vol.52
, pp. 1168-1173
-
-
Cho, B.1
Scarpace, D.2
Alexander, N.3
-
80
-
-
0037763945
-
Relationship of knee extension force to independence in sit-To-stand performance in patients receiving acute rehabilitation
-
Eriksrud, O. & Bohannon, R. W. Relationship of knee extension force to independence in sit-To-stand performance in patients receiving acute rehabilitation. Phys. Ther. 83, 544-551 (2003).
-
(2003)
Phys. Ther.
, vol.83
, pp. 544-551
-
-
Eriksrud, O.1
Bohannon, R.W.2
-
81
-
-
84959298394
-
Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-Aged and older adults
-
DeVan, A. E. et al. Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-Aged and older adults. J. Appl. Physiol. 120, 416-425 (2016).
-
(2016)
J. Appl. Physiol.
, vol.120
, pp. 416-425
-
-
DeVan, A.E.1
-
82
-
-
84977497128
-
Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-Aged and older adults
-
Kaplon, R. E. et al. Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-Aged and older adults. Aging 8, 1167-1183 (2016).
-
(2016)
Aging
, vol.8
, pp. 1167-1183
-
-
Kaplon, R.E.1
-
83
-
-
0026361048
-
One-sided or two-sided p values: Which most appropriately address the question of drug efficacy?
-
Peace, K. E. One-sided or two-sided p values: Which most appropriately address the question of drug efficacy? J. Biopharm. Stat. 1, 133-138 (1991).
-
(1991)
J. Biopharm. Stat.
, vol.1
, pp. 133-138
-
-
Peace, K.E.1
|