메뉴 건너뛰기




Volumn 17, Issue 3, 2018, Pages

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

Author keywords

Anxiety disorders; coping; DNA methylation; epigenetics; gene environment; histone modifications; microRNA; resilience

Indexed keywords

HISTONE; MICRORNA; SEROTONIN UPTAKE INHIBITOR;

EID: 85044575798     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12423     Document Type: Review
Times cited : (147)

References (179)
  • 2
  • 3
    • 77649240537 scopus 로고    scopus 로고
    • NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults
    • Amstadter, A.B., Koenen, K.C., Ruggiero, K.J., Acierno, R., Galea, S., Kilpatrick, D.G. & Gelernter, J. (2010) NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depress Anxiety 27, 270–275.
    • (2010) Depress Anxiety , vol.27 , pp. 270-275
    • Amstadter, A.B.1    Koenen, K.C.2    Ruggiero, K.J.3    Acierno, R.4    Galea, S.5    Kilpatrick, D.G.6    Gelernter, J.7
  • 4
    • 0038407848 scopus 로고    scopus 로고
    • Trajectories of brain development: point of vulnerability or window of opportunity?
    • Andersen, S.L. (2003) Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci Biobehav Rev 27, 3–18.
    • (2003) Neurosci Biobehav Rev , vol.27 , pp. 3-18
    • Andersen, S.L.1
  • 5
    • 41249084517 scopus 로고    scopus 로고
    • Stress, sensitive periods and maturational events in adolescent depression
    • Andersen, S.L. & Teicher, M.H. (2008) Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 31, 183–191.
    • (2008) Trends Neurosci , vol.31 , pp. 183-191
    • Andersen, S.L.1    Teicher, M.H.2
  • 6
    • 84913580377 scopus 로고    scopus 로고
    • Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
    • Babenko, O., Kovalchuk, I. & Metz, G.A. (2015) Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health. Neurosci Biobehav Rev 48, 70–91.
    • (2015) Neurosci Biobehav Rev , vol.48 , pp. 70-91
    • Babenko, O.1    Kovalchuk, I.2    Metz, G.A.3
  • 8
    • 0036069568 scopus 로고    scopus 로고
    • Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with panic disorder
    • Bandelow, B., Spath, C., Tichauer, G.A., Broocks, A., Hajak, G. & Ruther, E. (2002) Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with panic disorder. Compr Psychiatry 43, 269–278.
    • (2002) Compr Psychiatry , vol.43 , pp. 269-278
    • Bandelow, B.1    Spath, C.2    Tichauer, G.A.3    Broocks, A.4    Hajak, G.5    Ruther, E.6
  • 9
    • 13244291284 scopus 로고    scopus 로고
    • Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder
    • Bandelow, B., Charimo Torrente, A., Wedekind, D., Broocks, A., Hajak, G. & Ruther, E. (2004) Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder. Eur Arch Psychiatry Clin Neurosci 254, 397–405.
    • (2004) Eur Arch Psychiatry Clin Neurosci , vol.254 , pp. 397-405
    • Bandelow, B.1    Charimo Torrente, A.2    Wedekind, D.3    Broocks, A.4    Hajak, G.5    Ruther, E.6
  • 11
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel, D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 12
    • 84875922807 scopus 로고    scopus 로고
    • Global prevalence of anxiety disorders: a systematic review and meta-regression
    • Baxter, A.J., Scott, K.M., Vos, T. & Whiteford, H.A. (2013) Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med 43, 897–910.
    • (2013) Psychol Med , vol.43 , pp. 897-910
    • Baxter, A.J.1    Scott, K.M.2    Vos, T.3    Whiteford, H.A.4
  • 16
    • 70449469454 scopus 로고    scopus 로고
    • Beyond diathesis stress: differential susceptibility to environmental influences
    • Belsky, J. & Pluess, M. (2009) Beyond diathesis stress: differential susceptibility to environmental influences. Psychol Bull 135, 885–908.
    • (2009) Psychol Bull , vol.135 , pp. 885-908
    • Belsky, J.1    Pluess, M.2
  • 18
    • 84902238800 scopus 로고    scopus 로고
    • An analysis of early developmental trauma in social anxiety disorder and posttraumatic stress disorder
    • Bishop, M., Rosenstein, D., Bakelaar, S. & Seedat, S. (2014) An analysis of early developmental trauma in social anxiety disorder and posttraumatic stress disorder. Ann Gen Psychiatry 13, 16.
    • (2014) Ann Gen Psychiatry , vol.13 , pp. 16
    • Bishop, M.1    Rosenstein, D.2    Bakelaar, S.3    Seedat, S.4
  • 19
    • 0023232198 scopus 로고
    • Stressful life events and the onset of a generalized anxiety syndrome
    • Blazer, D., Hughes, D. & George, L.K. (1987) Stressful life events and the onset of a generalized anxiety syndrome. Am J Psychiatry 144, 1178–1183.
    • (1987) Am J Psychiatry , vol.144 , pp. 1178-1183
    • Blazer, D.1    Hughes, D.2    George, L.K.3
  • 21
    • 34247224239 scopus 로고    scopus 로고
    • Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
    • Bredy, T.W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y.E. & Barad, M. (2007) Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem 14, 268–276.
    • (2007) Learn Mem , vol.14 , pp. 268-276
    • Bredy, T.W.1    Wu, H.2    Crego, C.3    Zellhoefer, J.4    Sun, Y.E.5    Barad, M.6
  • 23
    • 33748086018 scopus 로고    scopus 로고
    • Treatment-resistant anxiety disorders
    • Bystritsky, A. (2006) Treatment-resistant anxiety disorders. Mol Psychiatry 11, 805–814.
    • (2006) Mol Psychiatry , vol.11 , pp. 805-814
    • Bystritsky, A.1
  • 26
    • 84940101430 scopus 로고    scopus 로고
    • DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women
    • Chagnon, Y.C., Potvin, O., Hudon, C. & Preville, M. (2015) DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Front Genet 6, 230.
    • (2015) Front Genet , vol.6 , pp. 230
    • Chagnon, Y.C.1    Potvin, O.2    Hudon, C.3    Preville, M.4
  • 27
    • 84976400637 scopus 로고    scopus 로고
    • Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder
    • Chen, S.D., Sun, X.Y., Niu, W., Kong, L.M., He, M.J., Fan, H.M., Li, W.S., Zhong, A.F., Zhang, L.Y. & Lu, J. (2016) Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder. Compr Psychiatry 69, 216–224.
    • (2016) Compr Psychiatry , vol.69 , pp. 216-224
    • Chen, S.D.1    Sun, X.Y.2    Niu, W.3    Kong, L.M.4    He, M.J.5    Fan, H.M.6    Li, W.S.7    Zhong, A.F.8    Zhang, L.Y.9    Lu, J.10
  • 28
    • 84876809485 scopus 로고    scopus 로고
    • Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder
    • Choe, A.Y., Kim, B., Lee, K.S., Lee, J.E., Lee, J.Y., Choi, T.K. & Lee, S.H. (2013) Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder. Neuropsychobiology 67, 192–200.
    • (2013) Neuropsychobiology , vol.67 , pp. 192-200
    • Choe, A.Y.1    Kim, B.2    Lee, K.S.3    Lee, J.E.4    Lee, J.Y.5    Choi, T.K.6    Lee, S.H.7
  • 29
    • 77952095395 scopus 로고    scopus 로고
    • Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication
    • Cougle, J.R., Timpano, K.R., Sachs-Ericsson, N., Keough, M.E. & Riccardi, C.J. (2010) Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication. Psychiatry Res 177, 150–155.
    • (2010) Psychiatry Res , vol.177 , pp. 150-155
    • Cougle, J.R.1    Timpano, K.R.2    Sachs-Ericsson, N.3    Keough, M.E.4    Riccardi, C.J.5
  • 32
    • 84857189974 scopus 로고    scopus 로고
    • Understanding transgenerational epigenetic inheritance via the gametes in mammals
    • Daxinger, L. & Whitelaw, E. (2012) Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet 13, 153–162.
    • (2012) Nat Rev Genet , vol.13 , pp. 153-162
    • Daxinger, L.1    Whitelaw, E.2
  • 33
    • 85011649906 scopus 로고    scopus 로고
    • GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder
    • Deckert, J., Weber, H., Villmann, C. et al. (2017) GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder. Mol Psychiatry.
    • (2017) Mol Psychiatry
    • Deckert, J.1    Weber, H.2    Villmann, C.3
  • 34
    • 84893691607 scopus 로고    scopus 로고
    • Parental olfactory experience influences behavior and neural structure in subsequent generations
    • Dias, B.G. & Ressler, K.J. (2014) Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci 17, 89–96.
    • (2014) Nat Neurosci , vol.17 , pp. 89-96
    • Dias, B.G.1    Ressler, K.J.2
  • 36
    • 77956202780 scopus 로고    scopus 로고
    • Imaging genetics of anxiety disorders
    • Domschke, K. & Dannlowski, U. (2010) Imaging genetics of anxiety disorders. NeuroImage 53, 822–831.
    • (2010) NeuroImage , vol.53 , pp. 822-831
    • Domschke, K.1    Dannlowski, U.2
  • 37
    • 84869096779 scopus 로고    scopus 로고
    • Genetics of anxiety disorders – status quo and quo vadis
    • Domschke, K. & Deckert, J. (2012) Genetics of anxiety disorders – status quo and quo vadis. Curr Pharm Des 18, 5691–5698.
    • (2012) Curr Pharm Des , vol.18 , pp. 5691-5698
    • Domschke, K.1    Deckert, J.2
  • 42
    • 84957309425 scopus 로고    scopus 로고
    • When mothering goes awry: challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving
    • Drury, S.S., Sanchez, M.M. & Gonzalez, A. (2016) When mothering goes awry: challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving. Horm Behav 77, 182–192.
    • (2016) Horm Behav , vol.77 , pp. 182-192
    • Drury, S.S.1    Sanchez, M.M.2    Gonzalez, A.3
  • 43
    • 84876007072 scopus 로고    scopus 로고
    • Power and predictive accuracy of polygenic risk scores
    • Dudbridge, F. (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9, e1003348.
    • (2013) PLoS Genet , vol.9
    • Dudbridge, F.1
  • 44
    • 84955721237 scopus 로고    scopus 로고
    • Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males
    • Duman, E.A. & Canli, T. (2015) Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males. Biol Mood Anxiety Disord 5, 2.
    • (2015) Biol Mood Anxiety Disord , vol.5 , pp. 2
    • Duman, E.A.1    Canli, T.2
  • 45
    • 38349158643 scopus 로고    scopus 로고
    • Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects
    • Elzinga, B.M., Roelofs, K., Tollenaar, M.S., Bakvis, P., van Pelt, J. & Spinhoven, P. (2008) Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 33, 227–237.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 227-237
    • Elzinga, B.M.1    Roelofs, K.2    Tollenaar, M.S.3    Bakvis, P.4    van Pelt, J.5    Spinhoven, P.6
  • 46
    • 71149115664 scopus 로고    scopus 로고
    • The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: a pilot study
    • Elzinga, B.M., Spinhoven, P., Berretty, E., de Jong, P. & Roelofs, K. (2010) The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: a pilot study. Biol Psychol 83, 1–6.
    • (2010) Biol Psychol , vol.83 , pp. 1-6
    • Elzinga, B.M.1    Spinhoven, P.2    Berretty, E.3    de Jong, P.4    Roelofs, K.5
  • 47
    • 85044617518 scopus 로고    scopus 로고
    • Anxiety associated increased CpG methylation in the promoter of Asb1: a translational approach evidenced by epidemiological and clinical studies and a murine model
    • Emeny, R.T., Baumert, J., Zannas, A.S. et al. (2017) Anxiety associated increased CpG methylation in the promoter of Asb1: a translational approach evidenced by epidemiological and clinical studies and a murine model. Neuropsychopharmacology.
    • (2017) Neuropsychopharmacology
    • Emeny, R.T.1    Baumert, J.2    Zannas, A.S.3
  • 48
    • 0040440831 scopus 로고    scopus 로고
    • General self-efficacy and control in relation to anxiety and cognitive performance
    • Endler, N.S., Speer, R.L., Johnson, J.M. & Flett, G.L. (2001) General self-efficacy and control in relation to anxiety and cognitive performance. Curr Psychol 20, 36–52.
    • (2001) Curr Psychol , vol.20 , pp. 36-52
    • Endler, N.S.1    Speer, R.L.2    Johnson, J.M.3    Flett, G.L.4
  • 49
    • 79957489903 scopus 로고    scopus 로고
    • TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    • Erhardt, A., Czibere, L., Roeske, D. et al. (2011) TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry 16, 647–663.
    • (2011) Mol Psychiatry , vol.16 , pp. 647-663
    • Erhardt, A.1    Czibere, L.2    Roeske, D.3
  • 51
    • 0021831757 scopus 로고
    • Life events preceding the onset of panic disorder
    • Faravelli, C. (1985) Life events preceding the onset of panic disorder. J Affect Disord 9, 103–105.
    • (1985) J Affect Disord , vol.9 , pp. 103-105
    • Faravelli, C.1
  • 52
    • 0024603837 scopus 로고
    • Recent life events and panic disorder
    • Faravelli, C. & Pallanti, S. (1989) Recent life events and panic disorder. Am J Psychiatry 146, 622–626.
    • (1989) Am J Psychiatry , vol.146 , pp. 622-626
    • Faravelli, C.1    Pallanti, S.2
  • 53
    • 34948866263 scopus 로고    scopus 로고
    • Epidemiology of life events: life events and psychiatric disorders in the Sesto Fiorentino study
    • Faravelli, C., Catena, M., Scarpato, A. & Ricca, V. (2007) Epidemiology of life events: life events and psychiatric disorders in the Sesto Fiorentino study. Psychother Psychosom 76, 361–368.
    • (2007) Psychother Psychosom , vol.76 , pp. 361-368
    • Faravelli, C.1    Catena, M.2    Scarpato, A.3    Ricca, V.4
  • 55
    • 66349093383 scopus 로고    scopus 로고
    • Psychobiology and molecular genetics of resilience
    • Feder, A., Nestler, E.J. & Charney, D.S. (2009) Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 10, 446–457.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 446-457
    • Feder, A.1    Nestler, E.J.2    Charney, D.S.3
  • 56
    • 84941023348 scopus 로고    scopus 로고
    • Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis
    • Fernandes, V. & Osorio, F.L. (2015) Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis. Eur Psychiatry 30, 756–764.
    • (2015) Eur Psychiatry , vol.30 , pp. 756-764
    • Fernandes, V.1    Osorio, F.L.2
  • 57
    • 79959759004 scopus 로고    scopus 로고
    • Parental and peer predictors of social anxiety in youth
    • Festa, C.C. & Ginsburg, G.S. (2011) Parental and peer predictors of social anxiety in youth. Child Psychiatry Hum Dev 42, 291–306.
    • (2011) Child Psychiatry Hum Dev , vol.42 , pp. 291-306
    • Festa, C.C.1    Ginsburg, G.S.2
  • 58
    • 84949894876 scopus 로고    scopus 로고
    • Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood
    • Fonzo, G.A., Ramsawh, H.J., Flagan, T.M., Simmons, A.N., Sullivan, S.G., Allard, C.B., Paulus, M.P. & Stein, M.B. (2016) Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood. Psychol Med 46, 1037–1054.
    • (2016) Psychol Med , vol.46 , pp. 1037-1054
    • Fonzo, G.A.1    Ramsawh, H.J.2    Flagan, T.M.3    Simmons, A.N.4    Sullivan, S.G.5    Allard, C.B.6    Paulus, M.P.7    Stein, M.B.8
  • 59
    • 84860739984 scopus 로고    scopus 로고
    • The impact of stressful life events on relapse of generalized anxiety disorder
    • Francis, J.L., Moitra, E., Dyck, I. & Keller, M.B. (2012) The impact of stressful life events on relapse of generalized anxiety disorder. Depress Anxiety 29, 386–391.
    • (2012) Depress Anxiety , vol.29 , pp. 386-391
    • Francis, J.L.1    Moitra, E.2    Dyck, I.3    Keller, M.B.4
  • 60
    • 84873523115 scopus 로고    scopus 로고
    • How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
    • Frodl, T. & O'Keane, V. (2013) How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis 52, 24–37.
    • (2013) Neurobiol Dis , vol.52 , pp. 24-37
    • Frodl, T.1    O'Keane, V.2
  • 61
    • 85044572181 scopus 로고    scopus 로고
    • Epigenetic germline inheritance in mammals: looking to the past to understand the future
    • Gapp, K. & Bohacek, J. (2017) Epigenetic germline inheritance in mammals: looking to the past to understand the future. Genes Brain Behav.
    • (2017) Genes Brain Behav
    • Gapp, K.1    Bohacek, J.2
  • 63
    • 21044439526 scopus 로고    scopus 로고
    • Childhood abuse and familial violence and the risk of panic attacks and panic disorder in young adulthood
    • Goodwin, R.D., Fergusson, D.M. & Horwood, L.J. (2005) Childhood abuse and familial violence and the risk of panic attacks and panic disorder in young adulthood. Psychol Med 35, 881–890.
    • (2005) Psychol Med , vol.35 , pp. 881-890
    • Goodwin, R.D.1    Fergusson, D.M.2    Horwood, L.J.3
  • 64
    • 78049526563 scopus 로고    scopus 로고
    • Resilience to depressive symptoms: the buffering effects of enhancing cognitive style and positive life events
    • Haeffel, G.J. & Vargas, I. (2011) Resilience to depressive symptoms: the buffering effects of enhancing cognitive style and positive life events. J Behav Ther Exp Psychiatry 42, 13–18.
    • (2011) J Behav Ther Exp Psychiatry , vol.42 , pp. 13-18
    • Haeffel, G.J.1    Vargas, I.2
  • 65
    • 0025784857 scopus 로고
    • Irrational beliefs, perceived availability of social support, and anxiety
    • Hart, K.E. & Hittner, J.B. (1991) Irrational beliefs, perceived availability of social support, and anxiety. J Clin Psychol 47, 582–587.
    • (1991) J Clin Psychol , vol.47 , pp. 582-587
    • Hart, K.E.1    Hittner, J.B.2
  • 66
    • 84897139220 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance: myths and mechanisms
    • Heard, E. & Martienssen, R.A. (2014) Transgenerational epigenetic inheritance: myths and mechanisms. Cell 157, 95–109.
    • (2014) Cell , vol.157 , pp. 95-109
    • Heard, E.1    Martienssen, R.A.2
  • 67
    • 0034596146 scopus 로고    scopus 로고
    • Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
    • Heim, C., Newport, D.J., Heit, S., Graham, Y.P., Wilcox, M., Bonsall, R., Miller, A.H. & Nemeroff, C.B. (2000) Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 284, 592–597.
    • (2000) JAMA , vol.284 , pp. 592-597
    • Heim, C.1    Newport, D.J.2    Heit, S.3    Graham, Y.P.4    Wilcox, M.5    Bonsall, R.6    Miller, A.H.7    Nemeroff, C.B.8
  • 68
    • 0034810295 scopus 로고    scopus 로고
    • A review and meta-analysis of the genetic epidemiology of anxiety disorders
    • Hettema, J.M., Neale, M.C. & Kendler, K.S. (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158, 1568–1578.
    • (2001) Am J Psychiatry , vol.158 , pp. 1568-1578
    • Hettema, J.M.1    Neale, M.C.2    Kendler, K.S.3
  • 69
    • 13244263000 scopus 로고    scopus 로고
    • The structure of genetic and environmental risk factors for anxiety disorders in men and women
    • Hettema, J.M., Prescott, C.A., Myers, J.M., Neale, M.C. & Kendler, K.S. (2005) The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 62, 182–189.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 182-189
    • Hettema, J.M.1    Prescott, C.A.2    Myers, J.M.3    Neale, M.C.4    Kendler, K.S.5
  • 70
    • 34047139442 scopus 로고    scopus 로고
    • Resilience: research evidence and conceptual considerations for posttraumatic stress disorder
    • Hoge, E.A., Austin, E.D. & Pollack, M.H. (2007) Resilience: research evidence and conceptual considerations for posttraumatic stress disorder. Depress Anxiety 24, 139–152.
    • (2007) Depress Anxiety , vol.24 , pp. 139-152
    • Hoge, E.A.1    Austin, E.D.2    Pollack, M.H.3
  • 71
    • 84925454578 scopus 로고    scopus 로고
    • Heterogeneity and individuality: microRNAs in mental disorders
    • Hommers, L.G., Domschke, K. & Deckert, J. (2015a) Heterogeneity and individuality: microRNAs in mental disorders. J Neural Transm 122, 79–97.
    • (2015) J Neural Transm , vol.122 , pp. 79-97
    • Hommers, L.G.1    Domschke, K.2    Deckert, J.3
  • 72
    • 84929519295 scopus 로고    scopus 로고
    • MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits
    • Hommers, L., Raab, A., Bohl, A. et al. (2015b) MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. Am J Med Genet B Neuropsychiatr Genet 168B, 296–306.
    • (2015) Am J Med Genet B Neuropsychiatr Genet , vol.168B , pp. 296-306
    • Hommers, L.1    Raab, A.2    Bohl, A.3
  • 73
    • 84918506772 scopus 로고    scopus 로고
    • Protective factors associated with resilient functioning in young adulthood after childhood exposure to violence
    • Howell, K.H. & Miller-Graff, L.E. (2014) Protective factors associated with resilient functioning in young adulthood after childhood exposure to violence. Child Abuse Negl 38, 1985–1994.
    • (2014) Child Abuse Negl , vol.38 , pp. 1985-1994
    • Howell, K.H.1    Miller-Graff, L.E.2
  • 74
    • 84946925863 scopus 로고    scopus 로고
    • Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
    • Jawahar, M.C., Murgatroyd, C., Harrison, E.L. & Baune, B.T. (2015) Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders. Clin Epigenetics 7, 122.
    • (2015) Clin Epigenetics , vol.7 , pp. 122
    • Jawahar, M.C.1    Murgatroyd, C.2    Harrison, E.L.3    Baune, B.T.4
  • 76
    • 84893795698 scopus 로고    scopus 로고
    • The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders
    • Jensen, K.P., Kranzler, H.R., Stein, M.B. & Gelernter, J. (2014) The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders. Am J Med Genet B Neuropsychiatr Genet 165B, 175–183.
    • (2014) Am J Med Genet B Neuropsychiatr Genet , vol.165B , pp. 175-183
    • Jensen, K.P.1    Kranzler, H.R.2    Stein, M.B.3    Gelernter, J.4
  • 77
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T. & Allis, C.D. (2001) Translating the histone code. Science 293, 1074–1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 78
  • 79
    • 0033762426 scopus 로고    scopus 로고
    • Comorbidity of mood and anxiety disorders
    • Kaufman, J. & Charney, D. (2000) Comorbidity of mood and anxiety disorders. Depress Anxiety 12(Suppl. 1), 69–76.
    • (2000) Depress Anxiety , vol.12 , pp. 69-76
    • Kaufman, J.1    Charney, D.2
  • 80
    • 0033010098 scopus 로고    scopus 로고
    • Fears and phobias: reliability and heritability
    • Kendler, K.S., Karkowski, L.M. & Prescott, C.A. (1999) Fears and phobias: reliability and heritability. Psychol Med 29, 539–553.
    • (1999) Psychol Med , vol.29 , pp. 539-553
    • Kendler, K.S.1    Karkowski, L.M.2    Prescott, C.A.3
  • 81
    • 0042655450 scopus 로고    scopus 로고
    • Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety
    • Kendler, K.S., Hettema, J.M., Butera, F., Gardner, C.O. & Prescott, C.A. (2003) Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 60, 789–796.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 789-796
    • Kendler, K.S.1    Hettema, J.M.2    Butera, F.3    Gardner, C.O.4    Prescott, C.A.5
  • 82
    • 20344385026 scopus 로고    scopus 로고
    • Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R. & Walters, E.E. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62, 593–602.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 593-602
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3    Jin, R.4    Merikangas, K.R.5    Walters, E.E.6
  • 83
    • 84865989655 scopus 로고    scopus 로고
    • Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
    • Kessler, R.C., Petukhova, M., Sampson, N.A., Zaslavsky, A.M. & Wittchen, H.U. (2012) Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res 21, 169–184.
    • (2012) Int J Methods Psychiatr Res , vol.21 , pp. 169-184
    • Kessler, R.C.1    Petukhova, M.2    Sampson, N.A.3    Zaslavsky, A.M.4    Wittchen, H.U.5
  • 84
    • 84941097601 scopus 로고    scopus 로고
    • Association of human microRNAs miR-22 and miR-491 polymorphisms with panic disorder with or without agoraphobia in a Korean population
    • Kim, B., Kim, M.K., Kim, S.W., Kim, K.M., Kim, H.S., An, H.J., Kim, J.O., Choi, T.K., Kim, N.K. & Lee, S.H. (2015) Association of human microRNAs miR-22 and miR-491 polymorphisms with panic disorder with or without agoraphobia in a Korean population. J Affect Disord 188, 118–126.
    • (2015) J Affect Disord , vol.188 , pp. 118-126
    • Kim, B.1    Kim, M.K.2    Kim, S.W.3    Kim, K.M.4    Kim, H.S.5    An, H.J.6    Kim, J.O.7    Choi, T.K.8    Kim, N.K.9    Lee, S.H.10
  • 86
    • 77956812756 scopus 로고    scopus 로고
    • Life events in panic disorder—an update on "candidate stressors"
    • Klauke, B., Deckert, J., Reif, A., Pauli, P. & Domschke, K. (2010) Life events in panic disorder—an update on "candidate stressors". Depress Anxiety 27, 716–730.
    • (2010) Depress Anxiety , vol.27 , pp. 716-730
    • Klauke, B.1    Deckert, J.2    Reif, A.3    Pauli, P.4    Domschke, K.5
  • 90
    • 84949558414 scopus 로고    scopus 로고
    • Models of intergenerational and transgenerational transmission of risk for psychopathology in mice
    • Klengel, T., Dias, B.G. & Ressler, K.J. (2016) Models of intergenerational and transgenerational transmission of risk for psychopathology in mice. Neuropsychopharmacology 41, 219–231.
    • (2016) Neuropsychopharmacology , vol.41 , pp. 219-231
    • Klengel, T.1    Dias, B.G.2    Ressler, K.J.3
  • 93
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T. (2007) Chromatin modifications and their function. Cell 128, 693–705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 94
    • 84919496045 scopus 로고    scopus 로고
    • Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder
    • Kwapis, J.L. & Wood, M.A. (2014) Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder. Trends Neurosci 37, 706–720.
    • (2014) Trends Neurosci , vol.37 , pp. 706-720
    • Kwapis, J.L.1    Wood, M.A.2
  • 95
    • 13944249193 scopus 로고    scopus 로고
    • Adolescent peer relations, friendships, and romantic relationships: do they predict social anxiety and depression?
    • La Greca, A.M. & Harrison, H.M. (2005) Adolescent peer relations, friendships, and romantic relationships: do they predict social anxiety and depression? J Clin Child Adolesc Psychol 34, 49–61.
    • (2005) J Clin Child Adolesc Psychol , vol.34 , pp. 49-61
    • La Greca, A.M.1    Harrison, H.M.2
  • 96
    • 85031311852 scopus 로고    scopus 로고
    • DNA methylation and clinical response to antidepressant medication in major depressive disorder: a review and recommendations
    • Lisoway, A.J., Zai, C.C., Tiwari, A.K. & Kennedy, J.L. (2017) DNA methylation and clinical response to antidepressant medication in major depressive disorder: a review and recommendations. Neurosci Lett.
    • (2017) Neurosci Lett
    • Lisoway, A.J.1    Zai, C.C.2    Tiwari, A.K.3    Kennedy, J.L.4
  • 97
    • 67349157695 scopus 로고    scopus 로고
    • Effects of stress throughout the lifespan on the brain, behaviour and cognition
    • Lupien, S.J., McEwen, B.S., Gunnar, M.R. & Heim, C. (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10, 434–445.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 434-445
    • Lupien, S.J.1    McEwen, B.S.2    Gunnar, M.R.3    Heim, C.4
  • 98
    • 77952386621 scopus 로고    scopus 로고
    • Developmental cascades linking stress inoculation, arousal regulation, and resilience
    • Lyons, D.M., Parker, K.J., Katz, M. & Schatzberg, A.F. (2009) Developmental cascades linking stress inoculation, arousal regulation, and resilience. Front Behav Neurosci 3, 32.
    • (2009) Front Behav Neurosci , vol.3 , pp. 32
    • Lyons, D.M.1    Parker, K.J.2    Katz, M.3    Schatzberg, A.F.4
  • 99
    • 84924170953 scopus 로고    scopus 로고
    • The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations
    • Maccari, S., Krugers, H.J., Morley-Fletcher, S., Szyf, M. & Brunton, P.J. (2014) The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol 26, 707–723.
    • (2014) J Neuroendocrinol , vol.26 , pp. 707-723
    • Maccari, S.1    Krugers, H.J.2    Morley-Fletcher, S.3    Szyf, M.4    Brunton, P.J.5
  • 101
    • 85002184010 scopus 로고    scopus 로고
    • The big role of small RNAs in anxiety and stress-related disorders
    • Malan-Muller, S. & Hemmings, S.M. (2017) The big role of small RNAs in anxiety and stress-related disorders. Vitam Horm 103, 85–129.
    • (2017) Vitam Horm , vol.103 , pp. 85-129
    • Malan-Muller, S.1    Hemmings, S.M.2
  • 102
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T.A., Collins, F.S., Cox, N.J. et al. (2009) Finding the missing heritability of complex diseases. Nature 461, 747–753.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 103
    • 77953912531 scopus 로고    scopus 로고
    • Advances in molecular genetics of panic disorder
    • Maron, E., Hettema, J.M. & Shlik, J. (2010) Advances in molecular genetics of panic disorder. Mol Psychiatry 15, 681–701.
    • (2010) Mol Psychiatry , vol.15 , pp. 681-701
    • Maron, E.1    Hettema, J.M.2    Shlik, J.3
  • 104
    • 85044604727 scopus 로고    scopus 로고
    • ISH NIA OS-01 the microRNA miR-19a-3p binds to a polymorphism in the gene for the noradrenaline transporter and may increase the risk of cardiovascular and psychiatric disease
    • &, (- ISH 2016 Abstract Book
    • Marques, F., Eikelis, N., Bayles, R., Straznicky, N., Hering, D., Esler, M., Head, G., Schlaich, M. & Lambert, G. (2016) ISH NIA OS-01 the microRNA miR-19a-3p binds to a polymorphism in the gene for the noradrenaline transporter and may increase the risk of cardiovascular and psychiatric disease. J Hypertens 34Suppl. 1 - ISH 2016 Abstract Book, e42.
    • (2016) J Hypertens , vol.34
    • Marques, F.1    Eikelis, N.2    Bayles, R.3    Straznicky, N.4    Hering, D.5    Esler, M.6    Head, G.7    Schlaich, M.8    Lambert, G.9
  • 105
    • 84965037271 scopus 로고    scopus 로고
    • MicroRNA's impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety
    • Martinetz, S. (2016) MicroRNA's impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety. Eur J Physiol 468, 1061–1069.
    • (2016) Eur J Physiol , vol.468 , pp. 1061-1069
    • Martinetz, S.1
  • 107
    • 79960584977 scopus 로고    scopus 로고
    • Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness
    • McLean, C.P., Asnaani, A., Litz, B.T. & Hofmann, S.G. (2011) Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 45, 1027–1035.
    • (2011) J Psychiatr Res , vol.45 , pp. 1027-1035
    • McLean, C.P.1    Asnaani, A.2    Litz, B.T.3    Hofmann, S.G.4
  • 108
    • 77957911410 scopus 로고    scopus 로고
    • Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    • Meaburn, E.L., Schalkwyk, L.C. & Mill, J. (2010) Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics 5, 578–582.
    • (2010) Epigenetics , vol.5 , pp. 578-582
    • Meaburn, E.L.1    Schalkwyk, L.C.2    Mill, J.3
  • 109
    • 84887020115 scopus 로고    scopus 로고
    • Cognitive emotion regulation strategies contributing to resilience in patients with depression and/or anxiety disorders
    • Min, J.A., Yu, J.J., Lee, C.U. & Chae, J.H. (2013) Cognitive emotion regulation strategies contributing to resilience in patients with depression and/or anxiety disorders. Compr Psychiatry 54, 1190–1197.
    • (2013) Compr Psychiatry , vol.54 , pp. 1190-1197
    • Min, J.A.1    Yu, J.J.2    Lee, C.U.3    Chae, J.H.4
  • 110
    • 84878342895 scopus 로고    scopus 로고
    • Cross-talk among epigenetic modifications: lessons from histone arginine methylation
    • Molina-Serrano, D., Schiza, V. & Kirmizis, A. (2013) Cross-talk among epigenetic modifications: lessons from histone arginine methylation. Biochem Soc Trans 41, 751–759.
    • (2013) Biochem Soc Trans , vol.41 , pp. 751-759
    • Molina-Serrano, D.1    Schiza, V.2    Kirmizis, A.3
  • 111
    • 84869096444 scopus 로고    scopus 로고
    • DNA methylation and its basic function
    • Moore, L.D., Le, T. & Fan, G. (2013) DNA methylation and its basic function. Neuropsychopharmacology 38, 23–38.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 23-38
    • Moore, L.D.1    Le, T.2    Fan, G.3
  • 113
    • 84872681404 scopus 로고    scopus 로고
    • Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients
    • Murphy, T.M., Mullins, N., Ryan, M. et al. (2013) Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients. Genes Brain Behav 12, 125–132.
    • (2013) Genes Brain Behav , vol.12 , pp. 125-132
    • Murphy, T.M.1    Mullins, N.2    Ryan, M.3
  • 114
    • 84924812551 scopus 로고    scopus 로고
    • Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes
    • Murphy, T.M., O'Donovan, A., Mullins, N., O'Farrelly, C., McCann, A. & Malone, K. (2015) Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet 25, 71–78.
    • (2015) Psychiatr Genet , vol.25 , pp. 71-78
    • Murphy, T.M.1    O'Donovan, A.2    Mullins, N.3    O'Farrelly, C.4    McCann, A.5    Malone, K.6
  • 115
    • 84862502708 scopus 로고    scopus 로고
    • Mismatch or cumulative stress: toward an integrated hypothesis of programming effects
    • Nederhof, E. & Schmidt, M.V. (2012) Mismatch or cumulative stress: toward an integrated hypothesis of programming effects. Physiol Behav 106, 691–700.
    • (2012) Physiol Behav , vol.106 , pp. 691-700
    • Nederhof, E.1    Schmidt, M.V.2
  • 118
    • 84055193505 scopus 로고    scopus 로고
    • The economic cost of brain disorders in Europe
    • Olesen, J., Gustavsson, A., Svensson, M., Wittchen, H.U., Jonsson, B., CDBE2010 Study Group & European Brain Council (2012) The economic cost of brain disorders in Europe. Eur J Neurol 19, 155–162.
    • (2012) Eur J Neurol , vol.19 , pp. 155-162
    • Olesen, J.1    Gustavsson, A.2    Svensson, M.3    Wittchen, H.U.4    Jonsson, B.5
  • 121
    • 85017324231 scopus 로고    scopus 로고
    • Anxiety among adults with a history of childhood adversity: psychological resilience moderates the indirect effect of emotion dysregulation
    • Poole, J.C., Dobson, K.S. & Pusch, D. (2017) Anxiety among adults with a history of childhood adversity: psychological resilience moderates the indirect effect of emotion dysregulation. J Affect Disord 217, 144–152.
    • (2017) J Affect Disord , vol.217 , pp. 144-152
    • Poole, J.C.1    Dobson, K.S.2    Pusch, D.3
  • 123
    • 85019552148 scopus 로고    scopus 로고
    • Differential histone acetylation in sub-regions of bed nucleus of the stria terminalis underlies fear consolidation and extinction
    • Ranjan, V., Singh, S., Siddiqui, S.A., Tripathi, S., Khan, M.Y. & Prakash, A. (2017) Differential histone acetylation in sub-regions of bed nucleus of the stria terminalis underlies fear consolidation and extinction. Psychiatry Invest 14, 350–359.
    • (2017) Psychiatry Invest , vol.14 , pp. 350-359
    • Ranjan, V.1    Singh, S.2    Siddiqui, S.A.3    Tripathi, S.4    Khan, M.Y.5    Prakash, A.6
  • 124
    • 84880686392 scopus 로고    scopus 로고
    • MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects
    • Rao, Y.S., Mott, N.N., Wang, Y., Chung, W.C. & Pak, T.R. (2013) MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects. Endocrinology 154, 2795–2806.
    • (2013) Endocrinology , vol.154 , pp. 2795-2806
    • Rao, Y.S.1    Mott, N.N.2    Wang, Y.3    Chung, W.C.4    Pak, T.R.5
  • 127
    • 84949624558 scopus 로고    scopus 로고
    • Hpa axis related genes and response to psychological therapies: genetics and epigenetics
    • Roberts, S., Keers, R., Lester, K.J. et al. (2015) Hpa axis related genes and response to psychological therapies: genetics and epigenetics. Depress Anxiety 32, 861–870.
    • (2015) Depress Anxiety , vol.32 , pp. 861-870
    • Roberts, S.1    Keers, R.2    Lester, K.J.3
  • 128
    • 84877935103 scopus 로고    scopus 로고
    • Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation
    • Rodgers, A.B., Morgan, C.P., Bronson, S.L., Revello, S. & Bale, T.L. (2013) Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J Neurosci 33, 9003–9012.
    • (2013) J Neurosci , vol.33 , pp. 9003-9012
    • Rodgers, A.B.1    Morgan, C.P.2    Bronson, S.L.3    Revello, S.4    Bale, T.L.5
  • 129
    • 0030434977 scopus 로고    scopus 로고
    • Preliminary investigation of the role of previous exposure to potentially traumatizing events in generalized anxiety disorder
    • Roemer, L., Molina, S., Litz, B.T. & Borkovec, T.D. (1996) Preliminary investigation of the role of previous exposure to potentially traumatizing events in generalized anxiety disorder. Depress Anxiety 4, 134–138.
    • (1996) Depress Anxiety , vol.4 , pp. 134-138
    • Roemer, L.1    Molina, S.2    Litz, B.T.3    Borkovec, T.D.4
  • 131
    • 85014052892 scopus 로고    scopus 로고
    • Does maternal mental well-being in pregnancy impact the early human epigenome?
    • Ryan, J., Mansell, T., Fransquet, P. & Saffery, R. (2017) Does maternal mental well-being in pregnancy impact the early human epigenome? Epigenomics 9, 313–332.
    • (2017) Epigenomics , vol.9 , pp. 313-332
    • Ryan, J.1    Mansell, T.2    Fransquet, P.3    Saffery, R.4
  • 132
    • 0036315095 scopus 로고    scopus 로고
    • History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder
    • Safren, S.A., Gershuny, B.S., Marzol, P., Otto, M.W. & Pollack, M.H. (2002) History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder. J Nerv Ment Dis 190, 453–456.
    • (2002) J Nerv Ment Dis , vol.190 , pp. 453-456
    • Safren, S.A.1    Gershuny, B.S.2    Marzol, P.3    Otto, M.W.4    Pollack, M.H.5
  • 136
    • 84961390398 scopus 로고    scopus 로고
    • The effects of daily stress on positive and negative mental health: mediation through self-efficacy
    • Schonfeld, P., Brailovskaia, J., Bieda, A., Zhang, X.C. & Margraf, J. (2016) The effects of daily stress on positive and negative mental health: mediation through self-efficacy. Int J Clin Health Psychol 16, 1–10.
    • (2016) Int J Clin Health Psychol , vol.16 , pp. 1-10
    • Schonfeld, P.1    Brailovskaia, J.2    Bieda, A.3    Zhang, X.C.4    Margraf, J.5
  • 138
    • 33751286460 scopus 로고    scopus 로고
    • Interpersonal problem areas and onset of panic disorder
    • Scocco, P., Barbieri, I. & Frank, E. (2007) Interpersonal problem areas and onset of panic disorder. Psychopathology 40, 8–13.
    • (2007) Psychopathology , vol.40 , pp. 8-13
    • Scocco, P.1    Barbieri, I.2    Frank, E.3
  • 139
    • 78649923432 scopus 로고    scopus 로고
    • Whatever does not kill us: cumulative lifetime adversity, vulnerability, and resilience
    • Seery, M.D., Holman, E.A. & Silver, R.C. (2010) Whatever does not kill us: cumulative lifetime adversity, vulnerability, and resilience. J Pers Soc Psychol 99, 1025–1041.
    • (2010) J Pers Soc Psychol , vol.99 , pp. 1025-1041
    • Seery, M.D.1    Holman, E.A.2    Silver, R.C.3
  • 140
    • 84880055594 scopus 로고    scopus 로고
    • An upside to adversity? Moderate cumulative lifetime adversity is associated with resilient responses in the face of controlled stressors
    • Seery, M.D., Leo, R.J., Lupien, S.P., Kondrak, C.L. & Almonte, J.L. (2013) An upside to adversity? Moderate cumulative lifetime adversity is associated with resilient responses in the face of controlled stressors. Psychol Sci 24, 1181–1189.
    • (2013) Psychol Sci , vol.24 , pp. 1181-1189
    • Seery, M.D.1    Leo, R.J.2    Lupien, S.P.3    Kondrak, C.L.4    Almonte, J.L.5
  • 141
    • 34247491963 scopus 로고    scopus 로고
    • Selective mutism and anxiety: a review of the current conceptualization of the disorder
    • Sharp, W.G., Sherman, C. & Gross, A.M. (2007) Selective mutism and anxiety: a review of the current conceptualization of the disorder. J Anxiety Disord 21, 568–579.
    • (2007) J Anxiety Disord , vol.21 , pp. 568-579
    • Sharp, W.G.1    Sherman, C.2    Gross, A.M.3
  • 143
    • 84867159536 scopus 로고    scopus 로고
    • Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men
    • Shumay, E., Logan, J., Volkow, N.D. & Fowler, J.S. (2012) Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics 7, 1151–1160.
    • (2012) Epigenetics , vol.7 , pp. 1151-1160
    • Shumay, E.1    Logan, J.2    Volkow, N.D.3    Fowler, J.S.4
  • 144
    • 85009742315 scopus 로고    scopus 로고
    • Enhanced histone acetylation in the infralimbic prefrontal cortex is associated with fear extinction
    • Siddiqui, S.A., Singh, S., Ranjan, V., Ugale, R., Saha, S. & Prakash, A. (2017) Enhanced histone acetylation in the infralimbic prefrontal cortex is associated with fear extinction. Cell Mol Neurobiol.
    • (2017) Cell Mol Neurobiol
    • Siddiqui, S.A.1    Singh, S.2    Ranjan, V.3    Ugale, R.4    Saha, S.5    Prakash, A.6
  • 145
    • 84940766140 scopus 로고    scopus 로고
    • Pediatric-onset and adult-onset separation anxiety disorder across countries in the World Mental Health Survey
    • Silove, D., Alonso, J., Bromet, E. et al. (2015) Pediatric-onset and adult-onset separation anxiety disorder across countries in the World Mental Health Survey. Am J Psychiatry 172, 647–656.
    • (2015) Am J Psychiatry , vol.172 , pp. 647-656
    • Silove, D.1    Alonso, J.2    Bromet, E.3
  • 146
    • 85000399021 scopus 로고    scopus 로고
    • Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms
    • Smearman, E.L., Almli, L.M., Conneely, K.N., Brody, G.H., Sales, J.M., Bradley, B., Ressler, K.J. & Smith, A.K. (2016) Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms. Child Dev 87, 122–134.
    • (2016) Child Dev , vol.87 , pp. 122-134
    • Smearman, E.L.1    Almli, L.M.2    Conneely, K.N.3    Brody, G.H.4    Sales, J.M.5    Bradley, B.6    Ressler, K.J.7    Smith, A.K.8
  • 147
    • 84949567515 scopus 로고    scopus 로고
    • The genetics of stress-related disorders: PTSD, depression, and anxiety disorders
    • Smoller, J.W. (2016) The genetics of stress-related disorders: PTSD, depression, and anxiety disorders. Neuropsychopharmacology 41, 297–319.
    • (2016) Neuropsychopharmacology , vol.41 , pp. 297-319
    • Smoller, J.W.1
  • 148
    • 0030071532 scopus 로고    scopus 로고
    • Childhood physical and sexual abuse in patients with anxiety disorders and in a community sample
    • Stein, M.B., Walker, J.R., Anderson, G., Hazen, A.L., Ross, C.A., Eldridge, G. & Forde, D.R. (1996) Childhood physical and sexual abuse in patients with anxiety disorders and in a community sample. Am J Psychiatry 153, 275–277.
    • (1996) Am J Psychiatry , vol.153 , pp. 275-277
    • Stein, M.B.1    Walker, J.R.2    Anderson, G.3    Hazen, A.L.4    Ross, C.A.5    Eldridge, G.6    Forde, D.R.7
  • 150
    • 84897410689 scopus 로고    scopus 로고
    • CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents
    • Sumner, J.A., McLaughlin, K.A., Walsh, K., Sheridan, M.A. & Koenen, K.C. (2014) CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents. Psychoneuroendocrinology 43, 71–80.
    • (2014) Psychoneuroendocrinology , vol.43 , pp. 71-80
    • Sumner, J.A.1    McLaughlin, K.A.2    Walsh, K.3    Sheridan, M.A.4    Koenen, K.C.5
  • 151
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki, M.M. & Bird, A. (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9, 465–476.
    • (2008) Nat Rev Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 152
    • 84893647814 scopus 로고    scopus 로고
    • Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning
    • Szyf, M. (2014) Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nat Neurosci 17, 2–4.
    • (2014) Nat Neurosci , vol.17 , pp. 2-4
    • Szyf, M.1
  • 153
    • 67049167753 scopus 로고    scopus 로고
    • Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical report
    • Teicher, M.H., Samson, J.A., Polcari, A. & Andersen, S.L. (2009) Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical report. J Clin Psychiatry 70, 684–691.
    • (2009) J Clin Psychiatry , vol.70 , pp. 684-691
    • Teicher, M.H.1    Samson, J.A.2    Polcari, A.3    Andersen, S.L.4
  • 154
    • 84988481260 scopus 로고    scopus 로고
    • The effects of childhood maltreatment on brain structure, function and connectivity
    • Teicher, M.H., Samson, J.A., Anderson, C.M. & Ohashi, K. (2016) The effects of childhood maltreatment on brain structure, function and connectivity. Nat Rev Neurosci 17, 652–666.
    • (2016) Nat Rev Neurosci , vol.17 , pp. 652-666
    • Teicher, M.H.1    Samson, J.A.2    Anderson, C.M.3    Ohashi, K.4
  • 155
    • 73549085850 scopus 로고    scopus 로고
    • DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker
    • Tost, J. (2010) DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Mol Biotechnol 44, 71–81.
    • (2010) Mol Biotechnol , vol.44 , pp. 71-81
    • Tost, J.1
  • 156
    • 84856277610 scopus 로고    scopus 로고
    • Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults
    • Tyrka, A.R., Price, L.H., Marsit, C., Walters, O.C. & Carpenter, L.L. (2012) Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One 7, e30148.
    • (2012) PLoS One , vol.7
    • Tyrka, A.R.1    Price, L.H.2    Marsit, C.3    Walters, O.C.4    Carpenter, L.L.5
  • 157
    • 84977274624 scopus 로고    scopus 로고
    • Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders
    • Tyrka, A.R., Parade, S.H., Welch, E.S., Ridout, K.K., Price, L.H., Marsit, C., Philip, N.S. & Carpenter, L.L. (2016) Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders. Transl Psychiatry 6, e848.
    • (2016) Transl Psychiatry , vol.6
    • Tyrka, A.R.1    Parade, S.H.2    Welch, E.S.3    Ridout, K.K.4    Price, L.H.5    Marsit, C.6    Philip, N.S.7    Carpenter, L.L.8
  • 158
    • 84889859861 scopus 로고    scopus 로고
    • Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence
    • Uddin, M., Sipahi, L., Li, J. & Koenen, K.C. (2013) Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence. Depress Anxiety 30, 1151–1160.
    • (2013) Depress Anxiety , vol.30 , pp. 1151-1160
    • Uddin, M.1    Sipahi, L.2    Li, J.3    Koenen, K.C.4
  • 160
    • 85019207628 scopus 로고    scopus 로고
    • Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness
    • Uher, R. & Zwicker, A. (2017) Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry 16, 121–129.
    • (2017) World Psychiatry , vol.16 , pp. 121-129
    • Uher, R.1    Zwicker, A.2
  • 164
    • 0002947085 scopus 로고
    • The epigenotype
    • Waddington, C.H. (1942) The epigenotype. Endeavour 1, 18–20.
    • (1942) Endeavour , vol.1 , pp. 18-20
    • Waddington, C.H.1
  • 166
    • 85014886223 scopus 로고    scopus 로고
    • Increased methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of patients with generalized anxiety disorder
    • Wang, W., Feng, J., Ji, C., Mu, X., Ma, Q., Fan, Y., Chen, C., Gao, C., Ma, X.C. & Zhu, F. (2017) Increased methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of patients with generalized anxiety disorder. J Psychiatr Res 91, 18–25.
    • (2017) J Psychiatr Res , vol.91 , pp. 18-25
    • Wang, W.1    Feng, J.2    Ji, C.3    Mu, X.4    Ma, Q.5    Fan, Y.6    Chen, C.7    Gao, C.8    Ma, X.C.9    Zhu, F.10
  • 168
    • 85009160421 scopus 로고    scopus 로고
    • Prenatal stressors in rodents: effects on behavior
    • Weinstock, M. (2017) Prenatal stressors in rodents: effects on behavior. Neurobiol Stress 6, 3–13.
    • (2017) Neurobiol Stress , vol.6 , pp. 3-13
    • Weinstock, M.1
  • 169
    • 84896976354 scopus 로고    scopus 로고
    • HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?
    • Whittle, N. & Singewald, N. (2014) HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand? Biochem Soc Trans 42, 569–581.
    • (2014) Biochem Soc Trans , vol.42 , pp. 569-581
    • Whittle, N.1    Singewald, N.2
  • 174
    • 77953958222 scopus 로고    scopus 로고
    • Timing is critical: gene, environment and timing interactions in genetics of suicide in children and adolescents
    • Zalsman, G. (2010) Timing is critical: gene, environment and timing interactions in genetics of suicide in children and adolescents. Eur Psychiatry 25, 284–286.
    • (2010) Eur Psychiatry , vol.25 , pp. 284-286
    • Zalsman, G.1
  • 175
    • 84947485614 scopus 로고    scopus 로고
    • Genetic vulnerability, timing of short-term stress and mood regulation: a rodent diffusion tensor imaging study
    • Zalsman, G., Gutman, A., Shbiro, L., Rosenan, R., Mann, J.J. & Weller, A. (2015) Genetic vulnerability, timing of short-term stress and mood regulation: a rodent diffusion tensor imaging study. Eur Neuropsychopharmacol 25, 2075–2085.
    • (2015) Eur Neuropsychopharmacol , vol.25 , pp. 2075-2085
    • Zalsman, G.1    Gutman, A.2    Shbiro, L.3    Rosenan, R.4    Mann, J.J.5    Weller, A.6
  • 176
    • 85015048128 scopus 로고    scopus 로고
    • Epigenetic programming by stress and glucocorticoids along the human lifespan
    • Zannas, A.S. & Chrousos, G.P. (2017) Epigenetic programming by stress and glucocorticoids along the human lifespan. Mol Psychiatry 22, 640–646.
    • (2017) Mol Psychiatry , vol.22 , pp. 640-646
    • Zannas, A.S.1    Chrousos, G.P.2
  • 179
    • 0017576536 scopus 로고
    • Vulnerability—a new view of schizophrenia
    • Zubin, J. & Spring, B. (1977) Vulnerability—a new view of schizophrenia. J Abnorm Psychol 86, 103–126.
    • (1977) J Abnorm Psychol , vol.86 , pp. 103-126
    • Zubin, J.1    Spring, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.