메뉴 건너뛰기




Volumn 7, Issue 1, 2015, Pages

Epigenetic alterations following early postnatal stress: A review on novel aetiological mechanisms of common psychiatric disorders

Author keywords

DNA methylation; Early life stress; Epigenetics; Histone acetylation; Maternal separation; Psychopathology; Stress responsive genes

Indexed keywords

ARGIPRESSIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR; ESTROGEN RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR; REELIN; SEROTONIN TRANSPORTER;

EID: 84946925863     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-015-0156-3     Document Type: Review
Times cited : (114)

References (98)
  • 1
    • 76149141815 scopus 로고    scopus 로고
    • Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: Associations with first onset of DSM-IV disorders
    • Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry. 2010;67(2):113-23.
    • (2010) Arch Gen Psychiatry , vol.67 , Issue.2 , pp. 113-123
    • Green, J.G.1    McLaughlin, K.A.2    Berglund, P.A.3    Gruber, M.J.4    Sampson, N.A.5    Zaslavsky, A.M.6
  • 3
    • 0033016957 scopus 로고    scopus 로고
    • Relationship of childhood maltreatment to the onset and course of major depression in adulthood
    • Bernet CZ, Stein MB. Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depress Anxiety. 1999;9(4):169-74.
    • (1999) Depress Anxiety , vol.9 , Issue.4 , pp. 169-174
    • Bernet, C.Z.1    Stein, M.B.2
  • 4
    • 84861647648 scopus 로고    scopus 로고
    • Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective-and cross-sectional cohort studies
    • Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies. Schizophr Bull. 2012;38(4):661-71.
    • (2012) Schizophr Bull , vol.38 , Issue.4 , pp. 661-671
    • Varese, F.1    Smeets, F.2    Drukker, M.3    Lieverse, R.4    Lataster, T.5    Viechtbauer, W.6
  • 5
    • 79961230893 scopus 로고    scopus 로고
    • Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions
    • Scott KM, Von Korff M, Angermeyer MC, Benjet C, Bruffaerts R, de Girolamo G, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry. 2011;68(8):838-44.
    • (2011) Arch Gen Psychiatry , vol.68 , Issue.8 , pp. 838-844
    • Scott, K.M.1    Von Korff, M.2    Angermeyer, M.C.3    Benjet, C.4    Bruffaerts, R.5    De Girolamo, G.6
  • 6
  • 8
    • 33847289264 scopus 로고    scopus 로고
    • Age of onset of child maltreatment predicts long-term mental health outcomes
    • Kaplow JB, Widom CS. Age of onset of child maltreatment predicts long-term mental health outcomes. J Abnorm Psychol. 2007;116(1):176-87.
    • (2007) J Abnorm Psychol , vol.116 , Issue.1 , pp. 176-187
    • Kaplow, J.B.1    Widom, C.S.2
  • 9
    • 77951244828 scopus 로고    scopus 로고
    • The clinical correlates of reported childhood sexual abuse: An association between age at trauma onset and severity of depression and PTSD in adults
    • Schoedl AF, Costa MC, Mari JJ, Mello MF, Tyrka AR, Carpenter LL, et al. The clinical correlates of reported childhood sexual abuse: an association between age at trauma onset and severity of depression and PTSD in adults. J Child Sex Abus. 2010;19(2):156-70.
    • (2010) J Child Sex Abus , vol.19 , Issue.2 , pp. 156-170
    • Schoedl, A.F.1    Costa, M.C.2    Mari, J.J.3    Mello, M.F.4    Tyrka, A.R.5    Carpenter, L.L.6
  • 10
    • 84982999268 scopus 로고    scopus 로고
    • Childhood poverty, chronic stress, and adult working memory
    • Evans GW, Schamberg MA. Childhood poverty, chronic stress, and adult working memory. Proc Natl Acad Sci. 2009;30:2009.
    • (2009) Proc Natl Acad Sci , vol.30 , pp. 2009
    • Evans, G.W.1    Schamberg, M.A.2
  • 11
    • 0032078822 scopus 로고    scopus 로고
    • Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study
    • Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4):245-58.
    • (1998) Am J Prev Med , vol.14 , Issue.4 , pp. 245-258
    • Felitti, V.J.1    A, R.F.2    Nordenberg, D.3    Williamson, D.F.4    Spitz, A.M.5    Edwards, V.6
  • 12
    • 0035883866 scopus 로고    scopus 로고
    • Adult onset of major depressive disorder in relation to early life violent victimisation: A casecontrol study
    • Wise LA, Zierler S, Krieger N, Harlow BL. Adult onset of major depressive disorder in relation to early life violent victimisation: a casecontrol study. Lancet. 2001;358(9285):881-7.
    • (2001) Lancet , vol.358 , Issue.9285 , pp. 881-887
    • Wise, L.A.1    Zierler, S.2    Krieger, N.3    Harlow, B.L.4
  • 13
    • 50949166644 scopus 로고    scopus 로고
    • Gender, victimization, and psychiatric outcomes
    • Gershon A, Minor K, Hayward C. Gender, victimization, and psychiatric outcomes. Psychol Med. 2008;38(10):1377-91.
    • (2008) Psychol Med , vol.38 , Issue.10 , pp. 1377
    • Gershon, A.1    Minor, K.2    Hayward, C.3
  • 14
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386-9.
    • (2003) Science , vol.301 , Issue.5631 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4    Craig, I.W.5    Harrington, H.6
  • 15
    • 84881665096 scopus 로고    scopus 로고
    • BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brainderived neurotrophic factor and depressive symptoms: A prospective study
    • Buchmann AF, Hellweg R, Rietschel M, Treutlein J, Witt SH, Zimmermann US, et al. BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brainderived neurotrophic factor and depressive symptoms: a prospective study. Eur Neuropsychopharmacol. 2013;23(8):902-9.
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.8 , pp. 902-909
    • Buchmann, A.F.1    Hellweg, R.2    Rietschel, M.3    Treutlein, J.4    Witt, S.H.5    Zimmermann, U.S.6
  • 16
    • 40949142290 scopus 로고    scopus 로고
    • Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    • Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 2008;299(11):1291-305.
    • (2008) JAMA , vol.299 , Issue.11 , pp. 1291-1305
    • Binder, E.B.1    Bradley, R.G.2    Liu, W.3    Epstein, M.P.4    Deveau, T.C.5    Mercer, K.B.6
  • 17
    • 46249091103 scopus 로고    scopus 로고
    • The link between childhood trauma and depression: Insights from HPA axis studies in humans
    • Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology. 2008;33(6):693-710.
    • (2008) Psychoneuroendocrinology , vol.33 , Issue.6 , pp. 693-710
    • Heim, C.1    Newport, D.J.2    Mletzko, T.3    Miller, A.H.4    Nemeroff, C.B.5
  • 19
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan P, Sasaki A, D’Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12(3):342-8.
    • (2009) Nat Neurosci , vol.12 , Issue.3 , pp. 342-348
    • McGowan, P.1    Sasaki, A.2    D’Alessio, A.C.3    Dymov, S.4    Labonte, B.5    Szyf, M.6
  • 22
    • 77952887606 scopus 로고    scopus 로고
    • The epigenetics of social adversity in early life: Implications for mental health outcomes
    • McGowan PO, Szyf M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol Dis. 2010;39(1):66-72.
    • (2010) Neurobiol Dis , vol.39 , Issue.1 , pp. 66-72
    • McGowan, P.O.1    Szyf, M.2
  • 23
    • 70549104872 scopus 로고    scopus 로고
    • Dynamic DNA methylation programs persistent adverse effects of early-life stress
    • Epub 009 Nov 8
    • Murgatroyd C, Patchev A, Wu Y, Micale V, Bockmuhl Y, Fischer D, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009;12(12):1559-66. doi:10.038/nn.2436. Epub 009 Nov 8.
    • (2009) Nat Neurosci , vol.12 , Issue.12 , pp. 1559-1566
    • Murgatroyd, C.1    Patchev, A.2    Wu, Y.3    Micale, V.4    Bockmuhl, Y.5    Fischer, D.6
  • 24
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 2000;23(5):477-501.
    • (2000) Neuropsychopharmacology , vol.23 , Issue.5 , pp. 477-501
    • Holsboer, F.1
  • 26
    • 0027936468 scopus 로고
    • Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients
    • Raadsheer FC, Hoogendijk WJ, Stam FC, Tilders FJ, Swaab DF. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology. 1994;60(4):436-44.
    • (1994) Neuroendocrinology , vol.60 , Issue.4 , pp. 436-444
    • Raadsheer, F.C.1    Hoogendijk, W.J.2    Stam, F.C.3    Tilders, F.J.4    Swaab, D.F.5
  • 27
  • 28
    • 85047699571 scopus 로고    scopus 로고
    • Early experience and serotonin transporter gene variation interact to influence primate CNS function
    • Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry. 2002;7(1):118-22.
    • (2002) Mol Psychiatry , vol.7 , Issue.1 , pp. 118-122
    • Bennett, A.J.1    Lesch, K.P.2    Heils, A.3    Long, J.C.4    Lorenz, J.G.5    Shoaf, S.E.6
  • 29
    • 7444232259 scopus 로고    scopus 로고
    • Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    • Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science. 2004; 306(5697):879-81.
    • (2004) Science , vol.306 , Issue.5697 , pp. 879-881
    • Ansorge, M.S.1    Zhou, M.2    Lira, A.3    Hen, R.4    Gingrich, J.A.5
  • 30
    • 67649327144 scopus 로고    scopus 로고
    • Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
    • Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR, et al. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry. 2009;14(7):681-95.
    • (2009) Mol Psychiatry , vol.14 , Issue.7 , pp. 681-695
    • Gatt, J.M.1    Nemeroff, C.B.2    Dobson-Stone, C.3    Paul, R.H.4    Bryant, R.A.5    Schofield, P.R.6
  • 31
    • 61849179516 scopus 로고    scopus 로고
    • Early life stress as a risk factor for mental health: Role of neurotrophins from rodents to nonhuman primates
    • Cirulli F, Francia N, Berry A, Aloe L, Alleva E, Suomi SJ. Early life stress as a risk factor for mental health: role of neurotrophins from rodents to nonhuman primates. Neurosci Biobehav Rev. 2009;33(4):573-85.
    • (2009) Neurosci Biobehav Rev , vol.33 , Issue.4 , pp. 573-585
    • Cirulli, F.1    Francia, N.2    Berry, A.3    Aloe, L.4    Alleva, E.5    Suomi, S.J.6
  • 32
    • 0036202956 scopus 로고    scopus 로고
    • Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    • Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109(2):143-8.
    • (2002) Psychiatry Res , vol.109 , Issue.2 , pp. 143-148
    • Karege, F.1    Perret, G.2    Bondolfi, G.3    Schwald, M.4    Bertschy, G.5    Aubry, J.M.6
  • 33
    • 0032884316 scopus 로고    scopus 로고
    • Trophic regulation of synaptic plasticity
    • Black IB. Trophic regulation of synaptic plasticity. J Neurobiol. 1999;41(1):108-18.
    • (1999) J Neurobiol , vol.41 , Issue.1 , pp. 108-118
    • Black, I.B.1
  • 34
    • 30544439942 scopus 로고    scopus 로고
    • Serotonin transporters: Implications for antidepressant drug development
    • White KJ, Walline CC, Barker EL. Serotonin transporters: implications for antidepressant drug development. AAPS J. 2005;7(2):E421-33.
    • (2005) AAPS J , vol.7 , Issue.2 , pp. E421-E433
    • White, K.J.1    Walline, C.C.2    Barker, E.L.3
  • 35
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274(5292):1527-31.
    • (1996) Science , vol.274 , Issue.5292 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5    Petri, S.6
  • 36
    • 0037462449 scopus 로고    scopus 로고
    • The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112(2):257-69.
    • (2003) Cell , vol.112 , Issue.2 , pp. 257
    • Egan, M.F.1    Kojima, M.2    Callicott, J.H.3    Goldberg, T.E.4    Kolachana, B.S.5    Bertolino, A.6
  • 37
    • 84907963640 scopus 로고    scopus 로고
    • Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain
    • van der Doelen RH, Calabrese F, Guidotti G, Geenen B, Riva MA, Kozicz T, et al. Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain. Front Behav Neurosci. 2014;8:355.
    • (2014) Front Behav Neurosci , vol.8 , pp. 355
    • Van Der Doelen, R.H.1    Calabrese, F.2    Guidotti, G.3    Geenen, B.4    Riva, M.A.5    Kozicz, T.6
  • 38
    • 0035372636 scopus 로고    scopus 로고
    • Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders
    • Osterlund MK, Hurd YL. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol. 2001;64(3):251-67.
    • (2001) Prog Neurobiol , vol.64 , Issue.3 , pp. 251-267
    • Osterlund, M.K.1    Hurd, Y.L.2
  • 39
    • 0242713012 scopus 로고    scopus 로고
    • Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area
    • Epub 2003 Jul 24
    • Champagne FA, Weaver IC, Diorio J, Sharma S, Meaney MJ. Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area. Endocrinology. 2003;144(11):4720-4. Epub 2003 Jul 24.
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4720
    • Champagne, F.A.1    Weaver, I.C.2    Diorio, J.3    Sharma, S.4    Meaney, M.J.5
  • 40
    • 79751534866 scopus 로고    scopus 로고
    • Long-term maternal separation differentially alters serum corticosterone levels and blood neutrophil activity in A/J and C57BL/6 mouse offspring
    • Epub 2011 Feb 9
    • Pinheiro M, Ferraz-de-Paula V, Ribeiro A, Sakai M, Bernardi M, Palermo-Neto J. Long-term maternal separation differentially alters serum corticosterone levels and blood neutrophil activity in A/J and C57BL/6 mouse offspring. Neuroimmunomodulation. 2011;18(3):184-90. Epub 2011 Feb 9.
    • (2011) Neuroimmunomodulation , vol.18 , Issue.3 , pp. 184
    • Pinheiro, M.1    Ferraz-De-Paula, V.2    Ribeiro, A.3    Sakai, M.4    Bernardi, M.5    Palermo-Neto, J.6
  • 41
    • 0036024263 scopus 로고    scopus 로고
    • Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus
    • Roceri M, Hendriks W, Racagni G, Ellenbroek BA, Riva MA. Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol Psychiatry. 2002;7(6):609-16.
    • (2002) Mol Psychiatry , vol.7 , Issue.6 , pp. 609-616
    • Roceri, M.1    Hendriks, W.2    Racagni, G.3    Ellenbroek, B.A.4    Riva, M.A.5
  • 42
    • 77957155780 scopus 로고    scopus 로고
    • Maternal separation with early weaning: A novel mouse model of early life neglect
    • George ED, Bordner KA, Elwafi HM, Simen AA. Maternal separation with early weaning: a novel mouse model of early life neglect. BMC Neurosci. 2010;11:123.
    • (2010) BMC Neurosci , vol.11 , pp. 123
    • George, E.D.1    Bordner, K.A.2    Elwafi, H.M.3    Simen, A.A.4
  • 43
    • 33847093463 scopus 로고    scopus 로고
    • The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: Altering epigenetic marks by immediate-early genes
    • Weaver ICG, D’Alessio AC, Brown SE, Hellstrom IC, Dymov S, Sharma S, et al. The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J Neurosci. 2007;27(7):1756-68.
    • (2007) J Neurosci , vol.27 , Issue.7 , pp. 1756-1768
    • Weaver, I.1    D’Alessio, A.C.2    Brown, S.E.3    Hellstrom, I.C.4    Dymov, S.5    Sharma, S.6
  • 44
    • 74449087422 scopus 로고    scopus 로고
    • Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 1(7) glucocorticoid receptor promoter region
    • Daniels WMU, Fairbairn L, Tilburg G, McEvoy C, Zigmond M, Russell V, et al. Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 1(7) glucocorticoid receptor promoter region. Metab Brain Dis. 2009;24(4):615-27.
    • (2009) Metab Brain Dis , vol.24 , Issue.4 , pp. 615-627
    • Daniels, W.1    Fairbairn, L.2    Tilburg, G.3    McEvoy, C.4    Zigmond, M.5    Russell, V.6
  • 45
    • 84883654510 scopus 로고    scopus 로고
    • Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse
    • Kember RL, Dempster EL, Lee TH, Schalkwyk LC, Mill J, Fernandes C. Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. Brain Behav. 2012;2(4):455-67.
    • (2012) Brain Behav , vol.2 , Issue.4 , pp. 455-467
    • Kember, R.L.1    Dempster, E.L.2    Lee, T.H.3    Schalkwyk, L.C.4    Mill, J.5    Fernandes, C.6
  • 47
    • 84862640477 scopus 로고    scopus 로고
    • Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood
    • Chen J, Evans A, Liu Y, Honda M, Saavedra J, Aguilera G. Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood. J Neuroendocrinol. 2012;24(7):1055-64.
    • (2012) J Neuroendocrinol , vol.24 , Issue.7 , pp. 1055-1064
    • Chen, J.1    Evans, A.2    Liu, Y.3    Honda, M.4    Saavedra, J.5    Aguilera, G.6
  • 48
    • 84899545808 scopus 로고    scopus 로고
    • Epigenetic upregulation of corticotrophin-releasing hormone mediates postnatal maternal separationinduced memory deficiency
    • Wang A, Nie W, Li H, Hou Y, Yu Z, Fan Q, et al. Epigenetic upregulation of corticotrophin-releasing hormone mediates postnatal maternal separationinduced memory deficiency. PLoS One. 2014;9(4):e94394.
    • (2014) Plos One , vol.9 , Issue.4
    • Wang, A.1    Nie, W.2    Li, H.3    Hou, Y.4    Yu, Z.5    Fan, Q.6
  • 49
    • 78650584064 scopus 로고    scopus 로고
    • CpG methylation of half-CRE sequences creates C/EBPalpha binding sites that activate some tissue-specific genes
    • Rishi V, Bhattacharya P, Chatterjee R, Rozenberg J, Zhao J, Glass K, et al. CpG methylation of half-CRE sequences creates C/EBPalpha binding sites that activate some tissue-specific genes. Proc Natl Acad Sci U S A. 2010;107(47):20311-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.47 , pp. 20311-20316
    • Rishi, V.1    Bhattacharya, P.2    Chatterjee, R.3    Rozenberg, J.4    Zhao, J.5    Glass, K.6
  • 50
    • 20144379523 scopus 로고    scopus 로고
    • Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
    • Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102(12):4459-64.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.12 , pp. 4459-4464
    • Zhang, X.1    Odom, D.T.2    Koo, S.H.3    Conkright, M.D.4    Canettieri, G.5    Best, J.6
  • 51
    • 84897416144 scopus 로고    scopus 로고
    • Polycomb binding precedes early-life stress responsive DNA methylation at the Avp enhancer
    • Murgatroyd C, Spengler D. Polycomb binding precedes early-life stress responsive DNA methylation at the Avp enhancer. PLoS One. 2014;9(3):e90277.
    • (2014) Plos One , vol.9 , Issue.3
    • Murgatroyd, C.1    Spengler, D.2
  • 52
    • 1642412555 scopus 로고    scopus 로고
    • Postnatal repeated maternal deprivation produces age-dependent changes of brainderived neurotrophic factor expression in selected rat brain regions
    • Roceri M, Cirulli F, Pressina C, Peretto P, Racagni G, Riva MA. Postnatal repeated maternal deprivation produces age-dependent changes of brainderived neurotrophic factor expression in selected rat brain regions. Biol Psychiatry. 2004;55(7):708-14.
    • (2004) Biol Psychiatry , vol.55 , Issue.7 , pp. 708-714
    • Roceri, M.1    Cirulli, F.2    Pressina, C.3    Peretto, P.4    Racagni, G.5    Riva, M.A.6
  • 53
    • 63449085750 scopus 로고    scopus 로고
    • Lasting epigenetic influence of earlylife adversity on the BDNF gene
    • Epub 9 Jan 15
    • Roth TL, Lubin FD, Funk A, Sweatt JD. Lasting epigenetic influence of earlylife adversity on the BDNF gene. Biol Psychiatry. 2009;65(9):760-9. doi:10.1016/j.biopsych.2008.11.028. Epub 9 Jan 15.
    • (2009) Biol Psychiatry , vol.65 , Issue.9 , pp. 760-769
    • Roth, T.L.1    Lubin, F.D.2    Funk, A.3    Sweatt, J.D.4
  • 54
    • 84867301311 scopus 로고    scopus 로고
    • Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life
    • Bai M, Zhu X, Zhang Y, Zhang S, Zhang L, Xue L, et al. Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life. PLoS One. 2012;7(10):e46921.
    • (2012) Plos One , vol.7 , Issue.10
    • Bai, M.1    Zhu, X.2    Zhang, Y.3    Zhang, S.4    Zhang, L.5    Xue, L.6
  • 55
    • 75749132798 scopus 로고    scopus 로고
    • Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques
    • Kinnally EL, Tarara E, Mason W, Mendoza S, Abel K, Lyons L, et al. Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques. Genes Brain Behav. 2010;9(1):45-52.
    • (2010) Genes Brain Behav , vol.9 , Issue.1 , pp. 45-52
    • Kinnally, E.L.1    Tarara, E.2    Mason, W.3    Mendoza, S.4    Abel, K.5    Lyons, L.6
  • 56
    • 34247574704 scopus 로고    scopus 로고
    • Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation
    • Lee J-H, Kim B-T, Kim HJ, Kim JG, Ryu V, Kang D-W, et al. Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation. Neurosci Res. 2007;58(1):32-9.
    • (2007) Neurosci Res , vol.58 , Issue.1 , pp. 32-39
    • Lee, J.-H.1    Kim, B.-T.2    Kim, H.J.3    Kim, J.G.4    Ryu, V.5    Kang, D.-W.6
  • 57
    • 77955143338 scopus 로고    scopus 로고
    • Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques
    • Kinnally EL, Capitanio JP, Leibel R, Deng L, LeDuc C, Haghighi F, et al. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010;9(6):575-82.
    • (2010) Genes Brain Behav , vol.9 , Issue.6 , pp. 575-582
    • Kinnally, E.L.1    Capitanio, J.P.2    Leibel, R.3    Deng, L.4    Leduc, C.5    Haghighi, F.6
  • 59
    • 33646784653 scopus 로고    scopus 로고
    • Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    • Champagne FA, Weaver ICG, Diorio J, Dymov S, Szyf M, Meaney MJ. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology. 2006;147(6):2909.
    • (2006) Endocrinology , vol.147 , Issue.6 , pp. 2909
    • Champagne, F.A.1    Weaver, I.2    Diorio, J.3    Dymov, S.4    Szyf, M.5    Meaney, M.J.6
  • 60
    • 0034011252 scopus 로고    scopus 로고
    • Decreased glutamic acid decarboxylase 67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia
    • Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA. Decreased glutamic acid decarboxylase 67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry. 2000;57(3):237-45.
    • (2000) Arch Gen Psychiatry , vol.57 , Issue.3 , pp. 237-245
    • Volk, D.W.1    Austin, M.C.2    Pierri, J.N.3    Sampson, A.R.4    Lewis, D.A.5
  • 61
    • 0036269901 scopus 로고    scopus 로고
    • Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    • Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes FM. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch Gen Psychiatry. 2002;59(6):521-9.
    • (2002) Arch Gen Psychiatry , vol.59 , Issue.6 , pp. 521-529
    • Heckers, S.1    Stone, D.2    Walsh, J.3    Shick, J.4    Koul, P.5    Benes, F.M.6
  • 62
    • 33847111254 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes
    • Kundakovic M, Chen Y, Costa E, Grayson D. DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007;71(3):644-53.
    • (2007) Mol Pharmacol , vol.71 , Issue.3 , pp. 644-653
    • Kundakovic, M.1    Chen, Y.2    Costa, E.3    Grayson, D.4
  • 64
    • 0033646608 scopus 로고    scopus 로고
    • Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression
    • Fatemi SH, Earle JA, McMenomy T. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry. 2000;5(6):654-63.
    • (2000) Mol Psychiatry , vol.5 , Issue.6 , pp. 654-663
    • Fatemi, S.H.1    Earle, J.A.2    McMenomy, T.3
  • 65
    • 0033759439 scopus 로고    scopus 로고
    • Decrease in Reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study
    • Guidotti A, Sharma R, Uzunov D, Costa E, Auta J, Davis JM, et al. Decrease in Reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry. 2000;57(11):1061-9.
    • (2000) Arch Gen Psychiatry , vol.57 , Issue.11 , pp. 1061-1069
    • Guidotti, A.1    Sharma, R.2    Uzunov, D.3    Costa, E.4    Auta, J.5    Davis, J.M.6
  • 66
    • 77956689355 scopus 로고    scopus 로고
    • Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus
    • Zhang T-Y, Hellstrom IC, Bagot R, Wen X, Diorio J, Meaney MJ. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. J Neurosci. 2010;30(39):13130-7. doi:10.1523/JNEUROSCI.1039-10.2010.
    • (2010) J Neurosci , vol.30 , Issue.39 , pp. 13130-13137
    • Zhang, T.-Y.1    Hellstrom, I.C.2    Bagot, R.3    Wen, X.4    Diorio, J.5    Meaney, M.J.6
  • 67
    • 78149336368 scopus 로고    scopus 로고
    • Retardation of neurobehavioral development and reelin down-regulation regulated by further DNA methylation in the hippocampus of the rat pups are associated with maternal deprivation
    • Qin L, Tu W, Sun X, Zhang J, Chen Y, Zhao H. Retardation of neurobehavioral development and reelin down-regulation regulated by further DNA methylation in the hippocampus of the rat pups are associated with maternal deprivation. Behav Brain Res. 2011;217(1):142-7.
    • (2011) Behav Brain Res , vol.217 , Issue.1 , pp. 142-147
    • Qin, L.1    Tu, W.2    Sun, X.3    Zhang, J.4    Chen, Y.5    Zhao, H.6
  • 68
    • 84555186893 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders
    • Aas M, Djurovic S, Athanasiu L, Steen NE, Agartz I, Lorentzen S, et al. Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders. Schizophr Bull. 2012;38(1):15-22.
    • (2012) Schizophr Bull , vol.38 , Issue.1 , pp. 15-22
    • Aas, M.1    Djurovic, S.2    Athanasiu, L.3    Steen, N.E.4    Agartz, I.5    Lorentzen, S.6
  • 70
    • 83755180447 scopus 로고    scopus 로고
    • Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: A link with the severity and type of trauma
    • Perroud N, Paoloni-Giacobino A, Prada P, Olie E, Salzmann A, Nicastro R, et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry. 2011;1:e59.
    • (2011) Transl Psychiatry , vol.1
    • Perroud, N.1    Paoloni-Giacobino, A.2    Prada, P.3    Olie, E.4    Salzmann, A.5    Nicastro, R.6
  • 71
    • 84856277610 scopus 로고    scopus 로고
    • Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: Preliminary findings in healthy adults
    • Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One. 2012;7(1):e30148.
    • (2012) Plos One , vol.7 , Issue.1
    • Tyrka, A.R.1    Price, L.H.2    Marsit, C.3    Walters, O.C.4    Carpenter, L.L.5
  • 72
    • 84928883695 scopus 로고    scopus 로고
    • Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
    • press
    • Murgatroyd C, Quinn J, Sharp H, Pickles A, Hill J. Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene. Transl Psychiatry. 2015. In press.
    • (2015) Transl Psychiatry
    • Murgatroyd, C.1    Quinn, J.2    Sharp, H.3    Pickles, A.4    Hill, J.5
  • 73
    • 46949090009 scopus 로고    scopus 로고
    • The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies
    • Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(5):543-9.
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147B , Issue.5 , pp. 543-549
    • Philibert, R.A.1    Sandhu, H.2    Hollenbeck, N.3    Gunter, T.4    Adams, W.5    Madan, A.6
  • 75
    • 78751618993 scopus 로고    scopus 로고
    • Methylation at 5HTT mediates the impact of child sex abuse on women’s antisocial behavior: An examination of the Iowa adoptee sample
    • Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at 5HTT mediates the impact of child sex abuse on women’s antisocial behavior: an examination of the Iowa adoptee sample. Psychosom Med. 2011;73(1):83-7.
    • (2011) Psychosom Med , vol.73 , Issue.1 , pp. 83-87
    • Beach, S.R.1    Brody, G.H.2    Todorov, A.A.3    Gunter, T.D.4    Philibert, R.A.5
  • 77
    • 84863057173 scopus 로고    scopus 로고
    • Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents
    • Naumova OY, Lee M, Koposov R, Szyf M, Dozier M, Grigorenko EL. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents. Dev Psychopathol. 2012;24(1):143-55.
    • (2012) Dev Psychopathol , vol.24 , Issue.1 , pp. 143-155
    • Naumova, O.Y.1    Lee, M.2    Koposov, R.3    Szyf, M.4    Dozier, M.5    Grigorenko, E.L.6
  • 78
    • 84862027231 scopus 로고    scopus 로고
    • Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse
    • Labonte B, Yerko V, Gross J, Mechawar N, Meaney MJ, Szyf M, et al. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry. 2012;72(1):41-8.
    • (2012) Biol Psychiatry , vol.72 , Issue.1 , pp. 41-48
    • Labonte, B.1    Yerko, V.2    Gross, J.3    Mechawar, N.4    Meaney, M.J.5    Szyf, M.6
  • 80
    • 84877850278 scopus 로고    scopus 로고
    • Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder
    • Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci U S A. 2013; 110(20):8302-7.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.20 , pp. 8302-8307
    • Mehta, D.1    Klengel, T.2    Conneely, K.N.3    Smith, A.K.4    Altmann, A.5    Pace, T.W.6
  • 82
    • 38349002755 scopus 로고    scopus 로고
    • Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
    • Champagne FA, Meaney MJ. Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behav Neurosci. 2007;121(6):1353-63.
    • (2007) Behav Neurosci , vol.121 , Issue.6 , pp. 1353-1363
    • Champagne, F.A.1    Meaney, M.J.2
  • 83
    • 81955164243 scopus 로고    scopus 로고
    • Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment
    • Levine A, Worrell TR, Zimnisky R, Schmauss C. Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol Dis. 2012;45(1):488-98.
    • (2012) Neurobiol Dis , vol.45 , Issue.1 , pp. 488-498
    • Levine, A.1    Worrell, T.R.2    Zimnisky, R.3    Schmauss, C.4
  • 84
    • 84897477173 scopus 로고    scopus 로고
    • Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation
    • Massart R, Suderman M, Provencal N, Yi C, Bennett AJ, Suomi S, et al. Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation. Neuroscience. 2014;268:139-48.
    • (2014) Neuroscience , vol.268 , pp. 139-148
    • Massart, R.1    Suderman, M.2    Provencal, N.3    Yi, C.4    Bennett, A.J.5    Suomi, S.6
  • 85
    • 32844459497 scopus 로고    scopus 로고
    • Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry
    • Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RCS, et al. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology. 2006;31(1):47-57.
    • (2006) Neuropsychopharmacology , vol.31 , Issue.1 , pp. 47-57
    • Maciag, D.1    Simpson, K.L.2    Coppinger, D.3    Lu, Y.4    Wang, Y.5    Lin, R.6
  • 86
    • 84880867623 scopus 로고    scopus 로고
    • DNA methylation of the BDNF gene and its relevance to psychiatric disorders
    • Ikegame T, Bundo M, Murata Y, Kasai K, Kato T, Iwamoto K. DNA methylation of the BDNF gene and its relevance to psychiatric disorders. J Hum Genet. 2013;58(7):434-8.
    • (2013) J Hum Genet , vol.58 , Issue.7 , pp. 434-438
    • Ikegame, T.1    Bundo, M.2    Murata, Y.3    Kasai, K.4    Kato, T.5    Iwamoto, K.6
  • 88
    • 36549042458 scopus 로고    scopus 로고
    • Interaction between BDNF and serotonin: Role in mood disorders
    • Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology. 2008;33(1):73-83.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.1 , pp. 73-83
    • Martinowich, K.1    Lu, B.2
  • 89
    • 0035840320 scopus 로고    scopus 로고
    • Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (TrkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
    • Madhav TR, Pei Q, Zetterstrom TS. Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF). Brain Res Mol Brain Res. 2001;93(1):56-63.
    • (2001) Brain Res Mol Brain Res , vol.93 , Issue.1 , pp. 56-63
    • Madhav, T.R.1    Pei, Q.2    Zetterstrom, T.S.3
  • 90
    • 0036549257 scopus 로고    scopus 로고
    • Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus
    • Solum DT, Handa RJ. Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. J Neurosci. 2002;22(7):2650-9.
    • (2002) J Neurosci , vol.22 , Issue.7 , pp. 2650-2659
    • Solum, D.T.1    Handa, R.J.2
  • 91
    • 84868134636 scopus 로고    scopus 로고
    • The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells
    • Provencal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, et al. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci. 2012;32(44):15626-42.
    • (2012) J Neurosci , vol.32 , Issue.44 , pp. 15626-15642
    • Provencal, N.1    Suderman, M.J.2    Guillemin, C.3    Massart, R.4    Ruggiero, A.5    Wang, D.6
  • 92
    • 84927797446 scopus 로고    scopus 로고
    • Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state
    • Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, et al. Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state. Transl Psychiatry. 2014;4:e448.
    • (2014) Transl Psychiatry , vol.4
    • Khulan, B.1    Manning, J.R.2    Dunbar, D.R.3    Seckl, J.R.4    Raikkonen, K.5    Eriksson, J.G.6
  • 94
    • 2042468714 scopus 로고
    • Infantile experience and resistance to physiological stress
    • Levine S. Infantile experience and resistance to physiological stress. Science. 1957;126(3270):405.
    • (1957) Science , vol.126 , Issue.3270 , pp. 405
    • Levine, S.1
  • 95
    • 0029022431 scopus 로고
    • Maternal deprivation and early weaning modulate experimental allergic encephalomyelitis in the rat
    • Laban O, Markovic B, Dimitruevic M, Jankovic B. Maternal deprivation and early weaning modulate experimental allergic encephalomyelitis in the rat. Brain Behav Immun. 1995;9(1):9-19.
    • (1995) Brain Behav Immun , vol.9 , Issue.1 , pp. 9-19
    • Laban, O.1    Markovic, B.2    Dimitruevic, M.3    Jankovic, B.4
  • 96
    • 0027195888 scopus 로고
    • Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
    • Plotsky P, Meaney M. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res. 1993;18(3):195-200.
    • (1993) Brain Res Mol Brain Res , vol.18 , Issue.3 , pp. 195-200
    • Plotsky, P.1    Meaney, M.2
  • 97
    • 15144344289 scopus 로고    scopus 로고
    • Maternal care, hippocampal glucocorticoid receptors, and hypothalamicpituitary-adrenal responses to stress
    • Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamicpituitary-adrenal responses to stress. Science. 1997;277(5332):1659.
    • (1997) Science , vol.277 , Issue.5332 , pp. 1659
    • Liu, D.1    Diorio, J.2    Tannenbaum, B.3    Caldji, C.4    Francis, D.5    Freedman, A.6
  • 98
    • 47749133462 scopus 로고    scopus 로고
    • Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    • McGowan PO, Sasaki A, Huang TC, Unterberger A, Suderman M, Ernst C, et al. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One. 2008;3(5):e2085.
    • (2008) Plos One , vol.3 , Issue.5
    • McGowan, P.O.1    Sasaki, A.2    Huang, T.C.3    Unterberger, A.4    Suderman, M.5    Ernst, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.