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Volumn 83, Issue 10, 2018, Pages 821-830

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model

Author keywords

Epigenetics; FKBP5; FKBP51; Gene by environment; Psychiatric disorders; Stress

Indexed keywords

ENVIRONMENTAL FACTOR; EPIGENETIC REPRESSION; FKBP5 GENE; GENE; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MENTAL DISEASE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; REVIEW; GENETIC EPIGENESIS; GENETICS; GENOTYPE; MENTAL STRESS; MUTATION;

EID: 85044276697     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2018.01.021     Document Type: Review
Times cited : (175)

References (121)
  • 1
    • 20044395965 scopus 로고    scopus 로고
    • Stress and the brain: From adaptation to disease
    • De Kloet, E.R., Joëls, M., Holsboer, F., Stress and the brain: From adaptation to disease. Nat Rev Neurosci 6 (2005), 463–475.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 463-475
    • De Kloet, E.R.1    Joëls, M.2    Holsboer, F.3
  • 2
    • 34547872322 scopus 로고    scopus 로고
    • The glucocorticoid responses are shaped by molecular chaperones
    • Grad, I., Picard, D., The glucocorticoid responses are shaped by molecular chaperones. Mol Cell Endocrinol 275 (2007), 2–12.
    • (2007) Mol Cell Endocrinol , vol.275 , pp. 2-12
    • Grad, I.1    Picard, D.2
  • 3
    • 0345144024 scopus 로고    scopus 로고
    • Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
    • Sinars, C.R., Cheung-Flynn, J., Rimerman, R.A., Scammell, J.G., Smith, D.F., Clardy, J., Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A 100 (2003), 868–873.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 868-873
    • Sinars, C.R.1    Cheung-Flynn, J.2    Rimerman, R.A.3    Scammell, J.G.4    Smith, D.F.5    Clardy, J.6
  • 4
    • 14244262261 scopus 로고    scopus 로고
    • FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
    • Wochnik, G.M., Ruegg, J., Abel, G.A., Schmidt, U., Holsboer, F., Rein, T., FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem 280 (2005), 4609–4616.
    • (2005) J Biol Chem , vol.280 , pp. 4609-4616
    • Wochnik, G.M.1    Ruegg, J.2    Abel, G.A.3    Schmidt, U.4    Holsboer, F.5    Rein, T.6
  • 5
    • 0035169503 scopus 로고    scopus 로고
    • Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates
    • Scammell, J.G., Denny, W.B., Valentine, D.L., Smith, D.F., Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen Comp Endocrinol 124 (2001), 152–165.
    • (2001) Gen Comp Endocrinol , vol.124 , pp. 152-165
    • Scammell, J.G.1    Denny, W.B.2    Valentine, D.L.3    Smith, D.F.4
  • 6
    • 84859769789 scopus 로고    scopus 로고
    • Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients
    • Menke, A., Arloth, J., Putz, B., Weber, P., Klengel, T., Mehta, D., et al. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology 37 (2012), 1455–1464.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1455-1464
    • Menke, A.1    Arloth, J.2    Putz, B.3    Weber, P.4    Klengel, T.5    Mehta, D.6
  • 7
    • 79951775578 scopus 로고    scopus 로고
    • Expression and regulation of the Fkbp5 gene in the adult mouse brain
    • Scharf, S.H., Liebl, C., Binder, E.B., Schmidt, M.V., Muller, M.B., Expression and regulation of the Fkbp5 gene in the adult mouse brain. PloS One, 6, 2011, e16883.
    • (2011) PloS One , vol.6
    • Scharf, S.H.1    Liebl, C.2    Binder, E.B.3    Schmidt, M.V.4    Muller, M.B.5
  • 8
    • 84983402602 scopus 로고    scopus 로고
    • FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change
    • Rein, T., FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change. Bioessays 38 (2016), 894–902.
    • (2016) Bioessays , vol.38 , pp. 894-902
    • Rein, T.1
  • 9
    • 84949553248 scopus 로고    scopus 로고
    • Gene-stress-epigenetic regulation of FKBP5: Clinical and translational implications
    • Zannas, A.S., Wiechmann, T., Gassen, N.C., Binder, E.B., Gene-stress-epigenetic regulation of FKBP5: Clinical and translational implications. Neuropsychopharmacology 41 (2016), 261–274.
    • (2016) Neuropsychopharmacology , vol.41 , pp. 261-274
    • Zannas, A.S.1    Wiechmann, T.2    Gassen, N.C.3    Binder, E.B.4
  • 10
    • 9644252785 scopus 로고    scopus 로고
    • Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    • Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Putz, B., et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36 (2004), 1319–1325.
    • (2004) Nat Genet , vol.36 , pp. 1319-1325
    • Binder, E.B.1    Salyakina, D.2    Lichtner, P.3    Wochnik, G.M.4    Ising, M.5    Putz, B.6
  • 12
    • 84876140223 scopus 로고    scopus 로고
    • Allele-specific epigenetic modification: A molecular mechanism for gene-environment interactions in stress-related psychiatric disorders?
    • Klengel, T., Binder, E.B., Allele-specific epigenetic modification: A molecular mechanism for gene-environment interactions in stress-related psychiatric disorders?. Epigenomics 5 (2013), 109–112.
    • (2013) Epigenomics , vol.5 , pp. 109-112
    • Klengel, T.1    Binder, E.B.2
  • 13
    • 78650167358 scopus 로고    scopus 로고
    • When adaptations go awry: Functional and dysfunctional aspects of social anxiety
    • Maner, J.K., Kenrick, D.T., When adaptations go awry: Functional and dysfunctional aspects of social anxiety. Soc Issues Policy Rev 4 (2010), 111–142.
    • (2010) Soc Issues Policy Rev , vol.4 , pp. 111-142
    • Maner, J.K.1    Kenrick, D.T.2
  • 15
    • 70350731477 scopus 로고    scopus 로고
    • The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
    • Binder, E.B., The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34:Suppl 1 (2009), S186–S195.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. S186-S195
    • Binder, E.B.1
  • 16
    • 84899957904 scopus 로고    scopus 로고
    • Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
    • Buchmann, A.F., Holz, N., Boecker, R., Blomeyer, D., Rietschel, M., Witt, S.H., et al. Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood. Eur Neuropsychopharmacol 24 (2014), 837–845.
    • (2014) Eur Neuropsychopharmacol , vol.24 , pp. 837-845
    • Buchmann, A.F.1    Holz, N.2    Boecker, R.3    Blomeyer, D.4    Rietschel, M.5    Witt, S.H.6
  • 18
    • 84926637212 scopus 로고    scopus 로고
    • FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls
    • Höhne, N., Poidinger, M., Merz, F., Pfister, H., Bruckl, T., Zimmermann, P., et al. FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. Int J Neuropsychopharmacol, 18(4), 2015, pyu087.
    • (2015) Int J Neuropsychopharmacol , vol.18 , Issue.4 , pp. pyu087
    • Höhne, N.1    Poidinger, M.2    Merz, F.3    Pfister, H.4    Bruckl, T.5    Zimmermann, P.6
  • 19
    • 48249091243 scopus 로고    scopus 로고
    • Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls
    • Ising, M., Depping, A.M., Siebertz, A., Lucae, S., Unschuld, P.G., Kloiber, S., et al. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 28 (2008), 389–398.
    • (2008) Eur J Neurosci , vol.28 , pp. 389-398
    • Ising, M.1    Depping, A.M.2    Siebertz, A.3    Lucae, S.4    Unschuld, P.G.5    Kloiber, S.6
  • 21
    • 40949142290 scopus 로고    scopus 로고
    • Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    • Binder, E.B., Bradley, R.G., Liu, W., Epstein, M.P., Deveau, T.C., Mercer, K.B., et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299 (2008), 1291–1305.
    • (2008) JAMA , vol.299 , pp. 1291-1305
    • Binder, E.B.1    Bradley, R.G.2    Liu, W.3    Epstein, M.P.4    Deveau, T.C.5    Mercer, K.B.6
  • 22
    • 80054916652 scopus 로고    scopus 로고
    • FK506 binding protein 5 shapes stress responsiveness: Modulation of neuroendocrine reactivity and coping behavior
    • Touma, C., Gassen, N.C., Herrmann, L., Cheung-Flynn, J., Bull, D.R., Ionescu, I.A., et al. FK506 binding protein 5 shapes stress responsiveness: Modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry 70 (2011), 928–936.
    • (2011) Biol Psychiatry , vol.70 , pp. 928-936
    • Touma, C.1    Gassen, N.C.2    Herrmann, L.3    Cheung-Flynn, J.4    Bull, D.R.5    Ionescu, I.A.6
  • 24
    • 85040451663 scopus 로고    scopus 로고
    • FKBP5 moderates the association between antenatal maternal depressive symptoms and neonatal brain morphology
    • Wang, C., Shen, M., Guillaume, B., Chong, Y.S., Chen, H., Fortier, M.V., et al. FKBP5 moderates the association between antenatal maternal depressive symptoms and neonatal brain morphology. Neuropsychopharmacology 43 (2018), 564–570.
    • (2018) Neuropsychopharmacology , vol.43 , pp. 564-570
    • Wang, C.1    Shen, M.2    Guillaume, B.3    Chong, Y.S.4    Chen, H.5    Fortier, M.V.6
  • 25
    • 85028035144 scopus 로고    scopus 로고
    • Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis
    • Wang, Q., Shelton, R.C., Dwivedi, Y., Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis. J Affect Disord 225 (2018), 422–428.
    • (2018) J Affect Disord , vol.225 , pp. 422-428
    • Wang, Q.1    Shelton, R.C.2    Dwivedi, Y.3
  • 26
    • 85016999443 scopus 로고    scopus 로고
    • Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
    • Culverhouse, R.C., Saccone, N.L., Horton, A.C., Ma, Y., Anstey, K.J., Banaschewski, T., et al. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry 23 (2018), 133–142.
    • (2018) Mol Psychiatry , vol.23 , pp. 133-142
    • Culverhouse, R.C.1    Saccone, N.L.2    Horton, A.C.3    Ma, Y.4    Anstey, K.J.5    Banaschewski, T.6
  • 27
    • 80051552041 scopus 로고    scopus 로고
    • The false-positive to false-negative ratio in epidemiologic studies
    • Ioannidis, J.P., Tarone, R., McLaughlin, J.K., The false-positive to false-negative ratio in epidemiologic studies. Epidemiology 22 (2011), 450–456.
    • (2011) Epidemiology , vol.22 , pp. 450-456
    • Ioannidis, J.P.1    Tarone, R.2    McLaughlin, J.K.3
  • 28
    • 84943771195 scopus 로고    scopus 로고
    • Understanding the candidate gene x environment interaction debate: Epistemological or evidential divide?
    • Munafo, M.R., Understanding the candidate gene x environment interaction debate: Epistemological or evidential divide?. Int J Epidemiol 44 (2015), 1130–1132.
    • (2015) Int J Epidemiol , vol.44 , pp. 1130-1132
    • Munafo, M.R.1
  • 29
    • 84921528220 scopus 로고    scopus 로고
    • Candidate gene-environment interaction research: Reflections and recommendations
    • Dick, D.M., Agrawal, A., Keller, M.C., Adkins, A., Aliev, F., Monroe, S., et al. Candidate gene-environment interaction research: Reflections and recommendations. Perspect Psychol Sci 10 (2015), 37–59.
    • (2015) Perspect Psychol Sci , vol.10 , pp. 37-59
    • Dick, D.M.1    Agrawal, A.2    Keller, M.C.3    Adkins, A.4    Aliev, F.5    Monroe, S.6
  • 30
    • 84876069737 scopus 로고    scopus 로고
    • FKBP5 and attention bias for threat: Associations with hippocampal function and shape
    • Fani, N., Gutman, D., Tone, E.B., Almli, L., Mercer, K.B., Davis, J., et al. FKBP5 and attention bias for threat: Associations with hippocampal function and shape. JAMA Psychiatry 70 (2013), 392–400.
    • (2013) JAMA Psychiatry , vol.70 , pp. 392-400
    • Fani, N.1    Gutman, D.2    Tone, E.B.3    Almli, L.4    Mercer, K.B.5    Davis, J.6
  • 31
    • 84931423394 scopus 로고    scopus 로고
    • Role of FKBP5 in emotion processing: Results on amygdala activity, connectivity and volume
    • Holz, N.E., Buchmann, A.F., Boecker, R., Blomeyer, D., Baumeister, S., Wolf, I., et al. Role of FKBP5 in emotion processing: Results on amygdala activity, connectivity and volume. Brain Struct Funct 220 (2015), 1355–1368.
    • (2015) Brain Struct Funct , vol.220 , pp. 1355-1368
    • Holz, N.E.1    Buchmann, A.F.2    Boecker, R.3    Blomeyer, D.4    Baumeister, S.5    Wolf, I.6
  • 32
    • 84896391713 scopus 로고    scopus 로고
    • Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children
    • Pagliaccio, D., Luby, J.L., Bogdan, R., Agrawal, A., Gaffrey, M.S., Belden, A.C., et al. Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children. Neuropsychopharmacology 39 (2014), 1245–1253.
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1245-1253
    • Pagliaccio, D.1    Luby, J.L.2    Bogdan, R.3    Agrawal, A.4    Gaffrey, M.S.5    Belden, A.C.6
  • 34
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, S.H., Ripke, S., Neale, B.M., Faraone, S.V., Purcell, S.M., et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45 (2013), 984–994.
    • (2013) Nat Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3    Faraone, S.V.4    Purcell, S.M.5
  • 35
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. Lancet 381 (2013), 1371–1379.
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 37
    • 84953326602 scopus 로고    scopus 로고
    • Associations between self-reported and objectively recorded early life stress, FKBP5 polymorphisms, and depressive symptoms in midlife
    • Lahti, J., Ala-Mikkula, H., Kajantie, E., Haljas, K., Eriksson, J.G., Raikkonen, K., Associations between self-reported and objectively recorded early life stress, FKBP5 polymorphisms, and depressive symptoms in midlife. Biol Psychiatry 80 (2016), 869–877.
    • (2016) Biol Psychiatry , vol.80 , pp. 869-877
    • Lahti, J.1    Ala-Mikkula, H.2    Kajantie, E.3    Haljas, K.4    Eriksson, J.G.5    Raikkonen, K.6
  • 39
    • 7644219666 scopus 로고    scopus 로고
    • Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids
    • Hubler, T.R., Scammell, J.G., Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 9 (2004), 243–252.
    • (2004) Cell Stress Chaperones , vol.9 , pp. 243-252
    • Hubler, T.R.1    Scammell, J.G.2
  • 40
    • 77249119220 scopus 로고    scopus 로고
    • Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions
    • Paakinaho, V., Makkonen, H., Jaaskelainen, T., Palvimo, J.J., Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol 24 (2010), 511–525.
    • (2010) Mol Endocrinol , vol.24 , pp. 511-525
    • Paakinaho, V.1    Makkonen, H.2    Jaaskelainen, T.3    Palvimo, J.J.4
  • 41
    • 84931041069 scopus 로고    scopus 로고
    • Epigenetics of stress-related psychiatric disorders and gene x environment interactions
    • Klengel, T., Binder, E.B., Epigenetics of stress-related psychiatric disorders and gene x environment interactions. Neuron 86 (2015), 1343–1357.
    • (2015) Neuron , vol.86 , pp. 1343-1357
    • Klengel, T.1    Binder, E.B.2
  • 42
    • 84982193774 scopus 로고    scopus 로고
    • DNA methylation at stress-related genes is associated with exposure to early life institutionalization
    • Non, A.L., Hollister, B.M., Humphreys, K.L., Childebayeva, A., Esteves, K., Zeanah, C.H., et al. DNA methylation at stress-related genes is associated with exposure to early life institutionalization. Am J Phys Anthropol 161 (2016), 84–93.
    • (2016) Am J Phys Anthropol , vol.161 , pp. 84-93
    • Non, A.L.1    Hollister, B.M.2    Humphreys, K.L.3    Childebayeva, A.4    Esteves, K.5    Zeanah, C.H.6
  • 44
    • 85042227221 scopus 로고    scopus 로고
    • Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity
    • Parade, S.H., Parent, J., Rabemananjara, K., Seifer, R., Marsit, C.J., Yang, B.Z., et al. Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity. Dev Psychopathol 29 (2017), 1627–1634.
    • (2017) Dev Psychopathol , vol.29 , pp. 1627-1634
    • Parade, S.H.1    Parent, J.2    Rabemananjara, K.3    Seifer, R.4    Marsit, C.J.5    Yang, B.Z.6
  • 45
    • 84899534761 scopus 로고    scopus 로고
    • Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure
    • Ewald, E.R., Wand, G.S., Seifuddin, F., Yang, X., Tamashiro, K.L., Potash, J.B., et al. Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure. Psychoneuroendocrinology 44 (2014), 112–122.
    • (2014) Psychoneuroendocrinology , vol.44 , pp. 112-122
    • Ewald, E.R.1    Wand, G.S.2    Seifuddin, F.3    Yang, X.4    Tamashiro, K.L.5    Potash, J.B.6
  • 46
    • 77956053977 scopus 로고    scopus 로고
    • Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice
    • Lee, R.S., Tamashiro, K.L., Yang, X., Purcell, R.H., Harvey, A., Willour, V.L., et al. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology 151 (2010), 4332–4343.
    • (2010) Endocrinology , vol.151 , pp. 4332-4343
    • Lee, R.S.1    Tamashiro, K.L.2    Yang, X.3    Purcell, R.H.4    Harvey, A.5    Willour, V.L.6
  • 47
    • 0035962634 scopus 로고    scopus 로고
    • In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action
    • Grange, T., Cappabianca, L., Flavin, M., Sassi, H., Thomassin, H., In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action. Oncogene 20 (2001), 3028–3038.
    • (2001) Oncogene , vol.20 , pp. 3028-3038
    • Grange, T.1    Cappabianca, L.2    Flavin, M.3    Sassi, H.4    Thomassin, H.5
  • 48
    • 0035901508 scopus 로고    scopus 로고
    • Glucocorticoid-induced DNA demethylation and gene memory during development
    • Thomassin, H., Flavin, M., Espinas, M.L., Grange, T., Glucocorticoid-induced DNA demethylation and gene memory during development. EMBO J 20 (2001), 1974–1983.
    • (2001) EMBO J , vol.20 , pp. 1974-1983
    • Thomassin, H.1    Flavin, M.2    Espinas, M.L.3    Grange, T.4
  • 50
    • 85044301910 scopus 로고    scopus 로고
    • Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression
    • Tozzi, L., Farrell, C., Booij, L., Doolin, K., Nemoda, Z., Szyf, M., et al. Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression. Neuropsychopharmacology 43 (2018), 1138–1145.
    • (2018) Neuropsychopharmacology , vol.43 , pp. 1138-1145
    • Tozzi, L.1    Farrell, C.2    Booij, L.3    Doolin, K.4    Nemoda, Z.5    Szyf, M.6
  • 51
    • 85032496411 scopus 로고    scopus 로고
    • Evidence for stress-like alterations in the HPA-axis in women taking oral contraceptives
    • Hertel, J., Konig, J., Homuth, G., Van der Auwera, S., Wittfeld, K., Pietzner, M., et al. Evidence for stress-like alterations in the HPA-axis in women taking oral contraceptives. Sci Rep, 7, 2017, 14111.
    • (2017) Sci Rep , vol.7 , pp. 14111
    • Hertel, J.1    Konig, J.2    Homuth, G.3    Van der Auwera, S.4    Wittfeld, K.5    Pietzner, M.6
  • 54
    • 84906996222 scopus 로고    scopus 로고
    • Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
    • Sabbagh, J.J., O'Leary, J.C. 3rd, Blair, L.J., Klengel, T., Nordhues, B.A., Fontaine, S.N., et al. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. PLoS One, 9, 2014, e107241.
    • (2014) PLoS One , vol.9 , pp. e107241
    • Sabbagh, J.J.1    O'Leary, J.C.2    Blair, L.J.3    Klengel, T.4    Nordhues, B.A.5    Fontaine, S.N.6
  • 55
    • 84994400059 scopus 로고    scopus 로고
    • Amygdalar microRNA-15a is essential for coping with chronic stress
    • Volk, N., Pape, J.C., Engel, M., Zannas, A.S., Cattane, N., Cattaneo, A., et al. Amygdalar microRNA-15a is essential for coping with chronic stress. Cell Rep 17 (2016), 1882–1891.
    • (2016) Cell Rep , vol.17 , pp. 1882-1891
    • Volk, N.1    Pape, J.C.2    Engel, M.3    Zannas, A.S.4    Cattane, N.5    Cattaneo, A.6
  • 56
    • 84983446607 scopus 로고    scopus 로고
    • MicroRNA-511 binds to FKBP5 mRNA, which encodes a chaperone protein, and regulates neuronal differentiation
    • Zheng, D., Sabbagh, J.J., Blair, L.J., Darling, A.L., Wen, X., Dickey, C.A., MicroRNA-511 binds to FKBP5 mRNA, which encodes a chaperone protein, and regulates neuronal differentiation. J Biol Chem 291 (2016), 17897–17906.
    • (2016) J Biol Chem , vol.291 , pp. 17897-17906
    • Zheng, D.1    Sabbagh, J.J.2    Blair, L.J.3    Darling, A.L.4    Wen, X.5    Dickey, C.A.6
  • 57
    • 84867301540 scopus 로고    scopus 로고
    • FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity
    • White, M.G., Bogdan, R., Fisher, P.M., Munoz, K.E., Williamson, D.E., Hariri, A.R., FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. Genes Brain Behav 11 (2012), 869–878.
    • (2012) Genes Brain Behav , vol.11 , pp. 869-878
    • White, M.G.1    Bogdan, R.2    Fisher, P.M.3    Munoz, K.E.4    Williamson, D.E.5    Hariri, A.R.6
  • 58
    • 84973131594 scopus 로고    scopus 로고
    • Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation
    • Pagliaccio, D., Luby, J.L., Bogdan, R., Agrawal, A., Gaffrey, M.S., Belden, A.C., et al. Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. J Abnorm Psychol 124 (2015), 817–833.
    • (2015) J Abnorm Psychol , vol.124 , pp. 817-833
    • Pagliaccio, D.1    Luby, J.L.2    Bogdan, R.3    Agrawal, A.4    Gaffrey, M.S.5    Belden, A.C.6
  • 59
    • 85042214279 scopus 로고    scopus 로고
    • Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study
    • Harms, M.B., Birn, R., Provencal, N., Wiechmann, T., Binder, E.B., Giakas, S.W., et al. Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study. Dev Psychopathol 29 (2017), 1895–1903.
    • (2017) Dev Psychopathol , vol.29 , pp. 1895-1903
    • Harms, M.B.1    Birn, R.2    Provencal, N.3    Wiechmann, T.4    Binder, E.B.5    Giakas, S.W.6
  • 60
    • 85036613127 scopus 로고    scopus 로고
    • Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse
    • Hart, H., Lim, L., Mehta, M.A., Chatzieffraimidou, A., Curtis, C., Xu, X., et al. Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse. PLoS One, 12, 2017, e0188744.
    • (2017) PLoS One , vol.12 , pp. e0188744
    • Hart, H.1    Lim, L.2    Mehta, M.A.3    Chatzieffraimidou, A.4    Curtis, C.5    Xu, X.6
  • 62
    • 80054096224 scopus 로고    scopus 로고
    • The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
    • Hartmann, J., Wagner, K.V., Liebl, C., Scharf, S.H., Wang, X.D., Wolf, M., et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology 62 (2012), 332–339.
    • (2012) Neuropharmacology , vol.62 , pp. 332-339
    • Hartmann, J.1    Wagner, K.V.2    Liebl, C.3    Scharf, S.H.4    Wang, X.D.5    Wolf, M.6
  • 64
    • 84896047974 scopus 로고    scopus 로고
    • Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice
    • Albu, S., Romanowski, C.P., Letizia Curzi, M., Jakubcakova, V., Flachskamm, C., Gassen, N.C., et al. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. J Sleep Res 23 (2014), 176–185.
    • (2014) J Sleep Res , vol.23 , pp. 176-185
    • Albu, S.1    Romanowski, C.P.2    Letizia Curzi, M.3    Jakubcakova, V.4    Flachskamm, C.5    Gassen, N.C.6
  • 66
    • 84931345970 scopus 로고    scopus 로고
    • Pharmacological inhibition of the psychiatric risk factor FKBP51 has anxiolytic properties
    • Hartmann, J., Wagner, K.V., Gaali, S., Kirschner, A., Kozany, C., Rühter, G., et al. Pharmacological inhibition of the psychiatric risk factor FKBP51 has anxiolytic properties. J Neurosci 35 (2015), 9007–9016.
    • (2015) J Neurosci , vol.35 , pp. 9007-9016
    • Hartmann, J.1    Wagner, K.V.2    Gaali, S.3    Kirschner, A.4    Kozany, C.5    Rühter, G.6
  • 67
    • 85008394115 scopus 로고    scopus 로고
    • A cross species study of heterogeneity in fear extinction learning in relation to FKBP5 variation and expression: Implications for the acute treatment of posttraumatic stress disorder
    • Galatzer-Levy, I.R., Andero, R., Sawamura, T., Jovanovic, T., Papini, S., Ressler, K.J., et al. A cross species study of heterogeneity in fear extinction learning in relation to FKBP5 variation and expression: Implications for the acute treatment of posttraumatic stress disorder. Neuropharmacology 116 (2017), 188–195.
    • (2017) Neuropharmacology , vol.116 , pp. 188-195
    • Galatzer-Levy, I.R.1    Andero, R.2    Sawamura, T.3    Jovanovic, T.4    Papini, S.5    Ressler, K.J.6
  • 68
  • 69
  • 71
    • 67649132626 scopus 로고    scopus 로고
    • Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    • Tatro, E.T., Everall, I.P., Masliah, E., Hult, B.J., Lucero, G., Chana, G., et al. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J Neuroimmune Pharmacol 4 (2009), 218–226.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 218-226
    • Tatro, E.T.1    Everall, I.P.2    Masliah, E.3    Hult, B.J.4    Lucero, G.5    Chana, G.6
  • 72
    • 84896809401 scopus 로고    scopus 로고
    • Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness
    • Sinclair, D., Fillman, S.G., Webster, M.J., Weickert, C.S., Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci Rep, 3, 2013, 3539.
    • (2013) Sci Rep , vol.3 , pp. 3539
    • Sinclair, D.1    Fillman, S.G.2    Webster, M.J.3    Weickert, C.S.4
  • 74
    • 85018835648 scopus 로고    scopus 로고
    • Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders
    • Darby, M.M., Yolken, R.H., Sabunciyan, S., Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders. Transl Psychiatry, 6, 2016, e890.
    • (2016) Transl Psychiatry , vol.6 , pp. e890
    • Darby, M.M.1    Yolken, R.H.2    Sabunciyan, S.3
  • 75
    • 84941084235 scopus 로고    scopus 로고
    • BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls
    • Young, K.A., Thompson, P.M., Cruz, D.A., Williamson, D.E., Selemon, L.D., BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls. Neurobiol Stress 2 (2015), 67–72.
    • (2015) Neurobiol Stress , vol.2 , pp. 67-72
    • Young, K.A.1    Thompson, P.M.2    Cruz, D.A.3    Williamson, D.E.4    Selemon, L.D.5
  • 76
    • 84928381824 scopus 로고    scopus 로고
    • Altered mRNA levels of glucocorticoid receptor, mineralocorticoid receptor, and co-chaperones (FKBP5 and PTGES3) in the middle frontal gyrus of autism spectrum disorder subjects
    • Patel, N., Crider, A., Pandya, C.D., Ahmed, A.O., Pillai, A., Altered mRNA levels of glucocorticoid receptor, mineralocorticoid receptor, and co-chaperones (FKBP5 and PTGES3) in the middle frontal gyrus of autism spectrum disorder subjects. Mol Neurobiol 53 (2016), 2090–2099.
    • (2016) Mol Neurobiol , vol.53 , pp. 2090-2099
    • Patel, N.1    Crider, A.2    Pandya, C.D.3    Ahmed, A.O.4    Pillai, A.5
  • 77
    • 84994681215 scopus 로고    scopus 로고
    • Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
    • Mamdani, F., Rollins, B., Morgan, L., Myers, R.M., Barchas, J.D., Schatzberg, A.F., et al. Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder. Transl Psychiatry, 5, 2015, e636.
    • (2015) Transl Psychiatry , vol.5 , pp. e636
    • Mamdani, F.1    Rollins, B.2    Morgan, L.3    Myers, R.M.4    Barchas, J.D.5    Schatzberg, A.F.6
  • 79
    • 84904419991 scopus 로고    scopus 로고
    • Interplay between diet-induced obesity and chronic stress in mice: Potential role of FKBP51
    • Balsevich, G., Uribe, A., Wagner, K.V., Hartmann, J., Santarelli, S., Labermaier, C., et al. Interplay between diet-induced obesity and chronic stress in mice: Potential role of FKBP51. J Endocrinol 222 (2014), 15–26.
    • (2014) J Endocrinol , vol.222 , pp. 15-26
    • Balsevich, G.1    Uribe, A.2    Wagner, K.V.3    Hartmann, J.4    Santarelli, S.5    Labermaier, C.6
  • 80
    • 84906234472 scopus 로고    scopus 로고
    • FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance
    • Pereira, M.J., Palming, J., Svensson, M.K., Rizell, M., Dalenback, J., Hammar, M., et al. FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance. Metabolism 63 (2014), 1198–1208.
    • (2014) Metabolism , vol.63 , pp. 1198-1208
    • Pereira, M.J.1    Palming, J.2    Svensson, M.K.3    Rizell, M.4    Dalenback, J.5    Hammar, M.6
  • 82
    • 84958630972 scopus 로고    scopus 로고
    • The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling
    • Maiaru, M., Tochiki, K.K., Cox, M.B., Annan, L.V., Bell, C.G., Feng, X., et al. The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. Sci Transl Med, 8, 2016, 325ra319.
    • (2016) Sci Transl Med , vol.8 , pp. 325ra319
    • Maiaru, M.1    Tochiki, K.K.2    Cox, M.B.3    Annan, L.V.4    Bell, C.G.5    Feng, X.6
  • 83
    • 84999751178 scopus 로고    scopus 로고
    • Examining FKBP5 mRNA expression in human iPSC-derived neural cells
    • Lieberman, R., Kranzler, H.R., Levine, E.S., Covault, J., Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Res 247 (2017), 172–181.
    • (2017) Psychiatry Res , vol.247 , pp. 172-181
    • Lieberman, R.1    Kranzler, H.R.2    Levine, E.S.3    Covault, J.4
  • 84
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • Lein, E.S., Hawrylycz, M.J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445 (2006), 168–176.
    • (2006) Nature , vol.445 , pp. 168-176
    • Lein, E.S.1    Hawrylycz, M.J.2    Ao, N.3    Ayres, M.4    Bensinger, A.5    Bernard, A.6
  • 86
    • 84863704522 scopus 로고    scopus 로고
    • Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders
    • Soontornniyomkij, V., Everall, I.P., Moore, D.J., Gouaux, B., Tatro, E.T., Gospodarev, V., et al. Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. J Neurovirol 18 (2012), 313–322.
    • (2012) J Neurovirol , vol.18 , pp. 313-322
    • Soontornniyomkij, V.1    Everall, I.P.2    Moore, D.J.3    Gouaux, B.4    Tatro, E.T.5    Gospodarev, V.6
  • 87
    • 85045707766 scopus 로고    scopus 로고
    • Immunophilins: New Biomarkers and Therapeutic Targets for Neurodegenerative Diseases
    • [dissertation] University of Pittsburgh Pittsburgh
    • Avramut, M., Immunophilins: New Biomarkers and Therapeutic Targets for Neurodegenerative Diseases. [dissertation], 2003, University of Pittsburgh, Pittsburgh.
    • (2003)
    • Avramut, M.1
  • 88
    • 0032541163 scopus 로고    scopus 로고
    • Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
    • Young, J.C., Obermann, W.M.J., Hartl, F.U., Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. Biol Chem 273 (1998), 18007–18010.
    • (1998) Biol Chem , vol.273 , pp. 18007-18010
    • Young, J.C.1    Obermann, W.M.J.2    Hartl, F.U.3
  • 91
    • 33845961032 scopus 로고    scopus 로고
    • Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins
    • Weiwad, M., Edlich, F., Kilka, S., Erdmann, F., Jarczowski, F., Dorn, M., et al. Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. Biochemistry 45 (2006), 15776–15784.
    • (2006) Biochemistry , vol.45 , pp. 15776-15784
    • Weiwad, M.1    Edlich, F.2    Kilka, S.3    Erdmann, F.4    Jarczowski, F.5    Dorn, M.6
  • 92
    • 1242318787 scopus 로고    scopus 로고
    • Identification of two calcineurin B-binding proteins: Tubulin and heat shock protein 60
    • Li, W., Handschumacher, R.E., Identification of two calcineurin B-binding proteins: Tubulin and heat shock protein 60. Biochim Biophys Acta 1599 (2002), 72–81.
    • (2002) Biochim Biophys Acta , vol.1599 , pp. 72-81
    • Li, W.1    Handschumacher, R.E.2
  • 93
    • 84866363467 scopus 로고    scopus 로고
    • Neural functions of calcineurin in synaptic plasticity and memory
    • Baumgartel, K., Mansuy, I.M., Neural functions of calcineurin in synaptic plasticity and memory. Learn Mem 19 (2012), 375–384.
    • (2012) Learn Mem , vol.19 , pp. 375-384
    • Baumgartel, K.1    Mansuy, I.M.2
  • 95
    • 84911002692 scopus 로고    scopus 로고
    • Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: Control on nuclear factor-kappaB signaling in consolidation and reconsolidation
    • de la Fuente, V., Federman, N., Fustinana, M.S., Zalcman, G., Romano, A., Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: Control on nuclear factor-kappaB signaling in consolidation and reconsolidation. Hippocampus 24 (2014), 1549–1561.
    • (2014) Hippocampus , vol.24 , pp. 1549-1561
    • de la Fuente, V.1    Federman, N.2    Fustinana, M.S.3    Zalcman, G.4    Romano, A.5
  • 96
    • 84856425070 scopus 로고    scopus 로고
    • Role of calcineurin in inhibiting disadvantageous associations
    • Shaw, J.A., Matlovich, N., Rushlow, W., Cain, P., Rajakumar, N., Role of calcineurin in inhibiting disadvantageous associations. Neuroscience 203 (2012), 144–152.
    • (2012) Neuroscience , vol.203 , pp. 144-152
    • Shaw, J.A.1    Matlovich, N.2    Rushlow, W.3    Cain, P.4    Rajakumar, N.5
  • 97
    • 12144289400 scopus 로고    scopus 로고
    • A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    • Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.O., Bergamini, G., Croughton, K., et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6 (2004), 97–105.
    • (2004) Nat Cell Biol , vol.6 , pp. 97-105
    • Bouwmeester, T.1    Bauch, A.2    Ruffner, H.3    Angrand, P.O.4    Bergamini, G.5    Croughton, K.6
  • 98
    • 9644252848 scopus 로고    scopus 로고
    • Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells
    • Romano, M.F., Avellino, R., Petrella, A., Bisogni, R., Romano, S., Venuta, S., Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer 40 (2004), 2829–2836.
    • (2004) Eur J Cancer , vol.40 , pp. 2829-2836
    • Romano, M.F.1    Avellino, R.2    Petrella, A.3    Bisogni, R.4    Romano, S.5    Venuta, S.6
  • 99
    • 84876888439 scopus 로고    scopus 로고
    • FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential
    • Romano, S., Staibano, S., Greco, A., Brunetti, A., Nappo, G., Ilardi, G., et al. FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. Cell Death Dis, 4, 2013, e578.
    • (2013) Cell Death Dis , vol.4 , pp. e578
    • Romano, S.1    Staibano, S.2    Greco, A.3    Brunetti, A.4    Nappo, G.5    Ilardi, G.6
  • 101
    • 39449109866 scopus 로고    scopus 로고
    • Characterization of a neuregulin-1 gene promoter: Positive regulation of type I isoforms by NF-κB
    • Frensing, T., Kaltschmidt, C., Schmitt-John, T., Characterization of a neuregulin-1 gene promoter: Positive regulation of type I isoforms by NF-κB. Biochim Biophys Acta 1779 (2008), 139–144.
    • (2008) Biochim Biophys Acta , vol.1779 , pp. 139-144
    • Frensing, T.1    Kaltschmidt, C.2    Schmitt-John, T.3
  • 102
    • 77950022786 scopus 로고    scopus 로고
    • Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
    • Rao, J.S., Harry, G.J., Rapoport, S.I., Kim, H.W., Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry 15 (2010), 384–392.
    • (2010) Mol Psychiatry , vol.15 , pp. 384-392
    • Rao, J.S.1    Harry, G.J.2    Rapoport, S.I.3    Kim, H.W.4
  • 104
    • 60349086577 scopus 로고    scopus 로고
    • The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia
    • Song, X.Q., Lv, L.X., Li, W.Q., Hao, Y.H., Zhao, J.P., The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry 65 (2009), 481–488.
    • (2009) Biol Psychiatry , vol.65 , pp. 481-488
    • Song, X.Q.1    Lv, L.X.2    Li, W.Q.3    Hao, Y.H.4    Zhao, J.P.5
  • 105
    • 84860711052 scopus 로고    scopus 로고
    • FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer
    • Hou, J., Wang, L., FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS One, 7, 2012, e36252.
    • (2012) PLoS One , vol.7
    • Hou, J.1    Wang, L.2
  • 106
    • 69249228672 scopus 로고    scopus 로고
    • FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
    • Pei, H., Li, L., Fridley, B.L., Jenkins, G.D., Kalari, K.R., Lingle, W., et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 16 (2009), 259–266.
    • (2009) Cancer Cell , vol.16 , pp. 259-266
    • Pei, H.1    Li, L.2    Fridley, B.L.3    Jenkins, G.D.4    Kalari, K.R.5    Lingle, W.6
  • 107
    • 85045715108 scopus 로고    scopus 로고
    • The Role of FKBP5 in Transcriptional Regulation and in Shaping Cellular Pathways of Psychopharmaca Action [dissertation]. Munich: LMU München: Faculty of Chemistry and Pharmacy.
    • Kollmannsberger LK (2016): The Role of FKBP5 in Transcriptional Regulation and in Shaping Cellular Pathways of Psychopharmaca Action [dissertation]. Munich: LMU München: Faculty of Chemistry and Pharmacy.
    • (2016)
    • Kollmannsberger, L.K.1
  • 108
    • 84938880388 scopus 로고    scopus 로고
    • FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action
    • Gassen, N.C., Hartmann, J., Schmidt, M.V., Rein, T., FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action. Autophagy 11 (2015), 578–580.
    • (2015) Autophagy , vol.11 , pp. 578-580
    • Gassen, N.C.1    Hartmann, J.2    Schmidt, M.V.3    Rein, T.4
  • 110
    • 77954874401 scopus 로고    scopus 로고
    • GSK3 signalling in neural development
    • Hur, E.M., Zhou, F.Q., GSK3 signalling in neural development. Nat Rev Neurosci 11 (2010), 539–551.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 539-551
    • Hur, E.M.1    Zhou, F.Q.2
  • 111
    • 0035967897 scopus 로고    scopus 로고
    • Regulation of GSK-3: A cellular multiprocessor
    • Harwood, A.J., Regulation of GSK-3: A cellular multiprocessor. Cell 105 (2001), 821–824.
    • (2001) Cell , vol.105 , pp. 821-824
    • Harwood, A.J.1
  • 113
    • 84945310626 scopus 로고    scopus 로고
    • Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
    • Sun, Y., Liu, W.Z., Liu, T., Feng, X., Yang, N., Zhou, H.F., Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res 35 (2015), 600–604.
    • (2015) J Recept Signal Transduct Res , vol.35 , pp. 600-604
    • Sun, Y.1    Liu, W.Z.2    Liu, T.3    Feng, X.4    Yang, N.5    Zhou, H.F.6
  • 114
    • 79957927567 scopus 로고    scopus 로고
    • Phosphorylation of human DNMT1: Implication of cyclin-dependent kinases
    • Lavoie, G., St-Pierre, Y., Phosphorylation of human DNMT1: Implication of cyclin-dependent kinases. Biochem Biophys Res Commun 409 (2011), 187–192.
    • (2011) Biochem Biophys Res Commun , vol.409 , pp. 187-192
    • Lavoie, G.1    St-Pierre, Y.2
  • 115
    • 84954470147 scopus 로고    scopus 로고
    • Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine
    • Gassen, N.C., Fries, G.R., Zannas, A.S., Hartmann, J., Zschocke, J., Hafner, K., et al. Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Sci Signal, 8, 2015, ra119.
    • (2015) Sci Signal , vol.8 , pp. ra119
    • Gassen, N.C.1    Fries, G.R.2    Zannas, A.S.3    Hartmann, J.4    Zschocke, J.5    Hafner, K.6
  • 116
  • 117
    • 80051935829 scopus 로고    scopus 로고
    • The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
    • Gallo, L.I., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D., The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress. J Biol Chem 286 (2011), 30152–30160.
    • (2011) J Biol Chem , vol.286 , pp. 30152-30160
    • Gallo, L.I.1    Lagadari, M.2    Piwien-Pilipuk, G.3    Galigniana, M.D.4
  • 118
    • 84890242641 scopus 로고    scopus 로고
    • Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation
    • Toneatto, J., Guber, S., Charo, N.L., Susperreguy, S., Schwartz, J., Galigniana, M.D., et al. Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation. J Cell Sci 126 (2013), 5357–5368.
    • (2013) J Cell Sci , vol.126 , pp. 5357-5368
    • Toneatto, J.1    Guber, S.2    Charo, N.L.3    Susperreguy, S.4    Schwartz, J.5    Galigniana, M.D.6
  • 119
    • 84900404337 scopus 로고    scopus 로고
    • Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN
    • Akiyama, T., Shiraishi, T., Qin, J., Konno, H., Akiyama, N., Shinzawa, M., et al. Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN. PLoS One, 9, 2014, e95992.
    • (2014) PLoS One , vol.9
    • Akiyama, T.1    Shiraishi, T.2    Qin, J.3    Konno, H.4    Akiyama, N.5    Shinzawa, M.6
  • 120
    • 84875194721 scopus 로고    scopus 로고
    • Severe life stress and oxidative stress in the brain: From animal models to human pathology
    • Schiavone, S., Jaquet, V., Trabace, L., Krause, K.H., Severe life stress and oxidative stress in the brain: From animal models to human pathology. Antioxid Redox Signal 18 (2013), 1475–1490.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1475-1490
    • Schiavone, S.1    Jaquet, V.2    Trabace, L.3    Krause, K.H.4


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