Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity

Development and Psychopathology

Volumn 29, Issue 5, 2017, Pages 1627-1634

  Parade, Stephanie H ^a,b   Parent, Justin ^a,b,c   Rabemananjara, Kantoniony ^b   Seifer, Ronald ^a,b   Marsit, Carmen J ^d   Yang, Bao Zhu ^e   Zhang, Huiping ^f   Tyrka, Audrey R ^a,g  

^a BROWN UNIVERSITY   (United States)

^b E P BRADLEY HOSPITAL   (United States)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^d EMORY UNIVERSITY   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g BUTLER HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; TACROLIMUS BINDING PROTEIN 5;

CHILD ABUSE; DNA METHYLATION; FEMALE; GENETICS; GENOTYPE; HUMAN; INTRON; MALE; PRESCHOOL CHILD;

CHILD ABUSE; CHILD, PRESCHOOL; DNA METHYLATION; FEMALE; GENOTYPE; HUMANS; INTRONS; MALE; TACROLIMUS BINDING PROTEINS;

EID: 85042227221     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579417001286     Document Type: Article

References (42)

1. Aiken, L. S., & West, S. G. (1991). Testing and interpreting interactions in multiple regression. Thous and Oaks, CA: Sage.
2. Alisch, R. S., Barwick, B. G., Chopra, P., Myrick, L. K., Satten, G. A., Conneely, K. N., & Warren, S. T. (2012). Age-associated DNA methylation in pediatric populations. Genome Research, 22, 623-632. doi:10.1101/gr.125187.11
3. Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In D. Cicchetti & S. L. Toth (Eds.), Child abuse, child development, and social policy (pp. 7-73). Norwood, NJ: Ablex.
4. Binder, E. B. (2009). The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology, 34, S186-S195. doi:10.1016/j. psyneuen.2009.05.021
5. Burns, B. J., Phillips, S. D., Wagner, H. R., Barth, R. P., Kolko, D. J., Campbell, Y., & Landsverk, J. (2004). Mental health need and access to mental health services by youths involved with child welfare: A national survey. Journal of the American Academy of Child & Adolescent Psychiatry, 43, 960-970. doi:10.1097/01.chi.0000127590.95585.65
6. Cioffi, D. L., Hubler, T. R., & Scammell, J. G. (2011). Organization and function of the FKBP52 and FKBP51 genes. Current Opinion in Pharmacology, 11, 308-313. doi:10.1016/j.coph.2011.03.013
7. Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007). Psychological stress and disease. Journal of the American Medical Association, 298, 1685-1687. doi:10.1001/jama.298.14.1685
8. de Kloet, E. R., Joels, M., & Holsboer, F. (2005). Stress and the brain: From adaptation to disease. Nature Reviews Neuroscience, 6, 463-475. doi:10.1038/nrn1683
9. Evans, G.W. (2003). A multimethodological analysis of cumulative risk and allostatic load among rural children. Developmental Psychology, 39, 924-933. doi:10.1037/0012-1649.39.5.924
10. Gilbert, R., Wisdom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009). Burden and consequences of child maltreatment in high-income countries. Lancet, 373, 68-81. doi:10.1016/S0140-6736(08)61706-7
11. Grippo, A. J., & Johnson, A. K. (2009). Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress, 12, 1-21. doi:10.1080/10253890802046281
12. Han, K., Won, E., Sim, Y., Kang, J., Han, C., Kim, Y., ⋯ Ham, B. (2017). Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder. Scientific Reports, 7, 42621. doi:10.1038/srep42621
13. Hohne, N., Poidinger, M., Merz, F., Pfister, H., Bruckl, T., Zimmermann, P., ⋯ Ising, M. (2015). FKBP5 genotype-dependent DNA methylation and mRNA regulation afterpsychosocial stress in remitted depression and healthy controls. International Journal of Neuropsychopharmacology, 18, pyu087. doi:10.1093/ijnp/pyu087
14. Hu, L., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1-55. doi:10.1080/10705519909540118
15. Ising, M., Depping, A. M., Siebertz, A., Lucae, S., Unschuld, P. G., Kloiber, S., ⋯ Holsboer, F. (2008). Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. European Journal Neuroscience, 28, 389-398. doi:10.1111/j.1460-9568.2008.06332.x
16. Kadmiel, M., & Cidlowski, J. A. (2013). Glucocorticoid receptor signaling in health and disease. Trends in Pharmacological Sciences, 34, 518-530. doi:10.1016/j.tips.2013.07.003
17. Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., ⋯ Binder, E. B. (2013). Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neuroscience, 16, 33-41. doi:10.1038/nn.3275
18. Laryea, G., Muglia, L., Arnett, M., & Muglia, L. J. (2015). Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice. Frontiers in Neuroendocrinology, 36, 150-164. doi:10.1016/j.yfrne.2014.09.002
19. Leszczynska-Rodziewicz, A., Szczepankiewicz, A., Narozna, B., Skibinska, M., Pawlak, J., Dmitrzak-Weglarz, M., & Hauser, J. (2014). Possible association between haplotypes of the FKBP5 gene and suicidal disorder, but not with melancholic depression and psychotic features, in the course of bipolar disorder. Neuropsychiatric Disease and Treatment, 10, 243-248. doi:10.2147/NDT.S54538
20. Little, R. J. (1988). A test of missing completely at random for multivariate data with missing values. Journal of the American Statistical Association, 83, 1198-1202. doi:10.2307/2290157
21. Martino, D., Loke, Y. J., Gordon, L., Ollikainen, M., Cruickshank, M. N., Saffery, R., & Craig, J. M. (2013). Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biology, 14, R42. doi:10.1186/gb-2013-14-5-r42
22. McArdle, J. J. (2009). Latent variable modeling of differences and changes with longitudinal data. Annual Review of Psychology, 60, 577-605. doi:10.1146/annurev.psych.60.110707.163612
23. McEwen, B. S. (2008). Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. European Journal of Pharmacology, 583, 174-185. doi:10.1016/j.ejphar.2007.11.071
24. Menke, A., Klengel, T., Rubel, J., Brückl, T., Pfister, H., Lucae, S., ⋯ Binder, E. B. (2013). Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes, Brain and Behavior, 12, 289-296. doi:10.1111/gbb.12026
25. Moore, L. D., Le, T., & Fan, G. (2013). DNA methylation and its basic function. Neuropsychopharmacology, 38, 23-38. doi:10.1038/npp.2012.112
26. Muthén, L. K., & Muthén, B. O. (1998-2012). Mplus user's guide (6th ed.). Los Angeles: Authors.
27. Non, A. L., Hollister, B. M., Humphreys, K. L., Childebayeva, A., Esteves, K., Zeanah., C., ⋯ Drury, S. (2016). DNA methylation at stress-related genes is associated with exposure to early life institutionalization. American Journal of Physical Anthropology, 61, 84-93. doi:10.1002/ajpa. 23010
28. Paquette, A. G., Lester, B. M., Koestler, D. C., Lesseur, C., Armstrong, D. A., & Marsit, C. J. (2014). Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort. PLOS ONE, 9, e104913. doi:10.1371/journal.pone.0104913
29. Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38, 904-909. doi:10.1038/ng1847
30. Purcell, S., Neale, B., Todd-Brown, K., Ferreira, M. A., Bender, D., Maller, J., ⋯ Sham, P. C. (2007). PLINK: A tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics, 81, 559-575. doi:10.1086/519795
31. Roberts, S., Keers, R., Lester, K. J., Coleman, J. R., Breen, G., Arendt, K., ⋯ Wong, C. C. (2015). HPA axis related genes and response to psychological therapies: Genetics and epigenetics. Depression and Anxiety, 32, 861-870. doi:10.1002/da.22430
32. Schmidt, U., Buell, D. R., Ionescu, I. A., Gassen, N. C., Holsboer, F., Cox, M. B., ⋯ Touma, C. (2015). A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology, 52, 43-58. doi:10.1016/j.psyneuen. 2014.11.005
33. Schneiderman, N., Ironson, G., & Siegel, S. D. (2005). Stress and health: Psychological, behavioral, and biological determinants. Annual Review Clinical Psychology, 1, 607-628. doi:10.1146/annurev.clinpsy.1.102803. 144141
34. Shonkoff, J. P., Boyce, W. T., & McEwen, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. Journal of the American Medical Association, 21, 2252-2259. doi:10.1001/jama. 2009.754
35. Suzuki, A., Matsumoto, Y., Sadahiro, R., Enokido, M., Goto, K., & Otani, K. (2014). Relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression. Comprehensive Psychiatry, 55, 1422-1425. doi:10.1016/j.comppsych.2014.04.019
36. Szczepankiewicz, A., Leszczynska-Rodziewicz, A., Pawlak, J., Narozna, B., Rajewska-Rager, A., Wilkosc, M., ⋯ Twarowska-Hauser, J. (2014). FKBP5 polymorphism is associated with major depression but not with bipolar disorder. Journal of Affective Disorders, 164, 33-37. doi:10.1016/j.jad.2014.04.002
37. Szyf, M. (2007). The dynamic epigenome and its implications in toxicology. Toxicological Sciences, 100, 7-23. doi:10.1093/toxsci/kfm177
38. Tatro, E. T., Everall, I. P., Kaul, M., & Achim, C. L. (2009). Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder. Brain Research, 1286, 1-12. doi:10.1016/j.brainres.2009.06.036
39. H of the glucocorticoid receptor gene promoter and exposure to adversity in pre-school aged children. Development and Psychopathology, 27, 577-585. doi:10.1017/S0954579415000176
40. US Department of Health and Human Services, Administration for Children and Families, Administration on Children, Youth and Families, Children's Bureau. (2017). Child Maltreatment 2015. Retrieved from http://www.acf.hhs.gov/programs/cb/research-data-technology/statistics-research/child-maltreatment
41. Van Zomeren-Dohm, A. A., Pitula, C. E., Koss, K. J., Thomas, K., & Gunnar, M. R. (2015). FKBP5 moderation of depressive symptoms in peer victimized, post-institutionalized children. Psychoneuroendocrinology, 51, 426-430. doi:10.1016/j.psyneuen.2014.10.003
42. Zannas, A. S., & Binder, E. B. (2014). Gene-environment interactions at the FKBP5 locus: Sensitive periods, mechanisms and pleiotropism. Genes, Brain and Behavior, 13, 25-37. doi:10.1111/gbb.12104