FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action

Autophagy

Volumn 11, Issue 3, 2015, Pages 578-580

  Gassen, Nils C ^a   Hartmann, Jakob ^a   Schmidt, Mathias V ^a   Rein, Theo ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Antidepressant; Autophagy; Beclin 1; Depression; FKBP5; FKBP51

Indexed keywords

ANTIDEPRESSANT AGENT; BECLIN 1; FK 506 BINDING PROTEIN; FK506 BINDING PROTEIN 5; UNCLASSIFIED DRUG; AMITRIPTYLINE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; BECN1 PROTEIN, MOUSE; CHAPERONE; HEAT SHOCK PROTEIN 90; MEMBRANE PROTEIN; PAROXETINE; TACROLIMUS BINDING PROTEIN 5;

ANTIDEPRESSANT ACTIVITY; ARTICLE; AUTOPHAGY; CORRELATIONAL STUDY; DEPRESSION; DRUG EFFECT; EX VIVO STUDY; KNOCKOUT MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOPRECIPITATION; METABOLISM; MOUSE; PHOSPHORYLATION;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BECLIN-1; BEHAVIOR, ANIMAL; DEPRESSION; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICE; MOLECULAR CHAPERONES; PAROXETINE; PHOSPHORYLATION; TACROLIMUS BINDING PROTEINS;

EID: 84938880388     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1017224     Document Type: Article

References (1)

1. Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, et al. Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans. Nestler E, ed. Plos Medicine 2014; 11(11): e1001755; http://dx. doi. org/10. 1371/journal. pmed. 1001755.