Characterization of a neuregulin-1 gene promoter: Positive regulation of type I isoforms by NF-κB

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1779, Issue 2, 2008, Pages 139-144

  Frensing, Timo ^a,b   Kaltschmidt, Christian ^b   Schmitt John, Thomas ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

Autoregulation; Breast cancer; Heregulin; Sp1; Transcriptional regulation; ZBP 89

Indexed keywords

ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; DOGS; GENES, REPORTER; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RATS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELA; TRANSCRIPTION INITIATION SITE;

MAMMALIA; MURINAE;

EID: 39449109866     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2007.11.007     Document Type: Article

References (29)

1. Yarden Y., and Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Rev., Mol. Cell Biol. 2 (2001) 127-137
2. Falls D.L. Neuregulins: functions, forms, and signaling strategies. Exp. Cell Res. 284 (2003) 14-30
3. Buonanno A., and Fischbach G.D. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11 (2001) 287-296
4. Meyer D., and Birchmeier C. Multiple essential functions of neuregulin in development. Nature 378 (1995) 386-390
5. Stove C., and Bracke M. Roles for neuregulins in human cancer. Clin. Exp. Metastasis 21 (2004) 665-684
6. Stefansson H., Steinthorsdottir V., Thorgeirsson T.E., Gulcher J.R., and Stefansson K. Neuregulin 1 and schizophrenia. Ann. Med. 36 (2004) 62-71
7. Kramer R., Bucay N., Kane D.J., Martin L.E., Tarpley J.E., and Theill L.E. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 4833-4838
8. Yang Y., Spitzer E., Meyer D., Sachs M., Niemann C., Hartmann G., Weidner K.M., Birchmeier C., and Birchmeier W. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol. 131 (1995) 215-226
9. Bai L., and Merchant J.L. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. J. Biol. Chem. 275 (2000) 30725-30733
10. Decker E.L., Nehmann N., Kampen E., Eibel H., Zipfel P.F., and Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 31 (2003) 911-921
11. Li L., Cleary S., Mandarano M.A., Long W., Birchmeier C., and Jones F.E. The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland. Oncogene 21 (2002) 4900-4907
12. Brantley D.M., Yull F.E., Muraoka R.S., Hicks D.J., Cook C.M., and Kerr L.D. Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech. Dev. 97 (2000) 149-155
13. Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V., and Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107 (2001) 763-775
14. Cao Y., and Karin M. NF-kappaB in mammary gland development and breast cancer. J. Mammary Gland Biol. Neoplasia 8 (2003) 215-223
15. Smale S.T., and Kadonaga J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72 (2003) 449-479
16. Hapgood J.P., Riedemann J., and Scherer S.D. Regulation of gene expression by GC-rich DNA cis-elements. Cell Biol. Int. 25 (2001) 17-31
17. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16 (1998) 225-260
18. Li X., and Stark G.R. NFkappaB-dependent signaling pathways. Exp. Hematol. 30 (2002) 285-296
19. Biswas D.K., Shi Q., Baily S., Strickland I., Ghosh S., Pardee A.B., and Iglehart J.D. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10137-10142
20. Tsai P.W., Shiah S.G., Lin M.T., Wu C.W., and Kuo M.L. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway. J. Biol. Chem. 278 (2003) 5750-5759
21. Pianetti S., Arsura M., Romieu-Mourez R., Coffey R.J., and Sonenshein G.E. Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene 20 (2001) 1287-1299
22. Bhat-Nakshatri P., Sweeney C.J., and Nakshatri H. Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells. Oncogene 21 (2002) 2066-2078
23. Alroy I., Soussan L., Seger R., and Yarden Y. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. Mol. Cell. Biol. 19 (1999) 1961-1972
24. Talukder A.H., Jorgensen H.F., Mandal M., Mishra S.K., Vadlamudi R.K., Clark B.F., Mendelsohn J., and Kumar R. Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies. J. Biol. Chem. 276 (2001) 5636-5642
25. Tsai M.S., Shamon-Taylor L.A., Mehmi I., Tang C.K., and Lupu R. Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. Oncogene 22 (2003) 761-768
26. Li Q., Ahmed S., and Loeb J.A. Development of an autocrine neuregulin signaling loop with malignant transformation of human breast epithelial cells. Cancer Res. 64 (2004) 7078-7085
27. Steinthorsdottir V., Stefansson H., Ghosh S., Birgisdottir B., Bjornsdottir S., Fasquel A.C., Olafsson O., Stefansson K., and Gulcher J.R. Multiple novel transcription initiation sites for NRG1. Gene 342 (2004) 97-105
28. Tan W., Wang Y., Gold B., Chen J., Dean M., Harrison P.J., Weinberger D.R., and Law A.J. Molecular cloning of a brain-specific, developmentally regulated Neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J. Biol. Chem. (2007)
29. Bours V., Burd P.R., Brown K., Villalobos J., Park S., Ryseck R.P., Bravo R., Kelly K., and Siebenlist U. A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol. Cell. Biol. 12 (1992) 685-695