Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Sabbagh, Jonathan J ^a   O'Leary, John C ^a   Blair, Laura J ^a   Klengel, Torsten ^b,c   Nordhues, Bryce A ^a   Fontaine, Sarah N ^a   Binder, Elisabeth B ^b,c   Dickey, Chad A ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; FK 506 BINDING PROTEIN; FK506 BINDING PROTEIN 51; UNCLASSIFIED DRUG; HYDROCORTISONE; TACROLIMUS BINDING PROTEIN 5;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; COPING BEHAVIOR; DNA METHYLATION; EPIGENETICS; EXECUTIVE FUNCTION; FEMALE; FK506 BINDING PROTEIN 5 GENE; GENE; GLUCOSE TOLERANCE; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; AGING; ANIMAL; BLOOD; GENETIC EPIGENESIS; GENETICS; KNOCKOUT MOUSE; LONGEVITY; MAJOR DEPRESSION; MENTAL STRESS; METABOLISM; PHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; UPREGULATION;

AGING; ANIMALS; DEPRESSIVE DISORDER, MAJOR; DNA METHYLATION; EPIGENESIS, GENETIC; HYDROCORTISONE; LONGEVITY; MICE; MICE, KNOCKOUT; POLYMORPHISM, SINGLE NUCLEOTIDE; RESILIENCE, PSYCHOLOGICAL; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; TACROLIMUS BINDING PROTEINS; UP-REGULATION;

EID: 84906996222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107241     Document Type: Article

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