CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Charpentier, M ^a   Khedher, A H Y ^a,b   Menoret, S ^c   Brion, A ^a   Lamribet, K ^a   Dardillac, E ^d   Boix, C ^a   Perrouault, L ^a   Tesson, L ^c   Geny, S ^a   De Cian, A ^a   Itier, J M ^b   Anegon, I ^c   Lopez, B ^d   Giovannangeli, C ^a   Concordet, J P ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b SANOFI   (France)

^c INSERM   (France)

^d INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN 9; GEMININ; GUIDE RNA; PROTEIN CTIP; UNCLASSIFIED DRUG; CARRIER PROTEIN; FUSION PROTEIN; NUCLEAR PROTEIN; RBBP8 PROTEIN, HUMAN;

CELL; CHEMICAL REACTION; EXPERIMENTAL STUDY; GENE; GENE EXPRESSION; GENOME; HOMOLOGY; PROTEIN; RNA;

AAVS1 GENE; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; DNA STRAND BREAKAGE; ENZYME PHOSPHORYLATION; GENE; GENE FUNCTION; HOMOLOGY DEPENDENT REPAIR; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; PROTEIN DOMAIN; TRANSGENE; ANIMAL; CELL LINE; CHEMISTRY; CRISPR CAS SYSTEM; DOUBLE STRANDED DNA BREAK; ENHANCER REGION; FEMALE; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; HOMOLOGOUS RECOMBINATION; INDEL MUTATION; METABOLISM; NUCLEOTIDE SEQUENCE; OOCYTE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; RAT; RECOMBINATION REPAIR; VIRUS DNA CELL DNA INTERACTION; ZYGOTE;

IPS; RATTUS;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; ENHANCER ELEMENTS, GENETIC; FEMALE; HCT116 CELLS; HEK293 CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; INDEL MUTATION; INDUCED PLURIPOTENT STEM CELLS; NUCLEAR PROTEINS; OOCYTES; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; RATS; RECOMBINANT FUSION PROTEINS; RECOMBINATIONAL DNA REPAIR; RNA, GUIDE; TRANSGENES; VIRUS INTEGRATION; ZYGOTE;

EID: 85044193162     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-03475-7     Document Type: Article

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