Activation of the sweet taste receptor, T1r3, by the artificial sweetener sucralose regulates the pulmonary endothelium

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 314, Issue 1, 2018, Pages L165-L176

  Harrington, Elizabeth O ^a,b   Vang, X Alexander ^a   Braza, Julie ^a,b   Shil, Aparna ^c   Chichger, Havovi ^c  

^a PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

^c ANGLIA RUSKIN UNIVERSITY   (United Kingdom)

Author keywords

Acute respiratory distress syndrome; Artificial sweeteners; Pulmonary endothelium; Sweet taste; T1R3

Indexed keywords

ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 27; LIPOPOLYSACCHARIDE; MYOSIN LIGHT CHAIN 2; P21 ACTIVATED KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P110ALPHA; PROTECTIVE AGENT; PROTEIN KINASE P60; RECEPTOR; SMALL INTERFERING RNA; SUCRALOSE; SWEET TASTE RECEPTOR T1R3; THROMBIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; ZINC SULFATE; G PROTEIN COUPLED RECEPTOR; SUCROSE; SWEETENING AGENT; TRICHLOROSUCROSE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIAL CELL; CELL CONTACT; CONTROLLED STUDY; EC50; ENDOTHELIAL DYSFUNCTION; GENE ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG ENDOTHELIUM; MALE; MRNA EXPRESSION LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PSEUDOMONAS AERUGINOSA; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SWEETNESS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CYTOLOGY; DRUG EFFECT; ISOLATION AND PURIFICATION; LUNG; METABOLISM; MICROBIOLOGY; MOUSE; PHOSPHORYLATION; PSEUDOMONAS INFECTION; TASTE; VASCULAR ENDOTHELIUM;

ANIMALS; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; LUNG; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SUCROSE; SWEETENING AGENTS; TASTE;

EID: 85043481136     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00490.2016     Document Type: Article

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