Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

Cell Stem Cell

Volumn 20, Issue 4, 2017, Pages 450-461.e4

  Alvarado, Alvaro G ^a,b   Thiagarajan, Praveena S ^a   Mulkearns Hubert, Erin E ^a   Silver, Daniel J ^a   Hale, James S ^a   Alban, Tyler J ^a,b   Turaga, Soumya M ^a   Jarrar, Awad ^a   Reizes, Ofer ^a,b,c   Longworth, Michelle S ^a   Vogelbaum, Michael A ^a,b,c   Lathia, Justin D ^a,b,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

cancer stem cells; glioblastoma; innate immunity; pluripotency transcription factors; RBBP5; TLR4

Indexed keywords

RETINOBLASTOMA BINDING PROTEIN; RETINOBLASTOMA BINDING PROTEIN 5; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; RBBP5 PROTEIN, HUMAN; TBK1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA STEM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; STEM CELL SELF-RENEWAL; TUMOR GROWTH; TUMOR HYPOXIA; TUMOR MICROENVIRONMENT; TUMOR NECROSIS; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CANCER STEM CELL; CELL SELF-RENEWAL; FEMALE; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SELF RENEWAL; FEMALE; GLIOBLASTOMA; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; MICE; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 85009789263     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.12.001     Document Type: Article

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