Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Nature Medicine

Volumn 24, Issue 3, 2018, Pages 292-303

  Bartelt, Alexander ^a   Widenmaier, Scott B ^a   Schlein, Christian ^a   Johann, Kornelia ^a   Goncalves, Renata L S ^a   Eguchi, Kosei ^a   Fischer, Alexander W ^a   Parlakgül, Günes ^a   Snyder, Nicole A ^a   Nguyen, Truc B ^a   Bruns, Oliver T ^b,e   Franke, Daniel ^b   Bawendi, Moungi G ^b   Lynes, Matthew D ^c   Leiria, Luiz O ^c   Tseng, Yu Hua ^c   Inouye, Karen E ^a   Arruda, Ana Paula ^a   Hotamisligil, Gökhan S ^a,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADIPONECTIN; AMINOTRANSFERASE; BETA GALACTOSIDASE; BORTEZOMIB; CARFILZOMIB; CASPASE; CD68 ANTIGEN; CELL PROTEIN; CHOLESTEROL; CRE RECOMBINASE; EPOXOMICIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEASOME; TAMOXIFEN; THAPSIGARGIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF1; TRIACYLGLYCEROL; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; X BOX BINDING PROTEIN 1; NRF1 PROTEIN, MOUSE; NUCLEAR RESPIRATORY FACTOR 1; PSME1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL METABOLISM; COLD ACCLIMATIZATION; CONTROLLED STUDY; DIETARY INTAKE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE DELETION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; INFLAMMATION; INSULIN SENSITIVITY; METABOLIC STRESS; MITOCHONDRION; MOUSE; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN QUALITY; QUALITY CONTROL; ACCLIMATIZATION; ANIMAL; ANIMAL MODEL; COLD; GENETICS; HOMEOSTASIS; INSULIN RESISTANCE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; THERMOGENESIS;

ACCLIMATIZATION; ADIPOSE TISSUE, BROWN; ANIMALS; COLD TEMPERATURE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MITOCHONDRIA; MODELS, ANIMAL; NUCLEAR RESPIRATORY FACTOR 1; OBESITY; PROTEASOME ENDOPEPTIDASE COMPLEX; THERMOGENESIS;

EID: 85042935892     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4481     Document Type: Article

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