NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

Cell

Volumn 171, Issue 5, 2017, Pages 1094.e15-1109.e15

  Widenmaier, Scott B ^a   Snyder, Nicole A ^a   Nguyen, Truc B ^a   Arduini, Alessandro ^a   Lee, Grace Y ^a   Arruda, Ana Paula ^a   Saksi, Jani ^a   Bartelt, Alexander ^a   Hotamisligil, Gökhan S ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

cholesterol; endoplasmic reticulum; immunometabolism; inflammation; liver; metabolism; Nfe2L1; Nrf1; stress

Indexed keywords

CD36 ANTIGEN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR NRF1; CHOLESTEROL; NRF1 PROTEIN, MOUSE; NUCLEAR RESPIRATORY FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CHOLESTEROL HOMEOSTASIS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM MEMBRANE; HOMEOSTASIS; IN VIVO STUDY; LIPID ANALYSIS; LIPID COMPOSITION; LIVER DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; ENDOPLASMIC RETICULUM; FATTY LIVER; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; LIVER; METABOLISM;

ANIMALS; CD36 ANTIGENS; CHOLESTEROL; ENDOPLASMIC RETICULUM; FATTY LIVER; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; LIVER; MICE; NUCLEAR RESPIRATORY FACTOR 1; TRANSCRIPTION, GENETIC;

EID: 85034065043     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.10.003     Document Type: Article

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